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Entry version 31 (26 Feb 2020)
Sequence version 2 (21 Mar 2012)
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Protein

Alpha-latrotoxin-Lh1a

Gene
N/A
Organism
Latrodectus hasselti (Redback spider)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Presynaptic neurotoxin that induces exhaustive neurotransmitter release from vertebrate (but not invertebrate) nerve terminals and endocrine cells. Binds to neurexin-1-alpha (NRXN1), adhesion G protein-coupled receptor L1 (ADGRL1, also known as latrophilin-1), and receptor-type tyrosine-protein phosphatase S (PTPRS), and induces neurotransmitter exocytosis through two calcium-dependent mechanisms (membrane pore formation and signaling via latrophilin) and a yet to be defined calcium-independent mechanism (By similarity).

Induces rapid muscle contracture and loss of twitch tension when added to the isolated and indirectly stimulated chick biventer cervicis nerve-muscle preparation.

By similarity1 Publication

Miscellaneous

Is the main neurotoxin responsible for the human envenomation syndrome known as latrodectism that results from bites by Latrodectus species.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionNeurotoxin, Presynaptic neurotoxin, Toxin
Biological processExocytosis

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Alpha-latrotoxin-Lh1a
Short name:
Alpha-LTX-Lh1a
Alternative name(s):
Alpha-latrotoxin
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiLatrodectus hasselti (Redback spider)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri256736 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaChelicerataArachnidaAraneaeAraneomorphaeEntelegynaeAraneoideaTheridiidaeLatrodectus

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Membrane, Secreted, Target cell membrane, Target membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the lethal dose (LD), paralytic dose (PD), effect dose (ED) or lethal concentration (LC) of a protein toxin.<p><a href='/help/toxic_dose' target='_top'>More...</a></p>Toxic dosei

LD50is 20 µg/kg by subcutaneous injection into mice.

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei‹1 – 7Sequence analysis›7
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_50007835708 – 1187Alpha-latrotoxin-Lh1aAdd BLAST1180
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section describes a propeptide, which is a part of a protein that is cleaved during maturation or activation. Once cleaved, a propeptide generally has no independent biological function.<p><a href='/help/propep' target='_top'>More...</a></p>PropeptideiPRO_00004159311188 – ›1351By similarityAdd BLAST›164

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi401 ↔ 1054Curated

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Processed by furin-like proteases at both the N- and C-termini.

Keywords - PTMi

Disulfide bond

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed by the venom gland.

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homotetramer; Homotetramerization is triggered by calcium and is responsible for non-vesicular release and calcium-dependent vesicular exocytosis.

By similarity

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
G0LXV8

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati446 – 477ANK 1Add BLAST32
Repeati478 – 509ANK 2Add BLAST32
Repeati513 – 542ANK 3Add BLAST30
Repeati547 – 577ANK 4Add BLAST31
Repeati581 – 610ANK 5Add BLAST30
Repeati614 – 644ANK 6Add BLAST31
Repeati648 – 678ANK 7Add BLAST31
Repeati683 – 711ANK 8Add BLAST29
Repeati717 – 746ANK 9Add BLAST30
Repeati750 – 779ANK 10Add BLAST30
Repeati783 – 812ANK 11Add BLAST30
Repeati816 – 846ANK 12Add BLAST31
Repeati850 – 879ANK 13Add BLAST30
Repeati883 – 912ANK 14Add BLAST30
Repeati916 – 945ANK 15Add BLAST30
Repeati959 – 991ANK 16Add BLAST33
Repeati992 – 1019ANK 17Add BLAST28
Repeati1023 – 1052ANK 18Add BLAST30
Repeati1056 – 1085ANK 19Add BLAST30
Repeati1089 – 1119ANK 20Add BLAST31
Repeati1125 – 1154ANK 21Add BLAST30
Repeati1158 – 1187ANK 22Add BLAST30

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni4 – 7Furin-like endopeptidase recognition region4
Regioni1184 – 1187Furin-like endopeptidase recognition region4

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

ANK repeat, Repeat, Signal, Transmembrane

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.25.40.20, 4 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR002110, Ankyrin_rpt
IPR020683, Ankyrin_rpt-contain_dom
IPR036770, Ankyrin_rpt-contain_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF12796, Ank_2, 5 hits

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR01415, ANKYRIN

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00248, ANK, 20 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48403, SSF48403, 3 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50297, ANK_REP_REGION, 1 hit
PS50088, ANK_REPEAT, 10 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Fragment.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

G0LXV8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
SLVRMRREGE EDLTLEEKAE LCSELELQQK YVDIGSNIIG DLSSLPIVGK
60 70 80 90 100
IVGTIAAAAM AVTHVASGRL DIEQTLGGCS DVPFDQIKEI LEERFNEIDR
110 120 130 140 150
KLESHSAALE EITKLVEKSI SAVEKTRKQM NKRFDEVMRS IQDAKVSPLV
160 170 180 190 200
SKINNFARYF DTEKERIRGL KLSDYILKLE EPNGILLHFK ESRTPRDDSL
210 220 230 240 250
QAPLFSIIQE RYAVPKSIDD ELAFKVLYAL LYGTQTYVSV MFFLLEQYSF
260 270 280 290 300
LANHYYEKGD LEKYDEYFNS LNNVFLDFKS SLVGTGTSNN EGLLDRVLQV
310 320 330 340 350
LVTVKNSEFL GLEKNGVNEM LNEKINLFNK IKVEIEGKQR MTLSETPENF
360 370 380 390 400
AQISFDKDIT TPIGDWRDGR EVRYAVQYAS ETLFSKISHW SDPVGVREKA
410 420 430 440 450
CPTLRMPVDQ TRRNILVFRK FDSSKPQLVG EITPYQSNFI DIDRDLYNTA
460 470 480 490 500
NNPDSAVGFK EFTKLNYDGA NIRATFEQGR TVFHAAAKSG NSRIMIGLTF
510 520 530 540 550
LVKSNELNQP DKKGYTPIHV AADSGNAGIV NLLIQRGVSI NSKTYNFLQT
560 570 580 590 600
PLHLAAQRGF VTTFQRLMES PEININERDK DGFTPLHYAV RGGERILEAF
610 620 630 640 650
INQIRIDLNA KSNKGLTPFH LAIIKDDWPV ASTLLGSKKV DVNAVDENNM
660 670 680 690 700
TALHYAAILG YLETTKQLIN LKEINADVVS SPGLLSALHY AILYKHDDVA
710 720 730 740 750
SFLLRSSNVN VNLKALGGIT PLHLAVIQGR TQILSLMFDI GVNIEQQTDE
760 770 780 790 800
KYTPLHLAAM SKYPELIQIL LDQGSNFEAK TNSGATPLHL ATFKGKSKAA
810 820 830 840 850
LILLNNEVNW RDTDENGQMP IHGAAMNGLL DVAQAIISID ATVLDIKDKN
860 870 880 890 900
SDTPLNLAAQ KSHIDVIKYF IDQGADINTR NKTGHAPLLA FSKKGNLDMV
910 920 930 940 950
KYLFDKNANV YIADNDGINF FYYAVRNGHL NIVKYAMSEK DKFEWSNIDN
960 970 980 990 1000
NRRDECPKEE CAISHFAVCD AVQFDKIEIV KYFVTTLGNF AICGPLHQAA
1010 1020 1030 1040 1050
RYGHLDIEKY LVEEEDLNVD GSKPDTPLCY ASENGHLAVV QYLVSNGAKV
1060 1070 1080 1090 1100
NHDCGNGMTA IDKAITKNHL QVVQFLAANG VDFRRKNKLG ATPFLTAVSE
1110 1120 1130 1140 1150
NAFDIAEYLI RENRQDIDIN EQNVDKETAL HLAVYYKNLQ MIKLLVKYGI
1160 1170 1180 1190 1200
DMTIRNAYDK TALDIATDLK NSNIVEYLKT KSGKFRREYK SSYGEHSLLQ
1210 1220 1230 1240 1250
TNKISSFIDG KNIEHDHPQF INADNESSQL FSDTASNIDV IGPLLLIDVL
1260 1270 1280 1290 1300
IRYFSKQGYI SKESDSASDG ITQAAALSIT EKFEDVLNSL HNESAKEQVD
1310 1320 1330 1340 1350
LAEVHGKVYA ALKSGRNSQI HPILCSSLKS ISTLKPEDME KLGSVIMNSH

S
Length:1,351
Mass (Da):151,407
Last modified:March 21, 2012 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i1200C1B85D42A908
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section is used for sequence fragments to indicate that the residue at the extremity of the sequence is not the actual terminal residue in the complete protein sequence.<p><a href='/help/non_ter' target='_top'>More...</a></p>Non-terminal residuei11
<p>This subsection of the 'Sequences' section is used to describe region(s) of a sequence for which the authors are unsure about the sequence assignment.<p><a href='/help/unsure' target='_top'>More...</a></p>Sequence uncertaintyi1202Assigned by comparison with orthologs1
Sequence uncertaintyi1215Assigned by comparison with orthologs1
Non-terminal residuei13511

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
FR851877 Genomic DNA Translation: CCA64564.1

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FR851877 Genomic DNA Translation: CCA64564.1

3D structure databases

SMRiG0LXV8
ModBaseiSearch...

Family and domain databases

Gene3Di1.25.40.20, 4 hits
InterProiView protein in InterPro
IPR002110, Ankyrin_rpt
IPR020683, Ankyrin_rpt-contain_dom
IPR036770, Ankyrin_rpt-contain_sf
PfamiView protein in Pfam
PF12796, Ank_2, 5 hits
PRINTSiPR01415, ANKYRIN
SMARTiView protein in SMART
SM00248, ANK, 20 hits
SUPFAMiSSF48403, SSF48403, 3 hits
PROSITEiView protein in PROSITE
PS50297, ANK_REP_REGION, 1 hit
PS50088, ANK_REPEAT, 10 hits

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiLATA_LATHA
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: G0LXV8
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 21, 2012
Last sequence update: March 21, 2012
Last modified: February 26, 2020
This is version 31 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programAnimal Toxin Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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