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Protein

Proteasome subunit beta

Gene

psmB

Organism
Methanococcus maripaludis X1
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation.UniRule annotationSAAS annotation

Catalytic activityi

Cleavage of peptide bonds with very broad specificity.UniRule annotationSAAS annotation

Enzyme regulationi

The formation of the proteasomal ATPase PAN-20S proteasome complex, via the docking of the C-termini of PAN into the intersubunit pockets in the alpha-rings, triggers opening of the gate for substrate entry. Interconversion between the open-gate and close-gate conformations leads to a dynamic regulation of the 20S proteasome proteolysis activity.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei15NucleophileUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Protease, Threonine proteaseUniRule annotationSAAS annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Proteasome subunit betaUniRule annotation (EC:3.4.25.1UniRule annotation)
Alternative name(s):
20S proteasome beta subunitUniRule annotation
Proteasome core protein PsmBUniRule annotation
Gene namesi
Name:psmBUniRule annotation
ORF Names:GYY_02780Imported
OrganismiMethanococcus maripaludis X1Imported
Taxonomic identifieri1053692 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanococciMethanococcalesMethanococcaceaeMethanococcus
Proteomesi
  • UP000008889 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotationSAAS annotation

GO - Cellular componenti

Keywords - Cellular componenti

CytoplasmUniRule annotationSAAS annotation, ProteasomeUniRule annotationSAAS annotationImported

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
PropeptideiPRO_50050534831 – 14Removed in mature form; by autocatalysisUniRule annotationAdd BLAST14

Keywords - PTMi

Autocatalytic cleavageUniRule annotation, ZymogenUniRule annotation

Interactioni

Subunit structurei

The 20S proteasome core is composed of 14 alpha and 14 beta subunits that assemble into four stacked heptameric rings, resulting in a barrel-shaped structure. The two inner rings, each composed of seven catalytic beta subunits, are sandwiched by two outer rings, each composed of seven alpha subunits. The catalytic chamber with the active sites is on the inside of the barrel. Has a gated structure, the ends of the cylinder being occluded by the N-termini of the alpha-subunits. Is capped at one or both ends by the proteasome regulatory ATPase, PAN.UniRule annotationSAAS annotation

Structurei

3D structure databases

ProteinModelPortaliG0H3W9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase T1B family.UniRule annotationSAAS annotation

Phylogenomic databases

KOiK03433
OMAiDLCVIRK
OrthoDBiPOG093Z0CM8

Family and domain databases

CDDicd03764 proteasome_beta_archeal, 1 hit
Gene3Di3.60.20.10, 1 hit
HAMAPiMF_02113_A Proteasome_B_A, 1 hit
InterProiView protein in InterPro
IPR029055 Ntn_hydrolases_N
IPR019983 Pept_T1A_Psome_bsu_arc
IPR000243 Pept_T1A_subB
IPR016050 Proteasome_bsu_CS
IPR001353 Proteasome_sua/b
IPR023333 Proteasome_suB-type
PfamiView protein in Pfam
PF00227 Proteasome, 1 hit
PRINTSiPR00141 PROTEASOME
SUPFAMiSSF56235 SSF56235, 1 hit
TIGRFAMsiTIGR03634 arc_protsome_B, 1 hit
PROSITEiView protein in PROSITE
PS00854 PROTEASOME_BETA_1, 1 hit
PS51476 PROTEASOME_BETA_2, 1 hit

Sequencei

Sequence statusi: Complete.

G0H3W9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MISNSEYHKE YMKGTTTVGL LCNDGVVLAT DKRATMGNLI ADKEAKKLYK
60 70 80 90 100
IDDYIAMTIA GSVGDAQSLI RLISAEAKIY KMRTGNNMTP LSCTTLISNV
110 120 130 140 150
LHGNRHYPLL TQLILGGYDL INGAKLFSLD PVGGINEESS FTATGSGSPT
160 170 180 190 200
AYGVLESEYK SDIAIEKGLL IAVKALSSAM QRDAYSGNGI SLAHINKDGV
210
KLYSDAEIEG FLKKINRKR
Length:219
Mass (Da):23,648
Last modified:October 19, 2011 - v1
Checksum:i7E24CC7CBEB4561D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002913 Genomic DNA Translation: AEK19435.1
RefSeqiWP_011170639.1, NC_015847.1

Genome annotation databases

GeneIDi36101377
KEGGimmd:GYY_02780
PATRICifig|1053692.7.peg.547

Similar proteinsi

Entry informationi

Entry nameiG0H3W9_METMI
AccessioniPrimary (citable) accession number: G0H3W9
Entry historyiIntegrated into UniProtKB/TrEMBL: October 19, 2011
Last sequence update: October 19, 2011
Last modified: May 23, 2018
This is version 43 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

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