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Protein

Pyruvate carboxylase

Gene

PYC

Organism
Zymoseptoria tritici (strain CBS 115943 / IPO323) (Speckled leaf blotch fungus) (Septoria tritici)
Status
Unreviewed-Annotation score: -Protein predictedi

Functioni

Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second.UniRule annotation

Catalytic activityi

ATP + pyruvate + HCO3- = ADP + phosphate + oxaloacetate.UniRule annotation

Cofactori

biotinUniRule annotationSAAS annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei159ATPUniRule annotation1
Binding sitei243ATPUniRule annotation1
Binding sitei278ATPUniRule annotation1
Active sitei335UniRule annotation1
Metal bindingi588Divalent metal cationUniRule annotation1
Binding sitei660SubstrateUniRule annotation1
Metal bindingi756Divalent metal cation; via carbamate groupUniRule annotation1
Metal bindingi786Divalent metal cationUniRule annotation1
Metal bindingi788Divalent metal cationUniRule annotation1
Binding sitei921SubstrateUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLigaseUniRule annotationSAAS annotationImported
LigandATP-bindingUniRule annotationSAAS annotation, BiotinUniRule annotationSAAS annotation, Metal-bindingUniRule annotation, Nucleotide-binding, PyruvateImported

Names & Taxonomyi

Protein namesi
Recommended name:
Pyruvate carboxylaseUniRule annotation (EC:6.4.1.1UniRule annotation)
Gene namesi
Name:PYCImported
ORF Names:MYCGRDRAFT_73616Imported
OrganismiZymoseptoria tritici (strain CBS 115943 / IPO323) (Speckled leaf blotch fungus) (Septoria tritici)Imported
Taxonomic identifieri336722 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaDothideomycetesDothideomycetidaeCapnodialesMycosphaerellaceaeZymoseptoria
Proteomesi
  • UP000008062 Componenti: Chromosome 7

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini41 – 493Biotin carboxylationInterPro annotationAdd BLAST453
Domaini163 – 360ATP-graspInterPro annotationAdd BLAST198
Domaini579 – 847Pyruvate carboxyltransferaseInterPro annotationAdd BLAST269
Domaini1116 – 1191Lipoyl-bindingInterPro annotationAdd BLAST76

Phylogenomic databases

InParanoidiF9XGC6
KOiK01958
OrthoDBiEOG092C0BFY

Family and domain databases

Gene3Di3.20.20.70, 1 hit
InterProiView protein in InterPro
IPR013785 Aldolase_TIM
IPR011761 ATP-grasp
IPR005481 BC-like_N
IPR001882 Biotin_BS
IPR011764 Biotin_carboxylation_dom
IPR005482 Biotin_COase_C
IPR000089 Biotin_lipoyl
IPR003379 Carboxylase_cons_dom
IPR005479 CbamoylP_synth_lsu-like_ATP-bd
IPR016185 PreATP-grasp_dom_sf
IPR000891 PYR_CT
IPR005930 Pyruv_COase
IPR011054 Rudment_hybrid_motif
IPR011053 Single_hybrid_motif
PfamiView protein in Pfam
PF02785 Biotin_carb_C, 1 hit
PF00289 Biotin_carb_N, 1 hit
PF00364 Biotin_lipoyl, 1 hit
PF02786 CPSase_L_D2, 1 hit
PF00682 HMGL-like, 1 hit
PF02436 PYC_OADA, 1 hit
PIRSFiPIRSF001594 Pyruv_carbox, 1 hit
SMARTiView protein in SMART
SM00878 Biotin_carb_C, 1 hit
SUPFAMiSSF51230 SSF51230, 1 hit
SSF51246 SSF51246, 1 hit
SSF52440 SSF52440, 1 hit
TIGRFAMsiTIGR01235 pyruv_carbox, 1 hit
PROSITEiView protein in PROSITE
PS50975 ATP_GRASP, 1 hit
PS50979 BC, 1 hit
PS00188 BIOTIN, 1 hit
PS50968 BIOTINYL_LIPOYL, 1 hit
PS00866 CPSASE_1, 1 hit
PS00867 CPSASE_2, 1 hit
PS50991 PYR_CT, 1 hit

Sequencei

Sequence statusi: Complete.

F9XGC6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSTTQKEKEN TDYGTPHADG DTHQDANTVH TRLRANSSIM QLNKILVANR
60 70 80 90 100
GEIPIRIFRT AHELSLQTVA VYSHEDRLSM HRQKADEAYV IGKRGQYTPV
110 120 130 140 150
GAYLAGDEII KIAKAHGVHF IHPGYGFLSE NYEFAKAVEA AGIIWVGPNP
160 170 180 190 200
ETINDLGDKV SARKLAAKAD VPTVPGTPGP VAKFEACKEF TDEYGFPIII
210 220 230 240 250
KAAFGGGGRG MRVVWKQEDL KDSFERATSE AKSAFGNGTV FIERFLYRPK
260 270 280 290 300
HIEVQLLGDN HGNVVHLYER DCSVQRRHQK VVELAPAKDL PQETRDAILN
310 320 330 340 350
DAVRLAKSAN YRNAGTAEFL VDQEGRHYFI EINPRIQVEH TITEEITGID
360 370 380 390 400
IVAAQIQIAA GASLEQLGLT QDRISTRGFA IQCRITTEDP AEQFKPDTGK
410 420 430 440 450
IEVYRSAGGN GVRLDGGNGF SGAVITPYYD SMLVKCTCLG STYEIARRKV
460 470 480 490 500
LRALVEFRIR GLKTNIPFLA SLLTHETFIE SKCWTTFIDD TPELFKLIGS
510 520 530 540 550
QNRAQKLLSY LGEVVVNGPQ VVGQIGESKF KGEAIIPTLY DDAGKEIDTS
560 570 580 590 600
VPCTKGWRNI IVEQGPEAFA KAMRKNKGCL IMDTTWRDAH QSLLATRMRT
610 620 630 640 650
IDLLNIAKET SYALSNAWAL ECWGGATFDV AMRFLYEDPW ERLRKMRKAV
660 670 680 690 700
PNIPFQMLLR GANGVAYSSL PDNAIYHFCE QAKKNGMDIF RVFDALNDTD
710 720 730 740 750
QLEVGVSAVL KAGGVAEGTV CYSGDMLNPE KKYNLEYYMK VVDKIVKMGA
760 770 780 790 800
HIIGVKDMAG VLKPKAARLL IGSIREKYPD IPIHVHTHDS AGTGVASMVA
810 820 830 840 850
CAQAGADAVD AATDSLSGTT SQPSIGALVA SLEGSDFEAG LNSHHLRALD
860 870 880 890 900
SYWAQVRMTY SPFEAWLTGP DPEVYEHEIP GGQLTNLIFQ ASQQGLGAQW
910 920 930 940 950
AQTKKAYEQA NDLLGDIVKV TPTSKVVGDL AQFMVSNNLT PEEVREKAKE
960 970 980 990 1000
LDFPSSVLEF FEGLMGQPYG GFPEPLRSDA LRDRRKMDKR PGHYLSPINF
1010 1020 1030 1040 1050
DEIREKLKEE YGGCSETDVA SYTMYAKVFQ DYKKFTAKYG DLSVLPTRYF
1060 1070 1080 1090 1100
LNKPEVGEEF SVELEKGKII ILKLLAVGPL SEQTGQREVF FETNGEMRQV
1110 1120 1130 1140 1150
TVQDSHASVE NVSRPKADSG DSSQVGAPMS GMVVEIRLKD GADVNKGDPI
1160 1170 1180 1190
AILSAMKMEM VISAPHSGKV ESMSVKEGDS VDSGDLVCKI AK
Length:1,192
Mass (Da):131,356
Last modified:October 19, 2011 - v1
Checksum:i98A0CC2D83F1849B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CM001202 Genomic DNA Translation: EGP86289.1
RefSeqiXP_003851313.1, XM_003851265.1

Genome annotation databases

EnsemblFungiiMycgr3T73616; Mycgr3P73616; Mycgr3G73616
GeneIDi13395304
KEGGiztr:MYCGRDRAFT_73616

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CM001202 Genomic DNA Translation: EGP86289.1
RefSeqiXP_003851313.1, XM_003851265.1

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiMycgr3T73616; Mycgr3P73616; Mycgr3G73616
GeneIDi13395304
KEGGiztr:MYCGRDRAFT_73616

Phylogenomic databases

InParanoidiF9XGC6
KOiK01958
OrthoDBiEOG092C0BFY

Family and domain databases

Gene3Di3.20.20.70, 1 hit
InterProiView protein in InterPro
IPR013785 Aldolase_TIM
IPR011761 ATP-grasp
IPR005481 BC-like_N
IPR001882 Biotin_BS
IPR011764 Biotin_carboxylation_dom
IPR005482 Biotin_COase_C
IPR000089 Biotin_lipoyl
IPR003379 Carboxylase_cons_dom
IPR005479 CbamoylP_synth_lsu-like_ATP-bd
IPR016185 PreATP-grasp_dom_sf
IPR000891 PYR_CT
IPR005930 Pyruv_COase
IPR011054 Rudment_hybrid_motif
IPR011053 Single_hybrid_motif
PfamiView protein in Pfam
PF02785 Biotin_carb_C, 1 hit
PF00289 Biotin_carb_N, 1 hit
PF00364 Biotin_lipoyl, 1 hit
PF02786 CPSase_L_D2, 1 hit
PF00682 HMGL-like, 1 hit
PF02436 PYC_OADA, 1 hit
PIRSFiPIRSF001594 Pyruv_carbox, 1 hit
SMARTiView protein in SMART
SM00878 Biotin_carb_C, 1 hit
SUPFAMiSSF51230 SSF51230, 1 hit
SSF51246 SSF51246, 1 hit
SSF52440 SSF52440, 1 hit
TIGRFAMsiTIGR01235 pyruv_carbox, 1 hit
PROSITEiView protein in PROSITE
PS50975 ATP_GRASP, 1 hit
PS50979 BC, 1 hit
PS00188 BIOTIN, 1 hit
PS50968 BIOTINYL_LIPOYL, 1 hit
PS00866 CPSASE_1, 1 hit
PS00867 CPSASE_2, 1 hit
PS50991 PYR_CT, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiF9XGC6_ZYMTI
AccessioniPrimary (citable) accession number: F9XGC6
Entry historyiIntegrated into UniProtKB/TrEMBL: October 19, 2011
Last sequence update: October 19, 2011
Last modified: April 25, 2018
This is version 48 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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