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Entry version 51 (29 Sep 2021)
Sequence version 1 (19 Oct 2011)
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Protein

Mechanosensitive ion channel protein

Gene

MYCGRDRAFT_67398

Organism
Zymoseptoria tritici (strain CBS 115943 / IPO323) (Speckled leaf blotch fungus) (Septoria tritici)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section specifies the position(s) of the calcium-binding region(s) within the protein. One common calcium-binding motif is the EF-hand, but other calcium-binding motifs also exist.<p><a href='/help/ca_bind' target='_top'>More...</a></p>Calcium bindingi480 – 491PROSITE-ProRule annotationAdd BLAST12

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

LigandCalciumPROSITE-ProRule annotation

Protein family/group databases

Transport Classification Database

More...
TCDBi
1.A.23.4.9, the small conductance mechanosensitive ion channel (mscs) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Mechanosensitive ion channel proteinUniRule annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
ORF Names:MYCGRDRAFT_67398Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiZymoseptoria tritici (strain CBS 115943 / IPO323) (Speckled leaf blotch fungus) (Septoria tritici)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri336722 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaDothideomycetesDothideomycetidaeMycosphaerellalesMycosphaerellaceaeZymoseptoria
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000008062 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei184 – 206HelicalSequence analysisAdd BLAST23
Transmembranei218 – 251HelicalSequence analysisAdd BLAST34
Transmembranei271 – 288HelicalSequence analysisAdd BLAST18
Transmembranei308 – 331HelicalSequence analysisAdd BLAST24
Transmembranei523 – 548HelicalSequence analysisAdd BLAST26

Keywords - Cellular componenti

Endoplasmic reticulumUniRule annotation, Membrane

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
1047171.Mycgr3P67398

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini467 – 502EF-handInterPro annotationAdd BLAST36

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 75DisorderedSequence analysisAdd BLAST75
Regioni80 – 99DisorderedSequence analysisAdd BLAST20
Regioni759 – 826DisorderedSequence analysisAdd BLAST68
Regioni864 – 932DisorderedSequence analysisAdd BLAST69
Regioni967 – 1025DisorderedSequence analysisAdd BLAST59

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili107 – 127Sequence analysisAdd BLAST21
Coiled coili669 – 689Sequence analysisAdd BLAST21

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi15 – 38Polar residuesSequence analysisAdd BLAST24
Compositional biasi794 – 826Polar residuesSequence analysisAdd BLAST33
Compositional biasi866 – 893Basic and acidic residuesSequence analysisAdd BLAST28
Compositional biasi967 – 989Polar residuesSequence analysisAdd BLAST23

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the MscS (TC 1.A.23) family. [View classification]UniRule annotationARBA annotation

Keywords - Domaini

Coiled coilSequence analysis, Transmembrane, Transmembrane helixSequence analysisARBA annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG4629, Eukaryota

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_010480_1_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
F9X0Q3

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.30.30.60, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR011992, EF-hand-dom_pair
IPR018247, EF_Hand_1_Ca_BS
IPR002048, EF_hand_dom
IPR010920, LSM_dom_sf
IPR016688, MscS-like_plants/fungi
IPR006685, MscS_channel
IPR023408, MscS_dom_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00924, MS_channel, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF017209, Memb_At2g17000_prd, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47473, SSF47473, 1 hit
SSF50182, SSF50182, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00018, EF_HAND_1, 1 hit
PS50222, EF_HAND_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

F9X0Q3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSDPPAAQGR TSLDGPTLPA YNVNNRQRGN SRGAGSTTDG TMVGEGEEYQ
60 70 80 90 100
PRRSSSKENQ LPPPTRPRAG SLLTVRTEYE PGDPLRSMAS PSQTREQAHR
110 120 130 140 150
LDDDLALLKI ERQISRIDEE LSRTKSAGAD TSKSRSRIDH VDEFDEATNP
160 170 180 190 200
VHERTAVYKP VESPATGFAK FVKHIHHSNW LVRYFTYIVP VVLILLIPLL
210 220 230 240 250
LGAYVFDDAL VGGVELMWFM IWLQIVWLTL WCGRILAKCL PVPIGLVASL
260 270 280 290 300
FTNNAKKWRD MGKQLELPGT IFFWWLAIEI SFLPTMINHQ RGRPSGTVRP
310 320 330 340 350
WMNTMNKVLV SFFVGAVLNF LEKILIQFIA ISFHLRTYAD RIDINKFQIG
360 370 380 390 400
SLTKLYTFSK RTIEMEDEEF EQKDEGGGSG ARTPGQALAD AAKTGKKALG
410 420 430 440 450
KFGDVAGKVA GDFTGKTVVA STHPTQVVLA LLHTTSGAQV LARRLYRTFA
460 470 480 490 500
REETATVISD DLRPAFENDD EADAAFTMFD KDMNGDISME ELEAVCVEIG
510 520 530 540 550
RERKSITASL KDLDSVVSKL DDVFMFIVVV IVILVFVSLI STSAAGVLTS
560 570 580 590 600
AGSAVLALSW LFSATAQEFL QSVIFVFVKH PFDVGDRVGI YGNTGALMRG
610 620 630 640 650
DDYFVKEISL LYTEFKKMEG HIVQAPNSYL NTLFILNQRR SGGLAEAVSI
660 670 680 690 700
TIKFGTTLEQ IESLRNRLLE FVQSEKREYQ NNILTELREI VEVHSLKLNV
710 720 730 740 750
VFFYKSNWQN EGLRLARRNK FFCAMMVIIQ ELGIEGPRMR EPGMRETFPM
760 770 780 790 800
YLANVPHTAS AGAGHNGNPD NPHGIHDNQQ NEEEFMDPPF VSPIPGQETS
810 820 830 840 850
TGSQAPHNRI NRGGSILRTR TRGESISQMT KRVDFSLGMQ NAAATDMSGD
860 870 880 890 900
VYEDRDPTRA QMNIIQASRD RERSRASQER VRESNELHLA RTTSREQPDF
910 920 930 940 950
APAGGGIVRR STSASVHRNR FFGRRKPAAG EEAMMESGMA EIPEEGGTTP
960 970 980 990 1000
HNRIDPRTGM VSPAAWRMTS DQSNLAPQNS ASTAAPPQLP RQVSGHGSLG
1010 1020
DVTNGSVPTY PPGHRPIGRA QTDVK
Length:1,025
Mass (Da):113,741
Last modified:October 19, 2011 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iF36ADEDD4526A03C
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
CM001196 Genomic DNA Translation: EGP91917.1

NCBI Reference Sequences

More...
RefSeqi
XP_003856941.1, XM_003856893.1

Genome annotation databases

Ensembl fungal genome annotation project

More...
EnsemblFungii
Mycgr3T67398; Mycgr3P67398; Mycgr3G67398

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
13398226

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
ztr:MYCGRDRAFT_67398

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CM001196 Genomic DNA Translation: EGP91917.1
RefSeqiXP_003856941.1, XM_003856893.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi1047171.Mycgr3P67398

Protein family/group databases

TCDBi1.A.23.4.9, the small conductance mechanosensitive ion channel (mscs) family

Genome annotation databases

EnsemblFungiiMycgr3T67398; Mycgr3P67398; Mycgr3G67398
GeneIDi13398226
KEGGiztr:MYCGRDRAFT_67398

Phylogenomic databases

eggNOGiKOG4629, Eukaryota
HOGENOMiCLU_010480_1_0_1
InParanoidiF9X0Q3

Family and domain databases

Gene3Di2.30.30.60, 1 hit
InterProiView protein in InterPro
IPR011992, EF-hand-dom_pair
IPR018247, EF_Hand_1_Ca_BS
IPR002048, EF_hand_dom
IPR010920, LSM_dom_sf
IPR016688, MscS-like_plants/fungi
IPR006685, MscS_channel
IPR023408, MscS_dom_sf
PfamiView protein in Pfam
PF00924, MS_channel, 1 hit
PIRSFiPIRSF017209, Memb_At2g17000_prd, 1 hit
SUPFAMiSSF47473, SSF47473, 1 hit
SSF50182, SSF50182, 1 hit
PROSITEiView protein in PROSITE
PS00018, EF_HAND_1, 1 hit
PS50222, EF_HAND_2, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiF9X0Q3_ZYMTI
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: F9X0Q3
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: October 19, 2011
Last sequence update: October 19, 2011
Last modified: September 29, 2021
This is version 51 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
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