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Entry version 73 (25 May 2022)
Sequence version 2 (03 Oct 2012)
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Protein
Submitted name:

Solute carrier family 12 member 4

Gene

Slc12a4

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processIon transport, Potassium transportARBA annotation, SymportARBA annotation, Transport
LigandChlorideARBA annotation, Potassium

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Solute carrier family 12 member 4
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Slc12a4Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 8

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:1309465, Slc12a4

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
HostDB:ENSMUSG00000017765

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei121 – 143HelicalSequence analysisAdd BLAST23
Transmembranei155 – 178HelicalSequence analysisAdd BLAST24
Transmembranei255 – 274HelicalSequence analysisAdd BLAST20
Transmembranei281 – 302HelicalSequence analysisAdd BLAST22
Transmembranei410 – 437HelicalSequence analysisAdd BLAST28
Transmembranei458 – 484HelicalSequence analysisAdd BLAST27
Transmembranei504 – 522HelicalSequence analysisAdd BLAST19
Transmembranei558 – 576HelicalSequence analysisAdd BLAST19
Transmembranei582 – 603HelicalSequence analysisAdd BLAST22
Transmembranei615 – 632HelicalSequence analysisAdd BLAST18

Keywords - Cellular componenti

Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
F8WIJ0

MaxQB - The MaxQuant DataBase

More...
MaxQBi
F8WIJ0

PeptideAtlas

More...
PeptideAtlasi
F8WIJ0

PRoteomics IDEntifications database

More...
PRIDEi
F8WIJ0

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
344920

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000017765, Expressed in molar tooth and 267 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
F8WIJ0, baseline and differential

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
F8WIJ0

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini125 – 302AA_permeaseInterPro annotationAdd BLAST178
Domaini420 – 697AA_permeaseInterPro annotationAdd BLAST278
Domaini711 – 829SLC12InterPro annotationAdd BLAST119
Domaini844 – 1087SLC12InterPro annotationAdd BLAST244

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni28 – 53DisorderedSequence analysisAdd BLAST26

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi28 – 43Basic and acidic residuesSequence analysisAdd BLAST16

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the SLC12A transporter family.ARBA annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysisARBA annotation

Phylogenomic databases

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000157672

Database of Orthologous Groups

More...
OrthoDBi
349744at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
F8WIJ0

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR004841, AA-permease/SLC12A_dom
IPR000622, KCC1
IPR000076, KCL_cotranspt
IPR018491, SLC12_C
IPR004842, SLC12A_fam

The PANTHER Classification System

More...
PANTHERi
PTHR11827, PTHR11827, 1 hit
PTHR11827:SF46, PTHR11827:SF46, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00324, AA_permease, 2 hits
PF03522, SLC12, 2 hits

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR01081, KCLTRNSPORT
PR01082, KCLTRNSPORT1

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR00930, 2a30, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

F8WIJ0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPHFTVVPVD GPRRGDYDNL EGLSWVDYGE RAEREDSDGE GQGNHRENSP
60 70 80 90 100
FLCPLDASRG NDYYDRNLAL FEEELDIRPK VSSLLGKLVS YTNLTQGAKE
110 120 130 140 150
HEEAESGEGG RRRAAKAPSM GTLMGVYLPC LQNIFGVILF LRLTWMVGTA
160 170 180 190 200
GVLQALLIVL ICCCCTLLTA ISMSAIATNG VVPAGGSYFM ISRSLGPEFG
210 220 230 240 250
GAVGLCFYLG TTFAAAMYIL GAIEILLTYI APPAAIFYPS GTHDMSSATL
260 270 280 290 300
NNMRVYGTIF LTLMTLVVFV GVKYVNKFAS LFLACVIISI LSIYAGGIKS
310 320 330 340 350
IFDPPVFPVC MLGNRTLSRD QFDICAKTVV VDNETVATRL WTFFCHSPNL
360 370 380 390 400
TADSCDPYFL LNNVTEIPGI PGAAAGVLQE NLWSAYLEKG EVVEKHGLPS
410 420 430 440 450
TDTLGLKESL SLYVVADIAT SFTVLVGIFF PSVTGIMAGS NRSGDLRDAQ
460 470 480 490 500
KSIPVGTILA IVTTSLVYFS SVILFGACIE GVVLRDKYGD GVSRNLVVGT
510 520 530 540 550
LAWPSPWVIV VGSFFSTCGA GLQSLTGAPR LLQAIAKDNI IPFLRVFGHG
560 570 580 590 600
KANGEPTWAL LLTALIAELG ILIASLDMVA PILSMFFLMC YLFVNLACAV
610 620 630 640 650
QTLLRTPNWR PRFKYYHWTL SFLGMSLCLA LMFVSSWYYA LVAMLIAGMI
660 670 680 690 700
YKYIEYQGAE KEWGDGIRGL SLSAARYALL RLEEGPPHTK NWRPQLLVLL
710 720 730 740 750
KLDEDLHVKY PRLLTFASQL KAGKGLTIVG SVIQGSFLES YGEAQAAEQT
760 770 780 790 800
IKNMMDIEKV KGFCQVVVAS KVREGLAHLI QSCGLGGMRH NSVVLGWPYG
810 820 830 840 850
WRQSEDPRAW KTFIDTVRCT TAAHLALLVP KNIAFYPSNH ERYLDGHIDV
860 870 880 890 900
WWIVHDGGML MLLPFLLRQH KVWKKCRMRI FTVAQMDDNS IQMKKDLAIF
910 920 930 940 950
LYHLRLEAEV EVVEMHNSDI SAYTYERTLM MEQRSQMLRQ MRLTKTERDR
960 970 980 990 1000
EAQLVKDRHS ALRLESLYSD EEEESVAGAD KIQMTWTRDK YMAEPWDPSH
1010 1020 1030 1040 1050
APDNFRELVH IKPDQSNVRR MHTAVKLNEV IVTRSHDARL VLLNMPGPPK
1060 1070 1080
NSEGDENYME FLEVLTEGLE RVLLVRGGGR EVITIYS
Length:1,087
Mass (Da):120,810
Last modified:October 3, 2012 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i901E4764CB4CC551
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q9JIS8S12A4_MOUSE
Solute carrier family 12 member 4
Slc12a4 Kcc1
1,085Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F6TQE2F6TQE2_MOUSE
Solute carrier family 12 member 4
Slc12a4
171Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

NCBI Reference Sequences

More...
RefSeqi
NP_001240733.1, NM_001253804.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000034370.17; ENSMUSP00000034370.10; ENSMUSG00000017765.18

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
20498

UCSC genome browser

More...
UCSCi
uc009nes.2, mouse

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

RefSeqiNP_001240733.1, NM_001253804.1

3D structure databases

SMRiF8WIJ0
ModBaseiSearch...

Proteomic databases

jPOSTiF8WIJ0
MaxQBiF8WIJ0
PeptideAtlasiF8WIJ0
PRIDEiF8WIJ0
ProteomicsDBi344920

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
29685, 182 antibodies from 31 providers

The DNASU plasmid repository

More...
DNASUi
20498

Genome annotation databases

EnsembliENSMUST00000034370.17; ENSMUSP00000034370.10; ENSMUSG00000017765.18
GeneIDi20498
UCSCiuc009nes.2, mouse

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
6560
MGIiMGI:1309465, Slc12a4
VEuPathDBiHostDB:ENSMUSG00000017765

Phylogenomic databases

GeneTreeiENSGT00940000157672
OrthoDBi349744at2759
PhylomeDBiF8WIJ0

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
20498, 1 hit in 73 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
Slc12a4, mouse

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000017765, Expressed in molar tooth and 267 other tissues
ExpressionAtlasiF8WIJ0, baseline and differential

Family and domain databases

InterProiView protein in InterPro
IPR004841, AA-permease/SLC12A_dom
IPR000622, KCC1
IPR000076, KCL_cotranspt
IPR018491, SLC12_C
IPR004842, SLC12A_fam
PANTHERiPTHR11827, PTHR11827, 1 hit
PTHR11827:SF46, PTHR11827:SF46, 1 hit
PfamiView protein in Pfam
PF00324, AA_permease, 2 hits
PF03522, SLC12, 2 hits
PRINTSiPR01081, KCLTRNSPORT
PR01082, KCLTRNSPORT1
TIGRFAMsiTIGR00930, 2a30, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiF8WIJ0_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: F8WIJ0
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: September 21, 2011
Last sequence update: October 3, 2012
Last modified: May 25, 2022
This is version 73 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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