UniProtKB - F8WIE5 (F8WIE5_MOUSE)
Protein
HECT-type E3 ubiquitin transferase
Gene
Hectd1
Organism
Mus musculus (Mouse)
Status
Functioni
Catalytic activityi
- S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.ARBA annotation EC:2.3.2.26
: protein ubiquitination Pathwayi
This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.ARBA annotationView all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 2579 | Glycyl thioester intermediatePROSITE-ProRule annotation | 1 |
GO - Molecular functioni
- metal ion binding Source: InterPro
- ubiquitin-protein transferase activity Source: InterPro
Keywordsi
Molecular function | TransferaseARBA annotation |
Biological process | Ubl conjugation pathwayPROSITE-ProRule annotationARBA annotation |
Enzyme and pathway databases
UniPathwayi | UPA00143 |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:Hectd1Imported |
Organismi | Mus musculus (Mouse)Imported |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:2384768, Hectd1 |
PTM / Processingi
Keywords - PTMi
PhosphoproteinARBA annotationProteomic databases
EPDi | F8WIE5 |
jPOSTi | F8WIE5 |
MaxQBi | F8WIE5 |
PeptideAtlasi | F8WIE5 |
PRIDEi | F8WIE5 |
ProteomicsDBi | 347540 |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000035247, Expressed in ear and 289 other tissues |
ExpressionAtlasi | F8WIE5, baseline and differential |
Genevisiblei | F8WIE5, MM |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 361 – 483 | ANK_REP_REGIONInterPro annotationAdd BLAST | 123 | |
Repeati | 395 – 427 | ANKPROSITE-ProRule annotationAdd BLAST | 33 | |
Repeati | 426 – 458 | ANKPROSITE-ProRule annotationAdd BLAST | 33 | |
Domaini | 1266 – 1338 | MIB/HERC2InterPro annotationAdd BLAST | 73 | |
Domaini | 2151 – 2610 | HECTInterPro annotationAdd BLAST | 460 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 247 – 268 | DisorderedSequence analysisAdd BLAST | 22 | |
Regioni | 450 – 469 | DisorderedSequence analysisAdd BLAST | 20 | |
Regioni | 489 – 513 | DisorderedSequence analysisAdd BLAST | 25 | |
Regioni | 627 – 657 | DisorderedSequence analysisAdd BLAST | 31 | |
Regioni | 707 – 748 | DisorderedSequence analysisAdd BLAST | 42 | |
Regioni | 1343 – 1389 | DisorderedSequence analysisAdd BLAST | 47 | |
Regioni | 1433 – 1475 | DisorderedSequence analysisAdd BLAST | 43 | |
Regioni | 1592 – 1611 | DisorderedSequence analysisAdd BLAST | 20 | |
Regioni | 1674 – 1756 | DisorderedSequence analysisAdd BLAST | 83 | |
Regioni | 1777 – 1801 | DisorderedSequence analysisAdd BLAST | 25 | |
Regioni | 2297 – 2318 | DisorderedSequence analysisAdd BLAST | 22 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 1245 – 1265 | Sequence analysisAdd BLAST | 21 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 252 – 268 | PolarSequence analysisAdd BLAST | 17 | |
Compositional biasi | 489 – 512 | PolyampholyteSequence analysisAdd BLAST | 24 | |
Compositional biasi | 733 – 748 | PolarSequence analysisAdd BLAST | 16 | |
Compositional biasi | 1345 – 1389 | PolarSequence analysisAdd BLAST | 45 | |
Compositional biasi | 1433 – 1457 | PolarSequence analysisAdd BLAST | 25 | |
Compositional biasi | 1675 – 1700 | AcidicSequence analysisAdd BLAST | 26 | |
Compositional biasi | 1701 – 1721 | PolyampholyteSequence analysisAdd BLAST | 21 | |
Compositional biasi | 1722 – 1736 | PolarSequence analysisAdd BLAST | 15 |
Sequence similaritiesi
Keywords - Domaini
ANK repeatPROSITE-ProRule annotation, Coiled coilSequence analysis, RepeatARBA annotationPhylogenomic databases
GeneTreei | ENSGT00940000156572 |
HOGENOMi | CLU_000869_0_0_1 |
OMAi | AKQWYDL |
OrthoDBi | 34110at2759 |
Family and domain databases
CDDi | cd00078, HECTc, 1 hit |
Gene3Di | 1.25.10.10, 1 hit 1.25.40.20, 1 hit 2.30.30.920, 1 hit 2.60.120.260, 1 hit |
InterProi | View protein in InterPro IPR002110, Ankyrin_rpt IPR020683, Ankyrin_rpt-contain_dom IPR036770, Ankyrin_rpt-contain_sf IPR011989, ARM-like IPR016024, ARM-type_fold IPR041200, FKBP3_BTHB IPR008979, Galactose-bd-like_sf IPR000569, HECT_dom IPR035983, Hect_E3_ubiquitin_ligase IPR010606, Mib_Herc2 IPR037252, Mib_Herc2_sf IPR012919, SUN_dom |
Pfami | View protein in Pfam PF12796, Ank_2, 1 hit PF18410, BTHB, 1 hit PF00632, HECT, 1 hit PF06701, MIB_HERC2, 1 hit PF07738, Sad1_UNC, 1 hit |
SMARTi | View protein in SMART SM00248, ANK, 3 hits SM00119, HECTc, 1 hit |
SUPFAMi | SSF159034, SSF159034, 1 hit SSF48371, SSF48371, 1 hit SSF48403, SSF48403, 1 hit SSF49785, SSF49785, 1 hit SSF56204, SSF56204, 1 hit |
PROSITEi | View protein in PROSITE PS50297, ANK_REP_REGION, 1 hit PS50088, ANK_REPEAT, 2 hits PS50237, HECT, 1 hit PS51416, MIB_HERC2, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
F8WIE5-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MADVDPDTLL EWLQMGQGDE RDMQLIALEQ LCMLLLMSDN VDRCFETCPP
60 70 80 90 100
RTFLPALCKI FLDESAPDNV LEVTARAITY YLDVSAECTR RIVGVDGAIK
110 120 130 140 150
ALCNRLVVVE LNNRTSRDLA EQCVKVLELI CTRESGAVFE AGGLNCVLTF
160 170 180 190 200
IRDSGHLVHK DTLHSAMAVV SRLCGKMEPQ DSSLEICVES LSSLLKHEDH
210 220 230 240 250
QVSDGALRCF ASLADRFTRR GVDPAPLAKH GLTEELLSRM AAAGGTVSGP
260 270 280 290 300
SSACKPGRST TGAPSAAADS KLSNQVSTIV SLLSTLCRGS PLVTHDLLRS
310 320 330 340 350
ELPDSIESAL QGDERCVLDT MRLVDLLLVL LFEGRKALPK SSAGSTGRIP
360 370 380 390 400
GLRRLDSSGE RSHRQLIDCI RSKDTDALID AIDTGAFEVN FMDDVGQTLL
410 420 430 440 450
NWASAFGTQE MVEFLCERGA DVNRGQRSSS LHYAACFGRP QVAKTLLRHG
460 470 480 490 500
ANPDLRDEDG KTPLDKARER GHSEVVAILQ SPGDWMCPVN KGDDKKKKDT
510 520 530 540 550
NKDEEECNEP RGDPEMAPLY LKRLLPVFAQ TFQHTMLPSI RKASLALIRK
560 570 580 590 600
MIHFCSEALL KEVCDSDVGH NLPTTLVEIT ATVLDQEDDD DGHLLALQII
610 620 630 640 650
RDLVDKGGDI FLDQLARLGV ISKVSALAGP SSDDENEEES KPEKEDEPQE
660 670 680 690 700
DAKELQQGKP YHWRDWSIIR GRDCLYIWSD AAALELSNGS NGWFRFILDG
710 720 730 740 750
KLATMYSSGS PEGGSDSSES RSEFLEKLQR ARGQVKPSTS SQPILSAPGP
760 770 780 790 800
TKLTVGNWSL TCLKEGEIAI HNSDGQQATI LKEDLPGFVF ESNRGTKHSF
810 820 830 840 850
TAETSLGSEF VTGWTGKRGR KLKSKLEKTK QKVRTMARDL YDDHFKAVES
860 870 880 890 900
MPRGVVVTLR NIATQLESSW ELHTNRQCIE GENTWRDLMK TALENLIVLL
910 920 930 940 950
KDENTISPYE MCSSGLVQAL LTVLNNSIDL DMKQDCSQLV ERINVFKTAF
960 970 980 990 1000
SESEDDESRP AVALIRKLIA VLESIERLPL HLYDTPGSTY NLQILTRRLR
1010 1020 1030 1040 1050
FRLERAPGET SLIDRTGRML KMEPLATVES LEQYLLKMVA KQWYDFDRSS
1060 1070 1080 1090 1100
FVFVRKLREG QNFIFRHQHD FDENGIIYWI GTNAKTAYEW VNPAAYGLVV
1110 1120 1130 1140 1150
VTSSEGRNLP YGRLEDILSR DNSALNCHSN DDKNAWFAID LGVWVIPSAY
1160 1170 1180 1190 1200
TLRHARGYGR SALRNWVFQV SKDGQNWTSL YTHVDDCSLN EPGSTATWPL
1210 1220 1230 1240 1250
DPAKDEKQGW RHVRLKQMGK NASGQTHYLS LSGFELYGTV NGVCEDQLGK
1260 1270 1280 1290 1300
AAKEAEANLR RQRRLVRSQV LKYMVPGARV IRGLDWKWRD QDGSPQGEGT
1310 1320 1330 1340 1350
VTGELHNGWI DVTWDAGGSN SYRMGAEGKF DLKLAPGYDP DTVASPKPVS
1360 1370 1380 1390 1400
STVSGTTQSW SSLVKNNCPD KTSAAAGSSS RKGSSSSVCS VASSSDISLA
1410 1420 1430 1440 1450
STKTERRSEI VMEHSIVSGA DVHEPIVVLS SAENVPQTEV GSSSSASTST
1460 1470 1480 1490 1500
LTAETGSENA ERKLGPDSSV RAPGESSAIS MGIVSVSSPD VSSVSELTNK
1510 1520 1530 1540 1550
EAASQRPLSS SASNRLSVSS LLAAGAPMSS SASVPNLSSR ETSSLESFVR
1560 1570 1580 1590 1600
RVANIARTNA TNNMNLSRSS SDNNTNTLGR NVMSTATSPL MGAQSFPNLT
1610 1620 1630 1640 1650
TPGTTSTVTM STSSVTSSSN VATATTVLSV GQSLSNTLTT SLTSTSSESD
1660 1670 1680 1690 1700
TGQEAEYSLY DFLDSCRAST LLAELDDDED LPEPDEEDDE NEDDNQEDQE
1710 1720 1730 1740 1750
YEEVMILRRP SLQRRAGSRS DVTHHVVTSQ LPQVPSGAGS RPVGEQEEEE
1760 1770 1780 1790 1800
YETKGGRRRA WDDDYVLKRQ FSALVPAFDP RPGRTNVQQT TDLEIPPPGT
1810 1820 1830 1840 1850
PHSELLEEVE CTPSPRLALT LKVTGLGTTR EVELPLTNFR STIFYYVQKL
1860 1870 1880 1890 1900
LQLSCNGNVK SDKLRRIWEP TYTIMYREMK DSDKEKENGK MGCWSIEHVE
1910 1920 1930 1940 1950
QYLGTDELPK NDLITYLQKN ADAAFLRHWK LTGTNKSIRK NRNCSQLIAA
1960 1970 1980 1990 2000
YKDFCEHGTK SGLNQGAISS LQSSDILNLT KEQPQAKAGN GQSPCGVEDV
2010 2020 2030 2040 2050
LQLLRILYIV ASDPYSRISQ EDGDEQPQFT FPPDEFTSKK ITTKILQQIE
2060 2070 2080 2090 2100
EPLALASGAL PDWCEQLTSK CPFLIPFETR QLYFTCTAFG ASRAIVWLQN
2110 2120 2130 2140 2150
RREATVERTR TTSSVRRDDP GEFRVGRLKH ERVKVPRGES LMEWAENVMQ
2160 2170 2180 2190 2200
IHADRKSVLE VEFLGEEGTG LGPTLEFYAL VAAEFQRTDL GTWLCDDNFP
2210 2220 2230 2240 2250
DDESRHVDLG GGLKPPGYYV QRSCGLFTAP FPQDSDELER ITKLFHFLGI
2260 2270 2280 2290 2300
FLAKCIQDNR LVDLPISKPF FKLMCMGDIK SNMSKLIYES RGDRDLHCTE
2310 2320 2330 2340 2350
SQSEASTEEG HDSLSVGSFE EDSKSEFILD PPKPKPPAWF NGILTWEDFE
2360 2370 2380 2390 2400
LVNPHRARFL KEIKDLAIKR RQILGNKSLS EDEKNTKLQE LVLRNPSGSG
2410 2420 2430 2440 2450
PPLSIEDLGL NFQFCPSSRI YGFTAVDLKP SGEDEMITMD NAEEYVDLMF
2460 2470 2480 2490 2500
DFCMHTGIQK QMEAFRDGFN KVFPMEKLSS FSHEEVQMIL CGNQSPSWAA
2510 2520 2530 2540 2550
EDIINYTEPK LGYTRDSPGF LRFVRVLCGM SSDERKAFLQ FTTGCSTLPP
2560 2570 2580 2590 2600
GGLANLHPRL TVVRKVDATD ASYPSVNTCV HYLKLPEYSS EEIMRERLLA
2610
ATMEKGFHLN
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketQ69ZR2 | HECD1_MOUSE | E3 ubiquitin-protein ligase HECTD1 | Hectd1 Kiaa1131, Opm | 2,618 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC157213 Genomic DNA No translation available. AC159644 Genomic DNA No translation available. |
RefSeqi | NP_659037.2, NM_144788.2 |
Genome annotation databases
Ensembli | ENSMUST00000042052; ENSMUSP00000046766; ENSMUSG00000035247 |
GeneIDi | 207304 |
KEGGi | mmu:207304 |
UCSCi | uc007nmz.2, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC157213 Genomic DNA No translation available. AC159644 Genomic DNA No translation available. |
RefSeqi | NP_659037.2, NM_144788.2 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Proteomic databases
EPDi | F8WIE5 |
jPOSTi | F8WIE5 |
MaxQBi | F8WIE5 |
PeptideAtlasi | F8WIE5 |
PRIDEi | F8WIE5 |
ProteomicsDBi | 347540 |
Protocols and materials databases
Antibodypediai | 5457, 111 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000042052; ENSMUSP00000046766; ENSMUSG00000035247 |
GeneIDi | 207304 |
KEGGi | mmu:207304 |
UCSCi | uc007nmz.2, mouse |
Organism-specific databases
CTDi | 25831 |
MGIi | MGI:2384768, Hectd1 |
Phylogenomic databases
GeneTreei | ENSGT00940000156572 |
HOGENOMi | CLU_000869_0_0_1 |
OMAi | AKQWYDL |
OrthoDBi | 34110at2759 |
Enzyme and pathway databases
UniPathwayi | UPA00143 |
Miscellaneous databases
BioGRID-ORCSi | 207304, 11 hits in 53 CRISPR screens |
ChiTaRSi | Hectd1, mouse |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000035247, Expressed in ear and 289 other tissues |
ExpressionAtlasi | F8WIE5, baseline and differential |
Genevisiblei | F8WIE5, MM |
Family and domain databases
CDDi | cd00078, HECTc, 1 hit |
Gene3Di | 1.25.10.10, 1 hit 1.25.40.20, 1 hit 2.30.30.920, 1 hit 2.60.120.260, 1 hit |
InterProi | View protein in InterPro IPR002110, Ankyrin_rpt IPR020683, Ankyrin_rpt-contain_dom IPR036770, Ankyrin_rpt-contain_sf IPR011989, ARM-like IPR016024, ARM-type_fold IPR041200, FKBP3_BTHB IPR008979, Galactose-bd-like_sf IPR000569, HECT_dom IPR035983, Hect_E3_ubiquitin_ligase IPR010606, Mib_Herc2 IPR037252, Mib_Herc2_sf IPR012919, SUN_dom |
Pfami | View protein in Pfam PF12796, Ank_2, 1 hit PF18410, BTHB, 1 hit PF00632, HECT, 1 hit PF06701, MIB_HERC2, 1 hit PF07738, Sad1_UNC, 1 hit |
SMARTi | View protein in SMART SM00248, ANK, 3 hits SM00119, HECTc, 1 hit |
SUPFAMi | SSF159034, SSF159034, 1 hit SSF48371, SSF48371, 1 hit SSF48403, SSF48403, 1 hit SSF49785, SSF49785, 1 hit SSF56204, SSF56204, 1 hit |
PROSITEi | View protein in PROSITE PS50297, ANK_REP_REGION, 1 hit PS50088, ANK_REPEAT, 2 hits PS50237, HECT, 1 hit PS51416, MIB_HERC2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | F8WIE5_MOUSE | |
Accessioni | F8WIE5Primary (citable) accession number: F8WIE5 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | September 21, 2011 |
Last sequence update: | September 21, 2011 | |
Last modified: | April 7, 2021 | |
This is version 80 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |