Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
We will be switching to the new UniProt website soon. Please explore and share your feedback. Take me to the new website.

UniProtKB - F8WIC0 (F8WIC0_MOUSE)

Entry version 74 (19 Jan 2022)
Sequence version 1 (21 Sep 2011)
Previous versions | rss
Add a publicationFeedback
Protein

Nucleoside-diphosphate kinase

Gene

Ak7

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionKinaseARBA annotation, Transferase

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Nucleoside-diphosphate kinaseARBA annotation (EC:2.7.4.6ARBA annotation)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Ak7Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 12

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...MGIi		MGI:1926051, Ak7

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSMUSG00000041323

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

MaxQB - The MaxQuant DataBase

More...MaxQBi		F8WIC0

PRoteomics IDEntifications database

More...PRIDEi		F8WIC0

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		365182

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSMUSG00000041323, Expressed in blastocyst and 141 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		F8WIC0, MM

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		F8WIC0

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni47 – 66DisorderedSequence analysisAdd BLAST20
Regioni417 – 436DisorderedSequence analysisAdd BLAST20

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili616 – 643Sequence analysisAdd BLAST28
Coiled coili648 – 668Sequence analysisAdd BLAST21

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi420 – 436Acidic residuesSequence analysisAdd BLAST17

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

Ensembl GeneTree

More...GeneTreei		ENSGT00390000015102

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_015567_1_0_1

Identification of Orthologs from Complete Genome Data

More...OMAi		NECKFRG

Database of Orthologous Groups

More...OrthoDBi		572856at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		F8WIC0

TreeFam database of animal gene trees

More...TreeFami		TF313982

Family and domain databases

Conserved Domains Database

More...CDDi		cd01428, ADK, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		3.40.50.300, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR000850, Adenylat/UMP-CMP_kin
IPR026867, AK7
IPR007858, Dpy-30_motif
IPR036291, NAD(P)-bd_dom_sf
IPR027417, P-loop_NTPase

The PANTHER Classification System

More...PANTHERi		PTHR23359, PTHR23359, 1 hit
PTHR23359:SF105, PTHR23359:SF105, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF05186, Dpy-30, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF51735, SSF51735, 1 hit
SSF52540, SSF52540, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

F8WIC0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAEEEVPATT EKVLKIQRVF INHLDTYSSG NIGKFLANCV AGASLEEIGE 
        60         70         80         90        100
EEEEEDETKS AVAPEAPTTK VKEGTFQIVG TLVKPESVKP DFAVEAYKGI 
       110        120        130        140        150
SREDLLSHLM ECDAVIYNIT ENVQQVEEAL WAVSALNEEI SHFEKRKVFI 
       160        170        180        190        200
LLSTVMTWAR SKPLDPDDNE VPFTEEDYRR RKHHPNFLDH INAEKIVLKF 
       210        220        230        240        250
GKNAKKFATY VVASGLQYGA EGGILHTFFK MAWLGEVPAL PVFGDGTNCI 
       260        270        280        290        300
PAIHVVDLAG VIQNIIDHVP KLHYLVAVDE AVHTLEDLVK CISKNTGPGK 
       310        320        330        340        350
IQKVPKENAF LTKDLTQEYL DHLLVNLRME ALFVKENFNI RWVAQTGFVE 
       360        370        380        390        400
NINSILKEYK QSRGLLPIKI CILGPPAVGK SSISEELAKY YKLHHIKMKD 
       410        420        430        440        450
VIAEAIAKLE AIVAPKDSVE GEEEGEEEEE EENVDDAQEL LDGIKESMEQ 
       460        470        480        490        500
NAGRLEDQYI IRFVKEKLKS MPCRNQGFIL DGFPKTYDQA KDLFNQEEEE 
       510        520        530        540        550
EEEEIRGKIF PYDKLITPEF VCGLDASDEF LKERVMNLPE SVVAGTHYSQ 
       560        570        580        590        600
DRFLRSLSHY RDINTDDETV FNYFDELEIH PIHIDVGKLE DAQNRLAIKQ 
       610        620        630        640        650
LIKEIGKPRN YGLTDEEKAE EEKKAAEERL AKEAAQTAEL EHKEAMEMAE 
       660        670        680        690        700
KIARWEEWNK RLEEVKREER ELLEVQSVPL RNYLMTYVMP TLMQGLNECC 
       710        720 
KVRPEDPVDF LAEYLFKNNP EMQ
Length:723
Mass (Da):82,538
Last modified:September 21, 2011 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i4D7D46A5FA4C0918
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q9D2H2KAD7_MOUSE
Adenylate kinase 7
Ak7
614Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

NCBI Reference Sequences

More...RefSeqi		NP_084463.1, NM_030187.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENSMUST00000040876; ENSMUSP00000043145; ENSMUSG00000041323

Database of genes from NCBI RefSeq genomes

More...GeneIDi		78801

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		mmu:78801

UCSC genome browser

More...UCSCi		uc007oyt.1, mouse

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

RefSeqiNP_084463.1, NM_030187.1

3D structure databases

SMRiF8WIC0
ModBaseiSearch...

Proteomic databases

MaxQBiF8WIC0
PRIDEiF8WIC0
ProteomicsDBi365182

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		165, 76 antibodies from 23 providers

Genome annotation databases

EnsembliENSMUST00000040876; ENSMUSP00000043145; ENSMUSG00000041323
GeneIDi78801
KEGGimmu:78801
UCSCiuc007oyt.1, mouse

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		122481
MGIiMGI:1926051, Ak7
VEuPathDBiHostDB:ENSMUSG00000041323

Phylogenomic databases

GeneTreeiENSGT00390000015102
HOGENOMiCLU_015567_1_0_1
OMAiNECKFRG
OrthoDBi572856at2759
PhylomeDBiF8WIC0
TreeFamiTF313982

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		78801, 0 hits in 66 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		Ak7, mouse

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSMUSG00000041323, Expressed in blastocyst and 141 other tissues
GenevisibleiF8WIC0, MM

Family and domain databases

CDDicd01428, ADK, 1 hit
Gene3Di3.40.50.300, 1 hit
InterProiView protein in InterPro
IPR000850, Adenylat/UMP-CMP_kin
IPR026867, AK7
IPR007858, Dpy-30_motif
IPR036291, NAD(P)-bd_dom_sf
IPR027417, P-loop_NTPase
PANTHERiPTHR23359, PTHR23359, 1 hit
PTHR23359:SF105, PTHR23359:SF105, 1 hit
PfamiView protein in Pfam
PF05186, Dpy-30, 1 hit
SUPFAMiSSF51735, SSF51735, 1 hit
SSF52540, SSF52540, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiF8WIC0_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: F8WIC0
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: September 21, 2011
Last sequence update: September 21, 2011
Last modified: January 19, 2022
This is version 74 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again