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Entry version 71 (07 Apr 2021)
Sequence version 1 (21 Sep 2011)
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Protein
Submitted name:

Protein phosphatase Slingshot homolog 1

Gene

Ssh1

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolase, Protein phosphataseARBA annotation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Protein phosphatase Slingshot homolog 1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Ssh1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 5

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:2686240, Ssh1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
F8WHT2

MaxQB - The MaxQuant DataBase

More...
MaxQBi
F8WHT2

PeptideAtlas

More...
PeptideAtlasi
F8WHT2

PRoteomics IDEntifications database

More...
PRIDEi
F8WHT2

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
322634

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000042121, Expressed in embryo and 255 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
F8WHT2

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini265 – 405Tyrosine-protein phosphataseInterPro annotationAdd BLAST141
Domaini327 – 384TYR_PHOSPHATASE_2InterPro annotationAdd BLAST58

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni533 – 588DisorderedSequence analysisAdd BLAST56
Regioni625 – 723DisorderedSequence analysisAdd BLAST99
Regioni815 – 857DisorderedSequence analysisAdd BLAST43
Regioni872 – 898DisorderedSequence analysisAdd BLAST27
Regioni942 – 999DisorderedSequence analysisAdd BLAST58

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi543 – 568PolyampholyteSequence analysisAdd BLAST26
Compositional biasi569 – 584PolarSequence analysisAdd BLAST16
Compositional biasi632 – 655PolarSequence analysisAdd BLAST24
Compositional biasi835 – 857PolarSequence analysisAdd BLAST23
Compositional biasi872 – 892PolarSequence analysisAdd BLAST21
Compositional biasi942 – 988PolarSequence analysisAdd BLAST47

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the protein-tyrosine phosphatase family.ARBA annotation

Phylogenomic databases

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000156133

Identification of Orthologs from Complete Genome Data

More...
OMAi
FLCRLDH

Database of Orthologous Groups

More...
OrthoDBi
1576308at2759

Family and domain databases

Conserved Domains Database

More...
CDDi
cd11652, SSH-N, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.90.190.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR014876, DEK_C
IPR043587, Phosphatase_SSH-like
IPR029021, Prot-tyrosine_phosphatase-like
IPR043588, SSH-N
IPR027233, SSH1
IPR016130, Tyr_Pase_AS
IPR000387, TYR_PHOSPHATASE_dom
IPR020422, TYR_PHOSPHATASE_DUAL_dom

The PANTHER Classification System

More...
PANTHERi
PTHR45864, PTHR45864, 1 hit
PTHR45864:SF5, PTHR45864:SF5, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF08766, DEK_C, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00195, DSPc, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF52799, SSF52799, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00383, TYR_PHOSPHATASE_1, 1 hit
PS50056, TYR_PHOSPHATASE_2, 1 hit
PS50054, TYR_PHOSPHATASE_DUAL, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

F8WHT2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVKGAALFLQ QGNSPQGQRS LQHPHKHAGD LPQHLQVMIN LLRCEDRIKL
60 70 80 90 100
AVRLESVWTD RVRYMVVVYT SGRQDTEENI LLGVDFSSKE SKSCTIGMVL
110 120 130 140 150
RLWSDTKIHL DGDGGFSVST AGRMHIFKPV SVQAMWSALQ VLHKACEVAR
160 170 180 190 200
RHNYFPGGVA LIWATYYESC ISSEQSCINE WNAMQDLEST RPDSPALFVD
210 220 230 240 250
KPTEGERTER LIKAKLRSIM MSQDLENVTS KEIRNELEKQ MNCNLKEFKE
260 270 280 290 300
FIDNEMLLIL GQMDKPSLIF DHLYLGSEWN ASNLEELQGS GVDYILNVTR
310 320 330 340 350
EIDNFFPGLF AYHNIRVYDE ETTDLLAHWN EAYHFINKAK RNHSKCLVHC
360 370 380 390 400
KMGVSRSAST VIAYAMKEFG WPLEKAYNYV KQKRSITRPN AGFMRQLSEY
410 420 430 440 450
EGILDASKQR HNKLWRQQPT DDTIAEPSEF LPETLDGALD AQLPCLDDTT
460 470 480 490 500
HPGLPRSLAP GGPALPCCFR RLSDPLLLPH HDETGGLVHL EDLEKDALLE
510 520 530 540 550
EEESQPVEVH KLVQHPQEGA RLCEKDVKRK LEFGNSKPRS DSLPQVEELE
560 570 580 590 600
KDGSPRTGRW RRASTQLDRS LLDQENLNNN NSKRSCPDDL ERDAMFGILS
610 620 630 640 650
KVKPPYTSCA DCMYPTAGGT PEAYMERHED PSSSAICTQP TFLPHVTSSP
660 670 680 690 700
MAHASSRSRA PERPASGPAN TSPFLLPAGS RKPDVSGSGA GAAPEPPASL
710 720 730 740 750
LEPSRETSKA LPKSLQLKNP HCDKNAANME VSAKEEPSPK KDPKPAKDLR
760 770 780 790 800
LLFSNEAEKP TTNSYLMQHQ ESIIQLQKAG LVRKHTKELE RLKSLPSDSP
810 820 830 840 850
AACRDSATCR LEASIPEEGS QEPAHPALCS QAGSEEQPVG GTLQKSPTST
860 870 880 890 900
LPRLDHTSNF SKDFLKTVCY TPTSSSISSN LTRSSSSDSI HSVRGKPGLV
910 920 930 940 950
KQRAQEIETR LRLAGLTVSS PLKRSHSLAK LGSLNFSTED LSSEADTSTI
960 970 980 990
ADSQDAKCGL SSSFLPEPQS APRDPAATSK SSGKSAPEHL KSPSRVNKS
Length:999
Mass (Da):110,769
Last modified:September 21, 2011 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i07C9DC53E21F9389
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q76I79SSH1_MOUSE
Protein phosphatase Slingshot homol...
Ssh1 Kiaa1298, Ssh1l
1,042Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F7CBJ9F7CBJ9_MOUSE
Protein phosphatase Slingshot homol...
Ssh1
76Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E0CXT3E0CXT3_MOUSE
Protein phosphatase Slingshot homol...
Ssh1
37Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AC145559 Genomic DNA No translation available.

NCBI Reference Sequences

More...
RefSeqi
XP_006530351.1, XM_006530288.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000077689; ENSMUSP00000076873; ENSMUSG00000042121

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
231637

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC145559 Genomic DNA No translation available.
RefSeqiXP_006530351.1, XM_006530288.3

3D structure databases

SMRiF8WHT2
ModBaseiSearch...

Proteomic databases

jPOSTiF8WHT2
MaxQBiF8WHT2
PeptideAtlasiF8WHT2
PRIDEiF8WHT2
ProteomicsDBi322634

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
18311, 190 antibodies

The DNASU plasmid repository

More...
DNASUi
231637

Genome annotation databases

EnsembliENSMUST00000077689; ENSMUSP00000076873; ENSMUSG00000042121
GeneIDi231637

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
54434
MGIiMGI:2686240, Ssh1

Phylogenomic databases

GeneTreeiENSGT00940000156133
OMAiFLCRLDH
OrthoDBi1576308at2759

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
231637, 3 hits in 52 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
Ssh1, mouse

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000042121, Expressed in embryo and 255 other tissues

Family and domain databases

CDDicd11652, SSH-N, 1 hit
Gene3Di3.90.190.10, 1 hit
InterProiView protein in InterPro
IPR014876, DEK_C
IPR043587, Phosphatase_SSH-like
IPR029021, Prot-tyrosine_phosphatase-like
IPR043588, SSH-N
IPR027233, SSH1
IPR016130, Tyr_Pase_AS
IPR000387, TYR_PHOSPHATASE_dom
IPR020422, TYR_PHOSPHATASE_DUAL_dom
PANTHERiPTHR45864, PTHR45864, 1 hit
PTHR45864:SF5, PTHR45864:SF5, 1 hit
PfamiView protein in Pfam
PF08766, DEK_C, 1 hit
SMARTiView protein in SMART
SM00195, DSPc, 1 hit
SUPFAMiSSF52799, SSF52799, 1 hit
PROSITEiView protein in PROSITE
PS00383, TYR_PHOSPHATASE_1, 1 hit
PS50056, TYR_PHOSPHATASE_2, 1 hit
PS50054, TYR_PHOSPHATASE_DUAL, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiF8WHT2_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: F8WHT2
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: September 21, 2011
Last sequence update: September 21, 2011
Last modified: April 7, 2021
This is version 71 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Proteomics identificationCombined sources, Reference proteomeImported
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