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Entry version 57 (31 Jul 2019)
Sequence version 1 (21 Sep 2011)
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Protein
Submitted name:

Ral GTPase-activating protein subunit beta

Gene

Ralgapb

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionGTPase activationPROSITE-ProRule annotation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Ral GTPase-activating protein subunit betaImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:RalgapbImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:2444531 Ralgapb

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
F8WHN4

MaxQB - The MaxQuant DataBase

More...
MaxQBi
F8WHN4

PRoteomics IDEntifications database

More...
PRIDEi
F8WHN4

PTM databases

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
F8WHN4

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000027652 Expressed in 239 organ(s), highest expression level in bone marrow

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
F8WHN4 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
F8WHN4 MM

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
F8WHN4

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1145 – 1389Rap-GAPInterPro annotationAdd BLAST245

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni355 – 437DisorderedSequence analysisAdd BLAST83
Regioni709 – 739DisorderedSequence analysisAdd BLAST31
Regioni1304 – 1332DisorderedSequence analysisAdd BLAST29

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi359 – 385PolarSequence analysisAdd BLAST27
Compositional biasi392 – 427PolarSequence analysisAdd BLAST36
Compositional biasi709 – 737PolarSequence analysisAdd BLAST29
Compositional biasi1304 – 1321PolarSequence analysisAdd BLAST18

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3652 Eukaryota
ENOG411027C LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00700000104550

Database of Orthologous Groups

More...
OrthoDBi
54832at2759

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.40.50.11210, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR039930 RALGAPB
IPR035974 Rap/Ran-GAP_sf
IPR000331 Rap_GAP_dom

The PANTHER Classification System

More...
PANTHERi
PTHR21344 PTHR21344, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF111347 SSF111347, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50085 RAPGAP, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 5 potential isoforms that are computationally mapped.Show allAlign All

F8WHN4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MYSEWRSLHL VIQSDQGHTS VLHSYPESVG REVANAVVRP LGQALGTSSV
60 70 80 90 100
AGSESLLKTD KEVKWTMEVI CYGLTLPLDG ETVKYCVDVY TDWIMALVLP
110 120 130 140 150
KDSIPLPIIK EPNLYVQSIL KHLQNLFVPR QEQGSSQIRL CLQVLRAIQK
160 170 180 190 200
LARESSIMAR ETWEVLLLFL LQINDILLAP PTVQGGIAEN LAEKLIGVLF
210 220 230 240 250
EVWLLACTRC FPTPPYWKTA KEMVANWRHH PAVVEQWSKV ICALTSRLLR
260 270 280 290 300
FTYGPSFPPF KVPDEDANLI PPEMDNECIA QTWFRFLHML SNPVDLSNPA
310 320 330 340 350
VISSTPKFQE QFLNVSGMPQ ELSQYPCLKH LPQIFFRAMR GISCLVDAFL
360 370 380 390 400
GISRPRSDSA PPTPVNRLSM PQSAAVNTTP PHNRRHRAVT VNKATMKTST
410 420 430 440 450
VTTAHTSKVQ HQASSTSPLS SPNQTSSEPR PLPAPRRPKV NSILNLFGSW
460 470 480 490 500
LFDAAFVHCK LHNGINRDNS MTAIATQASM EFRRKGSQMS TDTMVSNPVF
510 520 530 540 550
DASEFPDNYE AGRAEACGTL CRIFCSKKTG EEILPAYLSR FYMLLIQGLQ
560 570 580 590 600
INDYVCHPVL ASVILNSPPL FCCDLKGIDV VVPYFISALE TILPDRELSK
610 620 630 640 650
FKSYVNPTEL RRSSINILLS LLPLPHHFGT VRSEVVLEGK FSNDDSSSYD
660 670 680 690 700
KPITFLSLKL RLVNILIGAL QTETDPNNTQ MILGAMLNIV QDSALLEAIG
710 720 730 740 750
CQMEMGGGEN NLKSHSRTNS GISSASGGST EPTTPDSERP AQALLRDYDS
760 770 780 790 800
AAGLLIRSIH LVTQRLNSQW RQDMSISLAA LELLSGLAKV KVMVDSGDRK
810 820 830 840 850
RAISSVCSYI VYQCSRPAPL HSRDLHSMIV AAFQCLCVWL TEHPDMLDEK
860 870 880 890 900
DCLKEVLEIV ELGISGSKSK NSEQEVKYKG DKEPNPASMR VKDAAEATLT
910 920 930 940 950
CIMQLLGAFP SPSGPASPCS LVNETTLIKY SRLPTINKHS FRYFVLDNSV
960 970 980 990 1000
ILAMLEQPLG NEQNDFFPSV TVLVRGMSGR LAWAQQLCLL PRGAKANQKL
1010 1020 1030 1040 1050
FVPEPRPVPK NDVGFKYSVK HRPFPEEVDK IPFVKADLSI PDLHEIVTEE
1060 1070 1080 1090 1100
LEERHEKLRS GMAQQIAYEM HLEQQSEGEL QKRSFPDPVT DCKPPPPAQE
1110 1120 1130 1140 1150
FQTARLFLSH FGFLSLEALK EPANSRLPPH LIALDSTIPG FFDDIGYLDL
1160 1170 1180 1190 1200
LPCRPFDTVF IFYMKPGQKT NQEILKNVES SRNVQPHFLE FLLSLGWSVD
1210 1220 1230 1240 1250
VGKHPGWTGH VSTSWSINSC DDGEGSEPDE ITSSEDVGAS IFNGQKKVLY
1260 1270 1280 1290 1300
YADALTEIAF VVPSPVESLT DSLESNISDQ DSDSNMDLMP GILKQPPLTL
1310 1320 1330 1340 1350
ELVPNHTDSL NSSQRLSPSS RMKKLPQGRP VPPLGPETRV SVVWVERYDD
1360 1370 1380 1390 1400
IENFPLSDLM TEISTGVETT ANSSTSLRST TLEKEVPVIF IHPLNTGLFR
1410 1420 1430 1440 1450
IKIQGATGKF NMVIPLVDGM IVSRRALGFL VRQTVINICR RKRLESDSYS
1460 1470 1480 1490
PPHVRRKQKI TDIVNKYRNK QLEPEFYTAL FQEVGLKNCS S
Length:1,491
Mass (Da):166,176
Last modified:September 21, 2011 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i1697688B32875A6C
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q8BQZ4RLGPB_MOUSE
Ral GTPase-activating protein subun...
Ralgapb Kiaa1219
1,484Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9Q0J2E9Q0J2_MOUSE
Ral GTPase-activating protein subun...
Ralgapb
1,507Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A2ACC6A2ACC6_MOUSE
Ral GTPase-activating protein subun...
Ralgapb
1,495Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A2ACC7A2ACC7_MOUSE
Ral GTPase-activating protein subun...
Ralgapb
1,173Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A2APV5A2APV5_MOUSE
Ral GTPase-activating protein subun...
Ralgapb
19Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AL663091 Genomic DNA No translation available.
AL844513 Genomic DNA No translation available.

NCBI Reference Sequences

More...
RefSeqi
XP_011237792.1, XM_011239490.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000046274; ENSMUSP00000048430; ENSMUSG00000027652

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
228850

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL663091 Genomic DNA No translation available.
AL844513 Genomic DNA No translation available.
RefSeqiXP_011237792.1, XM_011239490.2

3D structure databases

SMRiF8WHN4
ModBaseiSearch...

PTM databases

SwissPalmiF8WHN4

Proteomic databases

EPDiF8WHN4
MaxQBiF8WHN4
PRIDEiF8WHN4

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000046274; ENSMUSP00000048430; ENSMUSG00000027652
GeneIDi228850

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
57148
MGIiMGI:2444531 Ralgapb

Phylogenomic databases

eggNOGiKOG3652 Eukaryota
ENOG411027C LUCA
GeneTreeiENSGT00700000104550
OrthoDBi54832at2759

Miscellaneous databases

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000027652 Expressed in 239 organ(s), highest expression level in bone marrow
ExpressionAtlasiF8WHN4 baseline and differential
GenevisibleiF8WHN4 MM

Family and domain databases

Gene3Di3.40.50.11210, 1 hit
InterProiView protein in InterPro
IPR039930 RALGAPB
IPR035974 Rap/Ran-GAP_sf
IPR000331 Rap_GAP_dom
PANTHERiPTHR21344 PTHR21344, 1 hit
SUPFAMiSSF111347 SSF111347, 1 hit
PROSITEiView protein in PROSITE
PS50085 RAPGAP, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiF8WHN4_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: F8WHN4
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: September 21, 2011
Last sequence update: September 21, 2011
Last modified: July 31, 2019
This is version 57 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
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