UniProtKB - F8WHB1 (F8WHB1_MOUSE)
Protein
Calcium-transporting ATPase
Gene
Atp2b2
Organism
Mus musculus (Mouse)
Status
Functioni
This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium.UniRule annotation
Caution
Lacks conserved residue(s) required for the propagation of feature annotation.UniRule annotation
Catalytic activityi
- EC:7.2.2.10UniRule annotation
GO - Molecular functioni
- ATP binding Source: UniProtKB-KW
- calcium-transporting ATPase activity involved in regulation of postsynaptic cytosolic calcium ion concentration Source: Ensembl
- calcium-transporting ATPase activity involved in regulation of presynaptic cytosolic calcium ion concentration Source: Ensembl
GO - Biological processi
- neuron differentiation Source: Ensembl
- sensory perception of sound Source: Ensembl
Keywordsi
Biological process | Calcium transportUniRule annotation, Ion transport, Transport |
Ligand | ATP-bindingUniRule annotationSAAS annotation, Calcium, Nucleotide-binding |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:Atp2b2Imported |
Organismi | Mus musculus (Mouse)Imported |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:105368 Atp2b2 |
Subcellular locationi
Other locations
- Membrane UniRule annotation; Multi-pass membrane protein UniRule annotation
Other locations
- cell Source: GOC
- cytoplasm Source: Ensembl
- GABA-ergic synapse Source: Ensembl
- glutamatergic synapse Source: Ensembl
- integral component of membrane Source: UniProtKB-KW
- postsynapse Source: GOC
- presynapse Source: GOC
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 98 – 121 | HelicalUniRule annotationAdd BLAST | 24 | |
Transmembranei | 151 – 170 | HelicalUniRule annotationAdd BLAST | 20 | |
Transmembranei | 402 – 423 | HelicalUniRule annotationAdd BLAST | 22 | |
Transmembranei | 443 – 469 | HelicalUniRule annotationAdd BLAST | 27 | |
Transmembranei | 955 – 973 | HelicalUniRule annotationAdd BLAST | 19 | |
Transmembranei | 1031 – 1051 | HelicalUniRule annotationAdd BLAST | 21 | |
Transmembranei | 1063 – 1084 | HelicalUniRule annotationAdd BLAST | 22 |
Keywords - Cellular componenti
MembraneExpressioni
Gene expression databases
Bgeei | ENSMUSG00000030302 Expressed in 164 organ(s), highest expression level in striatum |
ExpressionAtlasi | F8WHB1 baseline and differential |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 47 – 123 | Cation_ATPase_NInterPro annotationAdd BLAST | 77 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 24 | DisorderedSequence analysisAdd BLAST | 24 | |
Regioni | 296 – 382 | DisorderedSequence analysisAdd BLAST | 87 | |
Regioni | 1194 – 1243 | DisorderedSequence analysisAdd BLAST | 50 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 1 – 21 | PolarSequence analysisAdd BLAST | 21 | |
Compositional biasi | 326 – 351 | PolarSequence analysisAdd BLAST | 26 | |
Compositional biasi | 365 – 382 | PolyampholyteSequence analysisAdd BLAST | 18 | |
Compositional biasi | 1195 – 1243 | PolarSequence analysisAdd BLAST | 49 |
Sequence similaritiesi
Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIB subfamily. [View classification]UniRule annotation
Keywords - Domaini
Transmembrane, Transmembrane helixUniRule annotationSAAS annotationPhylogenomic databases
eggNOGi | KOG0204 Eukaryota ENOG410XNNC LUCA |
GeneTreei | ENSGT00940000161461 |
OrthoDBi | 115892at2759 |
PhylomeDBi | F8WHB1 |
Family and domain databases
Gene3Di | 3.40.1110.10, 1 hit |
InterProi | View protein in InterPro IPR030322 ATP2B2 IPR022141 ATP_Ca_trans_C IPR006068 ATPase_P-typ_cation-transptr_C IPR004014 ATPase_P-typ_cation-transptr_N IPR023299 ATPase_P-typ_cyto_dom_N IPR018303 ATPase_P-typ_P_site IPR023298 ATPase_P-typ_TM_dom_sf IPR008250 ATPase_P-typ_transduc_dom_A_sf IPR036412 HAD-like_sf IPR006408 P-type_ATPase_IIB IPR001757 P_typ_ATPase |
PANTHERi | PTHR24093:SF377 PTHR24093:SF377, 1 hit |
Pfami | View protein in Pfam PF12424 ATP_Ca_trans_C, 1 hit PF00689 Cation_ATPase_C, 1 hit PF00690 Cation_ATPase_N, 1 hit |
SMARTi | View protein in SMART SM00831 Cation_ATPase_N, 1 hit |
SUPFAMi | SSF56784 SSF56784, 1 hit SSF81653 SSF81653, 1 hit SSF81660 SSF81660, 1 hit SSF81665 SSF81665, 1 hit |
TIGRFAMsi | TIGR01517 ATPase-IIB_Ca, 1 hit TIGR01494 ATPase_P-type, 3 hits |
PROSITEi | View protein in PROSITE PS00154 ATPASE_E1_E2, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All
F8WHB1-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MGDMTNSDFY SKNQRNESSH GGEFGCTMEE LRSLMELRGT EAVVKIKETY
60 70 80 90 100
GDTEAICRRL KTSPVEGLPG TAPDLEKRKQ IFGQNFIPPK KPKTFLQLVW
110 120 130 140 150
EALQDVTLII LEIAAIISLG LSFYHPPGES NEGCATAQGG AEDEGEAEAG
160 170 180 190 200
WIEGAAILLS VICVVLVTAF NDWSKEKQFR GLQSRIEQEQ KFTVVRAGQV
210 220 230 240 250
VQIPVAEIVV GDIAQIKYGD LLPADGLFIQ GNDLKIDESS LTGESDQVRK
260 270 280 290 300
SVDKDPMLLS GTHVMEGSGR MVVTAVGVNS QTGIIFTLLG AGGEEEEKKD
310 320 330 340 350
KKGVKKGDGL QIPAADGAAP ANAAGSANAS LVNGKMQDGS ADSSQSKAKQ
360 370 380 390 400
QDGAAAMEMQ PLKSAEGGDA DDKKKANMHK KEKSVLQGKL TKLAVQIGKA
410 420 430 440 450
GLVMSAITVI ILVLYFTVDT FVVNKKPWLT ECTPVYVQYF VKFFIIGVTV
460 470 480 490 500
LVVAVPEGLP LAVTISLAYS VKKMMKDNNL VRHLDACETM GNATAICSDK
510 520 530 540 550
TGTLTTNRMT VVQAYVGDVH YKEIPDPSSI NAKTLELLVN AIAINSAYTT
560 570 580 590 600
KILPPEKEGA LPRQVGNKTE CGLLGFVLDL RQDYEPVRSQ MPEEKLYKVY
610 620 630 640 650
TFNSVRKSMS TVIKMPDESF RMYSKGASEI VLKKCCKILS GAGEARVFRP
660 670 680 690 700
RDRDEMVKKV IEPMACDGLR TICVAYRDFP SSPEPDWDNE NDILNELTCI
710 720 730 740 750
CVVGIEDPVR PEVPEAIRKC QRAGITVRMV TGDNINTARA IAIKCGIIHP
760 770 780 790 800
GEDFLCLEGK EFNRRIRNEK GEIEQERIDK IWPKLRVLAR SSPTDKHTLV
810 820 830 840 850
KGIIDSTHTE QRQVVAVTGD GTNDGPALKK ADVGFAMGIA GTDVAKEASD
860 870 880 890 900
IILTDDNFSS IVKAVMWGRN VYDSISKFLQ FQLTVNVVAV IVAFTGACIT
910 920 930 940 950
QDSPLKAVQM LWVNLIMDTF ASLALATEPP TETLLLRKPY GRNKPLISRT
960 970 980 990 1000
MMKNILGHAV YQLTLIFTLL FVGEKMFQID SGRNAPLHSP PSEHYTIIFN
1010 1020 1030 1040 1050
TFVMMQLFNE INARKIHGER NVFDGIFRNP IFCTIVLGTF AIQIVIVQFG
1060 1070 1080 1090 1100
GKPFSCSPLQ LDQWMWCIFI GLGELVWGQV IATIPTSRLK FLKEAGRLTQ
1110 1120 1130 1140 1150
KEEIPEEELN EDVEEIDHAE RELRRGQILW FRGLNRIQTQ IRVVKAFRSS
1160 1170 1180 1190 1200
LYEGLEKPES RTSIHNFMAH PEFRIEDSQP HIPLIDDTDL EEDAALKQNS
1210 1220 1230 1240
SPPSSLNKNN SAIDSGINLT TDTSKSATSS SPGSPIHSLE TSL
Computationally mapped potential isoform sequencesi
There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketQ9R0K7 | AT2B2_MOUSE | Plasma membrane calcium-transportin... | Atp2b2 Pmca2 | 1,198 | Annotation score: | ||
Q3UHH0 | Q3UHH0_MOUSE | Calcium-transporting ATPase | Atp2b2 | 1,194 | Annotation score: | ||
S4R1C4 | S4R1C4_MOUSE | Calcium-transporting ATPase | Atp2b2 | 1,154 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC117596 Genomic DNA No translation available. AC153590 Genomic DNA No translation available. |
RefSeqi | NP_001334294.1, NM_001347365.1 XP_011239463.1, XM_011241161.1 XP_011239464.1, XM_011241162.2 XP_011239465.1, XM_011241163.2 |
Genome annotation databases
Ensembli | ENSMUST00000101044; ENSMUSP00000098605; ENSMUSG00000030302 |
GeneIDi | 11941 |
UCSCi | uc009dho.1 mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC117596 Genomic DNA No translation available. AC153590 Genomic DNA No translation available. |
RefSeqi | NP_001334294.1, NM_001347365.1 XP_011239463.1, XM_011241161.1 XP_011239464.1, XM_011241162.2 XP_011239465.1, XM_011241163.2 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Proteomic databases
jPOSTi | F8WHB1 |
MaxQBi | F8WHB1 |
PeptideAtlasi | F8WHB1 |
PRIDEi | F8WHB1 |
Genome annotation databases
Ensembli | ENSMUST00000101044; ENSMUSP00000098605; ENSMUSG00000030302 |
GeneIDi | 11941 |
UCSCi | uc009dho.1 mouse |
Organism-specific databases
CTDi | 491 |
MGIi | MGI:105368 Atp2b2 |
Phylogenomic databases
eggNOGi | KOG0204 Eukaryota ENOG410XNNC LUCA |
GeneTreei | ENSGT00940000161461 |
OrthoDBi | 115892at2759 |
PhylomeDBi | F8WHB1 |
Miscellaneous databases
ChiTaRSi | Atp2b2 mouse |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000030302 Expressed in 164 organ(s), highest expression level in striatum |
ExpressionAtlasi | F8WHB1 baseline and differential |
Family and domain databases
Gene3Di | 3.40.1110.10, 1 hit |
InterProi | View protein in InterPro IPR030322 ATP2B2 IPR022141 ATP_Ca_trans_C IPR006068 ATPase_P-typ_cation-transptr_C IPR004014 ATPase_P-typ_cation-transptr_N IPR023299 ATPase_P-typ_cyto_dom_N IPR018303 ATPase_P-typ_P_site IPR023298 ATPase_P-typ_TM_dom_sf IPR008250 ATPase_P-typ_transduc_dom_A_sf IPR036412 HAD-like_sf IPR006408 P-type_ATPase_IIB IPR001757 P_typ_ATPase |
PANTHERi | PTHR24093:SF377 PTHR24093:SF377, 1 hit |
Pfami | View protein in Pfam PF12424 ATP_Ca_trans_C, 1 hit PF00689 Cation_ATPase_C, 1 hit PF00690 Cation_ATPase_N, 1 hit |
SMARTi | View protein in SMART SM00831 Cation_ATPase_N, 1 hit |
SUPFAMi | SSF56784 SSF56784, 1 hit SSF81653 SSF81653, 1 hit SSF81660 SSF81660, 1 hit SSF81665 SSF81665, 1 hit |
TIGRFAMsi | TIGR01517 ATPase-IIB_Ca, 1 hit TIGR01494 ATPase_P-type, 3 hits |
PROSITEi | View protein in PROSITE PS00154 ATPASE_E1_E2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | F8WHB1_MOUSE | |
Accessioni | F8WHB1Primary (citable) accession number: F8WHB1 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | September 21, 2011 |
Last sequence update: | September 21, 2011 | |
Last modified: | November 13, 2019 | |
This is version 77 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |