UniProtKB - F8WEZ8 (F8WEZ8_HUMAN)
Protein
Glutamate receptor
Gene
GRIK2
Organism
Homo sapiens (Human)
Status
Functioni
Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system.UniRule annotation
GO - Molecular functioni
- ionotropic glutamate receptor activity Source: InterPro
Keywordsi
Molecular function | Ion channel, Ligand-gated ion channelUniRule annotationARBA annotation, ReceptorUniRule annotationARBA annotation |
Biological process | Ion transport, Transport |
Names & Taxonomyi
Protein namesi | Recommended name: Glutamate receptorUniRule annotation |
Gene namesi | Name:GRIK2Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:4580, GRIK2 |
VEuPathDBi | HostDB:ENSG00000164418.19 |
Subcellular locationi
Plasma membrane
- Cell membrane UniRule annotation; Multi-pass membrane protein UniRule annotation
- postsynaptic cell membrane UniRule annotation
Other locations
- Membrane ARBA annotation; Multi-pass membrane protein ARBA annotation
Plasma Membrane
- postsynaptic membrane Source: UniProtKB-SubCell
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 525 – 544 | HelicalUniRule annotationAdd BLAST | 20 | |
Transmembranei | 601 – 623 | HelicalUniRule annotationAdd BLAST | 23 | |
Transmembranei | 782 – 806 | HelicalUniRule annotationAdd BLAST | 25 |
Keywords - Cellular componenti
Cell junction, Cell membraneUniRule annotationARBA annotation, Membrane, Postsynaptic cell membraneUniRule annotationARBA annotation, SynapseExpressioni
Gene expression databases
Bgeei | ENSG00000164418, Expressed in forebrain and 185 other tissues |
ExpressionAtlasi | F8WEZ8, baseline and differential |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 394 – 763 | PBPeInterPro annotationAdd BLAST | 370 | |
Domaini | 404 – 469 | Lig_chan-Glu_bdInterPro annotationAdd BLAST | 66 |
Sequence similaritiesi
Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. [View classification]UniRule annotation
Keywords - Domaini
SignalARBA annotation, Transmembrane, Transmembrane helixUniRule annotationARBA annotationPhylogenomic databases
OMAi | LFMERDT |
OrthoDBi | 188544at2759 |
Family and domain databases
InterProi | View protein in InterPro IPR001828, ANF_lig-bd_rcpt IPR019594, Glu/Gly-bd IPR001508, Iono_rcpt_met IPR001320, Iontro_rcpt IPR028082, Peripla_BP_I |
Pfami | View protein in Pfam PF01094, ANF_receptor, 1 hit PF00060, Lig_chan, 1 hit PF10613, Lig_chan-Glu_bd, 1 hit |
PRINTSi | PR00177, NMDARECEPTOR |
SMARTi | View protein in SMART SM00918, Lig_chan-Glu_bd, 1 hit SM00079, PBPe, 1 hit |
SUPFAMi | SSF53822, SSF53822, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 5 potential isoforms that are computationally mapped.Show allAlign All
F8WEZ8-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
GGIFEYVESG PMGAEELAFR FAVNTINRNR TLLPNTTLTY DTQKINLYDS
60 70 80 90 100
FEASKKACDQ LSLGVAAIFG PSHSSSANAV QSICNALGVP HIQTRWKHQV
110 120 130 140 150
SDNKDSFYVS LYPDFSSLSR AILDLVQFFK WKTVTVVYDD STGLIRLQEL
160 170 180 190 200
IKAPSRYNLR LKIRQLPADT KDAKPLLKEM KRGKEFHVIF DCSHEMAAGI
210 220 230 240 250
LKQALAMGMM TEYYHYIFTT LDLFALDVEP YRYSGVNMTG FRILNTENTQ
260 270 280 290 300
VSSIIEKWSM ERLQAPPKPD SGLLDGFMTT DAALMYDAVH VVSVAVQQFP
310 320 330 340 350
QMTVSSLQCN RHKPWRFGTR FMSLIKEAHW EGLTGRITFN KTNGLRTDFD
360 370 380 390 400
LDVISLKEEG LEKIGTWDPA SGLNMTESQK GKPANITDSL SNRSLIVTTI
410 420 430 440 450
LEEPYVLFKK SDKPLYGNDR FEGYCIDLLR ELSTILGFTY EIRLVEDGKY
460 470 480 490 500
GAQDDANGQW NGMVRELIDH KADLAVAPLA ITYVREKVID FSKPFMTLGI
510 520 530 540 550
SILYRKPNGT NPGVFSFLNP LSPDIWMYIL LAYLGVSCVL FVIARFSPYE
560 570 580 590 600
WYNPHPCNPD SDVVENNFTL LNSFWFGVGA LMQQGSELMP KALSTRIVGG
610 620 630 640 650
IWWFFTLIII SSYTANLAAF LTVERMESPI DSADDLAKQT KIEYGAVEDG
660 670 680 690 700
ATMTFFKKSK ISTYDKMWAF MSSRRQSVLV KSNEEGIQRV LTSDYAFLME
710 720 730 740 750
STTIEFVTQR NCNLTQIGGL IDSKGYGVGT PMGSPYRDKI TIAILQLQEE
760 770 780 790 800
GKLHMMKEKW WRGNGCPEEE SKEASALGVQ NIGGIFIVLA AGLVLSVFVA
810 820 830 840 850
VGEFLYKSKK NAQLEKRSFC SAMVEELRMS LKCQRRLKHK PQAPVIVKTE
860 870
EVINMHTFND RRLPGKETMA
Computationally mapped potential isoform sequencesi
There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketQ13002 | GRIK2_HUMAN | Glutamate receptor ionotropic, kain... | GRIK2 GLUR6 | 908 | Annotation score: | ||
A0A0A0MRL4 | A0A0A0MRL4_HUMAN | Glutamate receptor | GRIK2 | 74 | Annotation score: | ||
H7C2P5 | H7C2P5_HUMAN | Glutamate receptor ionotropic, kain... | GRIK2 | 182 | Annotation score: | ||
H7BZX7 | H7BZX7_HUMAN | Glutamate receptor ionotropic, kain... | GRIK2 | 180 | Annotation score: | ||
G3XAD3 | G3XAD3_HUMAN | Glutamate receptor ionotropic, kain... | GRIK2 hCG_16784 | 353 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL109919 Genomic DNA No translation available. AL365276 Genomic DNA No translation available. AP002528 Genomic DNA No translation available. AP002529 Genomic DNA No translation available. KC877163 Genomic DNA No translation available. KC877172 Genomic DNA No translation available. KC877175 Genomic DNA No translation available. |
Genome annotation databases
Ensembli | ENST00000369134; ENSP00000358130; ENSG00000164418 |
UCSCi | uc063qhf.1, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL109919 Genomic DNA No translation available. AL365276 Genomic DNA No translation available. AP002528 Genomic DNA No translation available. AP002529 Genomic DNA No translation available. KC877163 Genomic DNA No translation available. KC877172 Genomic DNA No translation available. KC877175 Genomic DNA No translation available. |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Proteomic databases
ProteomicsDBi | 32014 |
Protocols and materials databases
Antibodypediai | 3038, 345 antibodies |
Genome annotation databases
Ensembli | ENST00000369134; ENSP00000358130; ENSG00000164418 |
UCSCi | uc063qhf.1, human |
Organism-specific databases
HGNCi | HGNC:4580, GRIK2 |
OpenTargetsi | ENSG00000164418 |
VEuPathDBi | HostDB:ENSG00000164418.19 |
GenAtlasi | Search... |
Phylogenomic databases
OMAi | LFMERDT |
OrthoDBi | 188544at2759 |
Miscellaneous databases
ChiTaRSi | GRIK2, human |
Gene expression databases
Bgeei | ENSG00000164418, Expressed in forebrain and 185 other tissues |
ExpressionAtlasi | F8WEZ8, baseline and differential |
Family and domain databases
InterProi | View protein in InterPro IPR001828, ANF_lig-bd_rcpt IPR019594, Glu/Gly-bd IPR001508, Iono_rcpt_met IPR001320, Iontro_rcpt IPR028082, Peripla_BP_I |
Pfami | View protein in Pfam PF01094, ANF_receptor, 1 hit PF00060, Lig_chan, 1 hit PF10613, Lig_chan-Glu_bd, 1 hit |
PRINTSi | PR00177, NMDARECEPTOR |
SMARTi | View protein in SMART SM00918, Lig_chan-Glu_bd, 1 hit SM00079, PBPe, 1 hit |
SUPFAMi | SSF53822, SSF53822, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | F8WEZ8_HUMAN | |
Accessioni | F8WEZ8Primary (citable) accession number: F8WEZ8 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | September 21, 2011 |
Last sequence update: | October 29, 2014 | |
Last modified: | April 7, 2021 | |
This is version 71 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |