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Protein
Submitted name:

Ephrin type-B receptor 6

Gene

EPHB6

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi677 – 685ATPUniRule annotation9

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionReceptorSAAS annotation
LigandATP-bindingUniRule annotationSAAS annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Submitted name:
Ephrin type-B receptor 6Imported
Gene namesi
Name:EPHB6Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

EuPathDBiHostDB:ENSG00000106123.11
HGNCiHGNC:3396 EPHB6

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei596 – 620HelicalSequence analysisAdd BLAST25

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000106123

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 31Sequence analysisAdd BLAST31
ChainiPRO_501457168932 – 1022Sequence analysisAdd BLAST991

Expressioni

Gene expression databases

BgeeiENSG00000106123 Expressed in 193 organ(s), highest expression level in anterior cingulate cortex

Structurei

3D structure databases

SMRiF8WCM8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini33 – 238Eph LBDInterPro annotationAdd BLAST206
Domaini370 – 487Fibronectin type-IIIInterPro annotationAdd BLAST118
Domaini488 – 583Fibronectin type-IIIInterPro annotationAdd BLAST96
Domaini671 – 920Protein kinaseInterPro annotationAdd BLAST250
Domaini957 – 1013SAMInterPro annotationAdd BLAST57

Keywords - Domaini

RepeatSAAS annotation, SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

eggNOGiKOG0196 Eukaryota
COG0515 LUCA
GeneTreeiENSGT00760000118975
KOiK05114
OMAiYFQTLPQ
OrthoDBiEOG091G00W0

Family and domain databases

CDDicd00063 FN3, 2 hits
Gene3Di2.60.120.260, 1 hit
2.60.40.10, 2 hits
InterProiView protein in InterPro
IPR027936 Eph_TM
IPR001090 Ephrin_rcpt_lig-bd_dom
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR008979 Galactose-bd-like_sf
IPR009030 Growth_fac_rcpt_cys_sf
IPR013783 Ig-like_fold
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR001660 SAM
IPR013761 SAM/pointed_sf
IPR001245 Ser-Thr/Tyr_kinase_cat_dom
IPR011641 Tyr-kin_ephrin_A/B_rcpt-like
IPR016257 Tyr_kinase_ephrin_rcpt
IPR001426 Tyr_kinase_rcpt_V_CS
PfamiView protein in Pfam
PF14575 EphA2_TM, 1 hit
PF01404 Ephrin_lbd, 1 hit
PF07699 Ephrin_rec_like, 1 hit
PF00041 fn3, 2 hits
PF07714 Pkinase_Tyr, 1 hit
PF07647 SAM_2, 1 hit
PIRSFiPIRSF000666 TyrPK_ephrin_receptor, 1 hit
PRINTSiPR00109 TYRKINASE
SMARTiView protein in SMART
SM00615 EPH_lbd, 1 hit
SM01411 Ephrin_rec_like, 1 hit
SM00060 FN3, 2 hits
SM00454 SAM, 1 hit
SUPFAMiSSF47769 SSF47769, 1 hit
SSF49265 SSF49265, 1 hit
SSF49785 SSF49785, 1 hit
SSF56112 SSF56112, 1 hit
SSF57184 SSF57184, 2 hits
PROSITEiView protein in PROSITE
PS51550 EPH_LBD, 1 hit
PS50853 FN3, 2 hits
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00790 RECEPTOR_TYR_KIN_V_1, 1 hit
PS00791 RECEPTOR_TYR_KIN_V_2, 1 hit
PS50105 SAM_DOMAIN, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 8 potential isoforms that are computationally mapped.iShow all

F8WCM8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MATEGAAQLG NRVAGMVCSL WVLLLVSSVL ALEEVLLDTT GETSEIGWLT
60 70 80 90 100
YPPGGWDEVS VLDDQRRLTR TFEACHVAGA PPGTGQDNWL QTHFVERRGA
110 120 130 140 150
QRAHIRLHFS VRACSSLGVS GGTCRETFTL YYRQAEEPDS PDSVSSWHLK
160 170 180 190 200
RWTKVDTIAA DESFPSSSSS SSSSSSSAAW AVGPHGAGQR AGLQLNVKER
210 220 230 240 250
SFGPLTQRGF YVAFQDTGAC LALVAVRLFS YTCPAVLRSF ASFPETQASG
260 270 280 290 300
AGGASLVAAV GTCVAHAEPE EDGVGGQAGG SPPRLHCNGE GKWMVAVGGC
310 320 330 340 350
RCQPGYQPAR GDKACQACPR GLYKASAGNA PCSPCPARSH APNPAAPVCP
360 370 380 390 400
CLEGFYRASS DPPEAPCTGP PSAPQELWFE VQGSALMLHW RLPRELGGRG
410 420 430 440 450
DLLFNVVCKE CEGRQEPASG GGGTCHRCRD EVHFDPRQRG LTESRVLVGG
460 470 480 490 500
LRAHVPYILE VQAVNGVSEL SPDPPQAAAI NVSTSHEVPS AVPVVHQVSR
510 520 530 540 550
ASNSITVSWP QPDQTNGNIL DYQLRYYDQA EDESHSFTLT SETNTATVTQ
560 570 580 590 600
LSPGHIYGFQ VRARTAAGHG PYGGKVYFQT LPQGELSSQL PERLSLVIGS
610 620 630 640 650
ILGALAFLLL AAITVLAVVF QRKRRGTGYT EQLQQYSSPG LGVKYYIDPS
660 670 680 690 700
TYEDPCQAIR ELAREVDPAY IKIEEVIGTG SFGEVRQGRL QPRGRREQTV
710 720 730 740 750
AIQALWAGGA ESLQMTFLGR AAVLGQFQHP NILRLEGVVT KSRPLMVLTE
760 770 780 790 800
FMELGPLDSF LRQREGQFSS LQLVAMQRGV AAAMQYLSSF AFVHRSLSAH
810 820 830 840 850
SVLVNSHLVC KVARLGHSPQ GPSCLLRWAA PEVIAHGKHT TSSDVWSFGI
860 870 880 890 900
LMWEVMSYGE RPYWDMSEQE VLNAIEQEFR LPPPPGCPPG LHLLMLDTWQ
910 920 930 940 950
KDRARRPHFD QLVAAFDKMI RKPDTLQAGG DPGERPSQAL LTPVALDFPC
960 970 980 990 1000
LDSPQAWLSA IGLECYQDNF SKFGLCTFSD VAQLSLEDLP ALGITLAGHQ
1010 1020
KKLLHHIQLL QQHLRQQGSV EV
Length:1,022
Mass (Da):110,771
Last modified:October 29, 2014 - v2
Checksum:i5038EA11DEE6FFCE
GO

Computationally mapped potential isoform sequencesi

There are 8 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
O15197EPHB6_HUMAN
Ephrin type-B receptor 6
EPHB6
1,021Annotation score:
A0A0G2JNH7A0A0G2JNH7_HUMAN
Ephrin type-B receptor 6
EPHB6
1,022Annotation score:
J3KQU5J3KQU5_HUMAN
Ephrin type-B receptor 6
EPHB6
729Annotation score:
A0A0G2JNC5A0A0G2JNC5_HUMAN
Ephrin type-B receptor 6
EPHB6
729Annotation score:
A0A087WTE3A0A087WTE3_HUMAN
Ephrin type-B receptor 6
EPHB6
183Annotation score:
A0A087WZL4A0A087WZL4_HUMAN
Ephrin type-B receptor 6
EPHB6
50Annotation score:
A0A087WYP8A0A087WYP8_HUMAN
Ephrin type-B receptor 6
EPHB6
112Annotation score:
A0A0J9YXG1A0A0J9YXG1_HUMAN
Ephrin type-B receptor 6
EPHB6
118Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC245427 Genomic DNA No translation available.
RefSeqiNP_004436.4, NM_004445.5
XP_006715944.1, XM_006715881.2
XP_011514181.1, XM_011515879.1
XP_011514182.1, XM_011515880.1
UniGeneiHs.380089

Genome annotation databases

EnsembliENST00000422643; ENSP00000404786; ENSG00000106123
ENST00000619012; ENSP00000481994; ENSG00000106123
GeneIDi2051
KEGGihsa:2051
UCSCiuc033ans.2 human

Similar proteinsi

Entry informationi

Entry nameiF8WCM8_HUMAN
AccessioniPrimary (citable) accession number: F8WCM8
Entry historyiIntegrated into UniProtKB/TrEMBL: September 21, 2011
Last sequence update: October 29, 2014
Last modified: September 12, 2018
This is version 63 of the entry and version 2 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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