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Protein

Actin-related protein 2/3 complex subunit 4

Gene

ARPC4-TTLL3

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the mother actin filament.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActin-bindingUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Actin-related protein 2/3 complex subunit 4UniRule annotation
Gene namesi
Name:ARPC4-TTLL3Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

EuPathDBiHostDB:ENSG00000250151.9
HGNCiHGNC:38830 ARPC4-TTLL3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, CytoskeletonUniRule annotation

PTM / Processingi

Proteomic databases

EPDiF8WCF6
MaxQBiF8WCF6
PeptideAtlasiF8WCF6
PRIDEiF8WCF6

Expressioni

Gene expression databases

BgeeiENSG00000250151 Expressed in 89 organ(s), highest expression level in blood
ExpressionAtlasiF8WCF6 baseline and differential

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

IntActiF8WCF6, 1 interactor

Structurei

3D structure databases

ProteinModelPortaliF8WCF6
SMRiF8WCF6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ARPC4 family.UniRule annotation

Phylogenomic databases

eggNOGiKOG1876 Eukaryota
ENOG4111G2F LUCA
GeneTreeiENSGT00760000118951

Family and domain databases

Gene3Di3.30.1460.20, 1 hit
InterProiView protein in InterPro
IPR034666 ARPC2/4
IPR008384 ARPC4
PANTHERiPTHR22629 PTHR22629, 1 hit
PfamiView protein in Pfam
PF05856 ARPC4, 1 hit
PIRSFiPIRSF039100 ARPC4, 1 hit
SUPFAMiSSF69645 SSF69645, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.iShow all

F8WCF6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTATLRPYLS AVRATLQAAL CLENFSSQVV ERHNKPEVEV RSSKELLLQP
60 70 80 90 100
VTISRNEKEK VLIEGSINSV RVSIAVKQAD EIEKILCHKF MRFMMMRAEN
110 120 130 140 150
FFILRRKPVE GYDISFLITN FHTEQMYKHK LVDFVIHFME EIDKEISEMK
160 170 180
LSVNARARIV AEEFLKNVSR SSGEDPPRRL T
Length:181
Mass (Da):21,059
Last modified:September 21, 2011 - v1
Checksum:i3B1DFA94EFED0C50
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0A6YYG9A0A0A6YYG9_HUMAN
Protein ARPC4-TTLL3
ARPC4-TTLL3
625Annotation score:
H7C0A3H7C0A3_HUMAN
ARPC4-TTLL3 readthrough
ARPC4-TTLL3
167Annotation score:
F8WE39F8WE39_HUMAN
ARPC4-TTLL3 readthrough
ARPC4-TTLL3
47Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC022382 Genomic DNA No translation available.

Genome annotation databases

EnsembliENST00000424442; ENSP00000412284; ENSG00000250151
UCSCiuc062gml.1 human

Similar proteinsi

Entry informationi

Entry nameiF8WCF6_HUMAN
AccessioniPrimary (citable) accession number: F8WCF6
Entry historyiIntegrated into UniProtKB/TrEMBL: September 21, 2011
Last sequence update: September 21, 2011
Last modified: September 12, 2018
This is version 47 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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