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Protein

T-complex protein 1 subunit eta

Gene

CCT7

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. Known to play a role, in vitro, in the folding of actin and tubulin.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionChaperoneUniRule annotation
LigandATP-bindingUniRule annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
T-complex protein 1 subunit etaUniRule annotation
Short name:
TCP-1-etaUniRule annotation
Alternative name(s):
CCT-etaUniRule annotation
Gene namesi
Name:CCT7Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

EuPathDBiHostDB:ENSG00000135624.15
HGNCiHGNC:1622 CCT7

Subcellular locationi

Keywords - Cellular componenti

CytoplasmUniRule annotation

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000135624

PTM / Processingi

Proteomic databases

MaxQBiF8WAM2
PeptideAtlasiF8WAM2
PRIDEiF8WAM2

Expressioni

Gene expression databases

BgeeiENSG00000135624 Expressed in 235 organ(s), highest expression level in testis
ExpressionAtlasiF8WAM2 baseline and differential

Interactioni

Subunit structurei

Heterooligomeric complex of about 850 to 900 kDa that forms two stacked rings, 12 to 16 nm in diameter.UniRule annotation

GO - Molecular functioni

Structurei

3D structure databases

ProteinModelPortaliF8WAM2
SMRiF8WAM2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TCP-1 chaperonin family.UniRule annotation

Phylogenomic databases

eggNOGiKOG0360 Eukaryota
COG0459 LUCA
GeneTreeiENSGT00550000074832

Family and domain databases

Gene3Di1.10.560.10, 1 hit
InterProiView protein in InterPro
IPR012720 Chap_CCT_eta
IPR017998 Chaperone_TCP-1
IPR002194 Chaperonin_TCP-1_CS
IPR002423 Cpn60/TCP-1
IPR027413 GROEL-like_equatorial_sf
PANTHERiPTHR11353:SF22 PTHR11353:SF22, 1 hit
PfamiView protein in Pfam
PF00118 Cpn60_TCP1, 1 hit
PRINTSiPR00304 TCOMPLEXTCP1
SUPFAMiSSF48592 SSF48592, 1 hit
PROSITEiView protein in PROSITE
PS00751 TCP1_2, 1 hit
PS00995 TCP1_3, 1 hit

Sequence (1+)i

Sequence statusi: Fragment.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

F8WAM2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDKLIVDGRG KATISNDGAT ILKLLDVVHP AAKTLVDIAK SQDAEVGDGT
60 70 80 90
TSVTLLAAEF LKQVKPYVEE GLHPQIIIRA FRTATQLAVN KIKEIAVT
Length:98
Mass (Da):10,494
Last modified:September 21, 2011 - v1
Checksum:iF908535DF442C866
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q99832TCPH_HUMAN
T-complex protein 1 subunit eta
CCT7 CCTH, NIP7-1
543Annotation score:
F8WBP8F8WBP8_HUMAN
T-complex protein 1 subunit eta
CCT7
83Annotation score:
A0A0D9SG95A0A0D9SG95_HUMAN
T-complex protein 1 subunit eta
CCT7
83Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei98Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC010913 Genomic DNA No translation available.
KF456675 Genomic DNA No translation available.

Genome annotation databases

EnsembliENST00000399032; ENSP00000412996; ENSG00000135624
UCSCiuc061kpy.1 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC010913 Genomic DNA No translation available.
KF456675 Genomic DNA No translation available.

3D structure databases

ProteinModelPortaliF8WAM2
SMRiF8WAM2
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

MaxQBiF8WAM2
PeptideAtlasiF8WAM2
PRIDEiF8WAM2

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000399032; ENSP00000412996; ENSG00000135624
UCSCiuc061kpy.1 human

Organism-specific databases

EuPathDBiHostDB:ENSG00000135624.15
HGNCiHGNC:1622 CCT7
OpenTargetsiENSG00000135624
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0360 Eukaryota
COG0459 LUCA
GeneTreeiENSGT00550000074832

Miscellaneous databases

ChiTaRSiCCT7 human

Gene expression databases

BgeeiENSG00000135624 Expressed in 235 organ(s), highest expression level in testis
ExpressionAtlasiF8WAM2 baseline and differential

Family and domain databases

Gene3Di1.10.560.10, 1 hit
InterProiView protein in InterPro
IPR012720 Chap_CCT_eta
IPR017998 Chaperone_TCP-1
IPR002194 Chaperonin_TCP-1_CS
IPR002423 Cpn60/TCP-1
IPR027413 GROEL-like_equatorial_sf
PANTHERiPTHR11353:SF22 PTHR11353:SF22, 1 hit
PfamiView protein in Pfam
PF00118 Cpn60_TCP1, 1 hit
PRINTSiPR00304 TCOMPLEXTCP1
SUPFAMiSSF48592 SSF48592, 1 hit
PROSITEiView protein in PROSITE
PS00751 TCP1_2, 1 hit
PS00995 TCP1_3, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiF8WAM2_HUMAN
AccessioniPrimary (citable) accession number: F8WAM2
Entry historyiIntegrated into UniProtKB/TrEMBL: September 21, 2011
Last sequence update: September 21, 2011
Last modified: November 7, 2018
This is version 52 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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