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Protein

Eukaryotic translation initiation factor 2A

Gene

EIF2A

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Functions in the early steps of protein synthesis of a small number of specific mRNAs. Acts by directing the binding of methionyl-tRNAi to 40S ribosomal subunits. In contrast to the eIF-2 complex, it binds methionyl-tRNAi to 40S subunits in a codon-dependent manner, whereas the eIF-2 complex binds methionyl-tRNAi to 40S subunits in a GTP-dependent manner.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionInitiation factorUniRule annotationSAAS annotation
Biological processProtein biosynthesis, Translation regulationUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Eukaryotic translation initiation factor 2AUniRule annotation
Short name:
eIF-2AUniRule annotation
Gene namesi
Name:EIF2AImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

EuPathDBiHostDB:ENSG00000144895.11
HGNCiHGNC:3254 EIF2A

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000144895

PTM / Processingi

Proteomic databases

EPDiF8WAE5
MaxQBiF8WAE5
PeptideAtlasiF8WAE5
PRIDEiF8WAE5

Expressioni

Gene expression databases

BgeeiENSG00000144895 Expressed in 200 organ(s), highest expression level in secondary oocyte
ExpressionAtlasiF8WAE5 baseline and differential

Structurei

3D structure databases

ProteinModelPortaliF8WAE5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini211 – 406eIF2AInterPro annotationAdd BLAST196

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili528 – 576Sequence analysisAdd BLAST49

Sequence similaritiesi

Belongs to the WD repeat EIF2A family.UniRule annotation

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

eggNOGiKOG2315 Eukaryota
COG5354 LUCA
GeneTreeiENSGT00730000111053

Family and domain databases

Gene3Di2.130.10.10, 2 hits
InterProiView protein in InterPro
IPR011387 TIF2A
IPR013979 TIF_beta_prop-like
IPR015943 WD40/YVTN_repeat-like_dom_sf
PANTHERiPTHR13227 PTHR13227, 1 hit
PfamiView protein in Pfam
PF08662 eIF2A, 1 hit
PIRSFiPIRSF017222 eIF2A, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 7 potential isoforms that are computationally mapped.Show allAlign All

F8WAE5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAPSTPLLTV RGSEGLYMVN GPPHFTESTV FPRESGKNCK VCIFSKDGTL
60 70 80 90 100
FAWGNGENVT NKGLLHSFDL LKAVCLEFSP KNTVLATWQP YTTSKDGTAG
110 120 130 140 150
IPNLQLYDVK TGTCLKSFIQ KKMQNWCPSW SEDETLCARN VNNEVHFFEN
160 170 180 190 200
NNFNTIANKL HLQKINDFVL SPGPQPYKVA VYVPGSKGAP SFVRLYQYPN
210 220 230 240 250
FAGPHAALAN KSFFKADKVT MLWNKKATAV LVIASTDVDK TGASYYGEQT
260 270 280 290 300
LHYIATNGES AVVQLPKNGP IYDVVWNSSS TEFCAVYGFM PAKATIFNLK
310 320 330 340 350
CDPVFDFGTG PRNAAYYSPH GHILVLAGFG NLRGQMEVWD VKNYKLISKP
360 370 380 390 400
VASDSTYFAW CPDGEHILTA TCAPRLRVNN GYKIWHYTGS ILHKYDVPSN
410 420 430 440 450
AELWQVSWQP FLDGIFPAKT ITYQAVPSEV PNEEPKVATA YRPPALRNKP
460 470 480 490 500
ITNSKLHEEE PPQNMKPQSG NDKPLSKTAL KNQRKHEAKK AAKQEARSDK
510 520 530 540 550
SPDLAPTPAP QSTPRNTVSQ SISGDPEIDK KIKNLKKKLK AIEQLKEQAA
560 570 580
TGKQLEKNQL EKIQKETALL QELEDLELGI
Length:580
Mass (Da):64,449
Last modified:September 21, 2011 - v1
Checksum:i269E71ACD68CC3A2
GO

Computationally mapped potential isoform sequencesi

There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q9BY44EIF2A_HUMAN
Eukaryotic translation initiation f...
EIF2A CDA02, MSTP004, MSTP089
585Annotation score:
H7C5R5H7C5R5_HUMAN
Eukaryotic translation initiation f...
EIF2A
316Annotation score:
H7C5Q3H7C5Q3_HUMAN
Eukaryotic translation initiation f...
EIF2A
158Annotation score:
C9IZE1C9IZE1_HUMAN
Eukaryotic translation initiation f...
EIF2A
236Annotation score:
F8WAT3F8WAT3_HUMAN
Eukaryotic translation initiation f...
EIF2A
75Annotation score:
F8WF18F8WF18_HUMAN
Eukaryotic translation initiation f...
EIF2A
59Annotation score:
H7C5Q4H7C5Q4_HUMAN
Eukaryotic translation initiation f...
EIF2A
40Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC107426 Genomic DNA No translation available.
RefSeqiNP_001305974.1, NM_001319045.1
UniGeneiHs.655782

Genome annotation databases

EnsembliENST00000273435; ENSP00000273435; ENSG00000144895
GeneIDi83939
UCSCiuc062paf.1 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC107426 Genomic DNA No translation available.
RefSeqiNP_001305974.1, NM_001319045.1
UniGeneiHs.655782

3D structure databases

ProteinModelPortaliF8WAE5
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

EPDiF8WAE5
MaxQBiF8WAE5
PeptideAtlasiF8WAE5
PRIDEiF8WAE5

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000273435; ENSP00000273435; ENSG00000144895
GeneIDi83939
UCSCiuc062paf.1 human

Organism-specific databases

CTDi83939
EuPathDBiHostDB:ENSG00000144895.11
HGNCiHGNC:3254 EIF2A
OpenTargetsiENSG00000144895
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2315 Eukaryota
COG5354 LUCA
GeneTreeiENSGT00730000111053

Gene expression databases

BgeeiENSG00000144895 Expressed in 200 organ(s), highest expression level in secondary oocyte
ExpressionAtlasiF8WAE5 baseline and differential

Family and domain databases

Gene3Di2.130.10.10, 2 hits
InterProiView protein in InterPro
IPR011387 TIF2A
IPR013979 TIF_beta_prop-like
IPR015943 WD40/YVTN_repeat-like_dom_sf
PANTHERiPTHR13227 PTHR13227, 1 hit
PfamiView protein in Pfam
PF08662 eIF2A, 1 hit
PIRSFiPIRSF017222 eIF2A, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiF8WAE5_HUMAN
AccessioniPrimary (citable) accession number: F8WAE5
Entry historyiIntegrated into UniProtKB/TrEMBL: September 21, 2011
Last sequence update: September 21, 2011
Last modified: November 7, 2018
This is version 63 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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