Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

UniProtKB - F8W9Z1 (F8W9Z1_HUMAN)

Entry version 71 (10 Feb 2021)
Sequence version 1 (21 Sep 2011)
Previous versions | rss
Add a publicationFeedback
Protein

Voltage-dependent R-type calcium channel subunit alpha

Gene

CACNA1E

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1E gives rise to R-type calcium currents.UniRule annotation

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionCalcium channelUniRule annotationARBA annotation, Ion channel, Voltage-gated channelUniRule annotation
Biological processCalcium transport, Ion transport, Transport
LigandCalcium, Metal-bindingARBA annotation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Voltage-dependent R-type calcium channel subunit alphaUniRule annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CACNA1EImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:1392, CACNA1E

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000198216.10

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei93 – 110HelicalSequence analysisAdd BLAST18
Transmembranei130 – 150HelicalSequence analysisAdd BLAST21
Transmembranei162 – 180HelicalSequence analysisAdd BLAST19
Transmembranei221 – 243HelicalSequence analysisAdd BLAST23
Transmembranei295 – 316HelicalSequence analysisAdd BLAST22
Transmembranei328 – 350HelicalSequence analysisAdd BLAST23
Transmembranei477 – 497HelicalSequence analysisAdd BLAST21
Transmembranei503 – 521HelicalSequence analysisAdd BLAST19
Transmembranei603 – 625HelicalSequence analysisAdd BLAST23
Transmembranei680 – 703HelicalSequence analysisAdd BLAST24
Transmembranei1133 – 1152HelicalSequence analysisAdd BLAST20
Transmembranei1205 – 1224HelicalSequence analysisAdd BLAST20
Transmembranei1270 – 1292HelicalSequence analysisAdd BLAST23
Transmembranei1382 – 1407HelicalSequence analysisAdd BLAST26
Transmembranei1463 – 1481HelicalSequence analysisAdd BLAST19
Transmembranei1493 – 1516HelicalSequence analysisAdd BLAST24
Transmembranei1522 – 1540HelicalSequence analysisAdd BLAST19
Transmembranei1587 – 1605HelicalSequence analysisAdd BLAST19
Transmembranei1680 – 1704HelicalSequence analysisAdd BLAST25

Keywords - Cellular componenti

Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...OpenTargetsi		ENSG00000198216

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Keywords - PTMi

PhosphoproteinARBA annotation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		F8W9Z1

PRoteomics IDEntifications database

More...PRIDEi		F8W9Z1

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		30406

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000198216, Expressed in caudate nucleus and 88 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		F8W9Z1, baseline and differential

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1720 – 1755EF-handInterPro annotationAdd BLAST36

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 38DisorderedSequence analysisAdd BLAST38
Regioni832 – 965DisorderedSequence analysisAdd BLAST134
Regioni1084 – 1106DisorderedSequence analysisAdd BLAST23
Regioni1951 – 2151DisorderedSequence analysisAdd BLAST201
Regioni2187 – 2206DisorderedSequence analysisAdd BLAST20
Regioni2244 – 2276DisorderedSequence analysisAdd BLAST33

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili699 – 726Sequence analysisAdd BLAST28

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi17 – 31PolarSequence analysisAdd BLAST15
Compositional biasi931 – 963PolyampholyteSequence analysisAdd BLAST33
Compositional biasi1951 – 1977PolarSequence analysisAdd BLAST27
Compositional biasi1986 – 2000PolarSequence analysisAdd BLAST15
Compositional biasi2001 – 2015PolyampholyteSequence analysisAdd BLAST15
Compositional biasi2046 – 2103PolyampholyteSequence analysisAdd BLAST58
Compositional biasi2104 – 2137PolarSequence analysisAdd BLAST34

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. [View classification]UniRule annotation

Keywords - Domaini

Coiled coilSequence analysis, Transmembrane, Transmembrane helixSequence analysisARBA annotation

Phylogenomic databases

Ensembl GeneTree

More...GeneTreei		ENSGT00940000155601

Database of Orthologous Groups

More...OrthoDBi		172471at2759

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.20.120.350, 4 hits

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR002048, EF_hand_dom
IPR031649, GPHH_dom
IPR005821, Ion_trans_dom
IPR014873, VDCC_a1su_IQ
IPR005449, VDCC_R_a1su
IPR002077, VDCCAlpha1
IPR027359, Volt_channel_dom_sf

The PANTHER Classification System

More...PANTHERi		PTHR45628:SF5, PTHR45628:SF5, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF08763, Ca_chan_IQ, 1 hit
PF16905, GPHH, 1 hit
PF00520, Ion_trans, 4 hits

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR00167, CACHANNEL
PR01633, RVDCCALPHA1

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM01062, Ca_chan_IQ, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50222, EF_HAND_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All

F8W9Z1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MARFGEAVVA RPGSGDGDSD QSRNRQGTPV PASGQAAAYK QTKAQRARTM 
        60         70         80         90        100
ALYNPIPVRQ NCFTVNRSLF IFGEDNIVRK YAKKLIDWPP FEYMILATII 
       110        120        130        140        150
ANCIVLALEQ HLPEDDKTPM SRRLEKTEPY FIGIFCFEAG IKIVALGFIF 
       160        170        180        190        200
HKGSYLRNGW NVMDFIVVLS GILATAGTHF NTHVDLRTLR AVRVLRPLKL 
       210        220        230        240        250
VSGIPSLQIV LKSIMKAMVP LLQIGLLLFF AILMFAIIGL EFYSGKLHRA 
       260        270        280        290        300
CFMNNSGILE GFDPPHPCGV QGCPAGYECK DWIGPNDGIT QFDNILFAVL 
       310        320        330        340        350
TVFQCITMEG WTTVLYNTND ALGATWNWLY FIPLIIIGSF FVLNLVLGVL 
       360        370        380        390        400
SGEFAKERER VENRRAFMKL RRQQQIEREL NGYRAWIDKA EEVMLAEENK 
       410        420        430        440        450
NAGTSALEVL RRATIKRSRT EAMTRDSSDE HCVDISSVGT PLARASIKSA 
       460        470        480        490        500
KVDGVSYFRH KERLLRISIR HMVKSQVFYW IVLSLVALNT ACVAIVHHNQ 
       510        520        530        540        550
PQWLTHLLYY AEFLFLGLFL LEMSLKMYGM GPRLYFHSSF NCFDFGVTVG 
       560        570        580        590        600
SIFEVVWAIF RPGTSFGISV LRALRLLRIF KITKYWASLR NLVVSLMSSM 
       610        620        630        640        650
KSIISLLFLL FLFIVVFALL GMQLFGGRFN FNDGTPSANF DTFPAAIMTV 
       660        670        680        690        700
FQILTGEDWN EVMYNGIRSQ GGVSSGMWSA IYFIVLTLFG NYTLLNVFLA 
       710        720        730        740        750
IAVDNLANAQ ELTKDEQEEE EAFNQKHALQ KAKEVSPMSA PNMPSIERER 
       760        770        780        790        800
RRRHHMSVWE QRTSQLRKHM QMSSQEALNR EEAPTMNPLN PLNPLSSLNP 
       810        820        830        840        850
LNAHPSLYRR PRAIEGLALG LALEKFEEER ISRGGSLKGD GGDRSSALDN 
       860        870        880        890        900
QRTPLSLGQR EPPWLARPCH GNCDPTQQEA GGGEAVVTFE DRARHRQSQR 
       910        920        930        940        950
RSRHRRVRTE GKESSSASRS RSASQERSLD EAMPTEGEKD HELRGNHGAK 
       960        970        980        990       1000
EPTIQEERAQ DLRRTNSLMV SRGSGLAGGL DEADTPLVLP HPELEVGKHV 
      1010       1020       1030       1040       1050
VLTEQEPEGS SEQALLGNVQ LDMGRVISQS EPDLSCITAN TDKATTESTS 
      1060       1070       1080       1090       1100
VTVAIPDVDP LVDSTVVHIS NKTDGEASPL KEAEIREDEE EVEKKKQKKE 
      1110       1120       1130       1140       1150
KRETGKAMVP HSSMFIFSTT NPIRRACHYI VNLRYFEMCI LLVIAASSIA 
      1160       1170       1180       1190       1200
LAAEDPVLTN SERNKVLRYF DYVFTGVFTF EMVIKMIDQG LILQDGSYFR 
      1210       1220       1230       1240       1250
DLWNILDFVV VVGALVAFAL ANALGTNKGR DIKTIKSLRV LRVLRPLKTI 
      1260       1270       1280       1290       1300
KRLPKLKAVF DCVVTSLKNV FNILIVYKLF MFIFAVIAVQ LFKGKFFYCT 
      1310       1320       1330       1340       1350
DSSKDTEKEC IGNYVDHEKN KMEVKGREWK RHEFHYDNII WALLTLFTVS 
      1360       1370       1380       1390       1400
TGEGWPQVLQ HSVDVTEEDR GPSRSNRMEM SIFYVVYFVV FPFFFVNIFV 
      1410       1420       1430       1440       1450
ALIIITFQEQ GDKMMEECSL EKNERACIDF AISAKPLTRY MPQNRHTFQY 
      1460       1470       1480       1490       1500
RVWHFVVSPS FEYTIMAMIA LNTVVLMMKY YSAPCTYELA LKYLNIAFTM 
      1510       1520       1530       1540       1550
VFSLECVLKV IAFGFLNYFR DTWNIFDFIT VIGSITEIIL TDSKLVNTSG 
      1560       1570       1580       1590       1600
FNMSFLKLFR AARLIKLLRQ GYTIRILLWT FVQSFKALPY VCLLIAMLFF 
      1610       1620       1630       1640       1650
IYAIIGMQVF GNIKLDEESH INRHNNFRSF FGSLMLLFRS ATGEAWQEIM 
      1660       1670       1680       1690       1700
LSCLGEKGCE PDTTAPSGQN ENERCGTDLA YVYFVSFIFF CSFLMLNLFV 
      1710       1720       1730       1740       1750
AVIMDNFEYL TRDSSILGPH HLDEFVRVWA EYDRAACGRI HYTEMYEMLT 
      1760       1770       1780       1790       1800
LMSPPLGLGK RCPSKVAYKR LVLMNMPVAE DMTVHFTSTL MALIRTALDI 
      1810       1820       1830       1840       1850
KIAKGGADRQ QLDSELQKET LAIWPHLSQK MLDLLVPMPK ASDLTVGKIY 
      1860       1870       1880       1890       1900
AAMMIMDYYK QSKVKKQRQQ LEEQKNAPMF QRMEPSSLPQ EIIANAKALP 
      1910       1920       1930       1940       1950
YLQQDPVSGL SGRSGYPSMS PLSPQDIFQL ACMDPADDGQ FQERQSLEPE 
      1960       1970       1980       1990       2000
VSELKSVQPS NHGIYLPSDT QEHAGSGRAS SMPRLTVDPQ VVTDPSSMRR 
      2010       2020       2030       2040       2050
SFSTIRDKRS NSSWLEEFSM ERSSENTYKS RRRSYHSSLR LSAHRLNSDS 
      2060       2070       2080       2090       2100
GHKSDTHRSG GRERGRSKER KHLLSPDVSR CNSEERGTQA DWESPERRQS 
      2110       2120       2130       2140       2150
RSPSEGRSQT PNRQGTGSLS ESSIPSVSDT STPRRSRRQL PPVPPKPRPL 
      2160       2170       2180       2190       2200
LSYSSLIRHA GSISPPADGS EEGSPLTSQA LESNNACLTE SSNSPHPQQS 
      2210       2220       2230       2240       2250
QHASPQRYIS EPYLALHEDS HASDCGEEET LTFEAAVATS LGRSNTIGSA 
      2260       2270       2280       2290 
PPLRHSWQMP NGHYRRRRRG GPGPGMMCGA VNNLLSDTEE DDKC
Length:2,294
Mass (Da):259,219
Last modified:September 21, 2011 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i9821C5DA2F699849
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q15878CAC1E_HUMAN
Voltage-dependent R-type calcium ch...
CACNA1E CACH6, CACNL1A6
2,313Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
J3KP11J3KP11_HUMAN
Voltage-dependent R-type calcium ch...
CACNA1E
2,312Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PIE8E9PIE8_HUMAN
Voltage-dependent R-type calcium ch...
CACNA1E
583Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2R8Y7W1A0A2R8Y7W1_HUMAN
Voltage-dependent R-type calcium ch...
CACNA1E
110Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AL160059 Genomic DNA No translation available.
AL161734 Genomic DNA No translation available.
AL356500 Genomic DNA No translation available.
AL359270 Genomic DNA No translation available.
AL590624 Genomic DNA No translation available.
AL590998 Genomic DNA No translation available.
KF455083 Genomic DNA No translation available.
KF455110 Genomic DNA No translation available.

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000360108; ENSP00000353222; ENSG00000198216

UCSC genome browser

More...UCSCi		uc057nsr.1, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL160059 Genomic DNA No translation available.
AL161734 Genomic DNA No translation available.
AL356500 Genomic DNA No translation available.
AL359270 Genomic DNA No translation available.
AL590624 Genomic DNA No translation available.
AL590998 Genomic DNA No translation available.
KF455083 Genomic DNA No translation available.
KF455110 Genomic DNA No translation available.

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Proteomic databases

EPDiF8W9Z1
PRIDEiF8W9Z1
ProteomicsDBi30406

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		34433, 116 antibodies

Genome annotation databases

EnsembliENST00000360108; ENSP00000353222; ENSG00000198216
UCSCiuc057nsr.1, human

Organism-specific databases

HGNCiHGNC:1392, CACNA1E
OpenTargetsiENSG00000198216
VEuPathDBiHostDB:ENSG00000198216.10

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

GeneTreeiENSGT00940000155601
OrthoDBi172471at2759

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		CACNA1E, human

Gene expression databases

BgeeiENSG00000198216, Expressed in caudate nucleus and 88 other tissues
ExpressionAtlasiF8W9Z1, baseline and differential

Family and domain databases

Gene3Di1.20.120.350, 4 hits
InterProiView protein in InterPro
IPR002048, EF_hand_dom
IPR031649, GPHH_dom
IPR005821, Ion_trans_dom
IPR014873, VDCC_a1su_IQ
IPR005449, VDCC_R_a1su
IPR002077, VDCCAlpha1
IPR027359, Volt_channel_dom_sf
PANTHERiPTHR45628:SF5, PTHR45628:SF5, 1 hit
PfamiView protein in Pfam
PF08763, Ca_chan_IQ, 1 hit
PF16905, GPHH, 1 hit
PF00520, Ion_trans, 4 hits
PRINTSiPR00167, CACHANNEL
PR01633, RVDCCALPHA1
SMARTiView protein in SMART
SM01062, Ca_chan_IQ, 1 hit
PROSITEiView protein in PROSITE
PS50222, EF_HAND_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiF8W9Z1_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: F8W9Z1
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: September 21, 2011
Last sequence update: September 21, 2011
Last modified: February 10, 2021
This is version 71 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again