UniProtKB - F8W9Z1 (F8W9Z1_HUMAN)
Protein
Voltage-dependent R-type calcium channel subunit alpha
Gene
CACNA1E
Organism
Homo sapiens (Human)
Status
Functioni
Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1E gives rise to R-type calcium currents.UniRule annotation
Caution
Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation
GO - Molecular functioni
- calcium ion binding Source: InterPro
- voltage-gated calcium channel activity Source: InterPro
GO - Biological processi
- regulation of ion transmembrane transport Source: UniProtKB-KW
Keywordsi
Molecular function | Calcium channelUniRule annotationARBA annotation, Ion channel, Voltage-gated channelUniRule annotation |
Biological process | Calcium transport, Ion transport, Transport |
Ligand | Calcium, Metal-bindingARBA annotation |
Names & Taxonomyi
Protein namesi | Recommended name: Voltage-dependent R-type calcium channel subunit alphaUniRule annotation |
Gene namesi | Name:CACNA1EImported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:1392, CACNA1E |
VEuPathDBi | HostDB:ENSG00000198216.10 |
Subcellular locationi
Other locations
- Membrane UniRule annotationARBA annotation; Multi-pass membrane protein UniRule annotationARBA annotation
Plasma Membrane
- voltage-gated calcium channel complex Source: InterPro
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 93 – 110 | HelicalSequence analysisAdd BLAST | 18 | |
Transmembranei | 130 – 150 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 162 – 180 | HelicalSequence analysisAdd BLAST | 19 | |
Transmembranei | 221 – 243 | HelicalSequence analysisAdd BLAST | 23 | |
Transmembranei | 295 – 316 | HelicalSequence analysisAdd BLAST | 22 | |
Transmembranei | 328 – 350 | HelicalSequence analysisAdd BLAST | 23 | |
Transmembranei | 477 – 497 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 503 – 521 | HelicalSequence analysisAdd BLAST | 19 | |
Transmembranei | 603 – 625 | HelicalSequence analysisAdd BLAST | 23 | |
Transmembranei | 680 – 703 | HelicalSequence analysisAdd BLAST | 24 | |
Transmembranei | 1133 – 1152 | HelicalSequence analysisAdd BLAST | 20 | |
Transmembranei | 1205 – 1224 | HelicalSequence analysisAdd BLAST | 20 | |
Transmembranei | 1270 – 1292 | HelicalSequence analysisAdd BLAST | 23 | |
Transmembranei | 1382 – 1407 | HelicalSequence analysisAdd BLAST | 26 | |
Transmembranei | 1463 – 1481 | HelicalSequence analysisAdd BLAST | 19 | |
Transmembranei | 1493 – 1516 | HelicalSequence analysisAdd BLAST | 24 | |
Transmembranei | 1522 – 1540 | HelicalSequence analysisAdd BLAST | 19 | |
Transmembranei | 1587 – 1605 | HelicalSequence analysisAdd BLAST | 19 | |
Transmembranei | 1680 – 1704 | HelicalSequence analysisAdd BLAST | 25 |
Keywords - Cellular componenti
MembranePTM / Processingi
Keywords - PTMi
PhosphoproteinARBA annotationProteomic databases
EPDi | F8W9Z1 |
PRIDEi | F8W9Z1 |
ProteomicsDBi | 30406 |
Expressioni
Gene expression databases
Bgeei | ENSG00000198216, Expressed in caudate nucleus and 88 other tissues |
ExpressionAtlasi | F8W9Z1, baseline and differential |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 1720 – 1755 | EF-handInterPro annotationAdd BLAST | 36 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 38 | DisorderedSequence analysisAdd BLAST | 38 | |
Regioni | 832 – 965 | DisorderedSequence analysisAdd BLAST | 134 | |
Regioni | 1084 – 1106 | DisorderedSequence analysisAdd BLAST | 23 | |
Regioni | 1951 – 2151 | DisorderedSequence analysisAdd BLAST | 201 | |
Regioni | 2187 – 2206 | DisorderedSequence analysisAdd BLAST | 20 | |
Regioni | 2244 – 2276 | DisorderedSequence analysisAdd BLAST | 33 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 699 – 726 | Sequence analysisAdd BLAST | 28 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 17 – 31 | PolarSequence analysisAdd BLAST | 15 | |
Compositional biasi | 931 – 963 | PolyampholyteSequence analysisAdd BLAST | 33 | |
Compositional biasi | 1951 – 1977 | PolarSequence analysisAdd BLAST | 27 | |
Compositional biasi | 1986 – 2000 | PolarSequence analysisAdd BLAST | 15 | |
Compositional biasi | 2001 – 2015 | PolyampholyteSequence analysisAdd BLAST | 15 | |
Compositional biasi | 2046 – 2103 | PolyampholyteSequence analysisAdd BLAST | 58 | |
Compositional biasi | 2104 – 2137 | PolarSequence analysisAdd BLAST | 34 |
Sequence similaritiesi
Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. [View classification]UniRule annotation
Keywords - Domaini
Coiled coilSequence analysis, Transmembrane, Transmembrane helixSequence analysisARBA annotationPhylogenomic databases
GeneTreei | ENSGT00940000155601 |
OrthoDBi | 172471at2759 |
Family and domain databases
Gene3Di | 1.20.120.350, 4 hits |
InterProi | View protein in InterPro IPR002048, EF_hand_dom IPR031649, GPHH_dom IPR005821, Ion_trans_dom IPR014873, VDCC_a1su_IQ IPR005449, VDCC_R_a1su IPR002077, VDCCAlpha1 IPR027359, Volt_channel_dom_sf |
PANTHERi | PTHR45628:SF5, PTHR45628:SF5, 1 hit |
Pfami | View protein in Pfam PF08763, Ca_chan_IQ, 1 hit PF16905, GPHH, 1 hit PF00520, Ion_trans, 4 hits |
PRINTSi | PR00167, CACHANNEL PR01633, RVDCCALPHA1 |
SMARTi | View protein in SMART SM01062, Ca_chan_IQ, 1 hit |
PROSITEi | View protein in PROSITE PS50222, EF_HAND_2, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All
F8W9Z1-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MARFGEAVVA RPGSGDGDSD QSRNRQGTPV PASGQAAAYK QTKAQRARTM
60 70 80 90 100
ALYNPIPVRQ NCFTVNRSLF IFGEDNIVRK YAKKLIDWPP FEYMILATII
110 120 130 140 150
ANCIVLALEQ HLPEDDKTPM SRRLEKTEPY FIGIFCFEAG IKIVALGFIF
160 170 180 190 200
HKGSYLRNGW NVMDFIVVLS GILATAGTHF NTHVDLRTLR AVRVLRPLKL
210 220 230 240 250
VSGIPSLQIV LKSIMKAMVP LLQIGLLLFF AILMFAIIGL EFYSGKLHRA
260 270 280 290 300
CFMNNSGILE GFDPPHPCGV QGCPAGYECK DWIGPNDGIT QFDNILFAVL
310 320 330 340 350
TVFQCITMEG WTTVLYNTND ALGATWNWLY FIPLIIIGSF FVLNLVLGVL
360 370 380 390 400
SGEFAKERER VENRRAFMKL RRQQQIEREL NGYRAWIDKA EEVMLAEENK
410 420 430 440 450
NAGTSALEVL RRATIKRSRT EAMTRDSSDE HCVDISSVGT PLARASIKSA
460 470 480 490 500
KVDGVSYFRH KERLLRISIR HMVKSQVFYW IVLSLVALNT ACVAIVHHNQ
510 520 530 540 550
PQWLTHLLYY AEFLFLGLFL LEMSLKMYGM GPRLYFHSSF NCFDFGVTVG
560 570 580 590 600
SIFEVVWAIF RPGTSFGISV LRALRLLRIF KITKYWASLR NLVVSLMSSM
610 620 630 640 650
KSIISLLFLL FLFIVVFALL GMQLFGGRFN FNDGTPSANF DTFPAAIMTV
660 670 680 690 700
FQILTGEDWN EVMYNGIRSQ GGVSSGMWSA IYFIVLTLFG NYTLLNVFLA
710 720 730 740 750
IAVDNLANAQ ELTKDEQEEE EAFNQKHALQ KAKEVSPMSA PNMPSIERER
760 770 780 790 800
RRRHHMSVWE QRTSQLRKHM QMSSQEALNR EEAPTMNPLN PLNPLSSLNP
810 820 830 840 850
LNAHPSLYRR PRAIEGLALG LALEKFEEER ISRGGSLKGD GGDRSSALDN
860 870 880 890 900
QRTPLSLGQR EPPWLARPCH GNCDPTQQEA GGGEAVVTFE DRARHRQSQR
910 920 930 940 950
RSRHRRVRTE GKESSSASRS RSASQERSLD EAMPTEGEKD HELRGNHGAK
960 970 980 990 1000
EPTIQEERAQ DLRRTNSLMV SRGSGLAGGL DEADTPLVLP HPELEVGKHV
1010 1020 1030 1040 1050
VLTEQEPEGS SEQALLGNVQ LDMGRVISQS EPDLSCITAN TDKATTESTS
1060 1070 1080 1090 1100
VTVAIPDVDP LVDSTVVHIS NKTDGEASPL KEAEIREDEE EVEKKKQKKE
1110 1120 1130 1140 1150
KRETGKAMVP HSSMFIFSTT NPIRRACHYI VNLRYFEMCI LLVIAASSIA
1160 1170 1180 1190 1200
LAAEDPVLTN SERNKVLRYF DYVFTGVFTF EMVIKMIDQG LILQDGSYFR
1210 1220 1230 1240 1250
DLWNILDFVV VVGALVAFAL ANALGTNKGR DIKTIKSLRV LRVLRPLKTI
1260 1270 1280 1290 1300
KRLPKLKAVF DCVVTSLKNV FNILIVYKLF MFIFAVIAVQ LFKGKFFYCT
1310 1320 1330 1340 1350
DSSKDTEKEC IGNYVDHEKN KMEVKGREWK RHEFHYDNII WALLTLFTVS
1360 1370 1380 1390 1400
TGEGWPQVLQ HSVDVTEEDR GPSRSNRMEM SIFYVVYFVV FPFFFVNIFV
1410 1420 1430 1440 1450
ALIIITFQEQ GDKMMEECSL EKNERACIDF AISAKPLTRY MPQNRHTFQY
1460 1470 1480 1490 1500
RVWHFVVSPS FEYTIMAMIA LNTVVLMMKY YSAPCTYELA LKYLNIAFTM
1510 1520 1530 1540 1550
VFSLECVLKV IAFGFLNYFR DTWNIFDFIT VIGSITEIIL TDSKLVNTSG
1560 1570 1580 1590 1600
FNMSFLKLFR AARLIKLLRQ GYTIRILLWT FVQSFKALPY VCLLIAMLFF
1610 1620 1630 1640 1650
IYAIIGMQVF GNIKLDEESH INRHNNFRSF FGSLMLLFRS ATGEAWQEIM
1660 1670 1680 1690 1700
LSCLGEKGCE PDTTAPSGQN ENERCGTDLA YVYFVSFIFF CSFLMLNLFV
1710 1720 1730 1740 1750
AVIMDNFEYL TRDSSILGPH HLDEFVRVWA EYDRAACGRI HYTEMYEMLT
1760 1770 1780 1790 1800
LMSPPLGLGK RCPSKVAYKR LVLMNMPVAE DMTVHFTSTL MALIRTALDI
1810 1820 1830 1840 1850
KIAKGGADRQ QLDSELQKET LAIWPHLSQK MLDLLVPMPK ASDLTVGKIY
1860 1870 1880 1890 1900
AAMMIMDYYK QSKVKKQRQQ LEEQKNAPMF QRMEPSSLPQ EIIANAKALP
1910 1920 1930 1940 1950
YLQQDPVSGL SGRSGYPSMS PLSPQDIFQL ACMDPADDGQ FQERQSLEPE
1960 1970 1980 1990 2000
VSELKSVQPS NHGIYLPSDT QEHAGSGRAS SMPRLTVDPQ VVTDPSSMRR
2010 2020 2030 2040 2050
SFSTIRDKRS NSSWLEEFSM ERSSENTYKS RRRSYHSSLR LSAHRLNSDS
2060 2070 2080 2090 2100
GHKSDTHRSG GRERGRSKER KHLLSPDVSR CNSEERGTQA DWESPERRQS
2110 2120 2130 2140 2150
RSPSEGRSQT PNRQGTGSLS ESSIPSVSDT STPRRSRRQL PPVPPKPRPL
2160 2170 2180 2190 2200
LSYSSLIRHA GSISPPADGS EEGSPLTSQA LESNNACLTE SSNSPHPQQS
2210 2220 2230 2240 2250
QHASPQRYIS EPYLALHEDS HASDCGEEET LTFEAAVATS LGRSNTIGSA
2260 2270 2280 2290
PPLRHSWQMP NGHYRRRRRG GPGPGMMCGA VNNLLSDTEE DDKC
Computationally mapped potential isoform sequencesi
There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketQ15878 | CAC1E_HUMAN | Voltage-dependent R-type calcium ch... | CACNA1E CACH6, CACNL1A6 | 2,313 | Annotation score: | ||
J3KP11 | J3KP11_HUMAN | Voltage-dependent R-type calcium ch... | CACNA1E | 2,312 | Annotation score: | ||
E9PIE8 | E9PIE8_HUMAN | Voltage-dependent R-type calcium ch... | CACNA1E | 583 | Annotation score: | ||
A0A2R8Y7W1 | A0A2R8Y7W1_HUMAN | Voltage-dependent R-type calcium ch... | CACNA1E | 110 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL160059 Genomic DNA No translation available. AL161734 Genomic DNA No translation available. AL356500 Genomic DNA No translation available. AL359270 Genomic DNA No translation available. AL590624 Genomic DNA No translation available. AL590998 Genomic DNA No translation available. KF455083 Genomic DNA No translation available. KF455110 Genomic DNA No translation available. |
Genome annotation databases
Ensembli | ENST00000360108; ENSP00000353222; ENSG00000198216 |
UCSCi | uc057nsr.1, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL160059 Genomic DNA No translation available. AL161734 Genomic DNA No translation available. AL356500 Genomic DNA No translation available. AL359270 Genomic DNA No translation available. AL590624 Genomic DNA No translation available. AL590998 Genomic DNA No translation available. KF455083 Genomic DNA No translation available. KF455110 Genomic DNA No translation available. |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Proteomic databases
EPDi | F8W9Z1 |
PRIDEi | F8W9Z1 |
ProteomicsDBi | 30406 |
Protocols and materials databases
Antibodypediai | 34433, 116 antibodies |
Genome annotation databases
Ensembli | ENST00000360108; ENSP00000353222; ENSG00000198216 |
UCSCi | uc057nsr.1, human |
Organism-specific databases
HGNCi | HGNC:1392, CACNA1E |
OpenTargetsi | ENSG00000198216 |
VEuPathDBi | HostDB:ENSG00000198216.10 |
GenAtlasi | Search... |
Phylogenomic databases
GeneTreei | ENSGT00940000155601 |
OrthoDBi | 172471at2759 |
Miscellaneous databases
ChiTaRSi | CACNA1E, human |
Gene expression databases
Bgeei | ENSG00000198216, Expressed in caudate nucleus and 88 other tissues |
ExpressionAtlasi | F8W9Z1, baseline and differential |
Family and domain databases
Gene3Di | 1.20.120.350, 4 hits |
InterProi | View protein in InterPro IPR002048, EF_hand_dom IPR031649, GPHH_dom IPR005821, Ion_trans_dom IPR014873, VDCC_a1su_IQ IPR005449, VDCC_R_a1su IPR002077, VDCCAlpha1 IPR027359, Volt_channel_dom_sf |
PANTHERi | PTHR45628:SF5, PTHR45628:SF5, 1 hit |
Pfami | View protein in Pfam PF08763, Ca_chan_IQ, 1 hit PF16905, GPHH, 1 hit PF00520, Ion_trans, 4 hits |
PRINTSi | PR00167, CACHANNEL PR01633, RVDCCALPHA1 |
SMARTi | View protein in SMART SM01062, Ca_chan_IQ, 1 hit |
PROSITEi | View protein in PROSITE PS50222, EF_HAND_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | F8W9Z1_HUMAN | |
Accessioni | F8W9Z1Primary (citable) accession number: F8W9Z1 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | September 21, 2011 |
Last sequence update: | September 21, 2011 | |
Last modified: | February 10, 2021 | |
This is version 71 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |