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Entry version 72 (07 Oct 2020)
Sequence version 1 (21 Sep 2011)
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Protein

Non-specific serine/threonine protein kinase

Gene

WNK2

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Enzyme and pathway databases

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...
SignaLinki
F8W9F9

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Non-specific serine/threonine protein kinaseARBA annotation (EC:2.7.11.1ARBA annotation)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:WNK2Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 9

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000165238.16

Human Gene Nomenclature Database

More...
HGNCi
HGNC:14542, WNK2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...
OpenTargetsi
ENSG00000165238

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
F8W9F9

PeptideAtlas

More...
PeptideAtlasi
F8W9F9

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
30320

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
F8W9F9

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000165238, Expressed in apex of heart and 194 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
F8W9F9, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
F8W9F9, HS

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini195 – 453Protein kinaseInterPro annotationAdd BLAST259

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 75DisorderedSequence analysisAdd BLAST75
Regioni89 – 183DisorderedSequence analysisAdd BLAST95
Regioni579 – 630DisorderedSequence analysisAdd BLAST52
Regioni699 – 751DisorderedSequence analysisAdd BLAST53
Regioni917 – 1022DisorderedSequence analysisAdd BLAST106
Regioni1117 – 1185DisorderedSequence analysisAdd BLAST69
Regioni1262 – 1297DisorderedSequence analysisAdd BLAST36
Regioni1323 – 1443DisorderedSequence analysisAdd BLAST121
Regioni1455 – 1547DisorderedSequence analysisAdd BLAST93
Regioni1584 – 1828DisorderedSequence analysisAdd BLAST245
Regioni1933 – 1953DisorderedSequence analysisAdd BLAST21
Regioni1974 – 1998DisorderedSequence analysisAdd BLAST25
Regioni2086 – 2105DisorderedSequence analysisAdd BLAST20
Regioni2160 – 2217DisorderedSequence analysisAdd BLAST58

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili1894 – 1925Sequence analysisAdd BLAST32

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi146 – 172PolyampholyteSequence analysisAdd BLAST27
Compositional biasi601 – 630PolarSequence analysisAdd BLAST30
Compositional biasi705 – 751Pro-richSequence analysisAdd BLAST47
Compositional biasi939 – 1009Pro-richSequence analysisAdd BLAST71
Compositional biasi1117 – 1148PolarSequence analysisAdd BLAST32
Compositional biasi1165 – 1179BasicSequence analysisAdd BLAST15
Compositional biasi1275 – 1297PolarSequence analysisAdd BLAST23
Compositional biasi1324 – 1338Pro-richSequence analysisAdd BLAST15
Compositional biasi1339 – 1373PolarSequence analysisAdd BLAST35
Compositional biasi1374 – 1390Pro-richSequence analysisAdd BLAST17
Compositional biasi1406 – 1435PolarSequence analysisAdd BLAST30
Compositional biasi1471 – 1496Pro-richSequence analysisAdd BLAST26
Compositional biasi1517 – 1534Pro-richSequence analysisAdd BLAST18
Compositional biasi1635 – 1650PolarSequence analysisAdd BLAST16
Compositional biasi1733 – 1761PolarSequence analysisAdd BLAST29

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.ARBA annotation

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000157161

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_000550_3_0_1

Database of Orthologous Groups

More...
OrthoDBi
27514at2759

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR011009, Kinase-like_dom_sf
IPR024678, Kinase_OSR1/WNK_CCT
IPR000719, Prot_kinase_dom
IPR008271, Ser/Thr_kinase_AS

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF12202, OSR1_C, 1 hit
PF00069, Pkinase, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00220, S_TKc, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF56112, SSF56112, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50011, PROTEIN_KINASE_DOM, 1 hit
PS00108, PROTEIN_KINASE_ST, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 7 potential isoforms that are computationally mapped.Show allAlign All

F8W9F9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDGDGGRRDV PGTLMEPGRG AGPAGMAEPR AKAARPGPQR FLRRSVVESD
60 70 80 90 100
QEEPPGLEAA EAPGPQPPQP LQRRVLLLCK TRRLIAERAR GRPAAPAPAA
110 120 130 140 150
LVAQPGAPGA PADAGPEPVG TQEPGPDPIA AAVETAPAPD GGPREEAAAT
160 170 180 190 200
VRKEDEGAAE AKPEPGRTRR DEPEEEEDDE DDLKAVATSL DGRFLKFDIE
210 220 230 240 250
LGRGSFKTVY KGLDTETWVE VAWCELQDRK LTKLERQRFK EEAEMLKGLQ
260 270 280 290 300
HPNIVRFYDF WESSAKGKRC IVLVTELMTS GTLKTYLKRF KVMKPKVLRS
310 320 330 340 350
WCRQILKGLL FLHTRTPPII HRDLKCDNIF ITGPTGSVKI GDLGLATLKR
360 370 380 390 400
ASFAKSVIGT PEFMAPEMYE EHYDESVDVY AFGMCMLEMA TSEYPYSECQ
410 420 430 440 450
NAAQIYRKVT CGIKPASFEK VHDPEIKEII GECICKNKEE RYEIKDLLSH
460 470 480 490 500
AFFAEDTGVR VELAEEDHGR KSTIALRLWV EDPKKLKGKP KDNGAIEFTF
510 520 530 540 550
DLEKETPDEV AQEMIESGFF HESDVKIVAK SIRDRVALIQ WRRERIWPAL
560 570 580 590 600
QPKEQQDVGS PDKARGPPVP LQVQVTYHAQ AGQPGPPEPE EPEADQHLLP
610 620 630 640 650
PTLPTSATSL ASDSTFDSGQ GSTVYSDSQS SQQSVMLGSL ADAAPSPAQC
660 670 680 690 700
VCSPPVSEGP VLPQSLPSLG AYQQPTAAPG LPVGSVPAPA CPPSLQQHFP
710 720 730 740 750
DPAMSFAPVL PPPSTPMPTG PGQPAPPGQQ PPPLAQPTPL PQVLAPQPVV
760 770 780 790 800
PLQPVPPHLP PYLAPASQVG APAQLKPLQM PQAPLQPLAQ VPPQMPPIPV
810 820 830 840 850
VPPITPLAGI DGLPPALPDL PTATVPPVPP PQYFSPAVIL PSLAAPLPPA
860 870 880 890 900
SPALPLQAVK LPHPPGAPLA MPCRTIVPNA PATIPLLAVA PPGVAALSIH
910 920 930 940 950
SAVAQLPGQP VYPAAFPQMA PTDVPPSPHH TVQNMRATPP QPALPPQPTL
960 970 980 990 1000
PPQPVLPPQP TLPPQPVLPP QPTRPPQPVL PPQPMLPPQP VLPPQPALPV
1010 1020 1030 1040 1050
RPEPLQPHLP EQAAPAATPG SQILLGHPAP YAVDVAAQVP TVPVPPAAVL
1060 1070 1080 1090 1100
SPPLPEVLLP AAPELLPQFP SSLATVSASV QSVPTQTATL LPPANPPLPG
1110 1120 1130 1140 1150
GPGIASPCPT VQLTVEPVQE EQASQDKPPG LPQSCESYGG SDVTSGKELS
1160 1170 1180 1190 1200
DSCEGAFGGG RLEGRAARKH HRRSTRARSR QERASRPRLT ILNVCNTGDK
1210 1220 1230 1240 1250
MVECQLETHN HKMVTFKFDL DGDAPDEIAT YMVEHDFILQ AERETFIEQM
1260 1270 1280 1290 1300
KDVMDKAEDM LSEDTDADRG SDPGTSPPHL STCGLGTGEE SRQSQANAPV
1310 1320 1330 1340 1350
YQQNVLHTGK RWFIICPVAE HPAPEAPESS PPLPLSSLPP EASQDSAPYK
1360 1370 1380 1390 1400
DQLSSKEQPS FLASQQLLSQ AGPSNPPGAP PAPLAPSSPP VTALPQDGAA
1410 1420 1430 1440 1450
PATSTMPEPA SGTASQAGGP GTPQGLTSEL ETSQPLAETH EAPLAVQPLV
1460 1470 1480 1490 1500
VGLAPCTPAP EAASTRDASA PREPLPPPAP EPSPHSGTPQ PALGQPAPLL
1510 1520 1530 1540 1550
PAAVGAVSLA TSQLPSPPLG PTVPPQPPSA LESDGEGPPP RVGFVDSTIK
1560 1570 1580 1590 1600
SLDEKLRTLL YQEHVPTSSA SAGTPVEVGD RDFTLEPLRG DQPRSEVCGG
1610 1620 1630 1640 1650
DLALPPVPKE AVSGRVQLPQ PLVEKSELAP TRGAVMEQGT SSSMTAESSP
1660 1670 1680 1690 1700
RSMLGYDRDG RQVASDSHVV PSVPQDVPAF VRPARVEPTD RDGGEAGESS
1710 1720 1730 1740 1750
AEPPPSDMGT VGGQASHPQT LGARALGSPR KRPEQQDVSS PAKTVGRFSV
1760 1770 1780 1790 1800
VSTQDEWTLA SPHSLRYSAP PDVYLDEAPS SPDVKLAVRR AQTASSIEVG
1810 1820 1830 1840 1850
VGEPVSSDSG DEGPRARPPV QKQASLPVSG SVAGDFVKKA TAFLQRPSRA
1860 1870 1880 1890 1900
GSLGPETPSR VGMKVPTISV TSFHSQSSYI SSDNDSELED ADIKKELQSL
1910 1920 1930 1940 1950
REKHLKEISE LQSQQKQEIE ALYRRLGKPL PPNVGFFHTA PPTGRRRKTS
1960 1970 1980 1990 2000
KSKLKAGKLL NPLVRQLKVV ASSTGHLADS SRGPPAKDPA QASVGLTADS
2010 2020 2030 2040 2050
TGLSGKAVQT QQPCSVRASL SSDICSGLAS DGGGARGQGW TVYHPTSERV
2060 2070 2080 2090 2100
TYKSSSKPRA RFLSGPVSVS IWSALKRLCL GKEHSSRSST SSLAPGPEPG
2110 2120 2130 2140 2150
PQPALHVQAQ VNNSNNKKGT FTDDLHKLVD EWTSKTVGAA QLKPTLNQLK
2160 2170 2180 2190 2200
QTQKLQDMEA QAGWAAPGEA RAMTAPRAGV GMPRLPPAPG PLSTTVIPGA
2210
APTLSVPTPD PESEKPD
Length:2,217
Mass (Da):234,380
Last modified:September 21, 2011 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i60E5F2982D5235A1
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q9Y3S1WNK2_HUMAN
Serine/threonine-protein kinase WNK...
WNK2 KIAA1760, PRKWNK2, SDCCAG43, P/OKcl.13
2,297Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0Y7T5H0Y7T5_HUMAN
Non-specific serine/threonine prote...
WNK2
2,220Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0Y7R3H0Y7R3_HUMAN
Non-specific serine/threonine prote...
WNK2
1,773Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A6PVV2A6PVV2_HUMAN
Non-specific serine/threonine prote...
WNK2
790Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PCD1E9PCD1_HUMAN
Serine/threonine-protein kinase WNK...
WNK2
363Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0Y493H0Y493_HUMAN
Serine/threonine-protein kinase WNK...
WNK2
1,014Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0Y7J9H0Y7J9_HUMAN
Serine/threonine-protein kinase WNK...
WNK2
646Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AL354991 Genomic DNA No translation available.
AL390760 Genomic DNA No translation available.
AL583839 Genomic DNA No translation available.

NCBI Reference Sequences

More...
RefSeqi
NP_006639.3, NM_006648.3
XP_005252198.1, XM_005252141.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000395477; ENSP00000378860; ENSG00000165238

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
65268

UCSC genome browser

More...
UCSCi
uc004atj.3, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL354991 Genomic DNA No translation available.
AL390760 Genomic DNA No translation available.
AL583839 Genomic DNA No translation available.
RefSeqiNP_006639.3, NM_006648.3
XP_005252198.1, XM_005252141.2

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

PTM databases

iPTMnetiF8W9F9

Proteomic databases

MaxQBiF8W9F9
PeptideAtlasiF8W9F9
ProteomicsDBi30320

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
28371, 160 antibodies

Genome annotation databases

EnsembliENST00000395477; ENSP00000378860; ENSG00000165238
GeneIDi65268
UCSCiuc004atj.3, human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
65268
EuPathDBiHostDB:ENSG00000165238.16
HGNCiHGNC:14542, WNK2
OpenTargetsiENSG00000165238

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

GeneTreeiENSGT00940000157161
HOGENOMiCLU_000550_3_0_1
OrthoDBi27514at2759

Enzyme and pathway databases

SignaLinkiF8W9F9

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
65268, 4 hits in 131 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
WNK2, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
65268

Gene expression databases

BgeeiENSG00000165238, Expressed in apex of heart and 194 other tissues
ExpressionAtlasiF8W9F9, baseline and differential
GenevisibleiF8W9F9, HS

Family and domain databases

InterProiView protein in InterPro
IPR011009, Kinase-like_dom_sf
IPR024678, Kinase_OSR1/WNK_CCT
IPR000719, Prot_kinase_dom
IPR008271, Ser/Thr_kinase_AS
PfamiView protein in Pfam
PF12202, OSR1_C, 1 hit
PF00069, Pkinase, 1 hit
SMARTiView protein in SMART
SM00220, S_TKc, 1 hit
SUPFAMiSSF56112, SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS50011, PROTEIN_KINASE_DOM, 1 hit
PS00108, PROTEIN_KINASE_ST, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiF8W9F9_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: F8W9F9
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: September 21, 2011
Last sequence update: September 21, 2011
Last modified: October 7, 2020
This is version 72 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Proteomics identificationCombined sources, Reference proteomeImported
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