UniProtKB - F8W8T8 (F8W8T8_HUMAN)
Protein
Submitted name:
Acetyl-CoA carboxylase 2
Gene
ACACB
Organism
Homo sapiens (Human)
Status
Functioni
GO - Molecular functioni
- acetyl-CoA carboxylase activity Source: InterPro
- ATP binding Source: InterPro
GO - Biological processi
- fatty acid biosynthetic process Source: InterPro
Keywordsi
Molecular function | LigaseARBA annotation |
Names & Taxonomyi
Protein namesi | Submitted name: Acetyl-CoA carboxylase 2Imported |
Gene namesi | Name:ACACBImported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:85, ACACB |
VEuPathDBi | HostDB:ENSG00000076555.15 |
PTM / Processingi
Proteomic databases
MaxQBi | F8W8T8 |
PeptideAtlasi | F8W8T8 |
PRIDEi | F8W8T8 |
ProteomicsDBi | 30205 |
Expressioni
Gene expression databases
Bgeei | ENSG00000076555, Expressed in parietal pleura and 237 other tissues |
ExpressionAtlasi | F8W8T8, baseline and differential |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 361 – 691 | CoA carboxyltransferase N-terminalInterPro annotationAdd BLAST | 331 | |
Domaini | 695 – 858 | CoA carboxyltransferase C-terminalInterPro annotationAdd BLAST | 164 |
Phylogenomic databases
GeneTreei | ENSGT00940000155049 |
HOGENOMi | CLU_327036_0_0_1 |
Family and domain databases
InterProi | View protein in InterPro IPR034733, AcCoA_carboxyl IPR013537, AcCoA_COase_cen IPR029045, ClpP/crotonase-like_dom_sf IPR011763, COA_CT_C IPR011762, COA_CT_N |
Pfami | View protein in Pfam PF08326, ACC_central, 1 hit PF01039, Carboxyl_trans, 1 hit |
SUPFAMi | SSF52096, SSF52096, 2 hits |
PROSITEi | View protein in PROSITE PS50989, COA_CT_CTER, 1 hit PS50980, COA_CT_NTER, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 5 potential isoforms that are computationally mapped.Show allAlign All
F8W8T8-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MTVPISITNP DLLRHSTELF MDSGFSPLCQ RMGAMVAFRR FEDFTRNFDE
60 70 80 90 100
VISCFANVPK DTPLFSEART SLYSEDDCKS LREEPIHILN VSIQCADHLE
110 120 130 140 150
DEALVPILRT FVQSKKNILV DYGLRRITFL IAQEKEFPKF FTFRARDEFA
160 170 180 190 200
EDRIYRHLEP ALAFQLELNR MRNFDLTAVP CANHKMHLYL GAAKVKEGVE
210 220 230 240 250
VTDHRFFIRA IIRHSDLITK EASFEYLQNE GERLLLEAMD ELEVAFNNTS
260 270 280 290 300
VRTDCNHIFL NFVPTVIMDP FKIEESVRYM VMRYGSRLWK LRVLQAEVKI
310 320 330 340 350
NIRQTTTGSA VPIRLFITNE SGYYLDISLY KEVTDSRSGN IMFHSFGNKQ
360 370 380 390 400
GPQHGMLINT PYVTKDLLQA KRFQAQTLGT TYIYDFPEMF RQALFKLWGS
410 420 430 440 450
PDKYPKDILT YTELVLDSQG QLVEMNRLPG GNEVGMVAFK MRFKTQEYPE
460 470 480 490 500
GRDVIVIGND ITFRIGSFGP GEDLLYLRAS EMARAEGIPK IYVAANSGAR
510 520 530 540 550
IGMAEEIKHM FHVAWVDPED PHKGFKYLYL TPQDYTRISS LNSVHCKHIE
560 570 580 590 600
EGGESRYMIT DIIGKDDGLG VENLRGSGMI AGESSLAYEE IVTISLVTCR
610 620 630 640 650
AIGIGAYLVR LGQRVIQVEN SHIILTGASA LNKVLGREVY TSNNQLGGVQ
660 670 680 690 700
IMHYNGVSHI TVPDDFEGVY TILEWLSYMP KDNHSPVPII TPTDPIDREI
710 720 730 740 750
EFLPSRAPYD PRWMLAGRPH PTLKGTWQSG FFDHGSFKEI MAPWAQTVVT
760 770 780 790 800
GRARLGGIPV GVIAVETRTV EVAVPADPAN LDSEAKIIQQ AGQVWFPDSA
810 820 830 840 850
YKTAQAVKDF NREKLPLMIF ANWRGFSGGM KGCLGTWRDV SWWKIRAMLP
MHIGEGSV
Computationally mapped potential isoform sequencesi
There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketO00763 | ACACB_HUMAN | Acetyl-CoA carboxylase 2 | ACACB ACC2, ACCB | 2,458 | Annotation score: | ||
H0YGH5 | H0YGH5_HUMAN | Acetyl-CoA carboxylase 2 | ACACB | 859 | Annotation score: | ||
F5H5C3 | F5H5C3_HUMAN | Acetyl-CoA carboxylase 2 | ACACB | 143 | Annotation score: | ||
S4R3S7 | S4R3S7_HUMAN | Acetyl-CoA carboxylase 2 | ACACB | 155 | Annotation score: | ||
A0A087WUA1 | A0A087WUA1_HUMAN | Acetyl-CoA carboxylase 2 | ACACB | 112 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC007637 Genomic DNA No translation available. |
Genome annotation databases
Ensembli | ENST00000377854; ENSP00000367085; ENSG00000076555 |
UCSCi | uc058sxr.1, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC007637 Genomic DNA No translation available. |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Proteomic databases
MaxQBi | F8W8T8 |
PeptideAtlasi | F8W8T8 |
PRIDEi | F8W8T8 |
ProteomicsDBi | 30205 |
Protocols and materials databases
Antibodypediai | 1321, 185 antibodies |
Genome annotation databases
Ensembli | ENST00000377854; ENSP00000367085; ENSG00000076555 |
UCSCi | uc058sxr.1, human |
Organism-specific databases
HGNCi | HGNC:85, ACACB |
OpenTargetsi | ENSG00000076555 |
VEuPathDBi | HostDB:ENSG00000076555.15 |
GenAtlasi | Search... |
Phylogenomic databases
GeneTreei | ENSGT00940000155049 |
HOGENOMi | CLU_327036_0_0_1 |
Miscellaneous databases
ChiTaRSi | ACACB, human |
Gene expression databases
Bgeei | ENSG00000076555, Expressed in parietal pleura and 237 other tissues |
ExpressionAtlasi | F8W8T8, baseline and differential |
Family and domain databases
InterProi | View protein in InterPro IPR034733, AcCoA_carboxyl IPR013537, AcCoA_COase_cen IPR029045, ClpP/crotonase-like_dom_sf IPR011763, COA_CT_C IPR011762, COA_CT_N |
Pfami | View protein in Pfam PF08326, ACC_central, 1 hit PF01039, Carboxyl_trans, 1 hit |
SUPFAMi | SSF52096, SSF52096, 2 hits |
PROSITEi | View protein in PROSITE PS50989, COA_CT_CTER, 1 hit PS50980, COA_CT_NTER, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | F8W8T8_HUMAN | |
Accessioni | F8W8T8Primary (citable) accession number: F8W8T8 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | September 21, 2011 |
Last sequence update: | October 29, 2014 | |
Last modified: | April 7, 2021 | |
This is version 61 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |