ACACB

Functionⁱ

GO - Molecular functionⁱ

acetyl-CoA carboxylase activity Source: InterPro
ATP binding Source: InterPro

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

fatty acid biosynthetic process Source: InterPro

View the complete GO annotation on QuickGO ...

Names & Taxonomyⁱ

Protein namesⁱ	Submitted name: Acetyl-CoA carboxylase 2Imported
Gene namesⁱ	Name:ACACBImported
Organismⁱ	Homo sapiens (Human)Imported
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 12

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000076555.15
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:85 ACACB

Pathology & Biotechⁱ

Organism-specific databases

Open Targets More...OpenTargetsⁱ	ENSG00000076555

OpenTargetsⁱ

ENSG00000076555

PTM / Processingⁱ

Proteomic databases

EPDⁱ	F8W8T8
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	F8W8T8
PeptideAtlas More...PeptideAtlasⁱ	F8W8T8
PRIDEⁱ	F8W8T8

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000076555
ExpressionAtlasⁱ	F8W8T8 baseline and differential

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	F8W8T8
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	361 – 691	CoA carboxyltransferase N-terminalInterPro annotationAdd BLAST		331
Domainⁱ	695 – 858	CoA carboxyltransferase C-terminalInterPro annotationAdd BLAST		164

Phylogenomic databases

eggNOGⁱ	KOG0368 Eukaryota COG0439 LUCA COG0511 LUCA COG4799 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00550000074703

Family and domain databases

InterProⁱ	View protein in InterPro IPR034733 AcCoA_carboxyl IPR013537 AcCoA_COase_cen IPR029045 ClpP/crotonase-like_dom_sf IPR011763 COA_CT_C IPR011762 COA_CT_N
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF08326 ACC_central, 1 hit PF01039 Carboxyl_trans, 1 hit
SUPFAMⁱ	SSF52096 SSF52096, 2 hits
PROSITEⁱ	View protein in PROSITE PS50989 COA_CT_CTER, 1 hit PS50980 COA_CT_NTER, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

F8W8T8-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MTVPISITNP DLLRHSTELF MDSGFSPLCQ RMGAMVAFRR FEDFTRNFDE 
        60         70         80         90        100
VISCFANVPK DTPLFSEART SLYSEDDCKS LREEPIHILN VSIQCADHLE 
       110        120        130        140        150
DEALVPILRT FVQSKKNILV DYGLRRITFL IAQEKEFPKF FTFRARDEFA 
       160        170        180        190        200
EDRIYRHLEP ALAFQLELNR MRNFDLTAVP CANHKMHLYL GAAKVKEGVE 
       210        220        230        240        250
VTDHRFFIRA IIRHSDLITK EASFEYLQNE GERLLLEAMD ELEVAFNNTS 
       260        270        280        290        300
VRTDCNHIFL NFVPTVIMDP FKIEESVRYM VMRYGSRLWK LRVLQAEVKI 
       310        320        330        340        350
NIRQTTTGSA VPIRLFITNE SGYYLDISLY KEVTDSRSGN IMFHSFGNKQ 
       360        370        380        390        400
GPQHGMLINT PYVTKDLLQA KRFQAQTLGT TYIYDFPEMF RQALFKLWGS 
       410        420        430        440        450
PDKYPKDILT YTELVLDSQG QLVEMNRLPG GNEVGMVAFK MRFKTQEYPE 
       460        470        480        490        500
GRDVIVIGND ITFRIGSFGP GEDLLYLRAS EMARAEGIPK IYVAANSGAR 
       510        520        530        540        550
IGMAEEIKHM FHVAWVDPED PHKGFKYLYL TPQDYTRISS LNSVHCKHIE 
       560        570        580        590        600
EGGESRYMIT DIIGKDDGLG VENLRGSGMI AGESSLAYEE IVTISLVTCR 
       610        620        630        640        650
AIGIGAYLVR LGQRVIQVEN SHIILTGASA LNKVLGREVY TSNNQLGGVQ 
       660        670        680        690        700
IMHYNGVSHI TVPDDFEGVY TILEWLSYMP KDNHSPVPII TPTDPIDREI 
       710        720        730        740        750
EFLPSRAPYD PRWMLAGRPH PTLKGTWQSG FFDHGSFKEI MAPWAQTVVT 
       760        770        780        790        800
GRARLGGIPV GVIAVETRTV EVAVPADPAN LDSEAKIIQQ AGQVWFPDSA 
       810        820        830        840        850
YKTAQAVKDF NREKLPLMIF ANWRGFSGGM KGCLGTWRDV SWWKIRAMLP 

MHIGEGSV

Length:858

Mass (Da):97,372

Last modified:October 29, 2014 - v2

Checksum:ⁱ0ACCFDBC6C812B6F

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AC007637 Genomic DNA No translation available.

Select the link destinations:
EMBLⁱ
GenBankⁱ
DDBJⁱ

Links Updated

AC007637 Genomic DNA No translation available.

Genome annotation databases

Ensemblⁱ	ENST00000377854; ENSP00000367085; ENSG00000076555
UCSC genome browser More...UCSCⁱ	uc058sxr.1 human

Protein	Similar proteins		Species	Score	Length
F8W8T8	Acetyl-CoA carboxylase 2 (Fragment)		HUMAN		859
ACACB isoform 4 (Fragment)		PONAB		1060
Acetyl-CoA carboxylase beta		MACMU		858
Acetyl-CoA carboxylase beta		CERAT		858
Acetyl-CoA carboxylase beta		MACFA		858
+11

Protein	Similar proteins		Species	Score	Length
F8W8T8	Acetyl-CoA carboxylase 2 (Fragment)		HUMAN		859
ACACB isoform 4 (Fragment)		PONAB		1060
Acetyl-CoA carboxylase beta		GORGO		858
Acetyl-CoA carboxylase beta		PANPA		858
ACACB isoform 5		PANTR		858
+29

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AC007637 Genomic DNA No translation available.

Select the link destinations:
EMBLⁱ
GenBankⁱ
DDBJⁱ

Links Updated

AC007637 Genomic DNA No translation available.

3D structure databases

ProteinModelPortalⁱ	F8W8T8
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Proteomic databases

EPDⁱ	F8W8T8
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	F8W8T8
PeptideAtlas More...PeptideAtlasⁱ	F8W8T8
PRIDEⁱ	F8W8T8

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000377854; ENSP00000367085; ENSG00000076555
UCSC genome browser More...UCSCⁱ	uc058sxr.1 human

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000076555.15
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:85 ACACB
Open Targets More...OpenTargetsⁱ	ENSG00000076555
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG0368 Eukaryota COG0439 LUCA COG0511 LUCA COG4799 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00550000074703

Miscellaneous databases

ChiTaRSⁱ	ACACB human

ChiTaRSⁱ

ACACB human

Gene expression databases

Bgeeⁱ	ENSG00000076555
ExpressionAtlasⁱ	F8W8T8 baseline and differential

Family and domain databases

InterProⁱ	View protein in InterPro IPR034733 AcCoA_carboxyl IPR013537 AcCoA_COase_cen IPR029045 ClpP/crotonase-like_dom_sf IPR011763 COA_CT_C IPR011762 COA_CT_N
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF08326 ACC_central, 1 hit PF01039 Carboxyl_trans, 1 hit
SUPFAMⁱ	SSF52096 SSF52096, 2 hits
PROSITEⁱ	View protein in PROSITE PS50989 COA_CT_CTER, 1 hit PS50980 COA_CT_NTER, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	F8W8T8_HUMAN
Accessionⁱ	F8W8T8Primary (citable) accession number: F8W8T8
Entry historyⁱ	Integrated into UniProtKB/TrEMBL:	September 21, 2011
	Last sequence update:	October 29, 2014
	Last modified:	March 28, 2018
	This is version 49 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Unreviewed (UniProtKB/TrEMBL)
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

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Supporting data

UniProtKB - F8W8T8 (F8W8T8_HUMAN)

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Acetyl-CoA carboxylase 2

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Structureⁱ

Family & Domainsⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ