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UniProtKB - F8W8F7 (F8W8F7_HUMAN)
Protein
Submitted name:
Adhesion G protein-coupled receptor G3
Gene
ADGRG3
Organism
Homo sapiens (Human)
Status
Functioni
GO - Molecular functioni
- G protein-coupled receptor activity Source: UniProtKB-KW
GO - Biological processi
- cell surface receptor signaling pathway Source: InterPro
Keywordsi
Molecular function | G-protein coupled receptorARBA annotation, Receptor, Transducer |
Names & Taxonomyi
Protein namesi | Submitted name: Adhesion G protein-coupled receptor G3 |
Gene namesi | Name:ADGRG3 |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:13728, ADGRG3 |
VEuPathDBi | HostDB:ENSG00000182885 |
Subcellular locationi
Other locations
- Membrane ARBA annotation; Multi-pass membrane protein ARBA annotation
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 151 – 173 | HelicalSequence analysisAdd BLAST | 23 | |
Transmembranei | 185 – 205 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 225 – 246 | HelicalSequence analysisAdd BLAST | 22 | |
Transmembranei | 258 – 276 | HelicalSequence analysisAdd BLAST | 19 | |
Transmembranei | 309 – 335 | HelicalSequence analysisAdd BLAST | 27 | |
Transmembranei | 356 – 378 | HelicalSequence analysisAdd BLAST | 23 | |
Transmembranei | 384 – 406 | HelicalSequence analysisAdd BLAST | 23 |
Keywords - Cellular componenti
MembraneExpressioni
Gene expression databases
Bgeei | ENSG00000182885, Expressed in blood and 114 other tissues |
ExpressionAtlasi | F8W8F7, baseline and differential |
Structurei
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 92 – 141 | GPSInterPro annotationAdd BLAST | 50 | |
Domaini | 148 – 405 | G_PROTEIN_RECEP_F2_4InterPro annotationAdd BLAST | 258 |
Keywords - Domaini
Transmembrane, Transmembrane helixSequence analysisARBA annotationPhylogenomic databases
GeneTreei | ENSGT00940000154285 |
HOGENOMi | CLU_002753_3_9_1 |
OMAi | TLFKGPQ |
OrthoDBi | 501343at2759 |
Family and domain databases
Gene3Di | 2.60.220.50, 1 hit |
InterProi | View protein in InterPro IPR046338, GAIN_dom_sf IPR017981, GPCR_2-like IPR000832, GPCR_2_secretin-like IPR003910, GPR1/GPR3/GPR5 IPR000203, GPS |
Pfami | View protein in Pfam PF00002, 7tm_2, 1 hit PF01825, GPS, 1 hit |
PRINTSi | PR00249, GPCRSECRETIN PR01422, GPR56ORPHANR |
SMARTi | View protein in SMART SM00303, GPS, 1 hit |
PROSITEi | View protein in PROSITE PS50261, G_PROTEIN_RECEP_F2_4, 1 hit PS50221, GPS, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All
F8W8F7-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MKDEDKPPDR VRLPKSLFRS LPGNRSVVRL AVTILDIGPG TLFKGPRLGL
60 70 80 90 100
GDGSGVLNNR LVGLSVGQMH VTKLAEPLEI VFSHQRPPPN MTLTCVFWDV
110 120 130 140 150
TKGTTGDWSS EGCSTEVRPE GTVCCCDHLT FFALLLRPTL DQSTVHILTR
160 170 180 190 200
ISQAGCGVSM IFLAFTIILY AFLRLSRERF KSEDAPKIHV ALGGSLFLLN
210 220 230 240 250
LAFLVNVGSG SKGSDAACWA RGAVFHYFLL CAFTWMGLEA FHLYLLAVRV
260 270 280 290 300
FNTYFGHYFL KLSLVGWGLP ALMVIGTGSA NSYGLYTIRD RENRTSLELC
310 320 330 340 350
WFREGTTMYA LYITVHGYFL ITFLFGMVVL ALVVWKIFTL SRATAVKERG
360 370 380 390 400
KNRKKVLTLL GLSSLVGVTW GLAIFTPLGL STVYIFALFN SLQGVFICCW
410 420
FTILYLPSQS TTVSSSTARL DQAHSASQE
Computationally mapped potential isoform sequencesi
There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketQ86Y34 | AGRG3_HUMAN | Adhesion G protein-coupled receptor... | ADGRG3 GPR97, PGR26 | 549 | Annotation score: | ||
H3BRU4 | H3BRU4_HUMAN | Adhesion G protein-coupled receptor... | ADGRG3 | 315 | Annotation score: | ||
H3BS78 | H3BS78_HUMAN | Adhesion G protein-coupled receptor... | ADGRG3 | 69 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC018552 Genomic DNA No translation available. |
RefSeqi | NP_001295289.1, NM_001308360.1 |
Genome annotation databases
Ensembli | ENST00000450388.7; ENSP00000404803.3; ENSG00000182885.17 |
GeneIDi | 222487 |
UCSCi | uc010vhv.3, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC018552 Genomic DNA No translation available. |
RefSeqi | NP_001295289.1, NM_001308360.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Proteomic databases
PeptideAtlasi | F8W8F7 |
PRIDEi | F8W8F7 |
ProteomicsDBi | 30142 |
Protocols and materials databases
Antibodypediai | 15147, 161 antibodies from 26 providers |
DNASUi | 222487 |
Genome annotation databases
Ensembli | ENST00000450388.7; ENSP00000404803.3; ENSG00000182885.17 |
GeneIDi | 222487 |
UCSCi | uc010vhv.3, human |
Organism-specific databases
CTDi | 222487 |
HGNCi | HGNC:13728, ADGRG3 |
OpenTargetsi | ENSG00000182885 |
VEuPathDBi | HostDB:ENSG00000182885 |
GenAtlasi | Search... |
Phylogenomic databases
GeneTreei | ENSGT00940000154285 |
HOGENOMi | CLU_002753_3_9_1 |
OMAi | TLFKGPQ |
OrthoDBi | 501343at2759 |
Miscellaneous databases
BioGRID-ORCSi | 222487, 11 hits in 1071 CRISPR screens |
ChiTaRSi | ADGRG3, human |
GenomeRNAii | 222487 |
Gene expression databases
Bgeei | ENSG00000182885, Expressed in blood and 114 other tissues |
ExpressionAtlasi | F8W8F7, baseline and differential |
Family and domain databases
Gene3Di | 2.60.220.50, 1 hit |
InterProi | View protein in InterPro IPR046338, GAIN_dom_sf IPR017981, GPCR_2-like IPR000832, GPCR_2_secretin-like IPR003910, GPR1/GPR3/GPR5 IPR000203, GPS |
Pfami | View protein in Pfam PF00002, 7tm_2, 1 hit PF01825, GPS, 1 hit |
PRINTSi | PR00249, GPCRSECRETIN PR01422, GPR56ORPHANR |
SMARTi | View protein in SMART SM00303, GPS, 1 hit |
PROSITEi | View protein in PROSITE PS50261, G_PROTEIN_RECEP_F2_4, 1 hit PS50221, GPS, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | F8W8F7_HUMAN | |
Accessioni | F8W8F7Primary (citable) accession number: F8W8F7 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | September 21, 2011 |
Last sequence update: | September 21, 2011 | |
Last modified: | May 25, 2022 | |
This is version 72 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |