UniProtKB - F8W4B1 (F8W4B1_DANRE)
Protein
Submitted name:
Inositol 1,4,5-trisphosphate receptor, type 1a
Gene
itpr1a
Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Functioni
GO - Molecular functioni
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: GO_Central
- inositol 1,4,5 trisphosphate binding Source: InterPro
- inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity Source: InterPro
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: GO_Central
GO - Biological processi
- regulation of transcription, DNA-templated Source: GO_Central
Keywordsi
Molecular function | Calcium channelARBA annotation, Ion channel, Ligand-gated ion channelARBA annotation, ReceptorARBA annotation |
Biological process | Calcium transport, Ion transport, Transport |
Ligand | Calcium |
Names & Taxonomyi
Protein namesi | Submitted name: Inositol 1,4,5-trisphosphate receptor, type 1aImported |
Gene namesi | Name:itpr1aImported |
Organismi | Danio rerio (Zebrafish) (Brachydanio rerio)Imported |
Taxonomic identifieri | 7955 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Actinopterygii › Neopterygii › Teleostei › Ostariophysi › Cypriniformes › Danionidae › Danioninae › Danio |
Proteomesi |
|
Organism-specific databases
ZFINi | ZDB-GENE-070604-3, itpr1a |
Subcellular locationi
Endoplasmic reticulum
- Endoplasmic reticulum membrane ARBA annotation; Multi-pass membrane protein ARBA annotation
Other locations
- Membrane ARBA annotation; Multi-pass membrane protein ARBA annotation
Endoplasmic reticulum
- endoplasmic reticulum membrane Source: UniProtKB-SubCell
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 2224 – 2246 | HelicalSequence analysisAdd BLAST | 23 | |
Transmembranei | 2258 – 2275 | HelicalSequence analysisAdd BLAST | 18 | |
Transmembranei | 2305 – 2322 | HelicalSequence analysisAdd BLAST | 18 | |
Transmembranei | 2342 – 2369 | HelicalSequence analysisAdd BLAST | 28 | |
Transmembranei | 2390 – 2412 | HelicalSequence analysisAdd BLAST | 23 | |
Transmembranei | 2503 – 2526 | HelicalSequence analysisAdd BLAST | 24 |
Keywords - Cellular componenti
Endoplasmic reticulumARBA annotation, MembraneExpressioni
Gene expression databases
Bgeei | ENSDARG00000014655, Expressed in granulocyte and 24 other tissues |
ExpressionAtlasi | F8W4B1, baseline |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 112 – 166 | MIRInterPro annotationAdd BLAST | 55 | |
Domaini | 173 – 223 | MIRInterPro annotationAdd BLAST | 51 | |
Domaini | 231 – 287 | MIRInterPro annotationAdd BLAST | 57 | |
Domaini | 294 – 358 | MIRInterPro annotationAdd BLAST | 65 | |
Domaini | 379 – 435 | MIRInterPro annotationAdd BLAST | 57 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1148 – 1167 | DisorderedSequence analysisAdd BLAST | 20 | |
Regioni | 1830 – 1857 | DisorderedSequence analysisAdd BLAST | 28 | |
Regioni | 1878 – 1906 | DisorderedSequence analysisAdd BLAST | 29 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 1591 – 1611 | Sequence analysisAdd BLAST | 21 | |
Coiled coili | 2072 – 2092 | Sequence analysisAdd BLAST | 21 | |
Coiled coili | 2627 – 2661 | Sequence analysisAdd BLAST | 35 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 1151 – 1167 | PolarSequence analysisAdd BLAST | 17 | |
Compositional biasi | 1831 – 1857 | PolyampholyteSequence analysisAdd BLAST | 27 | |
Compositional biasi | 1878 – 1903 | PolyampholyteSequence analysisAdd BLAST | 26 |
Sequence similaritiesi
Belongs to the InsP3 receptor family.ARBA annotation
Keywords - Domaini
Coiled coilSequence analysis, RepeatARBA annotation, Transmembrane, Transmembrane helixSequence analysisARBA annotationPhylogenomic databases
eggNOGi | KOG3533, Eukaryota |
GeneTreei | ENSGT00940000155071 |
HOGENOMi | CLU_000206_1_0_1 |
OMAi | FCHYLPK |
OrthoDBi | 94996at2759 |
Family and domain databases
InterProi | View protein in InterPro IPR014821, Ins145_P3_rcpt IPR000493, InsP3_rcpt IPR005821, Ion_trans_dom IPR036300, MIR_dom_sf IPR016093, MIR_motif IPR013662, RIH_assoc-dom IPR000699, RIH_dom IPR035910, RyR/IP3R_RIH_dom_sf |
Pfami | View protein in Pfam PF08709, Ins145_P3_rec, 1 hit PF00520, Ion_trans, 1 hit PF02815, MIR, 1 hit PF08454, RIH_assoc, 1 hit PF01365, RYDR_ITPR, 2 hits |
PRINTSi | PR00779, INSP3RECEPTR |
SMARTi | View protein in SMART SM00472, MIR, 4 hits |
SUPFAMi | SSF100909, SSF100909, 2 hits SSF82109, SSF82109, 2 hits |
PROSITEi | View protein in PROSITE PS50919, MIR, 5 hits |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 12 potential isoforms that are computationally mapped.Show allAlign All
F8W4B1-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MVDKLSSFLH IGDVCSLYAE GSTSGFISTL GLVDDRCVVQ PDAGDLNNPP
60 70 80 90 100
KKFRDCLFRL CPMNRYSAQK QFWKAAKPGG TSTTDTVLLN KLHHAADLEK
110 120 130 140 150
KQNDSENKKL LGTVIQYGNV IQLLHLKSNK YLTVNKRLPA LLEKNAMRVT
160 170 180 190 200
LDAAGNEGSW FYIQPFYKLR SIGDNVVIGD KVVLNPVNAG QPLHASSHQL
210 220 230 240 250
VDNPGCNEVN SVNCTTSWKI VLFMKWSDNQ EIVLKGGDVV RLFHAEQEKF
260 270 280 290 300
LTCDEHRKKQ YVFLRTTGRQ SATSATSSKA LWEVEVVQHD PCRGGAGYWN
310 320 330 340 350
SLFRFKHLAT GHYLAAEVNP DYEEECLESR SSMDSEHEVI RARARNPQDK
360 370 380 390 400
VMYTLVSVPD GNDISSIFEL DPTTLRGGDS LVPRNSYVRL RHLCTNTWVH
410 420 430 440 450
STNQPIDKEE EKPVMLRIGT SPLKEDKEAF AIVPVSPAEV RDLDFANDAS
460 470 480 490 500
KVLASIAAKL EKGTITQNER RSVTKLLEDL VYFVVDIPSS AQDVLEITVN
510 520 530 540 550
KPNRERQKLM REQNILKQIF KLLQAPFTDS GDGPMLRLEE LADQRHAPFR
560 570 580 590 600
HICRLCYRVL RYSQQDYRKN QEYIAKQFRF MQKQIGYDVL AEDTITALLH
610 620 630 640 650
NNRKLLEKHI TAAEIDTFVS LVRKNREPRF LDYLSDLCVS MNKSIPVTQE
660 670 680 690 700
LICNAVLDPA NADILIETKL VLSRFEVAGT VLGEGAEEEE EDEEEVWLFW
710 720 730 740 750
KDSGGEVKSK SIRELAQDAK DGHTEDQEVI NYYRYQLNLF ARMCLDRQYL
760 770 780 790 800
AINKISAQLD VDLILRCMSD EDLPFDLRAS FCRMMLHMHV DRDPQEQVTP
810 820 830 840 850
VKYARLWSEI PSQISIDDYD NDGTSSDEVK ERFSQTMEFV ENYLRDVVCQ
860 870 880 890 900
SFPFSDKEKN KLTFEVVNLA RNLIYFGFYN FSDLLRLTKI LLAILDCVHI
910 920 930 940 950
STPFHIKLDR EPGKGSNVMR SIHGVGELMT QVVLRGGGFL PASSHNPPDR
960 970 980 990 1000
DEVKAQSEPQ KQDILVMDTK LKIIEILQFI LNVRLDYRIS CLLCIFKTEF
1010 1020 1030 1040 1050
DESNSQSEPS LSPESPASVQ GALDFEHIEE QAEGIFGGSE ENTPLDLDDH
1060 1070 1080 1090 1100
GGRTFLRVLL HLTMHDYPPL VSRALHLLFR HFSQRQEVLQ AFKQVQLLVT
1110 1120 1130 1140 1150
SQDVENYKQI KSDLDQLRSI VEKSELWVYK RQGSDSGLDA GEVTPEAHHK
1160 1170 1180 1190 1200
GVINSSRSNK PKVESTSSSN YRVVKEILLR LSKLCVLEGI SGKKNKKQQQ
1210 1220 1230 1240 1250
RLLRNMGAHS VVLELLQIPY EKGEDVQMQE IMTLAHQFLQ NFCAGNQQNQ
1260 1270 1280 1290 1300
ALLHKHINLF LNPGILEAVT MQHIFMNNFQ LCSEINERVV QHFVHCIETH
1310 1320 1330 1340 1350
GRSVHYLKFL QTIVKAENKF IKKCQDIVMA ELVTAGEDVL VFYNDRASFQ
1360 1370 1380 1390 1400
SLVQMMRLER ERLDESSALR YHIHLVELLA VCTEGKNVYT EIKCNSLLPL
1410 1420 1430 1440 1450
DDIVRVVTHE DCIPEVKMAY VNFLNHCYVD TEVEMKEIYT SNHMWKLFDD
1460 1470 1480 1490 1500
FLVDVCRVCN NTSDRKHADT VLERYVTETI MSIVTTFFSS PFSDQSTSLQ
1510 1520 1530 1540 1550
TRQPVFVQLL QGVFRVYHCN WLLPGQKGNV EACIKVLSDV AKGRAIAIPV
1560 1570 1580 1590 1600
DLDCQVNNLF MKSNNIVQKT ALSWRLSVRN ATRRDSVLTT SRDYRNIIER
1610 1620 1630 1640 1650
LQDIVSALEE RLRPLVQAEL SVLVDVLHRP ELLFPEHTEA HRKCESGGFI
1660 1670 1680 1690 1700
CKLIKHTKQL LEENEERLCI KVLQTLREMM TKDRGYGEKG EALRQLLVNR
1710 1720 1730 1740 1750
YYGFRSGGRR ESLTSFGNST LTPVGPIKSQ PGGLSRAEMS LMEVQCHLDR
1760 1770 1780 1790 1800
EGASDLVIDL IMNTTSDRVF HESILLAIAL LEGGNTIIQH SFFKRLTEDK
1810 1820 1830 1840 1850
NSEKFFRVFY DRMKVAQVEI KATVTVNTSD LGNKRRDDNT PDKDTPQRRR
1860 1870 1880 1890 1900
GKDSGVVVTD DAREQLLEAS AATKKAFGSY RRDADPEETF GTADGDKGGG
1910 1920 1930 1940 1950
DKGTEQGEMS PVILIMQPIL RFLQLLCENH NRDLQNFLRC QNNKNNYNLV
1960 1970 1980 1990 2000
CETLQFLDCI CGSTTGGLGL LGLYINQHNV ALINQTVESL TEYCQGPCHD
2010 2020 2030 2040 2050
NQNCIATHES NGIDIIIALI LNDINPLGRK RMDLVLELKN NASKLLLAIM
2060 2070 2080 2090 2100
ESRHDSENAE RILYNMRPKE LVEVMKMAYQ QGEAEFEDEE QENGEDHAAS
2110 2120 2130 2140 2150
PRNVGHNIYI LAHQLSRHNK ELQILLKPGG EDQALEYYTK HTSQIEIVRQ
2160 2170 2180 2190 2200
DRTMEQIVFP VPNICSFLTN ESKLRVYYGT ERDEQGSKIN DFFLHADDLF
2210 2220 2230 2240 2250
NEMRWQKKLR AQPVLYWCSR NMSFWSNVSF NLAVLINLLV AFFYPLDGVS
2260 2270 2280 2290 2300
ESQLEPSLSL LLWVCLLGSL GFVLMSPRPN AVRVLVISTV LQLGFSVGLQ
2310 2320 2330 2340 2350
HMLTLLGAFN VCNKIVFMLS FVGNRGSFTR GYRVMVMDRE FLFHLLYLLI
2360 2370 2380 2390 2400
CILGLFGHVF FYSLLLFDLV NREETLLNVI KSVTRNGRSI VLTAVLGLIL
2410 2420 2430 2440 2450
VYLFSIVGYM FFKDDFILEV NRISNGTLEE GVTLPAGFCD ARNGSCLSDD
2460 2470 2480 2490 2500
VDEDDVERAC DSLWMCMITV LSHGLRSGGG VGDVLRKPSK EERLFAARVV
2510 2520 2530 2540 2550
YDLLFFFLVI IIVLNLIFGV IIDTFADLRS EKQRKEEILK TTCFICGLER
2560 2570 2580 2590 2600
DKFDNKTVTF EEHIKEEHNL WHYLFFIVLV RVKDSTEYTG PESYVAQMIK
2610 2620 2630 2640 2650
EHNLDWFPRM RAMSLVSSDG EGEQNELRSL QEKLESTMRL VSNLTNQLTE
2660 2670 2680
LKEQMTEQRK HKQRLGLLGN PAHLNINPQQ PA
Computationally mapped potential isoform sequencesi
There are 12 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketE7F4G8 | E7F4G8_DANRE | Inositol 1,4,5-trisphosphate recept... | itpr1a | 2,730 | Annotation score: | ||
A0A2R8QAR1 | A0A2R8QAR1_DANRE | Inositol 1,4,5-trisphosphate recept... | itpr1a | 2,745 | Annotation score: | ||
A0A2R8QJM5 | A0A2R8QJM5_DANRE | Inositol 1,4,5-trisphosphate recept... | itpr1a | 2,707 | Annotation score: | ||
A0A2R8RSY9 | A0A2R8RSY9_DANRE | Inositol 1,4,5-trisphosphate recept... | itpr1a | 2,726 | Annotation score: | ||
A0A2R8PWX1 | A0A2R8PWX1_DANRE | Inositol 1,4,5-trisphosphate recept... | itpr1a | 2,730 | Annotation score: | ||
A0A2R8Q201 | A0A2R8Q201_DANRE | Inositol 1,4,5-trisphosphate recept... | itpr1a | 2,715 | Annotation score: | ||
A0A2R8QBV7 | A0A2R8QBV7_DANRE | Inositol 1,4,5-trisphosphate recept... | itpr1a | 2,726 | Annotation score: | ||
A0A2R8QHB5 | A0A2R8QHB5_DANRE | Inositol 1,4,5-trisphosphate recept... | itpr1a | 2,707 | Annotation score: | ||
A0A2R8RZ36 | A0A2R8RZ36_DANRE | Inositol 1,4,5-trisphosphate recept... | itpr1a | 2,745 | Annotation score: | ||
A0A2R8QFQ7 | A0A2R8QFQ7_DANRE | Inositol 1,4,5-trisphosphate recept... | itpr1a | 708 | Annotation score: | ||
There are more potential isoformsShow all |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BX957338 Genomic DNA No translation available. |
RefSeqi | XP_017212154.1, XM_017356665.1 |
Genome annotation databases
Ensembli | ENSDART00000149019; ENSDARP00000123931; ENSDARG00000014655 |
GeneIDi | 567611 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BX957338 Genomic DNA No translation available. |
RefSeqi | XP_017212154.1, XM_017356665.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
STRINGi | 7955.ENSDARP00000065091 |
Proteomic databases
PaxDbi | F8W4B1 |
Genome annotation databases
Ensembli | ENSDART00000149019; ENSDARP00000123931; ENSDARG00000014655 |
GeneIDi | 567611 |
Organism-specific databases
CTDi | 567611 |
ZFINi | ZDB-GENE-070604-3, itpr1a |
Phylogenomic databases
eggNOGi | KOG3533, Eukaryota |
GeneTreei | ENSGT00940000155071 |
HOGENOMi | CLU_000206_1_0_1 |
OMAi | FCHYLPK |
OrthoDBi | 94996at2759 |
Gene expression databases
Bgeei | ENSDARG00000014655, Expressed in granulocyte and 24 other tissues |
ExpressionAtlasi | F8W4B1, baseline |
Family and domain databases
InterProi | View protein in InterPro IPR014821, Ins145_P3_rcpt IPR000493, InsP3_rcpt IPR005821, Ion_trans_dom IPR036300, MIR_dom_sf IPR016093, MIR_motif IPR013662, RIH_assoc-dom IPR000699, RIH_dom IPR035910, RyR/IP3R_RIH_dom_sf |
Pfami | View protein in Pfam PF08709, Ins145_P3_rec, 1 hit PF00520, Ion_trans, 1 hit PF02815, MIR, 1 hit PF08454, RIH_assoc, 1 hit PF01365, RYDR_ITPR, 2 hits |
PRINTSi | PR00779, INSP3RECEPTR |
SMARTi | View protein in SMART SM00472, MIR, 4 hits |
SUPFAMi | SSF100909, SSF100909, 2 hits SSF82109, SSF82109, 2 hits |
PROSITEi | View protein in PROSITE PS50919, MIR, 5 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | F8W4B1_DANRE | |
Accessioni | F8W4B1Primary (citable) accession number: F8W4B1 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | September 21, 2011 |
Last sequence update: | September 21, 2011 | |
Last modified: | February 10, 2021 | |
This is version 68 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |