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UniProtKB - F8W4B1 (F8W4B1_DANRE)

Entry version 68 (10 Feb 2021)
Sequence version 1 (21 Sep 2011)
Previous versions | rss
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Protein
Submitted name:

Inositol 1,4,5-trisphosphate receptor, type 1a

Gene

itpr1a

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionCalcium channelARBA annotation, Ion channel, Ligand-gated ion channelARBA annotation, ReceptorARBA annotation
Biological processCalcium transport, Ion transport, Transport
LigandCalcium

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Inositol 1,4,5-trisphosphate receptor, type 1aImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:itpr1aImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7955 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Actinopterygii › Neopterygii › Teleostei › Ostariophysi › Cypriniformes › Danionidae › Danioninae › Danio
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000437 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 6

Organism-specific databases

Zebrafish Information Network genome database

More...ZFINi		ZDB-GENE-070604-3, itpr1a

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei2224 – 2246HelicalSequence analysisAdd BLAST23
Transmembranei2258 – 2275HelicalSequence analysisAdd BLAST18
Transmembranei2305 – 2322HelicalSequence analysisAdd BLAST18
Transmembranei2342 – 2369HelicalSequence analysisAdd BLAST28
Transmembranei2390 – 2412HelicalSequence analysisAdd BLAST23
Transmembranei2503 – 2526HelicalSequence analysisAdd BLAST24

Keywords - Cellular componenti

Endoplasmic reticulumARBA annotation, Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		F8W4B1

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSDARG00000014655, Expressed in granulocyte and 24 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		F8W4B1, baseline

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...STRINGi		7955.ENSDARP00000065091

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini112 – 166MIRInterPro annotationAdd BLAST55
Domaini173 – 223MIRInterPro annotationAdd BLAST51
Domaini231 – 287MIRInterPro annotationAdd BLAST57
Domaini294 – 358MIRInterPro annotationAdd BLAST65
Domaini379 – 435MIRInterPro annotationAdd BLAST57

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1148 – 1167DisorderedSequence analysisAdd BLAST20
Regioni1830 – 1857DisorderedSequence analysisAdd BLAST28
Regioni1878 – 1906DisorderedSequence analysisAdd BLAST29

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili1591 – 1611Sequence analysisAdd BLAST21
Coiled coili2072 – 2092Sequence analysisAdd BLAST21
Coiled coili2627 – 2661Sequence analysisAdd BLAST35

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1151 – 1167PolarSequence analysisAdd BLAST17
Compositional biasi1831 – 1857PolyampholyteSequence analysisAdd BLAST27
Compositional biasi1878 – 1903PolyampholyteSequence analysisAdd BLAST26

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the InsP3 receptor family.ARBA annotation

Keywords - Domaini

Coiled coilSequence analysis, RepeatARBA annotation, Transmembrane, Transmembrane helixSequence analysisARBA annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG3533, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000155071

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_000206_1_0_1

Identification of Orthologs from Complete Genome Data

More...OMAi		FCHYLPK

Database of Orthologous Groups

More...OrthoDBi		94996at2759

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR014821, Ins145_P3_rcpt
IPR000493, InsP3_rcpt
IPR005821, Ion_trans_dom
IPR036300, MIR_dom_sf
IPR016093, MIR_motif
IPR013662, RIH_assoc-dom
IPR000699, RIH_dom
IPR035910, RyR/IP3R_RIH_dom_sf

Pfam protein domain database

More...Pfami		View protein in Pfam
PF08709, Ins145_P3_rec, 1 hit
PF00520, Ion_trans, 1 hit
PF02815, MIR, 1 hit
PF08454, RIH_assoc, 1 hit
PF01365, RYDR_ITPR, 2 hits

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR00779, INSP3RECEPTR

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00472, MIR, 4 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF100909, SSF100909, 2 hits
SSF82109, SSF82109, 2 hits

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50919, MIR, 5 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 12 potential isoforms that are computationally mapped.Show allAlign All

F8W4B1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVDKLSSFLH IGDVCSLYAE GSTSGFISTL GLVDDRCVVQ PDAGDLNNPP 
        60         70         80         90        100
KKFRDCLFRL CPMNRYSAQK QFWKAAKPGG TSTTDTVLLN KLHHAADLEK 
       110        120        130        140        150
KQNDSENKKL LGTVIQYGNV IQLLHLKSNK YLTVNKRLPA LLEKNAMRVT 
       160        170        180        190        200
LDAAGNEGSW FYIQPFYKLR SIGDNVVIGD KVVLNPVNAG QPLHASSHQL 
       210        220        230        240        250
VDNPGCNEVN SVNCTTSWKI VLFMKWSDNQ EIVLKGGDVV RLFHAEQEKF 
       260        270        280        290        300
LTCDEHRKKQ YVFLRTTGRQ SATSATSSKA LWEVEVVQHD PCRGGAGYWN 
       310        320        330        340        350
SLFRFKHLAT GHYLAAEVNP DYEEECLESR SSMDSEHEVI RARARNPQDK 
       360        370        380        390        400
VMYTLVSVPD GNDISSIFEL DPTTLRGGDS LVPRNSYVRL RHLCTNTWVH 
       410        420        430        440        450
STNQPIDKEE EKPVMLRIGT SPLKEDKEAF AIVPVSPAEV RDLDFANDAS 
       460        470        480        490        500
KVLASIAAKL EKGTITQNER RSVTKLLEDL VYFVVDIPSS AQDVLEITVN 
       510        520        530        540        550
KPNRERQKLM REQNILKQIF KLLQAPFTDS GDGPMLRLEE LADQRHAPFR 
       560        570        580        590        600
HICRLCYRVL RYSQQDYRKN QEYIAKQFRF MQKQIGYDVL AEDTITALLH 
       610        620        630        640        650
NNRKLLEKHI TAAEIDTFVS LVRKNREPRF LDYLSDLCVS MNKSIPVTQE 
       660        670        680        690        700
LICNAVLDPA NADILIETKL VLSRFEVAGT VLGEGAEEEE EDEEEVWLFW 
       710        720        730        740        750
KDSGGEVKSK SIRELAQDAK DGHTEDQEVI NYYRYQLNLF ARMCLDRQYL 
       760        770        780        790        800
AINKISAQLD VDLILRCMSD EDLPFDLRAS FCRMMLHMHV DRDPQEQVTP 
       810        820        830        840        850
VKYARLWSEI PSQISIDDYD NDGTSSDEVK ERFSQTMEFV ENYLRDVVCQ 
       860        870        880        890        900
SFPFSDKEKN KLTFEVVNLA RNLIYFGFYN FSDLLRLTKI LLAILDCVHI 
       910        920        930        940        950
STPFHIKLDR EPGKGSNVMR SIHGVGELMT QVVLRGGGFL PASSHNPPDR 
       960        970        980        990       1000
DEVKAQSEPQ KQDILVMDTK LKIIEILQFI LNVRLDYRIS CLLCIFKTEF 
      1010       1020       1030       1040       1050
DESNSQSEPS LSPESPASVQ GALDFEHIEE QAEGIFGGSE ENTPLDLDDH 
      1060       1070       1080       1090       1100
GGRTFLRVLL HLTMHDYPPL VSRALHLLFR HFSQRQEVLQ AFKQVQLLVT 
      1110       1120       1130       1140       1150
SQDVENYKQI KSDLDQLRSI VEKSELWVYK RQGSDSGLDA GEVTPEAHHK 
      1160       1170       1180       1190       1200
GVINSSRSNK PKVESTSSSN YRVVKEILLR LSKLCVLEGI SGKKNKKQQQ 
      1210       1220       1230       1240       1250
RLLRNMGAHS VVLELLQIPY EKGEDVQMQE IMTLAHQFLQ NFCAGNQQNQ 
      1260       1270       1280       1290       1300
ALLHKHINLF LNPGILEAVT MQHIFMNNFQ LCSEINERVV QHFVHCIETH 
      1310       1320       1330       1340       1350
GRSVHYLKFL QTIVKAENKF IKKCQDIVMA ELVTAGEDVL VFYNDRASFQ 
      1360       1370       1380       1390       1400
SLVQMMRLER ERLDESSALR YHIHLVELLA VCTEGKNVYT EIKCNSLLPL 
      1410       1420       1430       1440       1450
DDIVRVVTHE DCIPEVKMAY VNFLNHCYVD TEVEMKEIYT SNHMWKLFDD 
      1460       1470       1480       1490       1500
FLVDVCRVCN NTSDRKHADT VLERYVTETI MSIVTTFFSS PFSDQSTSLQ 
      1510       1520       1530       1540       1550
TRQPVFVQLL QGVFRVYHCN WLLPGQKGNV EACIKVLSDV AKGRAIAIPV 
      1560       1570       1580       1590       1600
DLDCQVNNLF MKSNNIVQKT ALSWRLSVRN ATRRDSVLTT SRDYRNIIER 
      1610       1620       1630       1640       1650
LQDIVSALEE RLRPLVQAEL SVLVDVLHRP ELLFPEHTEA HRKCESGGFI 
      1660       1670       1680       1690       1700
CKLIKHTKQL LEENEERLCI KVLQTLREMM TKDRGYGEKG EALRQLLVNR 
      1710       1720       1730       1740       1750
YYGFRSGGRR ESLTSFGNST LTPVGPIKSQ PGGLSRAEMS LMEVQCHLDR 
      1760       1770       1780       1790       1800
EGASDLVIDL IMNTTSDRVF HESILLAIAL LEGGNTIIQH SFFKRLTEDK 
      1810       1820       1830       1840       1850
NSEKFFRVFY DRMKVAQVEI KATVTVNTSD LGNKRRDDNT PDKDTPQRRR 
      1860       1870       1880       1890       1900
GKDSGVVVTD DAREQLLEAS AATKKAFGSY RRDADPEETF GTADGDKGGG 
      1910       1920       1930       1940       1950
DKGTEQGEMS PVILIMQPIL RFLQLLCENH NRDLQNFLRC QNNKNNYNLV 
      1960       1970       1980       1990       2000
CETLQFLDCI CGSTTGGLGL LGLYINQHNV ALINQTVESL TEYCQGPCHD 
      2010       2020       2030       2040       2050
NQNCIATHES NGIDIIIALI LNDINPLGRK RMDLVLELKN NASKLLLAIM 
      2060       2070       2080       2090       2100
ESRHDSENAE RILYNMRPKE LVEVMKMAYQ QGEAEFEDEE QENGEDHAAS 
      2110       2120       2130       2140       2150
PRNVGHNIYI LAHQLSRHNK ELQILLKPGG EDQALEYYTK HTSQIEIVRQ 
      2160       2170       2180       2190       2200
DRTMEQIVFP VPNICSFLTN ESKLRVYYGT ERDEQGSKIN DFFLHADDLF 
      2210       2220       2230       2240       2250
NEMRWQKKLR AQPVLYWCSR NMSFWSNVSF NLAVLINLLV AFFYPLDGVS 
      2260       2270       2280       2290       2300
ESQLEPSLSL LLWVCLLGSL GFVLMSPRPN AVRVLVISTV LQLGFSVGLQ 
      2310       2320       2330       2340       2350
HMLTLLGAFN VCNKIVFMLS FVGNRGSFTR GYRVMVMDRE FLFHLLYLLI 
      2360       2370       2380       2390       2400
CILGLFGHVF FYSLLLFDLV NREETLLNVI KSVTRNGRSI VLTAVLGLIL 
      2410       2420       2430       2440       2450
VYLFSIVGYM FFKDDFILEV NRISNGTLEE GVTLPAGFCD ARNGSCLSDD 
      2460       2470       2480       2490       2500
VDEDDVERAC DSLWMCMITV LSHGLRSGGG VGDVLRKPSK EERLFAARVV 
      2510       2520       2530       2540       2550
YDLLFFFLVI IIVLNLIFGV IIDTFADLRS EKQRKEEILK TTCFICGLER 
      2560       2570       2580       2590       2600
DKFDNKTVTF EEHIKEEHNL WHYLFFIVLV RVKDSTEYTG PESYVAQMIK 
      2610       2620       2630       2640       2650
EHNLDWFPRM RAMSLVSSDG EGEQNELRSL QEKLESTMRL VSNLTNQLTE 
      2660       2670       2680 
LKEQMTEQRK HKQRLGLLGN PAHLNINPQQ PA
Length:2,682
Mass (Da):306,090
Last modified:September 21, 2011 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iF66C820E30621B0E
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 12 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E7F4G8E7F4G8_DANRE
Inositol 1,4,5-trisphosphate recept...
itpr1a
2,730Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2R8QAR1A0A2R8QAR1_DANRE
Inositol 1,4,5-trisphosphate recept...
itpr1a
2,745Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2R8QJM5A0A2R8QJM5_DANRE
Inositol 1,4,5-trisphosphate recept...
itpr1a
2,707Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2R8RSY9A0A2R8RSY9_DANRE
Inositol 1,4,5-trisphosphate recept...
itpr1a
2,726Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2R8PWX1A0A2R8PWX1_DANRE
Inositol 1,4,5-trisphosphate recept...
itpr1a
2,730Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2R8Q201A0A2R8Q201_DANRE
Inositol 1,4,5-trisphosphate recept...
itpr1a
2,715Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2R8QBV7A0A2R8QBV7_DANRE
Inositol 1,4,5-trisphosphate recept...
itpr1a
2,726Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2R8QHB5A0A2R8QHB5_DANRE
Inositol 1,4,5-trisphosphate recept...
itpr1a
2,707Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2R8RZ36A0A2R8RZ36_DANRE
Inositol 1,4,5-trisphosphate recept...
itpr1a
2,745Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2R8QFQ7A0A2R8QFQ7_DANRE
Inositol 1,4,5-trisphosphate recept...
itpr1a
708Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
There are more potential isoformsShow all

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
BX957338 Genomic DNA No translation available.

NCBI Reference Sequences

More...RefSeqi		XP_017212154.1, XM_017356665.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENSDART00000149019; ENSDARP00000123931; ENSDARG00000014655

Database of genes from NCBI RefSeq genomes

More...GeneIDi		567611

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX957338 Genomic DNA No translation available.
RefSeqiXP_017212154.1, XM_017356665.1

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Protein-protein interaction databases

STRINGi7955.ENSDARP00000065091

Proteomic databases

PaxDbiF8W4B1

Genome annotation databases

EnsembliENSDART00000149019; ENSDARP00000123931; ENSDARG00000014655
GeneIDi567611

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		567611
ZFINiZDB-GENE-070604-3, itpr1a

Phylogenomic databases

eggNOGiKOG3533, Eukaryota
GeneTreeiENSGT00940000155071
HOGENOMiCLU_000206_1_0_1
OMAiFCHYLPK
OrthoDBi94996at2759

Gene expression databases

BgeeiENSDARG00000014655, Expressed in granulocyte and 24 other tissues
ExpressionAtlasiF8W4B1, baseline

Family and domain databases

InterProiView protein in InterPro
IPR014821, Ins145_P3_rcpt
IPR000493, InsP3_rcpt
IPR005821, Ion_trans_dom
IPR036300, MIR_dom_sf
IPR016093, MIR_motif
IPR013662, RIH_assoc-dom
IPR000699, RIH_dom
IPR035910, RyR/IP3R_RIH_dom_sf
PfamiView protein in Pfam
PF08709, Ins145_P3_rec, 1 hit
PF00520, Ion_trans, 1 hit
PF02815, MIR, 1 hit
PF08454, RIH_assoc, 1 hit
PF01365, RYDR_ITPR, 2 hits
PRINTSiPR00779, INSP3RECEPTR
SMARTiView protein in SMART
SM00472, MIR, 4 hits
SUPFAMiSSF100909, SSF100909, 2 hits
SSF82109, SSF82109, 2 hits
PROSITEiView protein in PROSITE
PS50919, MIR, 5 hits

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiF8W4B1_DANRE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: F8W4B1
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: September 21, 2011
Last sequence update: September 21, 2011
Last modified: February 10, 2021
This is version 68 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
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