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Entry version 68 (10 Feb 2021)
Sequence version 1 (21 Sep 2011)
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Protein
Submitted name:

Inositol 1,4,5-trisphosphate receptor, type 1a

Gene

itpr1a

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionCalcium channelARBA annotation, Ion channel, Ligand-gated ion channelARBA annotation, ReceptorARBA annotation
Biological processCalcium transport, Ion transport, Transport
LigandCalcium

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Inositol 1,4,5-trisphosphate receptor, type 1aImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:itpr1aImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7955 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesDanionidaeDanioninaeDanio
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000437 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 6

Organism-specific databases

Zebrafish Information Network genome database

More...
ZFINi
ZDB-GENE-070604-3, itpr1a

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei2224 – 2246HelicalSequence analysisAdd BLAST23
Transmembranei2258 – 2275HelicalSequence analysisAdd BLAST18
Transmembranei2305 – 2322HelicalSequence analysisAdd BLAST18
Transmembranei2342 – 2369HelicalSequence analysisAdd BLAST28
Transmembranei2390 – 2412HelicalSequence analysisAdd BLAST23
Transmembranei2503 – 2526HelicalSequence analysisAdd BLAST24

Keywords - Cellular componenti

Endoplasmic reticulumARBA annotation, Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
F8W4B1

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSDARG00000014655, Expressed in granulocyte and 24 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
F8W4B1, baseline

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
7955.ENSDARP00000065091

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini112 – 166MIRInterPro annotationAdd BLAST55
Domaini173 – 223MIRInterPro annotationAdd BLAST51
Domaini231 – 287MIRInterPro annotationAdd BLAST57
Domaini294 – 358MIRInterPro annotationAdd BLAST65
Domaini379 – 435MIRInterPro annotationAdd BLAST57

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1148 – 1167DisorderedSequence analysisAdd BLAST20
Regioni1830 – 1857DisorderedSequence analysisAdd BLAST28
Regioni1878 – 1906DisorderedSequence analysisAdd BLAST29

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili1591 – 1611Sequence analysisAdd BLAST21
Coiled coili2072 – 2092Sequence analysisAdd BLAST21
Coiled coili2627 – 2661Sequence analysisAdd BLAST35

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1151 – 1167PolarSequence analysisAdd BLAST17
Compositional biasi1831 – 1857PolyampholyteSequence analysisAdd BLAST27
Compositional biasi1878 – 1903PolyampholyteSequence analysisAdd BLAST26

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the InsP3 receptor family.ARBA annotation

Keywords - Domaini

Coiled coilSequence analysis, RepeatARBA annotation, Transmembrane, Transmembrane helixSequence analysisARBA annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3533, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000155071

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_000206_1_0_1

Identification of Orthologs from Complete Genome Data

More...
OMAi
FCHYLPK

Database of Orthologous Groups

More...
OrthoDBi
94996at2759

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR014821, Ins145_P3_rcpt
IPR000493, InsP3_rcpt
IPR005821, Ion_trans_dom
IPR036300, MIR_dom_sf
IPR016093, MIR_motif
IPR013662, RIH_assoc-dom
IPR000699, RIH_dom
IPR035910, RyR/IP3R_RIH_dom_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF08709, Ins145_P3_rec, 1 hit
PF00520, Ion_trans, 1 hit
PF02815, MIR, 1 hit
PF08454, RIH_assoc, 1 hit
PF01365, RYDR_ITPR, 2 hits

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00779, INSP3RECEPTR

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00472, MIR, 4 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF100909, SSF100909, 2 hits
SSF82109, SSF82109, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50919, MIR, 5 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 12 potential isoforms that are computationally mapped.Show allAlign All

F8W4B1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVDKLSSFLH IGDVCSLYAE GSTSGFISTL GLVDDRCVVQ PDAGDLNNPP
60 70 80 90 100
KKFRDCLFRL CPMNRYSAQK QFWKAAKPGG TSTTDTVLLN KLHHAADLEK
110 120 130 140 150
KQNDSENKKL LGTVIQYGNV IQLLHLKSNK YLTVNKRLPA LLEKNAMRVT
160 170 180 190 200
LDAAGNEGSW FYIQPFYKLR SIGDNVVIGD KVVLNPVNAG QPLHASSHQL
210 220 230 240 250
VDNPGCNEVN SVNCTTSWKI VLFMKWSDNQ EIVLKGGDVV RLFHAEQEKF
260 270 280 290 300
LTCDEHRKKQ YVFLRTTGRQ SATSATSSKA LWEVEVVQHD PCRGGAGYWN
310 320 330 340 350
SLFRFKHLAT GHYLAAEVNP DYEEECLESR SSMDSEHEVI RARARNPQDK
360 370 380 390 400
VMYTLVSVPD GNDISSIFEL DPTTLRGGDS LVPRNSYVRL RHLCTNTWVH
410 420 430 440 450
STNQPIDKEE EKPVMLRIGT SPLKEDKEAF AIVPVSPAEV RDLDFANDAS
460 470 480 490 500
KVLASIAAKL EKGTITQNER RSVTKLLEDL VYFVVDIPSS AQDVLEITVN
510 520 530 540 550
KPNRERQKLM REQNILKQIF KLLQAPFTDS GDGPMLRLEE LADQRHAPFR
560 570 580 590 600
HICRLCYRVL RYSQQDYRKN QEYIAKQFRF MQKQIGYDVL AEDTITALLH
610 620 630 640 650
NNRKLLEKHI TAAEIDTFVS LVRKNREPRF LDYLSDLCVS MNKSIPVTQE
660 670 680 690 700
LICNAVLDPA NADILIETKL VLSRFEVAGT VLGEGAEEEE EDEEEVWLFW
710 720 730 740 750
KDSGGEVKSK SIRELAQDAK DGHTEDQEVI NYYRYQLNLF ARMCLDRQYL
760 770 780 790 800
AINKISAQLD VDLILRCMSD EDLPFDLRAS FCRMMLHMHV DRDPQEQVTP
810 820 830 840 850
VKYARLWSEI PSQISIDDYD NDGTSSDEVK ERFSQTMEFV ENYLRDVVCQ
860 870 880 890 900
SFPFSDKEKN KLTFEVVNLA RNLIYFGFYN FSDLLRLTKI LLAILDCVHI
910 920 930 940 950
STPFHIKLDR EPGKGSNVMR SIHGVGELMT QVVLRGGGFL PASSHNPPDR
960 970 980 990 1000
DEVKAQSEPQ KQDILVMDTK LKIIEILQFI LNVRLDYRIS CLLCIFKTEF
1010 1020 1030 1040 1050
DESNSQSEPS LSPESPASVQ GALDFEHIEE QAEGIFGGSE ENTPLDLDDH
1060 1070 1080 1090 1100
GGRTFLRVLL HLTMHDYPPL VSRALHLLFR HFSQRQEVLQ AFKQVQLLVT
1110 1120 1130 1140 1150
SQDVENYKQI KSDLDQLRSI VEKSELWVYK RQGSDSGLDA GEVTPEAHHK
1160 1170 1180 1190 1200
GVINSSRSNK PKVESTSSSN YRVVKEILLR LSKLCVLEGI SGKKNKKQQQ
1210 1220 1230 1240 1250
RLLRNMGAHS VVLELLQIPY EKGEDVQMQE IMTLAHQFLQ NFCAGNQQNQ
1260 1270 1280 1290 1300
ALLHKHINLF LNPGILEAVT MQHIFMNNFQ LCSEINERVV QHFVHCIETH
1310 1320 1330 1340 1350
GRSVHYLKFL QTIVKAENKF IKKCQDIVMA ELVTAGEDVL VFYNDRASFQ
1360 1370 1380 1390 1400
SLVQMMRLER ERLDESSALR YHIHLVELLA VCTEGKNVYT EIKCNSLLPL
1410 1420 1430 1440 1450
DDIVRVVTHE DCIPEVKMAY VNFLNHCYVD TEVEMKEIYT SNHMWKLFDD
1460 1470 1480 1490 1500
FLVDVCRVCN NTSDRKHADT VLERYVTETI MSIVTTFFSS PFSDQSTSLQ
1510 1520 1530 1540 1550
TRQPVFVQLL QGVFRVYHCN WLLPGQKGNV EACIKVLSDV AKGRAIAIPV
1560 1570 1580 1590 1600
DLDCQVNNLF MKSNNIVQKT ALSWRLSVRN ATRRDSVLTT SRDYRNIIER
1610 1620 1630 1640 1650
LQDIVSALEE RLRPLVQAEL SVLVDVLHRP ELLFPEHTEA HRKCESGGFI
1660 1670 1680 1690 1700
CKLIKHTKQL LEENEERLCI KVLQTLREMM TKDRGYGEKG EALRQLLVNR
1710 1720 1730 1740 1750
YYGFRSGGRR ESLTSFGNST LTPVGPIKSQ PGGLSRAEMS LMEVQCHLDR
1760 1770 1780 1790 1800
EGASDLVIDL IMNTTSDRVF HESILLAIAL LEGGNTIIQH SFFKRLTEDK
1810 1820 1830 1840 1850
NSEKFFRVFY DRMKVAQVEI KATVTVNTSD LGNKRRDDNT PDKDTPQRRR
1860 1870 1880 1890 1900
GKDSGVVVTD DAREQLLEAS AATKKAFGSY RRDADPEETF GTADGDKGGG
1910 1920 1930 1940 1950
DKGTEQGEMS PVILIMQPIL RFLQLLCENH NRDLQNFLRC QNNKNNYNLV
1960 1970 1980 1990 2000
CETLQFLDCI CGSTTGGLGL LGLYINQHNV ALINQTVESL TEYCQGPCHD
2010 2020 2030 2040 2050
NQNCIATHES NGIDIIIALI LNDINPLGRK RMDLVLELKN NASKLLLAIM
2060 2070 2080 2090 2100
ESRHDSENAE RILYNMRPKE LVEVMKMAYQ QGEAEFEDEE QENGEDHAAS
2110 2120 2130 2140 2150
PRNVGHNIYI LAHQLSRHNK ELQILLKPGG EDQALEYYTK HTSQIEIVRQ
2160 2170 2180 2190 2200
DRTMEQIVFP VPNICSFLTN ESKLRVYYGT ERDEQGSKIN DFFLHADDLF
2210 2220 2230 2240 2250
NEMRWQKKLR AQPVLYWCSR NMSFWSNVSF NLAVLINLLV AFFYPLDGVS
2260 2270 2280 2290 2300
ESQLEPSLSL LLWVCLLGSL GFVLMSPRPN AVRVLVISTV LQLGFSVGLQ
2310 2320 2330 2340 2350
HMLTLLGAFN VCNKIVFMLS FVGNRGSFTR GYRVMVMDRE FLFHLLYLLI
2360 2370 2380 2390 2400
CILGLFGHVF FYSLLLFDLV NREETLLNVI KSVTRNGRSI VLTAVLGLIL
2410 2420 2430 2440 2450
VYLFSIVGYM FFKDDFILEV NRISNGTLEE GVTLPAGFCD ARNGSCLSDD
2460 2470 2480 2490 2500
VDEDDVERAC DSLWMCMITV LSHGLRSGGG VGDVLRKPSK EERLFAARVV
2510 2520 2530 2540 2550
YDLLFFFLVI IIVLNLIFGV IIDTFADLRS EKQRKEEILK TTCFICGLER
2560 2570 2580 2590 2600
DKFDNKTVTF EEHIKEEHNL WHYLFFIVLV RVKDSTEYTG PESYVAQMIK
2610 2620 2630 2640 2650
EHNLDWFPRM RAMSLVSSDG EGEQNELRSL QEKLESTMRL VSNLTNQLTE
2660 2670 2680
LKEQMTEQRK HKQRLGLLGN PAHLNINPQQ PA
Length:2,682
Mass (Da):306,090
Last modified:September 21, 2011 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iF66C820E30621B0E
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 12 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E7F4G8E7F4G8_DANRE
Inositol 1,4,5-trisphosphate recept...
itpr1a
2,730Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2R8QAR1A0A2R8QAR1_DANRE
Inositol 1,4,5-trisphosphate recept...
itpr1a
2,745Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2R8QJM5A0A2R8QJM5_DANRE
Inositol 1,4,5-trisphosphate recept...
itpr1a
2,707Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2R8RSY9A0A2R8RSY9_DANRE
Inositol 1,4,5-trisphosphate recept...
itpr1a
2,726Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2R8PWX1A0A2R8PWX1_DANRE
Inositol 1,4,5-trisphosphate recept...
itpr1a
2,730Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2R8Q201A0A2R8Q201_DANRE
Inositol 1,4,5-trisphosphate recept...
itpr1a
2,715Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2R8QBV7A0A2R8QBV7_DANRE
Inositol 1,4,5-trisphosphate recept...
itpr1a
2,726Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2R8QHB5A0A2R8QHB5_DANRE
Inositol 1,4,5-trisphosphate recept...
itpr1a
2,707Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2R8RZ36A0A2R8RZ36_DANRE
Inositol 1,4,5-trisphosphate recept...
itpr1a
2,745Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2R8QFQ7A0A2R8QFQ7_DANRE
Inositol 1,4,5-trisphosphate recept...
itpr1a
708Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
There are more potential isoformsShow all

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
BX957338 Genomic DNA No translation available.

NCBI Reference Sequences

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RefSeqi
XP_017212154.1, XM_017356665.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSDART00000149019; ENSDARP00000123931; ENSDARG00000014655

Database of genes from NCBI RefSeq genomes

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GeneIDi
567611

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX957338 Genomic DNA No translation available.
RefSeqiXP_017212154.1, XM_017356665.1

3D structure databases

Database of comparative protein structure models

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ModBasei
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SWISS-MODEL Interactive Workspace

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SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi7955.ENSDARP00000065091

Proteomic databases

PaxDbiF8W4B1

Genome annotation databases

EnsembliENSDART00000149019; ENSDARP00000123931; ENSDARG00000014655
GeneIDi567611

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
567611
ZFINiZDB-GENE-070604-3, itpr1a

Phylogenomic databases

eggNOGiKOG3533, Eukaryota
GeneTreeiENSGT00940000155071
HOGENOMiCLU_000206_1_0_1
OMAiFCHYLPK
OrthoDBi94996at2759

Gene expression databases

BgeeiENSDARG00000014655, Expressed in granulocyte and 24 other tissues
ExpressionAtlasiF8W4B1, baseline

Family and domain databases

InterProiView protein in InterPro
IPR014821, Ins145_P3_rcpt
IPR000493, InsP3_rcpt
IPR005821, Ion_trans_dom
IPR036300, MIR_dom_sf
IPR016093, MIR_motif
IPR013662, RIH_assoc-dom
IPR000699, RIH_dom
IPR035910, RyR/IP3R_RIH_dom_sf
PfamiView protein in Pfam
PF08709, Ins145_P3_rec, 1 hit
PF00520, Ion_trans, 1 hit
PF02815, MIR, 1 hit
PF08454, RIH_assoc, 1 hit
PF01365, RYDR_ITPR, 2 hits
PRINTSiPR00779, INSP3RECEPTR
SMARTiView protein in SMART
SM00472, MIR, 4 hits
SUPFAMiSSF100909, SSF100909, 2 hits
SSF82109, SSF82109, 2 hits
PROSITEiView protein in PROSITE
PS50919, MIR, 5 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiF8W4B1_DANRE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: F8W4B1
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: September 21, 2011
Last sequence update: September 21, 2011
Last modified: February 10, 2021
This is version 68 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
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