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UniProtKB - F8W2W5 (F8W2W5_DANRE)

Entry version 76 (25 May 2022)
Sequence version 1 (21 Sep 2011)
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Protein
Submitted name:

Endothelial PAS domain protein 1a

Gene

epas1a

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActivatorARBA annotation, DNA-bindingARBA annotation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Endothelial PAS domain protein 1a
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:epas1aImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7955 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Actinopterygii › Neopterygii › Teleostei › Ostariophysi › Cypriniformes › Danionidae › Danioninae › Danio
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000437 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 12

Organism-specific databases

Zebrafish Information Network genome database

More...ZFINi		ZDB-GENE-030131-4490, epas1a

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei4034-hydroxyprolineUniRule annotation1
Modified residuei5364-hydroxyprolineUniRule annotation1
Modified residuei787(3S)-3-hydroxyasparagineUniRule annotation1

Keywords - PTMi

HydroxylationARBA annotation, Ubl conjugationARBA annotation

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSDARG00000008697, Expressed in pharyngeal gill and 27 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		F8W2W5, baseline and differential

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Complete GO annotation on QuickGO ...

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini14 – 67BHLHInterPro annotationAdd BLAST54
Domaini92 – 147PASInterPro annotationAdd BLAST56
Domaini248 – 299PASInterPro annotationAdd BLAST52

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 24DisorderedSequence analysisAdd BLAST24

Keywords - Domaini

RepeatARBA annotation

Phylogenomic databases

Ensembl GeneTree

More...GeneTreei		ENSGT00940000155930

Identification of Orthologs from Complete Genome Data

More...OMAi		HIVEEMC

Database of Orthologous Groups

More...OrthoDBi		547545at2759

Family and domain databases

Conserved Domains Database

More...CDDi		cd00130, PAS, 2 hits

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR011598, bHLH_dom
IPR014887, HIF-1_TAD_C
IPR021537, HIF_alpha_subunit
IPR036638, HLH_DNA-bd_sf
IPR001067, Nuc_translocat
IPR001610, PAC
IPR000014, PAS
IPR035965, PAS-like_dom_sf
IPR013767, PAS_fold
IPR013655, PAS_fold_3

Pfam protein domain database

More...Pfami		View protein in Pfam
PF11413, HIF-1, 1 hit
PF08778, HIF-1a_CTAD, 1 hit
PF00989, PAS, 1 hit
PF08447, PAS_3, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR00785, NCTRNSLOCATR

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00353, HLH, 1 hit
SM00086, PAC, 1 hit
SM00091, PAS, 2 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF47459, SSF47459, 1 hit
SSF55785, SSF55785, 2 hits

TIGRFAMs; a protein family database

More...TIGRFAMsi		TIGR00229, sensory_box, 2 hits

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50888, BHLH, 1 hit
PS50112, PAS, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

F8W2W5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTAEREKKRH PSERRKEKSR DAARCRRSKE TEVFYELAHQ LPLPHSISSH 
        60         70         80         90        100
LDKASIMRLA ISFLRTRKLF SSGHTVQQMR SQNLGQMDNL YLKSLEGFVI 
       110        120        130        140        150
VVTSDGDMIF LSENVSKFMG LTQVELTGHS IFDFTHPCDH EEIRENLSIK 
       160        170        180        190        200
SGPVYGRKGK EMSTSRDFFM RMKCTVTNRG RTVNLKSASW KVLHCTGHLQ 
       210        220        230        240        250
VCSSRPPQIL CGFSEPPLTC ITMLCAPIPH PSNVDTPLDS KTFMSRHSMD 
       260        270        280        290        300
MKFIYCDERV SSLIGYRPEE LLGRSVYEFC HALDSENMTK SHQNLCNKGQ 
       310        320        330        340        350
VVSGQYRMLA KNGGYVWVET QATVIYNNRN SQPQCIICIN YILSSVEEQS 
       360        370        380        390        400
VIFSLDQTEA LFKPYHTYDM GEIFSQNTSI SEPQNNLFTT LKEEPEELAQ 
       410        420        430        440        450
LAPMPGDAII ALDFERAEFE EATFFSKSSK LPAVGPSWVV DTPPDGSPER 
       460        470        480        490        500
NLSSLPSSFT VPQVPPAGKC TPCTTPCLSS CSSCSTPNSP VDCCGSGEWD 
       510        520        530        540        550
LKVELTEKLF APESGATNPT DSQLNLSDLD LETLAPYIPM DGEDFQLHPI 
       560        570        580        590        600
CLEEPVPDAG PGLSAAVQHS FSSVADLFQP LEKQRQSLHW PPDQLSQYEN 
       610        620        630        640        650
TNVGCMDDRN TGGPGQTCNF NVPPPHQRFF ENFTPVQKGM SLGQRALLNN 
       660        670        680        690        700
FKRKRQSEFP LSCSFSDIPK QVVAPHKSTD GMRKRMKPMN DDSCAFSVRK 
       710        720        730        740        750
SLSTSVLTDK FPCMQSGLVD PQACSRSVKG CPEDLKQHCT DSFCSNSSRQ 
       760        770        780        790        800
YNMMPSRKHT GMISQLLAPS FDSYCLPELT RYDCEVNMPL QGNLHLLQGS 
       810
DLLRALDQST
Length:810
Mass (Da):90,622
Last modified:September 21, 2011 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iBB4694879576D514
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E7FAJ1E7FAJ1_DANRE
Endothelial PAS domain protein 1a
epas1a
842Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
CR931998 Genomic DNA No translation available.

NCBI Reference Sequences

More...RefSeqi		XP_009305016.1, XM_009306741.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENSDART00000149198.2; ENSDARP00000124584.1; ENSDARG00000008697.10

Database of genes from NCBI RefSeq genomes

More...GeneIDi		566886

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR931998 Genomic DNA No translation available.
RefSeqiXP_009305016.1, XM_009306741.2

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Genome annotation databases

EnsembliENSDART00000149198.2; ENSDARP00000124584.1; ENSDARG00000008697.10
GeneIDi566886

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		566886
ZFINiZDB-GENE-030131-4490, epas1a

Phylogenomic databases

GeneTreeiENSGT00940000155930
OMAiHIVEEMC
OrthoDBi547545at2759

Gene expression databases

BgeeiENSDARG00000008697, Expressed in pharyngeal gill and 27 other tissues
ExpressionAtlasiF8W2W5, baseline and differential

Family and domain databases

CDDicd00130, PAS, 2 hits
InterProiView protein in InterPro
IPR011598, bHLH_dom
IPR014887, HIF-1_TAD_C
IPR021537, HIF_alpha_subunit
IPR036638, HLH_DNA-bd_sf
IPR001067, Nuc_translocat
IPR001610, PAC
IPR000014, PAS
IPR035965, PAS-like_dom_sf
IPR013767, PAS_fold
IPR013655, PAS_fold_3
PfamiView protein in Pfam
PF11413, HIF-1, 1 hit
PF08778, HIF-1a_CTAD, 1 hit
PF00989, PAS, 1 hit
PF08447, PAS_3, 1 hit
PRINTSiPR00785, NCTRNSLOCATR
SMARTiView protein in SMART
SM00353, HLH, 1 hit
SM00086, PAC, 1 hit
SM00091, PAS, 2 hits
SUPFAMiSSF47459, SSF47459, 1 hit
SSF55785, SSF55785, 2 hits
TIGRFAMsiTIGR00229, sensory_box, 2 hits
PROSITEiView protein in PROSITE
PS50888, BHLH, 1 hit
PS50112, PAS, 2 hits

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiF8W2W5_DANRE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: F8W2W5
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: September 21, 2011
Last sequence update: September 21, 2011
Last modified: May 25, 2022
This is version 76 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
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