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Protein
Submitted name:

SRY (sex determining region Y)-box 6

Gene

sox6

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi559 – 627HMG boxPROSITE-ProRule annotationAdd BLAST69

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-bindingPROSITE-ProRule annotationSAAS annotation

Enzyme and pathway databases

ReactomeiR-DRE-3769402 Deactivation of the beta-catenin transactivating complex

Names & Taxonomyi

Protein namesi
Submitted name:
SRY (sex determining region Y)-box 6Imported
Submitted name:
SRY-box containing protein 6Imported
Gene namesi
Name:sox6Imported
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)Imported
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi
  • UP000000437 Componenti: Chromosome 7

Organism-specific databases

ZFINiZDB-GENE-081120-6 sox6

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

NucleusPROSITE-ProRule annotation

PTM / Processingi

Proteomic databases

PRIDEiF8W2H3

Expressioni

Gene expression databases

BgeeiENSDARG00000015536 Expressed in 28 organ(s), highest expression level in embryo

Interactioni

Protein-protein interaction databases

STRINGi7955.ENSDARP00000124730

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini559 – 627HMG boxInterPro annotationAdd BLAST69

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili186 – 206Sequence analysisAdd BLAST21
Coiled coili208 – 259Sequence analysisAdd BLAST52
Coiled coili452 – 475Sequence analysisAdd BLAST24

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

eggNOGiKOG0528 Eukaryota
ENOG410YZNG LUCA
GeneTreeiENSGT00760000119274
HOGENOMiHOG000056455
HOVERGENiHBG003915
InParanoidiF8W2H3
KOiK09269
OrthoDBiEOG091G03D9
TreeFamiTF320471

Family and domain databases

Gene3Di1.10.30.10, 1 hit
InterProiView protein in InterPro
IPR009071 HMG_box_dom
IPR036910 HMG_box_dom_sf
IPR027153 SOX-6
PANTHERiPTHR10270:SF89 PTHR10270:SF89, 1 hit
PfamiView protein in Pfam
PF00505 HMG_box, 1 hit
SMARTiView protein in SMART
SM00398 HMG, 1 hit
SUPFAMiSSF47095 SSF47095, 1 hit
PROSITEiView protein in PROSITE
PS50118 HMG_BOX_2, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.iShow all

F8W2H3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSSKQATSPF TSTPDGGEDG VNQERMPWEK EENSESLVAP QLPLHNLLHN
60 70 80 90 100
KPPLEELQPI SSSVPPESDW DSLMSAQQRM ESDSNKVCSL YSFRNNSTSP
110 120 130 140 150
HKPEEGARER GDLLSSSAFG TPERRKGSLA DVVDTLKQKK LEEMTKTEQD
160 170 180 190 200
ESSCMEKLLS KDWKEKMERL NTGELLGEIK GTPESLAEKE RQLSTMITQL
210 220 230 240 250
ISLREQLLAA HDEQKKLAAS QMEKQRQQME LARQQQEQIA RQQQQLLQQQ
260 270 280 290 300
HKINLLQQQI QVQGHMPPLM IPIFPHDQRT LAAAAAAQQG FLFPPGMSYK
310 320 330 340 350
PGDNYPVQFI PSTMAAAAAS GLNPLQLQQL YAAQLASMQV SPGAKMPPLP
360 370 380 390 400
QPPNSAGQIS PSGLKNEKRS STPLAQVKEE GTQPLNLSAR PKTAEPIKSP
410 420 430 440 450
TSPTQSLFPG SKSSPNSLSK SGDIPSPIGG LGRGSSLDIL SSLNSTALFG
460 470 480 490 500
DQDAVMKAIQ EARKMREQIQ REQLQHHQQG MEVKLSALTS MGLNNCRTEK
510 520 530 540 550
ERSHYDNLGH HLSKLGEDGK IGHRVIDLTR PEDFEGGAST TEARVYREPR
560 570 580 590 600
GRNSNEPHIK RPMNAFMVWA KDERRKILQA FPDMHNSNIS KILGSRWKSM
610 620 630 640 650
TNQEKQPYYE EQARLSKIHL EKYPNYKYKP RPKRTCIIDG KKLRISEYKQ
660 670 680 690 700
MMRSRRQEMR QFFTVGQQPQ TQIPITTSAG VVYPGAITMA TTTPSPHMTS
710 720 730 740 750
DCSSASASPE PTIPVIQSTF NMKMEPGTMV PSDAVNGEDE MDMYEDFEDE
760
PKSDYSSEND THEPVSAN
Length:768
Mass (Da):85,791
Last modified:November 30, 2016 - v2
Checksum:i7E2C84C1F8AA68FB
GO

Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A2R8RIJ5A0A2R8RIJ5_DANRE
SRY (sex determining region Y)-box ...
sox6
784Annotation score:
A0A2R8QLT0A0A2R8QLT0_DANRE
SRY (sex determining region Y)-box ...
sox6
816Annotation score:
A0A1D5NSK3A0A1D5NSK3_DANRE
SRY (sex determining region Y)-box ...
sox6
785Annotation score:
A0A1D5NSY8A0A1D5NSY8_DANRE
SRY (sex determining region Y)-box ...
sox6
121Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX537340 Genomic DNA No translation available.
BX936427 Genomic DNA No translation available.
BX936464 Genomic DNA No translation available.
EU532205 mRNA Translation: ACB38138.1
RefSeqiNP_001116481.1, NM_001123009.1
UniGeneiDr.105964
Dr.135423
Dr.5234

Genome annotation databases

EnsembliENSDART00000100998; ENSDARP00000091770; ENSDARG00000015536
ENSDART00000150068; ENSDARP00000124730; ENSDARG00000015536
ENSDART00000185161; ENSDARP00000156079; ENSDARG00000015536
ENSDART00000193058; ENSDARP00000150954; ENSDARG00000015536
GeneIDi567154
KEGGidre:567154

Similar proteinsi

Entry informationi

Entry nameiF8W2H3_DANRE
AccessioniPrimary (citable) accession number: F8W2H3
Secondary accession number(s): B2CNY6, F6NZ61
Entry historyiIntegrated into UniProtKB/TrEMBL: September 21, 2011
Last sequence update: November 30, 2016
Last modified: September 12, 2018
This is version 60 of the entry and version 2 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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