UniProtKB - F8W2H3 (F8W2H3_DANRE)
Protein
Submitted name:
SRY-box containing protein 6
Gene
sox6
Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Functioni
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
DNA bindingi | 559 – 627 | HMG boxPROSITE-ProRule annotationAdd BLAST | 69 |
GO - Molecular functioni
- transcription regulatory region sequence-specific DNA binding Source: GO_Central
GO - Biological processi
- adipose tissue development Source: ZFIN
- cell fate commitment Source: GO_Central
- central nervous system development Source: GO_Central
- muscle cell fate specification Source: ZFIN
- negative regulation of transcription, DNA-templated Source: GO_Central
- positive regulation of chondrocyte differentiation Source: GO_Central
- positive regulation of transcription by RNA polymerase II Source: GO_Central
- skeletal muscle tissue development Source: ZFIN
Keywordsi
Molecular function | ActivatorARBA annotation, DNA-bindingPROSITE-ProRule annotationARBA annotation |
Biological process | Transcription, Transcription regulationARBA annotation |
Names & Taxonomyi
Protein namesi | Submitted name: SRY-box containing protein 6ImportedSubmitted name: SRY-box transcription factor 6Imported |
Gene namesi | Name:sox6Imported |
Organismi | Danio rerio (Zebrafish) (Brachydanio rerio)Imported |
Taxonomic identifieri | 7955 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Actinopterygii › Neopterygii › Teleostei › Ostariophysi › Cypriniformes › Danionidae › Danioninae › Danio |
Proteomesi |
|
Organism-specific databases
ZFINi | ZDB-GENE-081120-6, sox6 |
Subcellular locationi
Nucleus
- nucleus Source: GO_Central
Keywords - Cellular componenti
NucleusPROSITE-ProRule annotationARBA annotationExpressioni
Gene expression databases
Bgeei | ENSDARG00000015536, Expressed in embryo and 31 other tissues |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 559 – 627 | HMG boxInterPro annotationAdd BLAST | 69 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 127 | DisorderedSequence analysisAdd BLAST | 127 | |
Regioni | 342 – 429 | DisorderedSequence analysisAdd BLAST | 88 | |
Regioni | 724 – 768 | DisorderedSequence analysisAdd BLAST | 45 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 186 – 206 | Sequence analysisAdd BLAST | 21 | |
Coiled coili | 208 – 259 | Sequence analysisAdd BLAST | 52 | |
Coiled coili | 452 – 475 | Sequence analysisAdd BLAST | 24 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 1 – 18 | PolarSequence analysisAdd BLAST | 18 | |
Compositional biasi | 61 – 100 | PolarSequence analysisAdd BLAST | 40 | |
Compositional biasi | 356 – 423 | PolarSequence analysisAdd BLAST | 68 | |
Compositional biasi | 738 – 753 | AcidicSequence analysisAdd BLAST | 16 |
Keywords - Domaini
Coiled coilSequence analysisPhylogenomic databases
eggNOGi | KOG0528, Eukaryota |
GeneTreei | ENSGT00940000156433 |
HOGENOMi | CLU_018522_0_1_1 |
InParanoidi | F8W2H3 |
OrthoDBi | 465521at2759 |
TreeFami | TF320471 |
Family and domain databases
Gene3Di | 1.10.30.10, 1 hit |
InterProi | View protein in InterPro IPR009071, HMG_box_dom IPR036910, HMG_box_dom_sf IPR027153, SOX-6 |
PANTHERi | PTHR45789:SF1, PTHR45789:SF1, 2 hits |
Pfami | View protein in Pfam PF00505, HMG_box, 1 hit |
SMARTi | View protein in SMART SM00398, HMG, 1 hit |
SUPFAMi | SSF47095, SSF47095, 1 hit |
PROSITEi | View protein in PROSITE PS50118, HMG_BOX_2, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All
F8W2H3-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSSKQATSPF TSTPDGGEDG VNQERMPWEK EENSESLVAP QLPLHNLLHN
60 70 80 90 100
KPPLEELQPI SSSVPPESDW DSLMSAQQRM ESDSNKVCSL YSFRNNSTSP
110 120 130 140 150
HKPEEGARER GDLLSSSAFG TPERRKGSLA DVVDTLKQKK LEEMTKTEQD
160 170 180 190 200
ESSCMEKLLS KDWKEKMERL NTGELLGEIK GTPESLAEKE RQLSTMITQL
210 220 230 240 250
ISLREQLLAA HDEQKKLAAS QMEKQRQQME LARQQQEQIA RQQQQLLQQQ
260 270 280 290 300
HKINLLQQQI QVQGHMPPLM IPIFPHDQRT LAAAAAAQQG FLFPPGMSYK
310 320 330 340 350
PGDNYPVQFI PSTMAAAAAS GLNPLQLQQL YAAQLASMQV SPGAKMPPLP
360 370 380 390 400
QPPNSAGQIS PSGLKNEKRS STPLAQVKEE GTQPLNLSAR PKTAEPIKSP
410 420 430 440 450
TSPTQSLFPG SKSSPNSLSK SGDIPSPIGG LGRGSSLDIL SSLNSTALFG
460 470 480 490 500
DQDAVMKAIQ EARKMREQIQ REQLQHHQQG MEVKLSALTS MGLNNCRTEK
510 520 530 540 550
ERSHYDNLGH HLSKLGEDGK IGHRVIDLTR PEDFEGGAST TEARVYREPR
560 570 580 590 600
GRNSNEPHIK RPMNAFMVWA KDERRKILQA FPDMHNSNIS KILGSRWKSM
610 620 630 640 650
TNQEKQPYYE EQARLSKIHL EKYPNYKYKP RPKRTCIIDG KKLRISEYKQ
660 670 680 690 700
MMRSRRQEMR QFFTVGQQPQ TQIPITTSAG VVYPGAITMA TTTPSPHMTS
710 720 730 740 750
DCSSASASPE PTIPVIQSTF NMKMEPGTMV PSDAVNGEDE MDMYEDFEDE
760
PKSDYSSEND THEPVSAN
Computationally mapped potential isoform sequencesi
There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A2R8QLT0 | A0A2R8QLT0_DANRE | SRY-box transcription factor 6 | sox6 | 816 | Annotation score: | ||
A0A1D5NSK3 | A0A1D5NSK3_DANRE | SRY-box transcription factor 6 | sox6 | 785 | Annotation score: | ||
A0A2R8RIJ5 | A0A2R8RIJ5_DANRE | SRY-box transcription factor 6 | sox6 | 784 | Annotation score: | ||
A0A1D5NSY8 | A0A1D5NSY8_DANRE | SRY-box transcription factor 6 | sox6 | 121 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BX537340 Genomic DNA No translation available. BX936427 Genomic DNA No translation available. BX936464 Genomic DNA No translation available. EU532205 mRNA Translation: ACB38138.1 |
RefSeqi | NP_001116481.1, NM_001123009.1 |
Genome annotation databases
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BX537340 Genomic DNA No translation available. BX936427 Genomic DNA No translation available. BX936464 Genomic DNA No translation available. EU532205 mRNA Translation: ACB38138.1 |
RefSeqi | NP_001116481.1, NM_001123009.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
STRINGi | 7955.ENSDARP00000124730 |
Genome annotation databases
Organism-specific databases
CTDi | 55553 |
ZFINi | ZDB-GENE-081120-6, sox6 |
Phylogenomic databases
eggNOGi | KOG0528, Eukaryota |
GeneTreei | ENSGT00940000156433 |
HOGENOMi | CLU_018522_0_1_1 |
InParanoidi | F8W2H3 |
OrthoDBi | 465521at2759 |
TreeFami | TF320471 |
Gene expression databases
Bgeei | ENSDARG00000015536, Expressed in embryo and 31 other tissues |
Family and domain databases
Gene3Di | 1.10.30.10, 1 hit |
InterProi | View protein in InterPro IPR009071, HMG_box_dom IPR036910, HMG_box_dom_sf IPR027153, SOX-6 |
PANTHERi | PTHR45789:SF1, PTHR45789:SF1, 2 hits |
Pfami | View protein in Pfam PF00505, HMG_box, 1 hit |
SMARTi | View protein in SMART SM00398, HMG, 1 hit |
SUPFAMi | SSF47095, SSF47095, 1 hit |
PROSITEi | View protein in PROSITE PS50118, HMG_BOX_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | F8W2H3_DANRE | |
Accessioni | F8W2H3Primary (citable) accession number: F8W2H3 Secondary accession number(s): B2CNY6, F6NZ61 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | September 21, 2011 |
Last sequence update: | November 30, 2016 | |
Last modified: | February 10, 2021 | |
This is version 77 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |