SRY (sex determining region Y)-box 6

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• DNA binding Source: UniProtKB-UniRule

GO - Biological processⁱ

• adipose tissue development Source: ZFIN <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • "The transcription factor SOX6 contributes to the developmental origins of obesity by promoting adipogenesis."
    Leow S.C., Poschmann J., Too P.G., Yin J., Joseph R., McFarlane C., Dogra S., Shabbir A., Ingham P.W., Prabhakar S., Leow M.K., Lee Y.S., Ng K.L., Chong Y.S., Gluckman P.D., Stunkel W.
    Development 143:950-961(2016) [PubMed] [Europe PMC] [Abstract]
• cell fate commitment Source: GO_Central <p>Inferred from Biological aspect of Ancestor</p> <p>A type of phylogenetic evidence whereby an aspect of a descendent is inferred through the characterization of an aspect of a ancestral gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#iba">GO evidence code guide</a></p> Inferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief. Bioinformatics 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• muscle cell fate specification Source: ZFINInferred from mutant phenotypeⁱ
  • "The role of Sox6 in zebrafish muscle fiber type specification."
    Jackson H.E., Ono Y., Wang X., Elworthy S., Cunliffe V.T., Ingham P.W.
    Skelet Muscle 5:2-2(2015) [PubMed] [Europe PMC] [Abstract]
• negative regulation of transcription, DNA-templated Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief. Bioinformatics 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• positive regulation of transcription by RNA polymerase II Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief. Bioinformatics 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• skeletal muscle tissue development Source: ZFINInferred from mutant phenotypeⁱ
  • "Nfix Induces a Switch in Sox6 Transcriptional Activity to Regulate MyHC-I Expression in Fetal Muscle."
    Taglietti V., Maroli G., Cermenati S., Monteverde S., Ferrante A., Rossi G., Cossu G., Beltrame M., Messina G.
    Cell Rep 17:2354-2366(2016) [PubMed] [Europe PMC] [Abstract]

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

Keywords - Cellular componentⁱ

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

Protein-protein interaction databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Domains and Repeats

Coiled coil

Keywords - Domainⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)ⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All

        10         20         30         40         50
MSSKQATSPF TSTPDGGEDG VNQERMPWEK EENSESLVAP QLPLHNLLHN 
        60         70         80         90        100
KPPLEELQPI SSSVPPESDW DSLMSAQQRM ESDSNKVCSL YSFRNNSTSP 
       110        120        130        140        150
HKPEEGARER GDLLSSSAFG TPERRKGSLA DVVDTLKQKK LEEMTKTEQD 
       160        170        180        190        200
ESSCMEKLLS KDWKEKMERL NTGELLGEIK GTPESLAEKE RQLSTMITQL 
       210        220        230        240        250
ISLREQLLAA HDEQKKLAAS QMEKQRQQME LARQQQEQIA RQQQQLLQQQ 
       260        270        280        290        300
HKINLLQQQI QVQGHMPPLM IPIFPHDQRT LAAAAAAQQG FLFPPGMSYK 
       310        320        330        340        350
PGDNYPVQFI PSTMAAAAAS GLNPLQLQQL YAAQLASMQV SPGAKMPPLP 
       360        370        380        390        400
QPPNSAGQIS PSGLKNEKRS STPLAQVKEE GTQPLNLSAR PKTAEPIKSP 
       410        420        430        440        450
TSPTQSLFPG SKSSPNSLSK SGDIPSPIGG LGRGSSLDIL SSLNSTALFG 
       460        470        480        490        500
DQDAVMKAIQ EARKMREQIQ REQLQHHQQG MEVKLSALTS MGLNNCRTEK 
       510        520        530        540        550
ERSHYDNLGH HLSKLGEDGK IGHRVIDLTR PEDFEGGAST TEARVYREPR 
       560        570        580        590        600
GRNSNEPHIK RPMNAFMVWA KDERRKILQA FPDMHNSNIS KILGSRWKSM 
       610        620        630        640        650
TNQEKQPYYE EQARLSKIHL EKYPNYKYKP RPKRTCIIDG KKLRISEYKQ 
       660        670        680        690        700
MMRSRRQEMR QFFTVGQQPQ TQIPITTSAG VVYPGAITMA TTTPSPHMTS 
       710        720        730        740        750
DCSSASASPE PTIPVIQSTF NMKMEPGTMV PSDAVNGEDE MDMYEDFEDE 
       760 
PKSDYSSEND THEPVSAN                                    

Sequence databases

Genome annotation databases

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 100% Identity
• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ