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Protein
Submitted name:

Monocarboxylate transporter 2

Gene

SLC16A7

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Submitted name:
Monocarboxylate transporter 2Imported
Gene namesi
Name:SLC16A7Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

EuPathDBiHostDB:ENSG00000118596.11
HGNCiHGNC:10928 SLC16A7

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei18 – 36HelicalSequence analysisAdd BLAST19
Transmembranei58 – 80HelicalSequence analysisAdd BLAST23
Transmembranei87 – 106HelicalSequence analysisAdd BLAST20
Transmembranei112 – 134HelicalSequence analysisAdd BLAST23
Transmembranei146 – 164HelicalSequence analysisAdd BLAST19
Transmembranei176 – 198HelicalSequence analysisAdd BLAST23
Transmembranei247 – 268HelicalSequence analysisAdd BLAST22
Transmembranei280 – 303HelicalSequence analysisAdd BLAST24
Transmembranei315 – 335HelicalSequence analysisAdd BLAST21
Transmembranei341 – 359HelicalSequence analysisAdd BLAST19
Transmembranei405 – 427HelicalSequence analysisAdd BLAST23

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000118596

PTM / Processingi

Proteomic databases

MaxQBiF8W0N3
PeptideAtlasiF8W0N3
PRIDEiF8W0N3

Expressioni

Gene expression databases

BgeeiENSG00000118596 Expressed in 236 organ(s), highest expression level in heart left ventricle
ExpressionAtlasiF8W0N3 baseline and differential

Structurei

3D structure databases

ProteinModelPortaliF8W0N3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini19 – 435MFSInterPro annotationAdd BLAST417

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiENOG410IMVS Eukaryota
ENOG4111F0K LUCA
GeneTreeiENSGT00760000118926

Family and domain databases

CDDicd06174 MFS, 1 hit
InterProiView protein in InterPro
IPR004743 MCT
IPR027178 MCT2
IPR011701 MFS
IPR020846 MFS_dom
IPR036259 MFS_trans_sf
PANTHERiPTHR11360:SF25 PTHR11360:SF25, 1 hit
PfamiView protein in Pfam
PF07690 MFS_1, 1 hit
SUPFAMiSSF103473 SSF103473, 1 hit
TIGRFAMsiTIGR00892 2A0113, 1 hit
PROSITEiView protein in PROSITE
PS50850 MFS, 1 hit

Sequence (1+)i

Sequence statusi: Fragment.

This entry has 1 described isoform and 8 potential isoforms that are computationally mapped.Show allAlign All

F8W0N3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPPMPSAPPV HPPPDGGWGW IVVGAAFISI GFSYAFPKAV TVFFKEIQQI
60 70 80 90 100
FHTTYSEIAW ISSIMLAVMY AGGPVSSVLV NKYGSRPVVI AGGLLCCLGM
110 120 130 140 150
VLASFSSSVV QLYLTMGFIT GLGLAFNLQP ALTIIGKYFY RKRPMANGLA
160 170 180 190 200
MAGSPVFLSS LAPFNQYLFN TFGWKGSFLI LGSLLLNACV AGSLMRPLGP
210 220 230 240 250
NQTTSKSKNK TGKTEDDSSP KKIKTKKSTW EKVNKYLDFS LFKHRGFLIY
260 270 280 290 300
LSGNVIMFLG FFAPIIFLAP YAKDQGIDEY SAAFLLSVMA FVDMFARPSV
310 320 330 340 350
GLIANSKYIR PRIQYFFSFA IMFNGVCHLL CPLAQDYTSL VLYAVFFGLG
360 370 380 390 400
FGSVSSVLFE TLMDLVGAPR FSSAVGLVTI VECGPVLLGP PLAGKLVDLT
410 420 430
GEYKYMYMSC GAIVVAASVW LLIGNAINYR LLAKE
Length:435
Mass (Da):47,291
Last modified:September 21, 2011 - v1
Checksum:i92C79DA6AA36068F
GO

Computationally mapped potential isoform sequencesi

There are 8 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
O60669MOT2_HUMAN
Monocarboxylate transporter 2
SLC16A7 MCT2
478Annotation score:
F8VS95F8VS95_HUMAN
Monocarboxylate transporter 2
SLC16A7
131Annotation score:
F8W0U4F8W0U4_HUMAN
Monocarboxylate transporter 2
SLC16A7
78Annotation score:
F8VQS4F8VQS4_HUMAN
Monocarboxylate transporter 2
SLC16A7
97Annotation score:
F8VXG4F8VXG4_HUMAN
Monocarboxylate transporter 2
SLC16A7
83Annotation score:
F8VYZ2F8VYZ2_HUMAN
Monocarboxylate transporter 2
SLC16A7
84Annotation score:
F8W1M4F8W1M4_HUMAN
Monocarboxylate transporter 2
SLC16A7
141Annotation score:
F8VVU7F8VVU7_HUMAN
Monocarboxylate transporter 2
SLC16A7
84Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei435Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC079905 Genomic DNA No translation available.
AC119793 Genomic DNA No translation available.

Genome annotation databases

EnsembliENST00000548610; ENSP00000446722; ENSG00000118596
UCSCiuc058qfi.1 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC079905 Genomic DNA No translation available.
AC119793 Genomic DNA No translation available.

3D structure databases

ProteinModelPortaliF8W0N3
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

MaxQBiF8W0N3
PeptideAtlasiF8W0N3
PRIDEiF8W0N3

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000548610; ENSP00000446722; ENSG00000118596
UCSCiuc058qfi.1 human

Organism-specific databases

EuPathDBiHostDB:ENSG00000118596.11
HGNCiHGNC:10928 SLC16A7
OpenTargetsiENSG00000118596
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IMVS Eukaryota
ENOG4111F0K LUCA
GeneTreeiENSGT00760000118926

Miscellaneous databases

ChiTaRSiSLC16A7 human

Gene expression databases

BgeeiENSG00000118596 Expressed in 236 organ(s), highest expression level in heart left ventricle
ExpressionAtlasiF8W0N3 baseline and differential

Family and domain databases

CDDicd06174 MFS, 1 hit
InterProiView protein in InterPro
IPR004743 MCT
IPR027178 MCT2
IPR011701 MFS
IPR020846 MFS_dom
IPR036259 MFS_trans_sf
PANTHERiPTHR11360:SF25 PTHR11360:SF25, 1 hit
PfamiView protein in Pfam
PF07690 MFS_1, 1 hit
SUPFAMiSSF103473 SSF103473, 1 hit
TIGRFAMsiTIGR00892 2A0113, 1 hit
PROSITEiView protein in PROSITE
PS50850 MFS, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiF8W0N3_HUMAN
AccessioniPrimary (citable) accession number: F8W0N3
Entry historyiIntegrated into UniProtKB/TrEMBL: September 21, 2011
Last sequence update: September 21, 2011
Last modified: September 12, 2018
This is version 47 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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