UniProtKB - F8W0F6 (F8W0F6_HUMAN)
Protein
Submitted name:
Tubulin alpha-1A chain
Gene
TUBA1A
Organism
Homo sapiens (Human)
Status
Functioni
GO - Molecular functioni
- GTPase activity Source: InterPro
- GTP binding Source: UniProtKB-KW
- structural constituent of cytoskeleton Source: InterPro
GO - Biological processi
- microtubule-based process Source: InterPro
Keywordsi
Ligand | GTP-bindingARBA annotation, Nucleotide-binding |
Names & Taxonomyi
Protein namesi | Submitted name: Tubulin alpha-1A chainImported |
Gene namesi | Name:TUBA1AImported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000167552.13 |
HGNCi | HGNC:20766, TUBA1A |
Subcellular locationi
Cytoskeleton
- cytoskeleton ARBA annotation
Cytoskeleton
- microtubule Source: UniProtKB-KW
- microtubule cytoskeleton Source: HPA
Other locations
- cytoplasm Source: UniProtKB-KW
Keywords - Cellular componenti
Cytoplasm, CytoskeletonARBA annotation, MicrotubuleARBA annotationPTM / Processingi
Proteomic databases
MaxQBi | F8W0F6 |
PeptideAtlasi | F8W0F6 |
PRIDEi | F8W0F6 |
ProteomicsDBi | 29470 |
Expressioni
Gene expression databases
Bgeei | ENSG00000167552, Expressed in endothelial cell and 248 other tissues |
ExpressionAtlasi | F8W0F6, baseline and differential |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 3 – 83 | TubulinInterPro annotationAdd BLAST | 81 |
Sequence similaritiesi
Belongs to the tubulin family.ARBA annotation
Phylogenomic databases
GeneTreei | ENSGT00950000182825 |
HOGENOMi | CLU_1199464_0_0_1 |
Family and domain databases
Gene3Di | 3.40.50.1440, 1 hit |
InterProi | View protein in InterPro IPR002452, Alpha_tubulin IPR000217, Tubulin IPR036525, Tubulin/FtsZ_GTPase_sf IPR003008, Tubulin_FtsZ_GTPase |
PANTHERi | PTHR11588, PTHR11588, 1 hit |
Pfami | View protein in Pfam PF00091, Tubulin, 1 hit |
PRINTSi | PR01162, ALPHATUBULIN PR01161, TUBULIN |
SUPFAMi | SSF52490, SSF52490, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All
F8W0F6-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MRECISIHVG QAGVQIGNAC WELYCLEHGI QPDGQMPSDK TIGGGDDSFN
60 70 80 90 100
TFFSETGAGK HVPRAVFVDL EPTVIGELTS VTQVRSQGAG TGGLSWGAPL
110 120 130 140 150
VTHPLSLPAP RPSSSSPLLL PHHVLQMKFA LAPTASSSTL SNLSQAKKML
160 170 180 190 200
PITMPEGTTP LARRSLTSCW TEFASWPTSA RVSRASWFST ALVGELVLGS
210 220 230
PRCSWNVSQL IMARSPSWSS LFTRRPRFPQ L
Computationally mapped potential isoform sequencesi
There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketQ71U36 | TBA1A_HUMAN | Tubulin alpha-1A chain | TUBA1A TUBA3 | 451 | Annotation score: | ||
F8VQQ4 | F8VQQ4_HUMAN | Tubulin alpha chain | TUBA1A | 219 | Annotation score: | ||
F8VRZ4 | F8VRZ4_HUMAN | Tubulin alpha-1A chain | TUBA1A | 112 | Annotation score: | ||
F8VXZ7 | F8VXZ7_HUMAN | Tubulin alpha-1A chain | TUBA1A | 26 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC010173 Genomic DNA No translation available. |
Genome annotation databases
Ensembli | ENST00000546918; ENSP00000446613; ENSG00000167552 |
UCSCi | uc058nok.1, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC010173 Genomic DNA No translation available. |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Proteomic databases
MaxQBi | F8W0F6 |
PeptideAtlasi | F8W0F6 |
PRIDEi | F8W0F6 |
ProteomicsDBi | 29470 |
Protocols and materials databases
Antibodypediai | 3282, 640 antibodies |
Genome annotation databases
Ensembli | ENST00000546918; ENSP00000446613; ENSG00000167552 |
UCSCi | uc058nok.1, human |
Organism-specific databases
EuPathDBi | HostDB:ENSG00000167552.13 |
HGNCi | HGNC:20766, TUBA1A |
OpenTargetsi | ENSG00000167552 |
GenAtlasi | Search... |
Phylogenomic databases
GeneTreei | ENSGT00950000182825 |
HOGENOMi | CLU_1199464_0_0_1 |
Miscellaneous databases
ChiTaRSi | TUBA1A, human |
Gene expression databases
Bgeei | ENSG00000167552, Expressed in endothelial cell and 248 other tissues |
ExpressionAtlasi | F8W0F6, baseline and differential |
Family and domain databases
Gene3Di | 3.40.50.1440, 1 hit |
InterProi | View protein in InterPro IPR002452, Alpha_tubulin IPR000217, Tubulin IPR036525, Tubulin/FtsZ_GTPase_sf IPR003008, Tubulin_FtsZ_GTPase |
PANTHERi | PTHR11588, PTHR11588, 1 hit |
Pfami | View protein in Pfam PF00091, Tubulin, 1 hit |
PRINTSi | PR01162, ALPHATUBULIN PR01161, TUBULIN |
SUPFAMi | SSF52490, SSF52490, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | F8W0F6_HUMAN | |
Accessioni | F8W0F6Primary (citable) accession number: F8W0F6 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | September 21, 2011 |
Last sequence update: | September 21, 2011 | |
Last modified: | October 7, 2020 | |
This is version 61 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |