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Protein
Submitted name:

Cyclin-dependent kinase 4

Gene

CDK4

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

Keywordsi

Molecular functionKinase, Serine/threonine-protein kinaseUniRule annotation, Transferase
LigandATP-bindingUniRule annotation, Nucleotide-binding

Enzyme and pathway databases

SignaLinkiF8VYH9

Names & Taxonomyi

Protein namesi
Submitted name:
Cyclin-dependent kinase 4Imported
Gene namesi
Name:CDK4Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

EuPathDBiHostDB:ENSG00000135446.16
HGNCiHGNC:1773 CDK4

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000135446

PTM / Processingi

Proteomic databases

MaxQBiF8VYH9
PeptideAtlasiF8VYH9
PRIDEiF8VYH9

Expressioni

Gene expression databases

BgeeiENSG00000135446 Expressed in 225 organ(s), highest expression level in right ovary
ExpressionAtlasiF8VYH9 baseline and differential

Structurei

3D structure databases

ProteinModelPortaliF8VYH9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini6 – 170Protein kinaseInterPro annotationAdd BLAST165

Sequence similaritiesi

Belongs to the protein kinase superfamily.UniRule annotation

Phylogenomic databases

eggNOGiKOG0594 Eukaryota
ENOG410XPP3 LUCA
GeneTreeiENSGT00910000144030

Family and domain databases

InterProiView protein in InterPro
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR008271 Ser/Thr_kinase_AS
PfamiView protein in Pfam
PF00069 Pkinase, 1 hit
SMARTiView protein in SMART
SM00220 S_TKc, 1 hit
SUPFAMiSSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit

Sequence (1+)i

Sequence statusi: Fragment.

This entry has 1 described isoform and 10 potential isoforms that are computationally mapped.Show allAlign All

F8VYH9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MATSRYEPVA EIGVGAYGTV YKARDPHSGH FVALKSVRVP NGGGGGGGLP
60 70 80 90 100
ISTVREVALL RRLEAFEHPN VVRLMDVCAT SRTDREIKVT LVFEHVDQDL
110 120 130 140 150
RTYLDKAPPP GLPAETIKDL MRQFLRGLDF LHANCIVHRD LKPENILVTS
160 170
GGTVKLADFG LARIYSYQMA
Length:170
Mass (Da):18,686
Last modified:September 21, 2011 - v1
Checksum:i7FB6926885737AE8
GO

Computationally mapped potential isoform sequencesi

There are 10 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
P11802CDK4_HUMAN
Cyclin-dependent kinase 4
CDK4
303Annotation score:
F8VTV8F8VTV8_HUMAN
Cyclin-dependent kinase 4
CDK4
201Annotation score:
F8VWX7F8VWX7_HUMAN
Cyclin-dependent kinase 4
CDK4
203Annotation score:
F8VZ51F8VZ51_HUMAN
Cyclin-dependent kinase 4
CDK4
208Annotation score:
F8VZZ0F8VZZ0_HUMAN
Cyclin-dependent kinase 4
CDK4
186Annotation score:
F8VXD2F8VXD2_HUMAN
Cyclin-dependent kinase 4
CDK4
132Annotation score:
F8W1L8F8W1L8_HUMAN
Cyclin-dependent kinase 4
CDK4
115Annotation score:
F8VYY1F8VYY1_HUMAN
Cyclin-dependent kinase 4
CDK4
74Annotation score:
Q96BE9Q96BE9_HUMAN
CDK4 protein
CDK4 hCG_40151
111Annotation score:
F8VZ13F8VZ13_HUMAN
Cyclin-dependent kinase 4
CDK4
40Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei170Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC025165 Genomic DNA No translation available.

Genome annotation databases

EnsembliENST00000552388; ENSP00000448963; ENSG00000135446
UCSCiuc058qch.1 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC025165 Genomic DNA No translation available.

3D structure databases

ProteinModelPortaliF8VYH9
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

MaxQBiF8VYH9
PeptideAtlasiF8VYH9
PRIDEiF8VYH9

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000552388; ENSP00000448963; ENSG00000135446
UCSCiuc058qch.1 human

Organism-specific databases

EuPathDBiHostDB:ENSG00000135446.16
HGNCiHGNC:1773 CDK4
OpenTargetsiENSG00000135446
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0594 Eukaryota
ENOG410XPP3 LUCA
GeneTreeiENSGT00910000144030

Enzyme and pathway databases

SignaLinkiF8VYH9

Miscellaneous databases

ChiTaRSiCDK4 human

Gene expression databases

BgeeiENSG00000135446 Expressed in 225 organ(s), highest expression level in right ovary
ExpressionAtlasiF8VYH9 baseline and differential

Family and domain databases

InterProiView protein in InterPro
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR008271 Ser/Thr_kinase_AS
PfamiView protein in Pfam
PF00069 Pkinase, 1 hit
SMARTiView protein in SMART
SM00220 S_TKc, 1 hit
SUPFAMiSSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiF8VYH9_HUMAN
AccessioniPrimary (citable) accession number: F8VYH9
Entry historyiIntegrated into UniProtKB/TrEMBL: September 21, 2011
Last sequence update: September 21, 2011
Last modified: September 12, 2018
This is version 54 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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