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Protein
Submitted name:

ARF GTPase-activating protein GIT2

Gene

GIT2

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

Keywordsi

LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Submitted name:
ARF GTPase-activating protein GIT2Imported
Gene namesi
Name:GIT2Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

EuPathDBiHostDB:ENSG00000139436.20
HGNCiHGNC:4273 GIT2

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000139436

PTM / Processingi

Proteomic databases

EPDiF8VXI9
MaxQBiF8VXI9
PeptideAtlasiF8VXI9
PRIDEiF8VXI9

Expressioni

Gene expression databases

BgeeiENSG00000139436
ExpressionAtlasiF8VXI9 baseline and differential

Structurei

3D structure databases

ProteinModelPortaliF8VXI9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 124Arf-GAPInterPro annotationAdd BLAST124
Domaini132 – 221ANK_REP_REGIONInterPro annotationAdd BLAST90
Repeati166 – 198ANKPROSITE-ProRule annotationAdd BLAST33

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili407 – 427Sequence analysisAdd BLAST21
Coiled coili593 – 613Sequence analysisAdd BLAST21

Keywords - Domaini

ANK repeatPROSITE-ProRule annotation, Coiled coilSequence analysis, Zinc-fingerPROSITE-ProRule annotation

Phylogenomic databases

GeneTreeiENSGT00920000149085

Family and domain databases

CDDicd00204 ANK, 1 hit
Gene3Di1.25.40.20, 1 hit
3.30.40.160, 1 hit
InterProiView protein in InterPro
IPR002110 Ankyrin_rpt
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf
IPR037278 ARFGAP/RecO
IPR001164 ArfGAP_dom
IPR038508 ArfGAP_dom_sf
IPR022018 GIT1_C
IPR013724 GIT_SHD
PfamiView protein in Pfam
PF12796 Ank_2, 1 hit
PF01412 ArfGap, 1 hit
PF12205 GIT1_C, 1 hit
PF08518 GIT_SHD, 2 hits
PRINTSiPR00405 REVINTRACTNG
SMARTiView protein in SMART
SM00248 ANK, 3 hits
SM00105 ArfGap, 1 hit
SM00555 GIT, 2 hits
SUPFAMiSSF48403 SSF48403, 1 hit
SSF57863 SSF57863, 1 hit
PROSITEiView protein in PROSITE
PS50297 ANK_REP_REGION, 1 hit
PS50088 ANK_REPEAT, 1 hit
PS50115 ARFGAP, 1 hit

Sequencei

Sequence statusi: Complete.

F8VXI9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSKRLRSSEV CADCSGPDPS WASVNRGTFL CDECCSVHRS LGRHISQVRH
60 70 80 90 100
LKHTPWPPTL LQMVETLYNN GANSIWEHSL LDPASIMSGR RKANPQDKVH
110 120 130 140 150
PNKAEFIRAK YQMLAFVHRL PCRDDDSVTA KDLSKQLHSS VRTGNLETCL
160 170 180 190 200
RLLSLGAQAN FFHPEKGNTP LHVASKAGQI LQAELLAVYG ADPGTQDSSG
210 220 230 240 250
KTPVDYARQG GHHELAERLV EIQYELTDRL AFYLCGRKPD HKNGQHFIIP
260 270 280 290 300
QMADSLDLSE LAKAAKKKLQ SLSNHLFEEL AMDVYDEVDR RETDAVWLAT
310 320 330 340 350
QNHSALVTET TVVPFLPVNP EYSSTRNQGR QKLARFNAHE FATLVIDILS
360 370 380 390 400
DAKRRQQGSS LSGSKDNVEL ILKTINNQHS VESQDNDQPD YDSVASDEDT
410 420 430 440 450
DLETTASKTN RQKLQTLQSE NSNLRKQATT NVYQVQTGSE YTDTSNHSSL
460 470 480 490 500
KRRPSARGSR PMSMYETGSG QKPYLPMGEA SRPEESRMRL QPFPAHIGRS
510 520 530 540 550
ALVTSSSSLP SFPSTLSWSR DESARRASRL EKQNSTPESD YDNTPNDMEP
560 570 580 590 600
DGMGSSRKGR QRSMVWPGDG LVPDTAEPHV APSPTLPSTE DVIRKTEQIT
610 620 630 640 650
KNIQELLRAA QENKHDSYIP CSERIHVAVT EMAALFPKKP KSDMVRTSLR
660 670 680 690 700
LLTSSAYRLQ SECKKTLPGD PGSPTDVQLV TQQVIQCAYD IAKAAKQLVT

ITTKENNN
Length:708
Mass (Da):78,867
Last modified:September 21, 2011 - v1
Checksum:i63033BE7A6F68756
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC084876 Genomic DNA No translation available.
RefSeqiNP_001317082.1, NM_001330153.1
UniGeneiHs.434996

Genome annotation databases

EnsembliENST00000551209; ENSP00000448832; ENSG00000139436
GeneIDi9815
UCSCiuc058tax.1 human

Similar proteinsi

Entry informationi

Entry nameiF8VXI9_HUMAN
AccessioniPrimary (citable) accession number: F8VXI9
Entry historyiIntegrated into UniProtKB/TrEMBL: September 21, 2011
Last sequence update: September 21, 2011
Last modified: June 20, 2018
This is version 66 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

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