UniProtKB - F8VXC8 (F8VXC8_HUMAN)
Protein
Submitted name:
SWI/SNF complex subunit SMARCC2
Gene
SMARCC2
Organism
Homo sapiens (Human)
Status
Functioni
GO - Molecular functioni
- chromatin binding Source: Ensembl
GO - Biological processi
- negative regulation of transcription by RNA polymerase II Source: Ensembl
Names & Taxonomyi
Protein namesi | Submitted name: SWI/SNF complex subunit SMARCC2Imported |
Gene namesi | Name:SMARCC2Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:11105, SMARCC2 |
VEuPathDBi | HostDB:ENSG00000139613.11 |
Subcellular locationi
Nucleus
- nBAF complex Source: Ensembl
- npBAF complex Source: Ensembl
- nucleoplasm Source: HPA
- SWI/SNF complex Source: Ensembl
PTM / Processingi
Proteomic databases
EPDi | F8VXC8 |
MaxQBi | F8VXC8 |
PeptideAtlasi | F8VXC8 |
PRIDEi | F8VXC8 |
ProteomicsDBi | 29095 |
Expressioni
Gene expression databases
Bgeei | ENSG00000139613, Expressed in left lobe of thyroid gland and 246 other tissues |
ExpressionAtlasi | F8VXC8, baseline and differential |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 424 – 521 | SWIRMInterPro annotationAdd BLAST | 98 | |
Domaini | 627 – 678 | SANTInterPro annotationAdd BLAST | 52 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 257 – 413 | DisorderedSequence analysisAdd BLAST | 157 | |
Regioni | 543 – 569 | DisorderedSequence analysisAdd BLAST | 27 | |
Regioni | 755 – 883 | DisorderedSequence analysisAdd BLAST | 129 | |
Regioni | 978 – 1014 | DisorderedSequence analysisAdd BLAST | 37 | |
Regioni | 1028 – 1123 | DisorderedSequence analysisAdd BLAST | 96 | |
Regioni | 1213 – 1245 | DisorderedSequence analysisAdd BLAST | 33 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 258 – 292 | PolyampholyteSequence analysisAdd BLAST | 35 | |
Compositional biasi | 303 – 317 | PolyampholyteSequence analysisAdd BLAST | 15 | |
Compositional biasi | 326 – 348 | PolyampholyteSequence analysisAdd BLAST | 23 | |
Compositional biasi | 393 – 413 | PolyampholyteSequence analysisAdd BLAST | 21 | |
Compositional biasi | 777 – 883 | PolyampholyteSequence analysisAdd BLAST | 107 | |
Compositional biasi | 991 – 1009 | Pro-richSequence analysisAdd BLAST | 19 | |
Compositional biasi | 1042 – 1061 | PolarSequence analysisAdd BLAST | 20 | |
Compositional biasi | 1062 – 1090 | Pro-richSequence analysisAdd BLAST | 29 | |
Compositional biasi | 1218 – 1245 | Pro-richSequence analysisAdd BLAST | 28 |
Phylogenomic databases
GeneTreei | ENSGT00940000155746 |
OMAi | AGAMANF |
OrthoDBi | 683891at2759 |
Family and domain databases
Gene3Di | 1.10.10.10, 1 hit |
InterProi | View protein in InterPro IPR036420, BRCT_dom_sf IPR000953, Chromo/chromo_shadow_dom IPR009057, Homeobox-like_sf IPR001005, SANT/Myb IPR017884, SANT_dom IPR038044, SMARCC2 IPR032451, SMARCC_C IPR032450, SMARCC_N IPR007526, SWIRM IPR032448, SWIRM-assoc IPR036388, WH-like_DNA-bd_sf |
PANTHERi | PTHR12802:SF105, PTHR12802:SF105, 1 hit |
Pfami | View protein in Pfam PF00249, Myb_DNA-binding, 1 hit PF04433, SWIRM, 1 hit PF16495, SWIRM-assoc_1, 1 hit PF16496, SWIRM-assoc_2, 1 hit PF16498, SWIRM-assoc_3, 1 hit |
SMARTi | View protein in SMART SM00298, CHROMO, 1 hit SM00717, SANT, 1 hit |
SUPFAMi | SSF46689, SSF46689, 2 hits SSF52113, SSF52113, 1 hit |
PROSITEi | View protein in PROSITE PS51293, SANT, 1 hit PS50934, SWIRM, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All
F8VXC8-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAVRKKDGGP NVKYYEAADT VTQFDNVRLW LGKNYKKYIQ AEPPTNKSLS
60 70 80 90 100
SLVVQLLQFQ EEVFGKHVSN APLTKLPIKC FLDFKAGGSL CHILAAAYKF
110 120 130 140 150
KSDQGWRRYD FQNPSRMDRN VEMFMTIEKS LVQNNCLSRP NIFLCPEIEP
160 170 180 190 200
KLLGKLKDII KRHQGTVTED KNNASHVVYP VPGNLEEEEW VRPVMKRDKQ
210 220 230 240 250
VLLHWGYYPD SYDTWIPASE IEASVEDAPT PEKPRKVHAK WILDTDTFNE
260 270 280 290 300
WMNEEDYEVN DDKNPVSRRK KISAKTLTDE VNSPDSDRRD KKGGNYKKRK
310 320 330 340 350
RSPSPSPTPE AKKKNAKKGP STPYTKSKRG HREEEQEDLT KDMDEPSPVP
360 370 380 390 400
NVEEVTLPKT VNTKKDSESA PVKGGTMTDL DEQEDESMET TGKDEDENST
410 420 430 440 450
GNKGEQTKNP DLHEDNVTEQ THHIIIPSYA AWFDYNSVHA IERRALPEFF
460 470 480 490 500
NGKNKSKTPE IYLAYRNFMI DTYRLNPQEY LTSTACRRNL AGDVCAIMRV
510 520 530 540 550
HAFLEQWGLI NYQVDAESRP TPMGPPPTSH FHVLADTPSG LVPLQPKTPQ
560 570 580 590 600
GRQVDADTKA GRKGKELDDL VPETAKGKPE LQTSASQQML NFPDKGKEKP
610 620 630 640 650
TDMQNFGLRT DMYTKKNVPS KSKAAASATR EWTEQETLLL LEALEMYKDD
660 670 680 690 700
WNKVSEHVGS RTQDECILHF LRLPIEDPYL EDSEASLGPL AYQPIPFSQS
710 720 730 740 750
GNPVMSTVAF LASVVDPRVA SAAAKSALEE FSKMKEEVPT ALVEAHVRKV
760 770 780 790 800
EEAAKVTGKA DPAFGLESSG IAGTTSDEPE RIEESGNDEA RVEGQATDEK
810 820 830 840 850
KEPKEPREGG GAIEEEAKEK TSEAPKKDEE KGKEGDSEKE SEKSDGDPIV
860 870 880 890 900
DPEKEKEPKE GQEEVLKEVV ESEGERKTKV ERDIGEGNLS TAAAAALAAA
910 920 930 940 950
AVKAKHLAAV EERKIKSLVA LLVETQMKKL EIKLRHFEEL ETIMDREREA
960 970 980 990 1000
LEYQRQQLLA DRQAFHMEQL KYAEMRARQQ HFQQMHQQQQ QPPPALPPGS
1010 1020 1030 1040 1050
QPIPPTGAAG PPAVHGLAVA PASVVPAPAG SGAPPGSLGP SEQIGQAGST
1060 1070 1080 1090 1100
AGPQQQQPAG APQPGAVPPG VPPPGPHGPS PFPNQQTPPS MMPGAVPGSG
1110 1120 1130 1140 1150
HPGVAGNAPL GLPFGMPPPP PPPAPSIIPF GSLADSISIN LPAPPNLHGH
1160 1170 1180 1190 1200
HHHLPFAPGT LPPPNLPVSM ANPLHPNLPA TTTMPSSLPL GPGLGSAAAQ
1210 1220 1230 1240
SPAIVAAVQG NLLPSASPLP DPGTPLPPDP TAPSPGTVTP VPPPQ
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketQ8TAQ2 | SMRC2_HUMAN | SWI/SNF complex subunit SMARCC2 | SMARCC2 BAF170 | 1,214 | Annotation score: | ||
F8VZW6 | F8VZW6_HUMAN | SWI/SNF complex subunit SMARCC2 | SMARCC2 | 105 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC073896 Genomic DNA No translation available. |
RefSeqi | NP_001317217.1, NM_001330288.1 |
Genome annotation databases
Ensembli | ENST00000550164; ENSP00000449396; ENSG00000139613 |
GeneIDi | 6601 |
UCSCi | uc058pjl.1, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC073896 Genomic DNA No translation available. |
RefSeqi | NP_001317217.1, NM_001330288.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Proteomic databases
EPDi | F8VXC8 |
MaxQBi | F8VXC8 |
PeptideAtlasi | F8VXC8 |
PRIDEi | F8VXC8 |
ProteomicsDBi | 29095 |
Protocols and materials databases
Antibodypediai | 3811, 225 antibodies |
DNASUi | 6601 |
Genome annotation databases
Ensembli | ENST00000550164; ENSP00000449396; ENSG00000139613 |
GeneIDi | 6601 |
UCSCi | uc058pjl.1, human |
Organism-specific databases
CTDi | 6601 |
HGNCi | HGNC:11105, SMARCC2 |
OpenTargetsi | ENSG00000139613 |
VEuPathDBi | HostDB:ENSG00000139613.11 |
GenAtlasi | Search... |
Phylogenomic databases
GeneTreei | ENSGT00940000155746 |
OMAi | AGAMANF |
OrthoDBi | 683891at2759 |
Miscellaneous databases
BioGRID-ORCSi | 6601, 28 hits in 1000 CRISPR screens |
ChiTaRSi | SMARCC2, human |
GenomeRNAii | 6601 |
Gene expression databases
Bgeei | ENSG00000139613, Expressed in left lobe of thyroid gland and 246 other tissues |
ExpressionAtlasi | F8VXC8, baseline and differential |
Family and domain databases
Gene3Di | 1.10.10.10, 1 hit |
InterProi | View protein in InterPro IPR036420, BRCT_dom_sf IPR000953, Chromo/chromo_shadow_dom IPR009057, Homeobox-like_sf IPR001005, SANT/Myb IPR017884, SANT_dom IPR038044, SMARCC2 IPR032451, SMARCC_C IPR032450, SMARCC_N IPR007526, SWIRM IPR032448, SWIRM-assoc IPR036388, WH-like_DNA-bd_sf |
PANTHERi | PTHR12802:SF105, PTHR12802:SF105, 1 hit |
Pfami | View protein in Pfam PF00249, Myb_DNA-binding, 1 hit PF04433, SWIRM, 1 hit PF16495, SWIRM-assoc_1, 1 hit PF16496, SWIRM-assoc_2, 1 hit PF16498, SWIRM-assoc_3, 1 hit |
SMARTi | View protein in SMART SM00298, CHROMO, 1 hit SM00717, SANT, 1 hit |
SUPFAMi | SSF46689, SSF46689, 2 hits SSF52113, SSF52113, 1 hit |
PROSITEi | View protein in PROSITE PS51293, SANT, 1 hit PS50934, SWIRM, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | F8VXC8_HUMAN | |
Accessioni | F8VXC8Primary (citable) accession number: F8VXC8 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | September 21, 2011 |
Last sequence update: | September 21, 2011 | |
Last modified: | April 7, 2021 | |
This is version 82 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |