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Protein
Submitted name:

Dystrophin

Gene

DMD

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

Keywordsi

LigandMetal-binding, Zinc

Enzyme and pathway databases

SignaLinkiF8VX32

Names & Taxonomyi

Protein namesi
Submitted name:
DystrophinImported
Gene namesi
Name:DMDImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

EuPathDBiHostDB:ENSG00000198947.15
HGNCiHGNC:2928 DMD

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000198947

PTM / Processingi

Proteomic databases

MaxQBiF8VX32
PeptideAtlasiF8VX32
PRIDEiF8VX32

Expressioni

Gene expression databases

BgeeiENSG00000198947
ExpressionAtlasiF8VX32 baseline and differential

Interactioni

GO - Molecular functioni

Structurei

3D structure databases

ProteinModelPortaliF8VX32
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini595 – 628WWInterPro annotationAdd BLAST34
Domaini847 – 894ZZ-typeInterPro annotationAdd BLAST48

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili43 – 87Sequence analysisAdd BLAST45
Coiled coili94 – 114Sequence analysisAdd BLAST21
Coiled coili129 – 149Sequence analysisAdd BLAST21
Coiled coili462 – 496Sequence analysisAdd BLAST35
Coiled coili1023 – 1057Sequence analysisAdd BLAST35
Coiled coili1096 – 1130Sequence analysisAdd BLAST35

Keywords - Domaini

Coiled coilSequence analysis, RepeatSAAS annotation, Zinc-fingerPROSITE-ProRule annotationSAAS annotation

Phylogenomic databases

eggNOGiKOG4286 Eukaryota
COG5069 LUCA
GeneTreeiENSGT00760000119237

Family and domain databases

CDDicd00201 WW, 1 hit
InterProiView protein in InterPro
IPR016344 Dystrophin
IPR011992 EF-hand-dom_pair
IPR015153 EF-hand_dom_typ1
IPR015154 EF-hand_dom_typ2
IPR018159 Spectrin/alpha-actinin
IPR002017 Spectrin_repeat
IPR001202 WW_dom
IPR036020 WW_dom_sf
IPR000433 Znf_ZZ
PANTHERiPTHR44318:SF1 PTHR44318:SF1, 1 hit
PfamiView protein in Pfam
PF09068 EF-hand_2, 1 hit
PF09069 EF-hand_3, 1 hit
PF00435 Spectrin, 4 hits
PF00397 WW, 1 hit
PF00569 ZZ, 1 hit
SMARTiView protein in SMART
SM00150 SPEC, 5 hits
SM00456 WW, 1 hit
SM00291 ZnF_ZZ, 1 hit
SUPFAMiSSF47473 SSF47473, 2 hits
SSF51045 SSF51045, 1 hit
PROSITEiView protein in PROSITE
PS01159 WW_DOMAIN_1, 1 hit
PS50020 WW_DOMAIN_2, 1 hit
PS01357 ZF_ZZ_1, 1 hit
PS50135 ZF_ZZ_2, 1 hit

Sequencei

Sequence statusi: Complete.

F8VX32-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPSSLMLEVP ALADFNRAWT ELTDWLSLLD QVIKSQRVMV GDLEDINEMI
60 70 80 90 100
IKQKATMQDL EQRRPQLEEL ITAAQNLKNK TSNQEARTII TDRIERIQNQ
110 120 130 140 150
WDEVQEHLQN RRQQLNEMLK DSTQWLEAKE EAEQVLGQAR AKLESWKEGP
160 170 180 190 200
YTVDAIQKKI TETKQLAKDL RQWQTNVDVA NDLALKLLRD YSADDTRKVH
210 220 230 240 250
MITENINASW RSIHKRVSER EAALEETHRL LQQFPLDLEK FLAWLTEAET
260 270 280 290 300
TANVLQDATR KERLLEDSKG VKELMKQWQD LQGEIEAHTD VYHNLDENSQ
310 320 330 340 350
KILRSLEGSD DAVLLQRRLD NMNFKWSELR KKSLNIRSHL EASSDQWKRL
360 370 380 390 400
HLSLQELLVW LQLKDDELSR QAPIGGDFPA VQKQNDVHRA FKRELKTKEP
410 420 430 440 450
VIMSTLETVR IFLTEQPLEG LEKLYQEPRE LPPEERAQNV TRLLRKQAEE
460 470 480 490 500
VNTEWEKLNL HSADWQRKID ETLERLRELQ EATDELDLKL RQAEVIKGSW
510 520 530 540 550
QPVGDLLIDS LQDHLEKVKA LRGEIAPLKE NVSHVNDLAR QLTTLGIQLS
560 570 580 590 600
PYNLSTLEDL NTRWKLLQVA VEDRVRQLHE AHRDFGPASQ HFLSTSVQGP
610 620 630 640 650
WERAISPNKV PYYINHETQT TCWDHPKMTE LYQSLADLNN VRFSAYRTAM
660 670 680 690 700
KLRRLQKALC LDLLSLSAAC DALDQHNLKQ NDQPMDILQI INCLTTIYDR
710 720 730 740 750
LEQEHNNLVN VPLCVDMCLN WLLNVYDTGR TGRIRVLSFK TGIISLCKAH
760 770 780 790 800
LEDKYRYLFK QVASSTGFCD QRRLGLLLHD SIQIPRQLGE VASFGGSNIE
810 820 830 840 850
PSVRSCFQFA NNKPEIEAAL FLDWMRLEPQ SMVWLPVLHR VAAAETAKHQ
860 870 880 890 900
AKCNICKECP IIGFRYRSLK HFNYDICQSC FFSGRVAKGH KMHYPMVEYC
910 920 930 940 950
TPTTSGEDVR DFAKVLKNKF RTKRYFAKHP RMGYLPVQTV LEGDNMETPA
960 970 980 990 1000
SSPQLSHDDT HSRIEHYASR LAEMENSNGS YLNDSISPNE SIDDEHLLIQ
1010 1020 1030 1040 1050
HYCQSLNQDS PLSQPRSPAQ ILISLESEER GELERILADL EEENRNLQAE
1060 1070 1080 1090 1100
YDRLKQQHEH KGLSPLPSPP EMMPTSPQSP RDAELIAEAK LLRQHKGRLE
1110 1120 1130 1140 1150
ARMQILEDHN KQLESQLHRL RQLLEQPQAE AKVNGTTVSS PSTSLQRSDS
1160 1170 1180 1190 1200
SQPMLLRVVG SQTSDSMGEE DLLSPPQDTS TGLEEVMEQL NNSFPSSRGH
1210 1220 1230
NVGSLFHMAD DLGRAMESLV SVMTDEEGAE
Length:1,230
Mass (Da):141,774
Last modified:September 21, 2011 - v1
Checksum:i138942655CC11CA6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC006061 Genomic DNA No translation available.
AC078957 Genomic DNA No translation available.
AC078958 Genomic DNA No translation available.
AC079143 Genomic DNA No translation available.
AC079175 Genomic DNA No translation available.
AC079177 Genomic DNA No translation available.
AC079864 Genomic DNA No translation available.
AC090632 Genomic DNA No translation available.
AC093167 Genomic DNA No translation available.
AC093193 Genomic DNA No translation available.

Genome annotation databases

EnsembliENST00000359836; ENSP00000352894; ENSG00000198947
UCSCiuc004dcv.1 human

Similar proteinsi

Entry informationi

Entry nameiF8VX32_HUMAN
AccessioniPrimary (citable) accession number: F8VX32
Entry historyiIntegrated into UniProtKB/TrEMBL: September 21, 2011
Last sequence update: September 21, 2011
Last modified: June 20, 2018
This is version 57 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

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