UniProtKB - F8VVT9 (F8VVT9_HUMAN)
Protein
Submitted name:
Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2
Gene
AGAP2
Organism
Homo sapiens (Human)
Status
Functioni
GO - Molecular functioni
- GTPase activator activity Source: UniProtKB-KW
- GTPase activity Source: InterPro
- GTP binding Source: InterPro
- metal ion binding Source: UniProtKB-KW
- protein kinase activator activity Source: Ensembl
- protein kinase binding Source: Ensembl
GO - Biological processi
- mammary gland alveolus development Source: Ensembl
- negative regulation of extrinsic apoptotic signaling pathway in absence of ligand Source: Ensembl
- negative regulation of neuron apoptotic process Source: Ensembl
- positive regulation of mammary gland epithelial cell proliferation Source: Ensembl
- positive regulation of phosphatidylinositol 3-kinase signaling Source: Ensembl
- positive regulation of receptor signaling pathway via JAK-STAT Source: Ensembl
- positive regulation of transcription by RNA polymerase II Source: Ensembl
Keywordsi
Molecular function | GTPase activationARBA annotation |
Ligand | Metal-binding, Zinc |
Names & Taxonomyi
Protein namesi | Submitted name: Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2Imported |
Gene namesi | Name:AGAP2Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:16921, AGAP2 |
VEuPathDBi | HostDB:ENSG00000135439.11 |
Subcellular locationi
Cytosol
- cytosol Source: HPA
Nucleus
- nucleoplasm Source: HPA
Other locations
- Flemming body Source: HPA
PTM / Processingi
Proteomic databases
MaxQBi | F8VVT9 |
PeptideAtlasi | F8VVT9 |
PRIDEi | F8VVT9 |
ProteomicsDBi | 28883 |
Expressioni
Gene expression databases
Bgeei | ENSG00000135439, Expressed in right hemisphere of cerebellum and 195 other tissues |
ExpressionAtlasi | F8VVT9, baseline and differential |
Genevisiblei | F8VVT9, HS |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 676 – 910 | PHInterPro annotationAdd BLAST | 235 | |
Domaini | 931 – 1051 | Arf-GAPInterPro annotationAdd BLAST | 121 | |
Domaini | 1090 – 1147 | ANK_REP_REGIONInterPro annotationAdd BLAST | 58 | |
Repeati | 1090 – 1122 | ANKPROSITE-ProRule annotationAdd BLAST | 33 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 25 – 377 | DisorderedSequence analysisAdd BLAST | 353 | |
Regioni | 582 – 619 | DisorderedSequence analysisAdd BLAST | 38 | |
Regioni | 634 – 673 | DisorderedSequence analysisAdd BLAST | 40 | |
Regioni | 769 – 854 | DisorderedSequence analysisAdd BLAST | 86 | |
Regioni | 1153 – 1192 | DisorderedSequence analysisAdd BLAST | 40 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 57 – 73 | PolyampholyteSequence analysisAdd BLAST | 17 | |
Compositional biasi | 284 – 299 | Pro-richSequence analysisAdd BLAST | 16 | |
Compositional biasi | 582 – 617 | PolarSequence analysisAdd BLAST | 36 | |
Compositional biasi | 650 – 667 | PolyampholyteSequence analysisAdd BLAST | 18 | |
Compositional biasi | 1156 – 1177 | PolarSequence analysisAdd BLAST | 22 |
Sequence similaritiesi
Belongs to the centaurin gamma-like family.ARBA annotation
Keywords - Domaini
ANK repeatPROSITE-ProRule annotationARBA annotation, RepeatARBA annotation, Zinc-fingerPROSITE-ProRule annotationARBA annotationPhylogenomic databases
GeneTreei | ENSGT00940000158956 |
OMAi | PAKRKMW |
OrthoDBi | 751525at2759 |
PhylomeDBi | F8VVT9 |
TreeFami | TF317762 |
Family and domain databases
Gene3Di | 1.25.40.20, 1 hit 2.30.29.30, 2 hits 3.30.40.160, 1 hit |
InterProi | View protein in InterPro IPR002110, Ankyrin_rpt IPR020683, Ankyrin_rpt-contain_dom IPR036770, Ankyrin_rpt-contain_sf IPR037278, ARFGAP/RecO IPR001164, ArfGAP_dom IPR038508, ArfGAP_dom_sf IPR027417, P-loop_NTPase IPR011993, PH-like_dom_sf IPR001849, PH_domain IPR001806, Small_GTPase |
Pfami | View protein in Pfam PF12796, Ank_2, 1 hit PF01412, ArfGap, 1 hit PF00071, Ras, 1 hit |
PRINTSi | PR00405, REVINTRACTNG |
SMARTi | View protein in SMART SM00105, ArfGap, 1 hit SM00233, PH, 1 hit |
SUPFAMi | SSF48403, SSF48403, 1 hit SSF52540, SSF52540, 1 hit SSF57863, SSF57863, 1 hit |
PROSITEi | View protein in PROSITE PS50297, ANK_REP_REGION, 1 hit PS50088, ANK_REPEAT, 1 hit PS50115, ARFGAP, 1 hit PS50003, PH_DOMAIN, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All
F8VVT9-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSRGAGALQR RTTTYLISLT LVKLESVPPP PPSPSAAAAG AAGARGSETG
60 70 80 90 100
DPGSPRGAEE PGKKRHERLF HRQDALWIST SSAGTGGAEP PALSPAPASP
110 120 130 140 150
ARPVSPAPGR RLSLWAVPPG PPLSGGLSPD PKPGGAPTSS RRPLLSSPSW
160 170 180 190 200
GGPEPEGRAG GGIPGSSSPH PGTGSRRLKV APPPPAPKPC KTVTTSGAKA
210 220 230 240 250
GGGKGAGSRL SWPESEGKPR VKGSKSSAGT GASVSAAATA AAAGGGGSTA
260 270 280 290 300
STSGGVGAGA GARGKLSPRK GKSKTLDNSD LHPGPPAGSP PPLTLPPTPS
310 320 330 340 350
PATAVTAASA QPPGPAPPIT LEPPAPGLKR GREGGRASTR DRKMLKFISG
360 370 380 390 400
IFTKSTGGPP GSGPLPGPPS LSSGSGSREL LGAELRASPK AVINSQEWTL
410 420 430 440 450
SRSIPELRLG VLGDARSGKS SLIHRFLTGS YQVLEKTESE QYKKEMLVDG
460 470 480 490 500
QTHLVLIREE AGAPDAKFSG WADAVIFVFS LEDENSFQAV SRLHGQLSSL
510 520 530 540 550
RGEGRGGLAL ALVGTQDRIS ASSPRVVGDA RARALCADMK RCSYYETCAT
560 570 580 590 600
YGLNVDRVFQ EVAQKVVTLR KQQQLLAACK SLPSSPSHSA ASTPVAGQAS
610 620 630 640 650
NGGHTSDYSS SLPSSPNVGH RELRAEAAAV AGLSTPGSLH RAAKRRTSLF
660 670 680 690 700
ANRRGSDSEK RSLDSRGETT GSGRAIPIKQ SFLLKRSGNS LNKEWKKKYV
710 720 730 740 750
TLSSNGFLLY HPSINDYIHS THGKEMDLLR TTVKVPGKRP PRAISAFGPS
760 770 780 790 800
ASINGLVKDM STVQMGEGLE ATTPMPSPSP SPSSLQPPPD QTSKHLLKPD
810 820 830 840 850
RNLARALSTD CTPSGDLSPL SREPPPSPMV KKQRRKKLTT PSKTEGSAGQ
860 870 880 890 900
AEAKRKMWKL KSFGSLRNIY KAEENFEFLI VSSTGQTWHF EAASFEERDA
910 920 930 940 950
WVQAIESQIL ASLQCCESSK VKLRTDSQSE AVAIQAIRNA KGNSICVDCG
960 970 980 990 1000
APNPTWASLN LGALICIECS GIHRNLGTHL SRVRSLDLDD WPRELTLVLT
1010 1020 1030 1040 1050
AIGNDTANRV WESDTRGRAK PSRDSSREER ESWIRAKYEQ LLFLAPLSTS
1060 1070 1080 1090 1100
EEPLGRQLWA AVQAQDVATV LLLLAHARHG PLDTSVEDPQ LRSPLHLAAE
1110 1120 1130 1140 1150
LAHVVITQLL LWYGADVAAR DAQGRTALFY ARQAGSQLCA DILLQHGCPG
1160 1170 1180 1190
EGGSAATTPS AATTPSITAT PSPRRRSSAA SVGRADAPVA LV
Computationally mapped potential isoform sequencesi
There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketQ99490 | AGAP2_HUMAN | Arf-GAP with GTPase, ANK repeat and... | AGAP2 CENTG1, KIAA0167 | 1,192 | Annotation score: | ||
J3KNM6 | J3KNM6_HUMAN | Arf-GAP with GTPase, ANK repeat and... | AGAP2 | 1,036 | Annotation score: | ||
H0YHB1 | H0YHB1_HUMAN | Arf-GAP with GTPase, ANK repeat and... | AGAP2 | 169 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC025165 Genomic DNA No translation available. |
RefSeqi | NP_001116244.1, NM_001122772.2 XP_016874261.1, XM_017018772.1 |
Genome annotation databases
Ensembli | ENST00000547588; ENSP00000449241; ENSG00000135439 |
GeneIDi | 116986 |
KEGGi | hsa:116986 |
UCSCi | uc001spq.4, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC025165 Genomic DNA No translation available. |
RefSeqi | NP_001116244.1, NM_001122772.2 XP_016874261.1, XM_017018772.1 |
3D structure databases
SMRi | F8VVT9 |
ModBasei | Search... |
Proteomic databases
MaxQBi | F8VVT9 |
PeptideAtlasi | F8VVT9 |
PRIDEi | F8VVT9 |
ProteomicsDBi | 28883 |
Protocols and materials databases
Antibodypediai | 16354, 290 antibodies |
DNASUi | 116986 |
Genome annotation databases
Ensembli | ENST00000547588; ENSP00000449241; ENSG00000135439 |
GeneIDi | 116986 |
KEGGi | hsa:116986 |
UCSCi | uc001spq.4, human |
Organism-specific databases
CTDi | 116986 |
HGNCi | HGNC:16921, AGAP2 |
OpenTargetsi | ENSG00000135439 |
VEuPathDBi | HostDB:ENSG00000135439.11 |
GenAtlasi | Search... |
Phylogenomic databases
GeneTreei | ENSGT00940000158956 |
OMAi | PAKRKMW |
OrthoDBi | 751525at2759 |
PhylomeDBi | F8VVT9 |
TreeFami | TF317762 |
Miscellaneous databases
BioGRID-ORCSi | 116986, 34 hits in 988 CRISPR screens |
ChiTaRSi | AGAP2, human |
GenomeRNAii | 116986 |
Gene expression databases
Bgeei | ENSG00000135439, Expressed in right hemisphere of cerebellum and 195 other tissues |
ExpressionAtlasi | F8VVT9, baseline and differential |
Genevisiblei | F8VVT9, HS |
Family and domain databases
Gene3Di | 1.25.40.20, 1 hit 2.30.29.30, 2 hits 3.30.40.160, 1 hit |
InterProi | View protein in InterPro IPR002110, Ankyrin_rpt IPR020683, Ankyrin_rpt-contain_dom IPR036770, Ankyrin_rpt-contain_sf IPR037278, ARFGAP/RecO IPR001164, ArfGAP_dom IPR038508, ArfGAP_dom_sf IPR027417, P-loop_NTPase IPR011993, PH-like_dom_sf IPR001849, PH_domain IPR001806, Small_GTPase |
Pfami | View protein in Pfam PF12796, Ank_2, 1 hit PF01412, ArfGap, 1 hit PF00071, Ras, 1 hit |
PRINTSi | PR00405, REVINTRACTNG |
SMARTi | View protein in SMART SM00105, ArfGap, 1 hit SM00233, PH, 1 hit |
SUPFAMi | SSF48403, SSF48403, 1 hit SSF52540, SSF52540, 1 hit SSF57863, SSF57863, 1 hit |
PROSITEi | View protein in PROSITE PS50297, ANK_REP_REGION, 1 hit PS50088, ANK_REPEAT, 1 hit PS50115, ARFGAP, 1 hit PS50003, PH_DOMAIN, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | F8VVT9_HUMAN | |
Accessioni | F8VVT9Primary (citable) accession number: F8VVT9 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | September 21, 2011 |
Last sequence update: | September 21, 2011 | |
Last modified: | April 7, 2021 | |
This is version 87 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |