UniProtKB - F8VUA7 (F8VUA7_HUMAN)

BLAST

>tr|F8VUA7|F8VUA7_HUMAN Oxysterol-binding protein (Fragment) OS=Homo sapiens OX=9606 GN=OSBPL8 PE=1 SV=8
MKEESSQRRFSSCTGVLPVLFPPRIDGRKLVRNASFGGYNELSPSLPGFERGKEDISQNK
DESSLSMSKSKSESKLYNGSEKDSSTSSKLTKKESLKVQKKNYREEKKRATKELLSTITD
PSVIVMADWLKIRGTLKSWTKLWCVLKPGVLLIYKTQKNGQWVGTVLLNACEIIERPSKK
DGFCFKLFHPLEQSIWAVKGPKGEAVGSITQPLPSSYLIIRATSESDGRCWMDALELALK
CSSLLKRTMIREGKEHDLSVSSDSTHVTFYGLLRANNLHSGDNFQLNDSEIERQHFKDQD
MYSDKSDKENDQEHDESDNEVMGKSEESDTDTSERQDDSYIEPEPVEPLKETTYTEQSHE
ELGEAGEASQTETVSEENKSLIWTLLKQVRPGMDLSKVVLPTFILEPRSFLDKLSDYYYH
ADFLSEAALEENPYFRLKKVVKWYLSGFYKKPKGLKKPYNPILGETFRCLWIHPRTNSKT
FYIAEQVSHHPPISAFYVSNRKDGFCLSGSILAKSKFYGNSLSAILEGEARLTFLNRGED
YVMTMPYAHCKGILYGTMTLELGGTVNITCQKTGYSAILEFKLKPFLGSSDCVNQISGKL
KLGKEVLATLEGHWDSEVFITDKKTDNSEVFWNPTPDIKQWRLIRHTVKFEEQGDFESEK
LWQRVTRAINAKDQTEATQEKYVLEEAQRQAARD

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History
Entry version 63 (12 Sep 2018)
Sequence version 8 (05 Oct 2016)
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Protein

Oxysterol-binding protein

Gene

OSBPL8

Organism

Homo sapiens (Human)

Status

Unreviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

GO - Biological processⁱ

lipid transport Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Biological process	Lipid transportUniRule annotation, Transport

Biological process

Lipid transportUniRule annotation, Transport

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Oxysterol-binding proteinUniRule annotation
Gene namesⁱ	Name:OSBPL8Imported
Organismⁱ	Homo sapiens (Human)Imported
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 12

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000091039.16
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:16396 OSBPL8

Pathology & Biotechⁱ

Organism-specific databases

Open Targets More...OpenTargetsⁱ	ENSG00000091039

OpenTargetsⁱ

ENSG00000091039

PTM / Processingⁱ

Proteomic databases

PeptideAtlas More...PeptideAtlasⁱ	F8VUA7
PRIDEⁱ	F8VUA7

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000091039 Expressed in 249 organ(s), highest expression level in blood
ExpressionAtlasⁱ	F8VUA7 baseline and differential

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	F8VUA7
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	123 – 240	PHInterPro annotationAdd BLAST		118

Coiled coil

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Coiled coilⁱ	93 – 113	Sequence analysisAdd BLAST		21

Sequence similaritiesⁱ

Belongs to the OSBP family.UniRule annotation

Keywords - Domainⁱ

Coiled coilSequence analysis

Phylogenomic databases

eggNOGⁱ	KOG2210 Eukaryota ENOG410XRW6 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00550000074515

Family and domain databases

Gene3Dⁱ	2.30.29.30, 1 hit
InterProⁱ	View protein in InterPro IPR037239 OSBP_sf IPR000648 Oxysterol-bd IPR018494 Oxysterol-bd_CS IPR011993 PH-like_dom_sf IPR001849 PH_domain
PANTHERⁱ	PTHR10972 PTHR10972, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF01237 Oxysterol_BP, 1 hit PF00169 PH, 1 hit
SMARTⁱ	View protein in SMART SM00233 PH, 1 hit
SUPFAMⁱ	SSF144000 SSF144000, 1 hit
PROSITEⁱ	View protein in PROSITE PS01013 OSBP, 1 hit PS50003 PH_DOMAIN, 1 hit

Sequence (1+)ⁱ

Sequence statusⁱ: Fragment.

This entry has 1 described isoform and 9 potential isoforms that are computationally mapped.Show all Align All

F8VUA7-1 [UniParc]FASTA Add to basket

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        10         20         30         40         50
MKEESSQRRF SSCTGVLPVL FPPRIDGRKL VRNASFGGYN ELSPSLPGFE 
        60         70         80         90        100
RGKEDISQNK DESSLSMSKS KSESKLYNGS EKDSSTSSKL TKKESLKVQK 
       110        120        130        140        150
KNYREEKKRA TKELLSTITD PSVIVMADWL KIRGTLKSWT KLWCVLKPGV 
       160        170        180        190        200
LLIYKTQKNG QWVGTVLLNA CEIIERPSKK DGFCFKLFHP LEQSIWAVKG 
       210        220        230        240        250
PKGEAVGSIT QPLPSSYLII RATSESDGRC WMDALELALK CSSLLKRTMI 
       260        270        280        290        300
REGKEHDLSV SSDSTHVTFY GLLRANNLHS GDNFQLNDSE IERQHFKDQD 
       310        320        330        340        350
MYSDKSDKEN DQEHDESDNE VMGKSEESDT DTSERQDDSY IEPEPVEPLK 
       360        370        380        390        400
ETTYTEQSHE ELGEAGEASQ TETVSEENKS LIWTLLKQVR PGMDLSKVVL 
       410        420        430        440        450
PTFILEPRSF LDKLSDYYYH ADFLSEAALE ENPYFRLKKV VKWYLSGFYK 
       460        470        480        490        500
KPKGLKKPYN PILGETFRCL WIHPRTNSKT FYIAEQVSHH PPISAFYVSN 
       510        520        530        540        550
RKDGFCLSGS ILAKSKFYGN SLSAILEGEA RLTFLNRGED YVMTMPYAHC 
       560        570        580        590        600
KGILYGTMTL ELGGTVNITC QKTGYSAILE FKLKPFLGSS DCVNQISGKL 
       610        620        630        640        650
KLGKEVLATL EGHWDSEVFI TDKKTDNSEV FWNPTPDIKQ WRLIRHTVKF 
       660        670        680        690 
EEQGDFESEK LWQRVTRAIN AKDQTEATQE KYVLEEAQRQ AARD

Length:694

Mass (Da):79,053

Last modified:October 5, 2016 - v8

Checksum:ⁱDF3C3AA1EEC90432

Computationally mapped potential isoform sequencesⁱ

There are 9 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

Q9BZF1	OSBL8_HUMAN	Oxysterol-binding protein-related p... Oxysterol-binding protein-related protein 8, ORP-8, OSBP-related protein 8	OSBPL8 KIAA1451, ORP8, OSBP10	889	Annotation score:
F8VQX7	F8VQX7_HUMAN	Oxysterol-binding protein Oxysterol-binding protein	OSBPL8	721	Annotation score:
F8VZ43	F8VZ43_HUMAN	Oxysterol-binding protein-related p... Oxysterol-binding protein-related protein 8	OSBPL8	157	Annotation score:
F8VVE7	F8VVE7_HUMAN	Oxysterol-binding protein-related p... Oxysterol-binding protein-related protein 8	OSBPL8	111	Annotation score:
F8VVD3	F8VVD3_HUMAN	Oxysterol-binding protein-related p... Oxysterol-binding protein-related protein 8	OSBPL8	76	Annotation score:
F8VZB8	F8VZB8_HUMAN	Oxysterol-binding protein-related p... Oxysterol-binding protein-related protein 8	OSBPL8	58	Annotation score:
F8W060	F8W060_HUMAN	Oxysterol-binding protein-related p... Oxysterol-binding protein-related protein 8	OSBPL8	52	Annotation score:
F8W1F1	F8W1F1_HUMAN	Oxysterol-binding protein-related p... Oxysterol-binding protein-related protein 8	OSBPL8	28	Annotation score:
F8VS33	F8VS33_HUMAN	Oxysterol-binding protein-related p... Oxysterol-binding protein-related protein 8	OSBPL8	41	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Non-terminal residueⁱ	694	Imported		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AC117491 Genomic DNA No translation available. AC122687 Genomic DNA No translation available. AC124943 Genomic DNA No translation available.

Select the link destinations:
EMBLⁱ
GenBankⁱ
DDBJⁱ

Links Updated

AC117491 Genomic DNA No translation available.
AC122687 Genomic DNA No translation available.
AC124943 Genomic DNA No translation available.

Genome annotation databases

Ensemblⁱ	ENST00000546946; ENSP00000447893; ENSG00000091039
UCSC genome browser More...UCSCⁱ	uc058rdx.1 human

Protein	Similar proteins		Species	Score	Length	Source
F8VUA7	Oxysterol-binding protein-related protein 8	)	HUMAN		889	UniRef90_Q9BZF1
Oxysterol-binding protein-related protein 8		MOUSE		889
Oxysterol-binding protein		PANTR		889
Oxysterol-binding protein		PANPA		847
Oxysterol-binding protein (Fragment)		PONAB		501
+437

Protein	Similar proteins		Species	Score	Length	Source
F8VUA7	Oxysterol-binding protein-related protein 8	)	HUMAN		889	UniRef50_Q9BZF1
Oxysterol-binding protein-related protein 8		MOUSE		889
Oxysterol-binding protein		PANTR		889
Oxysterol-binding protein		PANPA		847
Oxysterol-binding protein (Fragment)		PONAB		501
+1173

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AC117491 Genomic DNA No translation available. AC122687 Genomic DNA No translation available. AC124943 Genomic DNA No translation available.

Select the link destinations:
EMBLⁱ
GenBankⁱ
DDBJⁱ

Links Updated

AC117491 Genomic DNA No translation available.
AC122687 Genomic DNA No translation available.
AC124943 Genomic DNA No translation available.

3D structure databases

ProteinModelPortalⁱ	F8VUA7
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Proteomic databases

PeptideAtlasⁱ	F8VUA7
PRIDEⁱ	F8VUA7

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000546946; ENSP00000447893; ENSG00000091039
UCSCⁱ	uc058rdx.1 human

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000091039.16
HGNCⁱ	HGNC:16396 OSBPL8
OpenTargetsⁱ	ENSG00000091039
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG2210 Eukaryota ENOG410XRW6 LUCA
GeneTreeⁱ	ENSGT00550000074515

Miscellaneous databases

ChiTaRSⁱ	OSBPL8 human

ChiTaRSⁱ

OSBPL8 human

Gene expression databases

Bgeeⁱ	ENSG00000091039 Expressed in 249 organ(s), highest expression level in blood
ExpressionAtlasⁱ	F8VUA7 baseline and differential

Family and domain databases

Gene3Dⁱ	2.30.29.30, 1 hit
InterProⁱ	View protein in InterPro IPR037239 OSBP_sf IPR000648 Oxysterol-bd IPR018494 Oxysterol-bd_CS IPR011993 PH-like_dom_sf IPR001849 PH_domain
PANTHERⁱ	PTHR10972 PTHR10972, 1 hit
Pfamⁱ	View protein in Pfam PF01237 Oxysterol_BP, 1 hit PF00169 PH, 1 hit
SMARTⁱ	View protein in SMART SM00233 PH, 1 hit
SUPFAMⁱ	SSF144000 SSF144000, 1 hit
PROSITEⁱ	View protein in PROSITE PS01013 OSBP, 1 hit PS50003 PH_DOMAIN, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	F8VUA7_HUMAN
Accessionⁱ	F8VUA7Primary (citable) accession number: F8VUA7
Entry historyⁱ	Integrated into UniProtKB/TrEMBL:	September 21, 2011
	Last sequence update:	October 5, 2016
	Last modified:	September 12, 2018
	This is version 63 of the entry and version 8 of the sequence. See complete history.
Entry statusⁱ	Unreviewed (UniProtKB/TrEMBL)
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

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UniParc

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UniProtKB - F8VUA7 (F8VUA7_HUMAN)

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Oxysterol-binding protein

OSBPL8

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Coiled coil

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Experimental Info

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

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Functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ