Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Oxysterol-binding protein

Gene

OSBPL8

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Biological processi

Keywordsi

Biological processLipid transportUniRule annotation, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Oxysterol-binding proteinUniRule annotation
Gene namesi
Name:OSBPL8Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

EuPathDBiHostDB:ENSG00000091039.16
HGNCiHGNC:16396 OSBPL8

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000091039

PTM / Processingi

Proteomic databases

PeptideAtlasiF8VUA7
PRIDEiF8VUA7

Expressioni

Gene expression databases

BgeeiENSG00000091039 Expressed in 249 organ(s), highest expression level in blood
ExpressionAtlasiF8VUA7 baseline and differential

Structurei

3D structure databases

ProteinModelPortaliF8VUA7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini123 – 240PHInterPro annotationAdd BLAST118

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili93 – 113Sequence analysisAdd BLAST21

Sequence similaritiesi

Belongs to the OSBP family.UniRule annotation

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

eggNOGiKOG2210 Eukaryota
ENOG410XRW6 LUCA
GeneTreeiENSGT00550000074515

Family and domain databases

Gene3Di2.30.29.30, 1 hit
InterProiView protein in InterPro
IPR037239 OSBP_sf
IPR000648 Oxysterol-bd
IPR018494 Oxysterol-bd_CS
IPR011993 PH-like_dom_sf
IPR001849 PH_domain
PANTHERiPTHR10972 PTHR10972, 1 hit
PfamiView protein in Pfam
PF01237 Oxysterol_BP, 1 hit
PF00169 PH, 1 hit
SMARTiView protein in SMART
SM00233 PH, 1 hit
SUPFAMiSSF144000 SSF144000, 1 hit
PROSITEiView protein in PROSITE
PS01013 OSBP, 1 hit
PS50003 PH_DOMAIN, 1 hit

Sequence (1+)i

Sequence statusi: Fragment.

This entry has 1 described isoform and 9 potential isoforms that are computationally mapped.Show allAlign All

F8VUA7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKEESSQRRF SSCTGVLPVL FPPRIDGRKL VRNASFGGYN ELSPSLPGFE
60 70 80 90 100
RGKEDISQNK DESSLSMSKS KSESKLYNGS EKDSSTSSKL TKKESLKVQK
110 120 130 140 150
KNYREEKKRA TKELLSTITD PSVIVMADWL KIRGTLKSWT KLWCVLKPGV
160 170 180 190 200
LLIYKTQKNG QWVGTVLLNA CEIIERPSKK DGFCFKLFHP LEQSIWAVKG
210 220 230 240 250
PKGEAVGSIT QPLPSSYLII RATSESDGRC WMDALELALK CSSLLKRTMI
260 270 280 290 300
REGKEHDLSV SSDSTHVTFY GLLRANNLHS GDNFQLNDSE IERQHFKDQD
310 320 330 340 350
MYSDKSDKEN DQEHDESDNE VMGKSEESDT DTSERQDDSY IEPEPVEPLK
360 370 380 390 400
ETTYTEQSHE ELGEAGEASQ TETVSEENKS LIWTLLKQVR PGMDLSKVVL
410 420 430 440 450
PTFILEPRSF LDKLSDYYYH ADFLSEAALE ENPYFRLKKV VKWYLSGFYK
460 470 480 490 500
KPKGLKKPYN PILGETFRCL WIHPRTNSKT FYIAEQVSHH PPISAFYVSN
510 520 530 540 550
RKDGFCLSGS ILAKSKFYGN SLSAILEGEA RLTFLNRGED YVMTMPYAHC
560 570 580 590 600
KGILYGTMTL ELGGTVNITC QKTGYSAILE FKLKPFLGSS DCVNQISGKL
610 620 630 640 650
KLGKEVLATL EGHWDSEVFI TDKKTDNSEV FWNPTPDIKQ WRLIRHTVKF
660 670 680 690
EEQGDFESEK LWQRVTRAIN AKDQTEATQE KYVLEEAQRQ AARD
Length:694
Mass (Da):79,053
Last modified:October 5, 2016 - v8
Checksum:iDF3C3AA1EEC90432
GO

Computationally mapped potential isoform sequencesi

There are 9 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q9BZF1OSBL8_HUMAN
Oxysterol-binding protein-related p...
OSBPL8 KIAA1451, ORP8, OSBP10
889Annotation score:
F8VQX7F8VQX7_HUMAN
Oxysterol-binding protein
OSBPL8
721Annotation score:
F8VZ43F8VZ43_HUMAN
Oxysterol-binding protein-related p...
OSBPL8
157Annotation score:
F8VVE7F8VVE7_HUMAN
Oxysterol-binding protein-related p...
OSBPL8
111Annotation score:
F8VVD3F8VVD3_HUMAN
Oxysterol-binding protein-related p...
OSBPL8
76Annotation score:
F8VZB8F8VZB8_HUMAN
Oxysterol-binding protein-related p...
OSBPL8
58Annotation score:
F8W060F8W060_HUMAN
Oxysterol-binding protein-related p...
OSBPL8
52Annotation score:
F8W1F1F8W1F1_HUMAN
Oxysterol-binding protein-related p...
OSBPL8
28Annotation score:
F8VS33F8VS33_HUMAN
Oxysterol-binding protein-related p...
OSBPL8
41Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei694Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC117491 Genomic DNA No translation available.
AC122687 Genomic DNA No translation available.
AC124943 Genomic DNA No translation available.

Genome annotation databases

EnsembliENST00000546946; ENSP00000447893; ENSG00000091039
UCSCiuc058rdx.1 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC117491 Genomic DNA No translation available.
AC122687 Genomic DNA No translation available.
AC124943 Genomic DNA No translation available.

3D structure databases

ProteinModelPortaliF8VUA7
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PeptideAtlasiF8VUA7
PRIDEiF8VUA7

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000546946; ENSP00000447893; ENSG00000091039
UCSCiuc058rdx.1 human

Organism-specific databases

EuPathDBiHostDB:ENSG00000091039.16
HGNCiHGNC:16396 OSBPL8
OpenTargetsiENSG00000091039
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2210 Eukaryota
ENOG410XRW6 LUCA
GeneTreeiENSGT00550000074515

Miscellaneous databases

ChiTaRSiOSBPL8 human

Gene expression databases

BgeeiENSG00000091039 Expressed in 249 organ(s), highest expression level in blood
ExpressionAtlasiF8VUA7 baseline and differential

Family and domain databases

Gene3Di2.30.29.30, 1 hit
InterProiView protein in InterPro
IPR037239 OSBP_sf
IPR000648 Oxysterol-bd
IPR018494 Oxysterol-bd_CS
IPR011993 PH-like_dom_sf
IPR001849 PH_domain
PANTHERiPTHR10972 PTHR10972, 1 hit
PfamiView protein in Pfam
PF01237 Oxysterol_BP, 1 hit
PF00169 PH, 1 hit
SMARTiView protein in SMART
SM00233 PH, 1 hit
SUPFAMiSSF144000 SSF144000, 1 hit
PROSITEiView protein in PROSITE
PS01013 OSBP, 1 hit
PS50003 PH_DOMAIN, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiF8VUA7_HUMAN
AccessioniPrimary (citable) accession number: F8VUA7
Entry historyiIntegrated into UniProtKB/TrEMBL: September 21, 2011
Last sequence update: October 5, 2016
Last modified: September 12, 2018
This is version 63 of the entry and version 8 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again