UniProtKB - F8VUA7 (F8VUA7_HUMAN)
Protein
Oxysterol-binding protein
Gene
OSBPL8
Organism
Homo sapiens (Human)
Status
Functioni
GO - Biological processi
- lipid transport Source: UniProtKB-KW
Keywordsi
Biological process | Lipid transportUniRule annotation, Transport |
Names & Taxonomyi
Protein namesi | Recommended name: Oxysterol-binding proteinUniRule annotation |
Gene namesi | Name:OSBPL8Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:16396 OSBPL8 |
PTM / Processingi
Proteomic databases
jPOSTi | F8VUA7 |
PeptideAtlasi | F8VUA7 |
PRIDEi | F8VUA7 |
ProteomicsDBi | 28716 |
Expressioni
Gene expression databases
Bgeei | ENSG00000091039 Expressed in 249 organ(s), highest expression level in blood |
ExpressionAtlasi | F8VUA7 baseline and differential |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 123 – 240 | PHInterPro annotationAdd BLAST | 118 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 21 | DisorderedSequence analysisAdd BLAST | 21 | |
Regioni | 36 – 104 | DisorderedSequence analysisAdd BLAST | 69 | |
Regioni | 297 – 374 | DisorderedSequence analysisAdd BLAST | 78 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 61 – 85 | PolarSequence analysisAdd BLAST | 25 | |
Compositional biasi | 86 – 104 | PolyampholyteSequence analysisAdd BLAST | 19 | |
Compositional biasi | 297 – 345 | PolyampholyteSequence analysisAdd BLAST | 49 |
Sequence similaritiesi
Belongs to the OSBP family.UniRule annotation
Phylogenomic databases
eggNOGi | KOG2210 Eukaryota ENOG410XRW6 LUCA |
GeneTreei | ENSGT00940000156622 |
Family and domain databases
Gene3Di | 2.30.29.30, 1 hit |
InterProi | View protein in InterPro IPR037239 OSBP_sf IPR000648 Oxysterol-bd IPR018494 Oxysterol-bd_CS IPR011993 PH-like_dom_sf IPR001849 PH_domain |
PANTHERi | PTHR10972 PTHR10972, 1 hit |
Pfami | View protein in Pfam PF01237 Oxysterol_BP, 1 hit PF00169 PH, 1 hit |
SMARTi | View protein in SMART SM00233 PH, 1 hit |
SUPFAMi | SSF144000 SSF144000, 1 hit |
PROSITEi | View protein in PROSITE PS01013 OSBP, 1 hit PS50003 PH_DOMAIN, 1 hit |
(1+)i Sequence
Sequence statusi: Fragment.
This entry has 1 described isoform and 9 potential isoforms that are computationally mapped.Show allAlign All
F8VUA7-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MKEESSQRRF SSCTGVLPVL FPPRIDGRKL VRNASFGGYN ELSPSLPGFE
60 70 80 90 100
RGKEDISQNK DESSLSMSKS KSESKLYNGS EKDSSTSSKL TKKESLKVQK
110 120 130 140 150
KNYREEKKRA TKELLSTITD PSVIVMADWL KIRGTLKSWT KLWCVLKPGV
160 170 180 190 200
LLIYKTQKNG QWVGTVLLNA CEIIERPSKK DGFCFKLFHP LEQSIWAVKG
210 220 230 240 250
PKGEAVGSIT QPLPSSYLII RATSESDGRC WMDALELALK CSSLLKRTMI
260 270 280 290 300
REGKEHDLSV SSDSTHVTFY GLLRANNLHS GDNFQLNDSE IERQHFKDQD
310 320 330 340 350
MYSDKSDKEN DQEHDESDNE VMGKSEESDT DTSERQDDSY IEPEPVEPLK
360 370 380 390 400
ETTYTEQSHE ELGEAGEASQ TETVSEENKS LIWTLLKQVR PGMDLSKVVL
410 420 430 440 450
PTFILEPRSF LDKLSDYYYH ADFLSEAALE ENPYFRLKKV VKWYLSGFYK
460 470 480 490 500
KPKGLKKPYN PILGETFRCL WIHPRTNSKT FYIAEQVSHH PPISAFYVSN
510 520 530 540 550
RKDGFCLSGS ILAKSKFYGN SLSAILEGEA RLTFLNRGED YVMTMPYAHC
560 570 580 590 600
KGILYGTMTL ELGGTVNITC QKTGYSAILE FKLKPFLGSS DCVNQISGKL
610 620 630 640 650
KLGKEVLATL EGHWDSEVFI TDKKTDNSEV FWNPTPDIKQ WRLIRHTVKF
660 670 680 690
EEQGDFESEK LWQRVTRAIN AKDQTEATQE KYVLEEAQRQ AARD
Computationally mapped potential isoform sequencesi
There are 9 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketQ9BZF1 | OSBL8_HUMAN | Oxysterol-binding protein-related p... | OSBPL8 KIAA1451, ORP8, OSBP10 | 889 | Annotation score: | ||
F8VQX7 | F8VQX7_HUMAN | Oxysterol-binding protein | OSBPL8 | 721 | Annotation score: | ||
F8VVD3 | F8VVD3_HUMAN | Oxysterol-binding protein-related p... | OSBPL8 | 76 | Annotation score: | ||
F8VVE7 | F8VVE7_HUMAN | Oxysterol-binding protein-related p... | OSBPL8 | 111 | Annotation score: | ||
F8VZ43 | F8VZ43_HUMAN | Oxysterol-binding protein-related p... | OSBPL8 | 157 | Annotation score: | ||
F8VZB8 | F8VZB8_HUMAN | Oxysterol-binding protein-related p... | OSBPL8 | 58 | Annotation score: | ||
F8W060 | F8W060_HUMAN | Oxysterol-binding protein-related p... | OSBPL8 | 52 | Annotation score: | ||
F8W1F1 | F8W1F1_HUMAN | Oxysterol-binding protein-related p... | OSBPL8 | 28 | Annotation score: | ||
F8VS33 | F8VS33_HUMAN | Oxysterol-binding protein-related p... | OSBPL8 | 41 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Non-terminal residuei | 694 | Imported | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC117491 Genomic DNA No translation available. AC122687 Genomic DNA No translation available. AC124943 Genomic DNA No translation available. |
Genome annotation databases
Ensembli | ENST00000546946; ENSP00000447893; ENSG00000091039 |
UCSCi | uc058rdx.1 human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC117491 Genomic DNA No translation available. AC122687 Genomic DNA No translation available. AC124943 Genomic DNA No translation available. |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
IntActi | F8VUA7, 5 interactors |
Proteomic databases
jPOSTi | F8VUA7 |
PeptideAtlasi | F8VUA7 |
PRIDEi | F8VUA7 |
ProteomicsDBi | 28716 |
Genome annotation databases
Ensembli | ENST00000546946; ENSP00000447893; ENSG00000091039 |
UCSCi | uc058rdx.1 human |
Organism-specific databases
HGNCi | HGNC:16396 OSBPL8 |
OpenTargetsi | ENSG00000091039 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG2210 Eukaryota ENOG410XRW6 LUCA |
GeneTreei | ENSGT00940000156622 |
Miscellaneous databases
ChiTaRSi | OSBPL8 human |
Gene expression databases
Bgeei | ENSG00000091039 Expressed in 249 organ(s), highest expression level in blood |
ExpressionAtlasi | F8VUA7 baseline and differential |
Family and domain databases
Gene3Di | 2.30.29.30, 1 hit |
InterProi | View protein in InterPro IPR037239 OSBP_sf IPR000648 Oxysterol-bd IPR018494 Oxysterol-bd_CS IPR011993 PH-like_dom_sf IPR001849 PH_domain |
PANTHERi | PTHR10972 PTHR10972, 1 hit |
Pfami | View protein in Pfam PF01237 Oxysterol_BP, 1 hit PF00169 PH, 1 hit |
SMARTi | View protein in SMART SM00233 PH, 1 hit |
SUPFAMi | SSF144000 SSF144000, 1 hit |
PROSITEi | View protein in PROSITE PS01013 OSBP, 1 hit PS50003 PH_DOMAIN, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | F8VUA7_HUMAN | |
Accessioni | F8VUA7Primary (citable) accession number: F8VUA7 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | September 21, 2011 |
Last sequence update: | October 5, 2016 | |
Last modified: | July 31, 2019 | |
This is version 68 of the entry and version 8 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |