Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

RNA binding protein fox-1 homolog

Gene

RBFOX1

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Protein predictedi

Functioni

RNA-binding protein that regulates alternative splicing events.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionRNA-bindingUniRule annotation
Biological processmRNA processing, mRNA splicingUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
RNA binding protein fox-1 homologUniRule annotation
Gene namesi
Name:RBFOX1Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

EuPathDBiHostDB:ENSG00000078328.19
HGNCiHGNC:18222 RBFOX1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

NucleusUniRule annotation

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000078328

PTM / Processingi

Proteomic databases

MaxQBiF8VRS4
PeptideAtlasiF8VRS4
PRIDEiF8VRS4

Expressioni

Gene expression databases

BgeeiENSG00000078328 Expressed in 177 organ(s), highest expression level in putamen
ExpressionAtlasiF8VRS4 baseline and differential

Structurei

3D structure databases

ProteinModelPortaliF8VRS4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini152 – 210RRMInterPro annotationAdd BLAST59

Phylogenomic databases

GeneTreeiENSGT00390000013767

Family and domain databases

Gene3Di3.30.70.330, 2 hits
InterProiView protein in InterPro
IPR025670 Fox-1_C_dom
IPR012677 Nucleotide-bd_a/b_plait_sf
IPR035979 RBD_domain_sf
IPR017325 RNA-bd_Fox-1
IPR000504 RRM_dom
PfamiView protein in Pfam
PF12414 Fox-1_C, 1 hit
PF00076 RRM_1, 1 hit
PIRSFiPIRSF037932 Ataxin_2_bd_A2BP, 2 hits
SMARTiView protein in SMART
SM00360 RRM, 1 hit
SUPFAMiSSF54928 SSF54928, 1 hit
PROSITEiView protein in PROSITE
PS50102 RRM, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 12 potential isoforms that are computationally mapped.Show allAlign All

F8VRS4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKSWQLIAVV GDALQDIKAD CNTCVEIEDR KVSRQQMNCE REQLRGNQEA
60 70 80 90 100
AAAPDTMAQP YASAQFAPPQ NGIPAEYTAP HPHPAPEYTG QTTVPEHTLN
110 120 130 140 150
LYPPAQTHSE QSPADTSAQT VSGTATTDDA APTDGQPQTQ PSENTENKSQ
160 170 180 190 200
PKRLHVSNIP FRFRDPDLRQ MFGGFGFVTF ENSADADRAR EKLHGTVVEG
210 220 230 240 250
RKIEVNNATA RVMTNKKTVN PYTNGWKLNP VVGAVYSPEF YAGTVLLCQA
260 270 280 290 300
NQEGSSMYSA PSSLVYTSAM PGFPYPAATA AAAYRGAHLR GRGRTVYNTF
310 320 330 340 350
RAAAPPPPIP AYGGVVYQDG FYGADIYGGY AAYRYAQPTP ATAAAYSDRN
360 370 380 390
QFVFVAADEI SCNTSAVTDE FMLPTPTTTH LLQPPPTALV P
Length:391
Mass (Da):42,264
Last modified:September 21, 2011 - v1
Checksum:i57E892A0AD8CC397
GO

Computationally mapped potential isoform sequencesi

There are 12 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q9NWB1RFOX1_HUMAN
RNA binding protein fox-1 homolog 1
RBFOX1 A2BP, A2BP1, FOX1, HRNBP1
397Annotation score:
B7Z1U7B7Z1U7_HUMAN
RNA binding protein fox-1 homolog
RBFOX1
425Annotation score:
J3KNW3J3KNW3_HUMAN
RNA binding protein fox-1 homolog
RBFOX1
402Annotation score:
A0A087X2B1A0A087X2B1_HUMAN
RNA binding protein fox-1 homolog
RBFOX1
375Annotation score:
F5H0M1F5H0M1_HUMAN
RNA binding protein fox-1 homolog
RBFOX1
380Annotation score:
F8VZG9F8VZG9_HUMAN
RNA-binding protein fox-1 homolog 1
RBFOX1
466Annotation score:
I3L1D4I3L1D4_HUMAN
RNA-binding protein fox-1 homolog 1
RBFOX1
189Annotation score:
F8VZY7F8VZY7_HUMAN
RNA-binding protein fox-1 homolog 1
RBFOX1
263Annotation score:
F8VR27F8VR27_HUMAN
RNA-binding protein fox-1 homolog 1
RBFOX1
262Annotation score:
A0A286YEU2A0A286YEU2_HUMAN
RNA-binding protein fox-1 homolog 1
RBFOX1
582Annotation score:
There are more potential isoformsShow all

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC005347 Genomic DNA No translation available.
AC005364 Genomic DNA No translation available.
AC005563 Genomic DNA No translation available.
AC005569 Genomic DNA No translation available.
AC005737 Genomic DNA No translation available.
AC012175 Genomic DNA No translation available.
AC023822 Genomic DNA No translation available.
AC074051 Genomic DNA No translation available.
KF495794 Genomic DNA No translation available.

Genome annotation databases

EnsembliENST00000552089; ENSP00000448496; ENSG00000078328
UCSCiuc059qms.1 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC005347 Genomic DNA No translation available.
AC005364 Genomic DNA No translation available.
AC005563 Genomic DNA No translation available.
AC005569 Genomic DNA No translation available.
AC005737 Genomic DNA No translation available.
AC012175 Genomic DNA No translation available.
AC023822 Genomic DNA No translation available.
AC074051 Genomic DNA No translation available.
KF495794 Genomic DNA No translation available.

3D structure databases

ProteinModelPortaliF8VRS4
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

MaxQBiF8VRS4
PeptideAtlasiF8VRS4
PRIDEiF8VRS4

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000552089; ENSP00000448496; ENSG00000078328
UCSCiuc059qms.1 human

Organism-specific databases

EuPathDBiHostDB:ENSG00000078328.19
HGNCiHGNC:18222 RBFOX1
OpenTargetsiENSG00000078328
GenAtlasiSearch...

Phylogenomic databases

GeneTreeiENSGT00390000013767

Miscellaneous databases

ChiTaRSiRBFOX1 human

Gene expression databases

BgeeiENSG00000078328 Expressed in 177 organ(s), highest expression level in putamen
ExpressionAtlasiF8VRS4 baseline and differential

Family and domain databases

Gene3Di3.30.70.330, 2 hits
InterProiView protein in InterPro
IPR025670 Fox-1_C_dom
IPR012677 Nucleotide-bd_a/b_plait_sf
IPR035979 RBD_domain_sf
IPR017325 RNA-bd_Fox-1
IPR000504 RRM_dom
PfamiView protein in Pfam
PF12414 Fox-1_C, 1 hit
PF00076 RRM_1, 1 hit
PIRSFiPIRSF037932 Ataxin_2_bd_A2BP, 2 hits
SMARTiView protein in SMART
SM00360 RRM, 1 hit
SUPFAMiSSF54928 SSF54928, 1 hit
PROSITEiView protein in PROSITE
PS50102 RRM, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiF8VRS4_HUMAN
AccessioniPrimary (citable) accession number: F8VRS4
Entry historyiIntegrated into UniProtKB/TrEMBL: September 21, 2011
Last sequence update: September 21, 2011
Last modified: September 12, 2018
This is version 44 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again