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Entry version 80 (07 Apr 2021)
Sequence version 1 (21 Sep 2011)
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Protein
Submitted name:

Neuronal PAS domain-containing protein 3

Gene

NPAS3

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Neuronal PAS domain-containing protein 3Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:NPAS3Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 14

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:19311, NPAS3

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
HostDB:ENSG00000151322.18

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...
OpenTargetsi
ENSG00000151322

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

PRoteomics IDEntifications database

More...
PRIDEi
F8VR32

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
28390

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000151322, Expressed in corpus callosum and 185 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
F8VR32, baseline and differential

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini58 – 111BHLHInterPro annotationAdd BLAST54
Domaini158 – 222PASInterPro annotationAdd BLAST65
Domaini339 – 394PASInterPro annotationAdd BLAST56

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni119 – 138DisorderedSequence analysisAdd BLAST20
Regioni220 – 258DisorderedSequence analysisAdd BLAST39
Regioni457 – 554DisorderedSequence analysisAdd BLAST98
Regioni567 – 646DisorderedSequence analysisAdd BLAST80
Regioni662 – 730DisorderedSequence analysisAdd BLAST69
Regioni747 – 785DisorderedSequence analysisAdd BLAST39

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi230 – 258PolarSequence analysisAdd BLAST29
Compositional biasi461 – 511PolyampholyteSequence analysisAdd BLAST51
Compositional biasi525 – 546PolyampholyteSequence analysisAdd BLAST22
Compositional biasi572 – 597PolarSequence analysisAdd BLAST26
Compositional biasi601 – 617BasicSequence analysisAdd BLAST17
Compositional biasi662 – 695PolarSequence analysisAdd BLAST34

Phylogenomic databases

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000158051

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_009542_1_0_1

Identification of Orthologs from Complete Genome Data

More...
OMAi
SEDCELR

Database of Orthologous Groups

More...
OrthoDBi
922461at2759

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00130, PAS, 2 hits

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
4.10.280.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR011598, bHLH_dom
IPR036638, HLH_DNA-bd_sf
IPR000014, PAS
IPR035965, PAS-like_dom_sf
IPR013767, PAS_fold
IPR013655, PAS_fold_3

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00989, PAS, 1 hit
PF08447, PAS_3, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00353, HLH, 1 hit
SM00091, PAS, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47459, SSF47459, 1 hit
SSF55785, SSF55785, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50888, BHLH, 1 hit
PS50112, PAS, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 6 potential isoforms that are computationally mapped.Show allAlign All

F8VR32-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGRAGAAANG TPQNVQGITS YQQRITAQHP LPNQSECRKI YRYDGIYCES
60 70 80 90 100
TYQNLQALRK EKSRDAARSR RGKENFEFYE LAKLLPLPAA ITSQLDKASI
110 120 130 140 150
IRLTISYLKM RDFANQGDPP WNLRMEGPPP NTSVKGAQRR RSPSALAIEV
160 170 180 190 200
FEAHLGSHIL QSLDGFVFAL NQEGKFLYIS ETVSIYLGLS QVELTGSSVF
210 220 230 240 250
DYVHPGDHVE MAEQLGMKLP PGRGLLSQGT AEDGASSASS SSQSETPEPV
260 270 280 290 300
ESTSPSLLTT DNTLERSFFI RMKSTLTKRG VHIKSSGYKV IHITGRLRLR
310 320 330 340 350
VSLSHGRTVP SQIMGLVVVA HALPPPTINE VRIDCHMFVT RVNMDLNIIY
360 370 380 390 400
CENRISDYMD LTPVDIVGKR CYHFIHAEDV EGIRHSHLDL LNKGQCVTKY
410 420 430 440 450
YRWMQKNGGY IWIQSSATIA INAKNANEKN IIWVNYLLSN PEYKDTPMDI
460 470 480 490 500
AQLPHLPEKT SESSETSDSE SDSKDTSGIT EDNENSKSDE KGNQSENSED
510 520 530 540 550
PEPDRKKSGN ACDNDMNCND DGHSSSNPDS RDSDDSFEHS DFENPKAGED
560 570 580 590 600
GFGALGAMQI KVERYVESES DLRLQNCESL TSDSAKDSDS AGEAGAQASS
610 620 630 640 650
KHQKRKKRRK RQKGGSASRR RLSSASSPGG LDAGLVEPPR LLSSPNSASV
660 670 680 690 700
LKIKTEISEP INFDNDSSIW NYPPNREISR NESPYSMTKP PSSEHFPSPQ
710 720 730 740 750
GGGGGGGGGG GLHVAIPDSV LTPPGADGAA ARKTQFGASA TAALAPVASD
760 770 780 790 800
PLSPPLSASP RDKHPGNGGG GGGGGGGAGG GGPSASNSLL YTGDLEALQR
810 820 830 840 850
LQAGNVVLPL VHRVTGTLAA TSTAAQRVYT TGTIRYAPAE VTLAMQSNLL
860 870 880 890 900
PNAHAVNFVD VNSPGFGLDP KTPMEMLYHH VHRLNMSGPF GGAVSAASLT
910 920 930
QMPAGNVFTT AEGLFSTLPF PVYSNGIHAA QTLERKED
Length:938
Mass (Da):101,038
Last modified:September 21, 2011 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i4FD019CBCCA7C342
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q8IXF0NPAS3_HUMAN
Neuronal PAS domain-containing prot...
NPAS3 BHLHE12, MOP6, PASD6
933Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8VS42F8VS42_HUMAN
Neuronal PAS domain-containing prot...
NPAS3
935Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8W0C2F8W0C2_HUMAN
Neuronal PAS domain-containing prot...
NPAS3
155Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YI42H0YI42_HUMAN
Neuronal PAS domain-containing prot...
NPAS3
132Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YHB6H0YHB6_HUMAN
Neuronal PAS domain-containing prot...
NPAS3
125Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YHU7H0YHU7_HUMAN
Neuronal PAS domain-containing prot...
NPAS3
13Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AL109769 Genomic DNA No translation available.
AL139296 Genomic DNA No translation available.
AL158802 Genomic DNA No translation available.
AL355886 Genomic DNA No translation available.
KC877517 Genomic DNA No translation available.
KC877522 Genomic DNA No translation available.
KF455852 Genomic DNA No translation available.

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000551492; ENSP00000450392; ENSG00000151322

UCSC genome browser

More...
UCSCi
uc059aqq.1, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL109769 Genomic DNA No translation available.
AL139296 Genomic DNA No translation available.
AL158802 Genomic DNA No translation available.
AL355886 Genomic DNA No translation available.
KC877517 Genomic DNA No translation available.
KC877522 Genomic DNA No translation available.
KF455852 Genomic DNA No translation available.

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Proteomic databases

PRIDEiF8VR32
ProteomicsDBi28390

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
136, 126 antibodies

Genome annotation databases

EnsembliENST00000551492; ENSP00000450392; ENSG00000151322
UCSCiuc059aqq.1, human

Organism-specific databases

HGNCiHGNC:19311, NPAS3
OpenTargetsiENSG00000151322
VEuPathDBiHostDB:ENSG00000151322.18

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

GeneTreeiENSGT00940000158051
HOGENOMiCLU_009542_1_0_1
OMAiSEDCELR
OrthoDBi922461at2759

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
NPAS3, human

Gene expression databases

BgeeiENSG00000151322, Expressed in corpus callosum and 185 other tissues
ExpressionAtlasiF8VR32, baseline and differential

Family and domain databases

CDDicd00130, PAS, 2 hits
Gene3Di4.10.280.10, 1 hit
InterProiView protein in InterPro
IPR011598, bHLH_dom
IPR036638, HLH_DNA-bd_sf
IPR000014, PAS
IPR035965, PAS-like_dom_sf
IPR013767, PAS_fold
IPR013655, PAS_fold_3
PfamiView protein in Pfam
PF00989, PAS, 1 hit
PF08447, PAS_3, 1 hit
SMARTiView protein in SMART
SM00353, HLH, 1 hit
SM00091, PAS, 2 hits
SUPFAMiSSF47459, SSF47459, 1 hit
SSF55785, SSF55785, 2 hits
PROSITEiView protein in PROSITE
PS50888, BHLH, 1 hit
PS50112, PAS, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiF8VR32_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: F8VR32
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: September 21, 2011
Last sequence update: September 21, 2011
Last modified: April 7, 2021
This is version 80 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Technical termi

Proteomics identificationCombined sources, Reference proteomeImported
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