UniProtKB - F8VQQ4 (F8VQQ4_HUMAN)
Tubulin alpha chain
TUBA1A
Functioni
GO - Molecular functioni
- GTPase activity Source: UniProtKB-UniRule
- GTP binding Source: UniProtKB-UniRule
- structural constituent of cytoskeleton Source: InterPro
GO - Biological processi
- microtubule-based process Source: InterPro
Keywordsi
Ligand | GTP-bindingUniRule annotationARBA annotation, Nucleotide-binding |
Names & Taxonomyi
Protein namesi | Recommended name: Tubulin alpha chainUniRule annotation |
Gene namesi | Name:TUBA1AImported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000167552.13 |
HGNCi | HGNC:20766, TUBA1A |
Subcellular locationi
Cytoskeleton
- cytoskeleton ARBA annotation
Cytoskeleton
- microtubule Source: UniProtKB-KW
Other locations
- cytoplasm Source: UniProtKB-KW
Keywords - Cellular componenti
Cytoplasm, CytoskeletonARBA annotation, MicrotubuleUniRule annotationARBA annotationPTM / Processingi
Proteomic databases
MaxQBi | F8VQQ4 |
PeptideAtlasi | F8VQQ4 |
PRIDEi | F8VQQ4 |
ProteomicsDBi | 28337 |
Expressioni
Gene expression databases
Bgeei | ENSG00000167552, Expressed in endothelial cell and 248 other tissues |
ExpressionAtlasi | F8VQQ4, baseline and differential |
Interactioni
Subunit structurei
Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.
UniRule annotationFamily & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 14 – 211 | TubulinInterPro annotationAdd BLAST | 198 |
Sequence similaritiesi
Phylogenomic databases
GeneTreei | ENSGT00950000182825 |
Family and domain databases
Gene3Di | 3.40.50.1440, 1 hit |
InterProi | View protein in InterPro IPR002452, Alpha_tubulin IPR000217, Tubulin IPR036525, Tubulin/FtsZ_GTPase_sf IPR017975, Tubulin_CS IPR003008, Tubulin_FtsZ_GTPase |
PANTHERi | PTHR11588, PTHR11588, 1 hit |
Pfami | View protein in Pfam PF00091, Tubulin, 1 hit |
PRINTSi | PR01162, ALPHATUBULIN PR01161, TUBULIN |
SMARTi | View protein in SMART SM00864, Tubulin, 1 hit |
SUPFAMi | SSF52490, SSF52490, 1 hit |
PROSITEi | View protein in PROSITE PS00227, TUBULIN, 1 hit |
(1+)i Sequence
Sequence statusi: Fragment.
This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All
10 20 30 40 50
MPSDKTIGGG DDSFNTFFSE TGAGKHVPRA VFVDLEPTVI DEVRTGTYRQ
60 70 80 90 100
LFHPEQLITG KEDAANNYAR GHYTIGKEII DLVLDRIRKL ADQCTGLQGF
110 120 130 140 150
LVFHSFGGGT GSGFTSLLME RLSVDYGKKS KLEFSIYPAP QVSTAVVEPY
160 170 180 190 200
NSILTTHTTL EHSDCAFMVD NEAIYDICRR NLDIERPTYT NLNRLIGQIV
210
SSITASLRFD GALNVDLTE
Computationally mapped potential isoform sequencesi
There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketQ71U36 | TBA1A_HUMAN | Tubulin alpha-1A chain | TUBA1A TUBA3 | 451 | Annotation score: | ||
F8W0F6 | F8W0F6_HUMAN | Tubulin alpha-1A chain | TUBA1A | 231 | Annotation score: | ||
F8VRZ4 | F8VRZ4_HUMAN | Tubulin alpha-1A chain | TUBA1A | 112 | Annotation score: | ||
F8VXZ7 | F8VXZ7_HUMAN | Tubulin alpha-1A chain | TUBA1A | 26 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Non-terminal residuei | 219 | Imported | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC010173 Genomic DNA No translation available. |
Genome annotation databases
Ensembli | ENST00000547939; ENSP00000450268; ENSG00000167552 |
UCSCi | uc058noj.1, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC010173 Genomic DNA No translation available. |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Proteomic databases
MaxQBi | F8VQQ4 |
PeptideAtlasi | F8VQQ4 |
PRIDEi | F8VQQ4 |
ProteomicsDBi | 28337 |
Protocols and materials databases
Antibodypediai | 3282, 640 antibodies |
Genome annotation databases
Ensembli | ENST00000547939; ENSP00000450268; ENSG00000167552 |
UCSCi | uc058noj.1, human |
Organism-specific databases
EuPathDBi | HostDB:ENSG00000167552.13 |
HGNCi | HGNC:20766, TUBA1A |
OpenTargetsi | ENSG00000167552 |
GenAtlasi | Search... |
Phylogenomic databases
GeneTreei | ENSGT00950000182825 |
Miscellaneous databases
ChiTaRSi | TUBA1A, human |
Gene expression databases
Bgeei | ENSG00000167552, Expressed in endothelial cell and 248 other tissues |
ExpressionAtlasi | F8VQQ4, baseline and differential |
Family and domain databases
Gene3Di | 3.40.50.1440, 1 hit |
InterProi | View protein in InterPro IPR002452, Alpha_tubulin IPR000217, Tubulin IPR036525, Tubulin/FtsZ_GTPase_sf IPR017975, Tubulin_CS IPR003008, Tubulin_FtsZ_GTPase |
PANTHERi | PTHR11588, PTHR11588, 1 hit |
Pfami | View protein in Pfam PF00091, Tubulin, 1 hit |
PRINTSi | PR01162, ALPHATUBULIN PR01161, TUBULIN |
SMARTi | View protein in SMART SM00864, Tubulin, 1 hit |
SUPFAMi | SSF52490, SSF52490, 1 hit |
PROSITEi | View protein in PROSITE PS00227, TUBULIN, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | F8VQQ4_HUMAN | |
Accessioni | F8VQQ4Primary (citable) accession number: F8VQQ4 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | September 21, 2011 |
Last sequence update: | September 21, 2011 | |
Last modified: | October 7, 2020 | |
This is version 66 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |