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Protein

12-(S)-hydroxy-5,8,10,14-eicosatetraenoic acid receptor

Gene

Gpr31

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

High-affinity receptor for 12-(S)-hydroxy-5,8,10,14-eicosatetraenoic acid (12-S-HETE). 12-(S)-HETE is an arachidonic acid metabolite secreted by platelets and tumor cells, and known to induce endothelial cells retraction allowing invasive cell access to the subendothelial matrix, which is a critical step for extravasation or metastasis. Ligand-binding lead to activation of ERK1/2 (MAPK3/MAPK1), MEK, and NF-kappa-B (By similarity).By similarity

GO - Molecular functioni

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-MMU-418594 G alpha (i) signalling events
R-MMU-444209 Free fatty acid receptors

Names & Taxonomyi

Protein namesi
Recommended name:
12-(S)-hydroxy-5,8,10,14-eicosatetraenoic acid receptor
Short name:
12-(S)-HETE receptor
Short name:
12-HETER
Alternative name(s):
G-protein coupled receptor 31
Gene namesi
Name:Gpr31
Synonyms:Gpr31b, Gpr31c
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 17

Organism-specific databases

MGIiMGI:1354372 Gpr31b

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 16ExtracellularSequence analysisAdd BLAST16
Transmembranei17 – 37Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini38 – 52CytoplasmicSequence analysisAdd BLAST15
Transmembranei53 – 73Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini74 – 91ExtracellularSequence analysisAdd BLAST18
Transmembranei92 – 110Helical; Name=3Sequence analysisAdd BLAST19
Topological domaini111 – 131CytoplasmicSequence analysisAdd BLAST21
Transmembranei132 – 152Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini153 – 180ExtracellularSequence analysisAdd BLAST28
Transmembranei181 – 201Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini202 – 219CytoplasmicSequence analysisAdd BLAST18
Transmembranei220 – 240Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini241 – 265ExtracellularSequence analysisAdd BLAST25
Transmembranei266 – 284Helical; Name=7Sequence analysisAdd BLAST19
Topological domaini285 – 319CytoplasmicSequence analysisAdd BLAST35

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Chemistry databases

GuidetoPHARMACOLOGYi98

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004153401 – 31912-(S)-hydroxy-5,8,10,14-eicosatetraenoic acid receptorAdd BLAST319

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi5N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiF8VQN3
PRIDEiF8VQN3

Expressioni

Gene expression databases

BgeeiENSMUSG00000071311 Expressed in 14 organ(s), highest expression level in colon

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000089237

Structurei

3D structure databases

ProteinModelPortaliF8VQN3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IE56 Eukaryota
ENOG410ZU85 LUCA
GeneTreeiENSGT00510000046798
HOGENOMiHOG000285939
HOVERGENiHBG100615
InParanoidiF8VQN3
KOiK08406
OMAiLKVWKPY
OrthoDBiEOG091G0G4Y
PhylomeDBiF8VQN3
TreeFamiTF337237

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequencei

Sequence statusi: Complete.

F8VQN3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MERTNCSAAS TVVETAVGTM LTLECVLGLM GNAVALWTFF YRLKVWKPYA
60 70 80 90 100
VYLFNLVVAD LLLATSLPFF AAFYLKGKTW KLGHMPCQVL LFLLAFSRGV
110 120 130 140 150
GVAFLTTVAL DRYLRVVHPR LRVNLLSLRA AWGISSLIWL LMVVLTPQNL
160 170 180 190 200
LTCRTTQNST ECPSFYPTGG AKAIATCQEV LFFLQVLLPF GLISFCNSGL
210 220 230 240 250
IRTLQKRLRE SDKQPRIRRA RVLVAIVLLL FGLCFLPSVL TRVLVHIFQE
260 270 280 290 300
FKSCSVQQAI VRASDIAGSL TCLHSTLSPA IYCFSNPAFT HSYRKVLKSL
310
RGRRKAAESP SDNLRDSYS
Length:319
Mass (Da):35,642
Last modified:September 21, 2011 - v1
Checksum:i562F575FED1DCBA5
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti3R → H in AAF26668 (PubMed:10501965).Curated1
Sequence conflicti67L → V in AAF26668 (PubMed:10501965).Curated1
Sequence conflicti89V → L in AAF26668 (PubMed:10501965).Curated1
Sequence conflicti98R → C in AAF26668 (PubMed:10501965).Curated1
Sequence conflicti106T → M in AAF26668 (PubMed:10501965).Curated1
Sequence conflicti115R → H in AAF26668 (PubMed:10501965).Curated1
Sequence conflicti171A → T in AAF26668 (PubMed:10501965).Curated1
Sequence conflicti209R → S in AAF26668 (PubMed:10501965).Curated1
Sequence conflicti216R → T in AAF26668 (PubMed:10501965).Curated1
Sequence conflicti227V → M in AAF26668 (PubMed:10501965).Curated1
Sequence conflicti261V → M in AAF26668 (PubMed:10501965).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF140708 Genomic DNA Translation: AAF26668.1
AC166360 Genomic DNA No translation available.
CCDSiCCDS37438.1
RefSeqiNP_001013854.2, NM_001013832.2
UniGeneiMm.335670
Mm.390936

Genome annotation databases

EnsembliENSMUST00000091648; ENSMUSP00000089237; ENSMUSG00000071311
GeneIDi436440
KEGGimmu:436440
UCSCiuc008alx.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF140708 Genomic DNA Translation: AAF26668.1
AC166360 Genomic DNA No translation available.
CCDSiCCDS37438.1
RefSeqiNP_001013854.2, NM_001013832.2
UniGeneiMm.335670
Mm.390936

3D structure databases

ProteinModelPortaliF8VQN3
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000089237

Chemistry databases

GuidetoPHARMACOLOGYi98

Protein family/group databases

GPCRDBiSearch...

Proteomic databases

PaxDbiF8VQN3
PRIDEiF8VQN3

Protocols and materials databases

DNASUi436440
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000091648; ENSMUSP00000089237; ENSMUSG00000071311
GeneIDi436440
KEGGimmu:436440
UCSCiuc008alx.1 mouse

Organism-specific databases

CTDi436440
MGIiMGI:1354372 Gpr31b

Phylogenomic databases

eggNOGiENOG410IE56 Eukaryota
ENOG410ZU85 LUCA
GeneTreeiENSGT00510000046798
HOGENOMiHOG000285939
HOVERGENiHBG100615
InParanoidiF8VQN3
KOiK08406
OMAiLKVWKPY
OrthoDBiEOG091G0G4Y
PhylomeDBiF8VQN3
TreeFamiTF337237

Enzyme and pathway databases

ReactomeiR-MMU-418594 G alpha (i) signalling events
R-MMU-444209 Free fatty acid receptors

Miscellaneous databases

PROiPR:F8VQN3
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000071311 Expressed in 14 organ(s), highest expression level in colon

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiGPR31_MOUSE
AccessioniPrimary (citable) accession number: F8VQN3
Secondary accession number(s): Q9JLS1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 25, 2012
Last sequence update: September 21, 2011
Last modified: November 7, 2018
This is version 46 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
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Main funding by: National Institutes of Health

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