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Entry version 68 (08 May 2019)
Sequence version 1 (21 Sep 2011)
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Protein
Submitted name:

Sucrase isomaltase (alpha-glucosidase)

Gene

Sis

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-MMU-189085 Digestion of dietary carbohydrate

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Sucrase isomaltase (alpha-glucosidase)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SisImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:1917233 Sis

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei12 – 32HelicalSequence analysisAdd BLAST21

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Membrane

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000027790 Expressed in 11 organ(s), highest expression level in colon

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000129116

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini51 – 100P-typeInterPro annotationAdd BLAST50
Domaini922 – 969P-typeInterPro annotationAdd BLAST48

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1065 Eukaryota
COG1501 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000161633

KEGG Orthology (KO)

More...
KOi
K01203

Identification of Orthologs from Complete Genome Data

More...
OMAi
RYEVPHQ

Database of Orthologous Groups

More...
OrthoDBi
151244at2759

TreeFam database of animal gene trees

More...
TreeFami
TF314577

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00111 Trefoil, 2 hits

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.40.1180, 4 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR031727 Gal_mutarotase_N
IPR011013 Gal_mutarotase_sf_dom
IPR000322 Glyco_hydro_31
IPR030458 Glyco_hydro_31_AS
IPR030459 Glyco_hydro_31_CS
IPR025887 Glyco_hydro_31_N_dom
IPR013780 Glyco_hydro_b
IPR017853 Glycoside_hydrolase_SF
IPR017957 P_trefoil_CS
IPR000519 P_trefoil_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF13802 Gal_mutarotas_2, 1 hit
PF01055 Glyco_hydro_31, 2 hits
PF16863 NtCtMGAM_N, 2 hits
PF00088 Trefoil, 2 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00018 PD, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF51445 SSF51445, 2 hits
SSF74650 SSF74650, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00129 GLYCOSYL_HYDROL_F31_1, 2 hits
PS00707 GLYCOSYL_HYDROL_F31_2, 2 hits
PS00025 P_TREFOIL_1, 1 hit
PS51448 P_TREFOIL_2, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

F8VQM5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAKKKFSGLE ISLIVLFIIV TIIAIALVVV LATKVPAVEE VKSPTSTPSP
60 70 80 90 100
GRCPPEQGEP LNERINCIPE QHPTKAKCEE RGCCWRPWNN TIIPWCFFAD
110 120 130 140 150
NHGYTAASVT NDNSGLKATL SRIPSPTLFG EDIKSVLLTT QSQTRNRFRF
160 170 180 190 200
KLTDPNNKRY EVPHQFVKDG NGIPAADTLY DVKVSENPFS IKVIRKSNNK
210 220 230 240 250
VLFDTSIGPL VYSNQYLQIS TRLPSEYIYG FGEHIHKRFR HDLYWKTWPI
260 270 280 290 300
FTRDEIPGDN NHNLYGHQTF FMGIEDNSGK SYGVFLMNSN AMEVFIQPTP
310 320 330 340 350
IITYRVTGGV LDFYIFLGDT PEQVVQQYQE LIGRPAMPAY WNLGFQLSRW
360 370 380 390 400
NYVSLDKVKE VVRRNREAGI PYDAQVTDID YMEDKKDFTY DEVAFKGLPE
410 420 430 440 450
FAQDLHNHGQ KYIIILDPAI SINKRANGAE YQTYVRGNEQ NVWVKESDGT
460 470 480 490 500
TSLIGEVWPG LTVYPDFTNP RTWEWWANEC NLFHQQVEYD GLWIDMNEVS
510 520 530 540 550
SFIHGSQKGC APNLLNYPPF TPGILDKIMY SKTLCMDAVQ HWGNQYDVHS
560 570 580 590 600
LYGYSMAIAT EKAVEKVFPN KRSFILTRST FAGSGHHAAH WLGDNTASWE
610 620 630 640 650
QMEWSITGML EFGMFGMPLV GADICGFLAN TTEELCRRWM QLGAFYPFSR
660 670 680 690 700
NHNAEGYAEQ DPAFWGADSL LVNTSRHYLT IRYTLLPFLY TLFYRAHAFG
710 720 730 740 750
ETVARPFLHE FYEDPNSWIE DTQFLWGPAL LITPVLRPET KYVSAYIPDA
760 770 780 790 800
TWYDYETGEK RPWRKQRVDM YLPEDKIGLH LRGGYIIPTQ QPDVTTTASR
810 820 830 840 850
KNPLGLIVAL DENQAAKGEL FWDDGESKDT IEKKIYILYE FSVSNNNLIV
860 870 880 890 900
NCTHSSYPEG NTLVFKTIKV LGLSATVTAV TVGENDQQMN PHLAFTFDAF
910 920 930 940 950
NKILSITDLT FNLGKTFIVR WTTQSFSDNE KFTCYPDVGT ATEKTCVERG
960 970 980 990 1000
CIWEPVSGLA NVPPCYFPSN HNPYLLTSTQ KLATGITAEL QLNPASARIK
1010 1020 1030 1040 1050
LPSNPISTLR VEVKYHKNDM LQFKIYDAHH KRYEVPVPLN IPDTPTSSEE
1060 1070 1080 1090 1100
NRLYDVEIKE NPFGIQVRRR STGKLIWDSC LPGFAFNDQF IQISTRLPSQ
1110 1120 1130 1140 1150
YLYGFGEAEH TAFKRNLNWH TWGMFTRDQP PGYKLNSYGF HPYYMALEDE
1160 1170 1180 1190 1200
GNAHGVLLQN SNGMDVTFQP TPALTYRTIG GILDFYMFLG PTPEGATKQY
1210 1220 1230 1240 1250
HEVIGFPVMP PYWALGFQLC RYGYRNTSEI EQLYNDMKAA QIPYDVQYTD
1260 1270 1280 1290 1300
INYMERQLDF TIGERFKTLP QFVEKIRKEG MKYIVILDPA ISGNETQPYP
1310 1320 1330 1340 1350
AFERGIQKDV FVKWPNTNDI CWAKVWPDLP NITIDETITE DEAVNASRAH
1360 1370 1380 1390 1400
VAFPDFFRNS TSEWWTREIY DFYNEKMKFD GLWIDMNEPS SFVNGTVTNK
1410 1420 1430 1440 1450
CRNDTLNYPP YFPELTKRNE GLHFRTMCME TEHILSDGSS VLHYDVHNLY
1460 1470 1480 1490 1500
GWSQVKPTLD ALRNTTGLRG IVISRSTYPT AGRWGGHWLG DNYANWENLE
1510 1520 1530 1540 1550
KSLIGMLEFN LFGIPYVGAD ICGFFNDSEY HLCARWMQVG AFYPYSRNHN
1560 1570 1580 1590 1600
IQFTRRQDPV SWNETFAQMS KKVLEIRYTL LPYFYTQMHE AHIHGGTVIR
1610 1620 1630 1640 1650
PLMHEFFDDK ETWEIYKQFL WGPAFMVTPV IGPFQTAVNG YVPKARWFDY
1660 1670 1680 1690 1700
HTGEDIKVRG KLQTFSAPFD TINLHVRGGY ILPCQEPAQN TYYSRQKYMK
1710 1720 1730 1740 1750
LIVAADDNQT AKGTLFWDDG ESIDTYEKNQ YTLIEFNLNQ KNLTSTVLKD
1760 1770 1780 1790 1800
GYRNKSEMKL GSIYVWGKGT TSISQVNLTY GGNEQQLSFT QDEAKEILTI
1810
DLKNVTVTLD EPIQISWS
Length:1,818
Mass (Da):208,984
Last modified:September 21, 2011 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i2AEA9C6D08F12AE0
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AC102399 Genomic DNA No translation available.
AC164406 Genomic DNA No translation available.

NCBI Reference Sequences

More...
RefSeqi
NP_001074606.1, NM_001081137.1
XP_006502107.1, XM_006502044.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000094190; ENSMUSP00000091742; ENSMUSG00000027790
ENSMUST00000167334; ENSMUSP00000129116; ENSMUSG00000027790

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
69983

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:69983

UCSC genome browser

More...
UCSCi
uc008pmq.1 mouse

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC102399 Genomic DNA No translation available.
AC164406 Genomic DNA No translation available.
RefSeqiNP_001074606.1, NM_001081137.1
XP_006502107.1, XM_006502044.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000129116

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000094190; ENSMUSP00000091742; ENSMUSG00000027790
ENSMUST00000167334; ENSMUSP00000129116; ENSMUSG00000027790
GeneIDi69983
KEGGimmu:69983
UCSCiuc008pmq.1 mouse

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
69983
MGIiMGI:1917233 Sis

Phylogenomic databases

eggNOGiKOG1065 Eukaryota
COG1501 LUCA
GeneTreeiENSGT00940000161633
KOiK01203
OMAiRYEVPHQ
OrthoDBi151244at2759
TreeFamiTF314577

Enzyme and pathway databases

ReactomeiR-MMU-189085 Digestion of dietary carbohydrate

Miscellaneous databases

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000027790 Expressed in 11 organ(s), highest expression level in colon

Family and domain databases

CDDicd00111 Trefoil, 2 hits
Gene3Di2.60.40.1180, 4 hits
InterProiView protein in InterPro
IPR031727 Gal_mutarotase_N
IPR011013 Gal_mutarotase_sf_dom
IPR000322 Glyco_hydro_31
IPR030458 Glyco_hydro_31_AS
IPR030459 Glyco_hydro_31_CS
IPR025887 Glyco_hydro_31_N_dom
IPR013780 Glyco_hydro_b
IPR017853 Glycoside_hydrolase_SF
IPR017957 P_trefoil_CS
IPR000519 P_trefoil_dom
PfamiView protein in Pfam
PF13802 Gal_mutarotas_2, 1 hit
PF01055 Glyco_hydro_31, 2 hits
PF16863 NtCtMGAM_N, 2 hits
PF00088 Trefoil, 2 hits
SMARTiView protein in SMART
SM00018 PD, 2 hits
SUPFAMiSSF51445 SSF51445, 2 hits
SSF74650 SSF74650, 2 hits
PROSITEiView protein in PROSITE
PS00129 GLYCOSYL_HYDROL_F31_1, 2 hits
PS00707 GLYCOSYL_HYDROL_F31_2, 2 hits
PS00025 P_TREFOIL_1, 1 hit
PS51448 P_TREFOIL_2, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiF8VQM5_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: F8VQM5
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: September 21, 2011
Last sequence update: September 21, 2011
Last modified: May 8, 2019
This is version 68 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
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