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Protein
Submitted name:

Acetylcholine receptor subunit gamma

Gene

Chrng

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

GO - Molecular functioni

Keywordsi

Molecular functionIon channel, Ligand-gated ion channelSAAS annotation, ReceptorSAAS annotation
Biological processIon transport, Transport

Enzyme and pathway databases

ReactomeiR-MMU-629587 Highly sodium permeable acetylcholine nicotinic receptors

Names & Taxonomyi

Protein namesi
Submitted name:
Acetylcholine receptor subunit gammaImported
Gene namesi
Name:ChrngImported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:87895 Chrng

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei242 – 264HelicalSequence analysisAdd BLAST23
Transmembranei276 – 296HelicalSequence analysisAdd BLAST21
Transmembranei308 – 331HelicalSequence analysisAdd BLAST24
Transmembranei477 – 499HelicalSequence analysisAdd BLAST23

Keywords - Cellular componenti

Cell junction, Cell membraneSAAS annotation, Membrane, Postsynaptic cell membraneSAAS annotation, Synapse

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22Sequence analysisAdd BLAST22
ChainiPRO_500337932123 – 519Sequence analysisAdd BLAST497

Keywords - PTMi

Disulfide bondSAAS annotation

Proteomic databases

PRIDEiF8VQK4

Expressioni

Gene expression databases

BgeeiENSMUSG00000026253 Expressed in 65 organ(s), highest expression level in masseter muscle
ExpressionAtlasiF8VQK4 baseline and differential
GenevisibleiF8VQK4 MM

Structurei

3D structure databases

ProteinModelPortaliF8VQK4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini26 – 241Neur_chan_LBDInterPro annotationAdd BLAST216
Domaini248 – 494Neur_chan_membInterPro annotationAdd BLAST247

Sequence similaritiesi

Belongs to the ligand-gated ion channel (TC 1.A.9) family. [View classification]UniRule annotationSAAS annotation

Keywords - Domaini

SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

eggNOGiKOG3645 Eukaryota
ENOG410XQGR LUCA
GeneTreeiENSGT00910000144023
KOiK04818
OMAiCNLIARA
OrthoDBiEOG091G0R20
TreeFamiTF315605

Family and domain databases

Gene3Di2.70.170.10, 1 hit
InterProiView protein in InterPro
IPR006202 Neur_chan_lig-bd
IPR036734 Neur_chan_lig-bd_sf
IPR006201 Neur_channel
IPR036719 Neuro-gated_channel_TM_sf
IPR006029 Neurotrans-gated_channel_TM
IPR018000 Neurotransmitter_ion_chnl_CS
IPR002394 Nicotinic_acetylcholine_rcpt
PANTHERiPTHR18945 PTHR18945, 1 hit
PfamiView protein in Pfam
PF02931 Neur_chan_LBD, 1 hit
PF02932 Neur_chan_memb, 1 hit
PRINTSiPR00254 NICOTINICR
PR00252 NRIONCHANNEL
SUPFAMiSSF63712 SSF63712, 1 hit
SSF90112 SSF90112, 1 hit
PROSITEiView protein in PROSITE
PS00236 NEUROTR_ION_CHANNEL, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All

F8VQK4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MQGGQRPQLL LLLLAVCLGA QSRNQEERLL ADLMRNYDPH LRPAERDSDV
60 70 80 90 100
VNVSLKLTLT NLISLNEREE ALTTNVWIEM QWCDYRLRWD PKDYEGLWIL
110 120 130 140 150
RVPSTMVWRP DIVLENNVDG VFEVALYCNV LVSPDGCIYW LPPAIFRSSC
160 170 180 190 200
SISVTYFPFD WQNCSLVFQS QTYSTSEINL QLSQEDGQAI EWIFIDPEAF
210 220 230 240 250
TENGEWAIRH RPAKMLLDSV APAEEAGHQK VVFYLLIQRK PLFYVINIIA
260 270 280 290 300
PCVLISSVAI LIYFLPAKAG GQKCTVATNV LLAQTVFLFL VAKKVPETSQ
310 320 330 340 350
AVPLISKYLT FLMVVTILIV VNSVVVLNVS LRSPHTHSMA RGVRKVFLRL
360 370 380 390 400
LPQLLRMHVR PLAPAAVQDA RFRLQNGSSS GWPIMAREEG DLCLPRSELL
410 420 430 440 450
FRQRQRNGLV QAVLEKLENG PEVRQSQEFC GSLKQASPAI QACVDACNLM
460 470 480 490 500
ARARRQQSHF DSGNEEWLLV GRVLDRVCFL AMLSLFICGT AGIFLMAHYN
510
QVPDLPFPGD PRPYLPLPD
Length:519
Mass (Da):58,708
Last modified:September 21, 2011 - v1
Checksum:i858407F30C347868
GO

Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
P04760ACHG_MOUSE
Acetylcholine receptor subunit gamm...
Chrng Acrg
519Annotation score:
I0B502I0B502_MOUSE
Acetylcholine receptor subunit gamm...
Chrng
220Annotation score:
H8YHW6H8YHW6_MOUSE
Acetylcholine receptor subunit gamm...
Chrng
146Annotation score:
A0A087WP27A0A087WP27_MOUSE
Acetylcholine receptor subunit gamm...
Chrng
255Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC102611 Genomic DNA No translation available.
RefSeqiNP_033734.3, NM_009604.3
UniGeneiMm.2810

Genome annotation databases

EnsembliENSMUST00000027470; ENSMUSP00000027470; ENSMUSG00000026253
GeneIDi11449
KEGGimmu:11449
UCSCiuc007bwh.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC102611 Genomic DNA No translation available.
RefSeqiNP_033734.3, NM_009604.3
UniGeneiMm.2810

3D structure databases

ProteinModelPortaliF8VQK4
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiF8VQK4

Protocols and materials databases

DNASUi11449
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000027470; ENSMUSP00000027470; ENSMUSG00000026253
GeneIDi11449
KEGGimmu:11449
UCSCiuc007bwh.1 mouse

Organism-specific databases

CTDi1146
MGIiMGI:87895 Chrng

Phylogenomic databases

eggNOGiKOG3645 Eukaryota
ENOG410XQGR LUCA
GeneTreeiENSGT00910000144023
KOiK04818
OMAiCNLIARA
OrthoDBiEOG091G0R20
TreeFamiTF315605

Enzyme and pathway databases

ReactomeiR-MMU-629587 Highly sodium permeable acetylcholine nicotinic receptors

Miscellaneous databases

SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000026253 Expressed in 65 organ(s), highest expression level in masseter muscle
ExpressionAtlasiF8VQK4 baseline and differential
GenevisibleiF8VQK4 MM

Family and domain databases

Gene3Di2.70.170.10, 1 hit
InterProiView protein in InterPro
IPR006202 Neur_chan_lig-bd
IPR036734 Neur_chan_lig-bd_sf
IPR006201 Neur_channel
IPR036719 Neuro-gated_channel_TM_sf
IPR006029 Neurotrans-gated_channel_TM
IPR018000 Neurotransmitter_ion_chnl_CS
IPR002394 Nicotinic_acetylcholine_rcpt
PANTHERiPTHR18945 PTHR18945, 1 hit
PfamiView protein in Pfam
PF02931 Neur_chan_LBD, 1 hit
PF02932 Neur_chan_memb, 1 hit
PRINTSiPR00254 NICOTINICR
PR00252 NRIONCHANNEL
SUPFAMiSSF63712 SSF63712, 1 hit
SSF90112 SSF90112, 1 hit
PROSITEiView protein in PROSITE
PS00236 NEUROTR_ION_CHANNEL, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiF8VQK4_MOUSE
AccessioniPrimary (citable) accession number: F8VQK4
Entry historyiIntegrated into UniProtKB/TrEMBL: September 21, 2011
Last sequence update: September 21, 2011
Last modified: November 7, 2018
This is version 58 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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