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Protein
Submitted name:

Guanylate cyclase 1, soluble, alpha 2

Gene

Gucy1a2

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

  • intracellular signal transduction Source: InterPro
  • positive regulation of nitric oxide mediated signal transduction Source: MGI

Keywordsi

Molecular functionLyaseUniRule annotationSAAS annotation
LigandNucleotide-bindingSAAS annotation

Names & Taxonomyi

Protein namesi
Submitted name:
Guanylate cyclase 1, soluble, alpha 2Imported
Gene namesi
Name:Gucy1a2Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:2660877 Gucy1a2

Subcellular locationi

PTM / Processingi

Proteomic databases

MaxQBiF8VQK3
PaxDbiF8VQK3
PeptideAtlasiF8VQK3
PRIDEiF8VQK3

PTM databases

iPTMnetiF8VQK3
PhosphoSitePlusiF8VQK3

Expressioni

Gene expression databases

BgeeiENSMUSG00000041624 Expressed in 23 organ(s), highest expression level in cerebral cortex
GenevisibleiF8VQK3 MM

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000111398

Structurei

3D structure databases

ProteinModelPortaliF8VQK3
SMRiF8VQK3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini519 – 646Guanylate cyclaseInterPro annotationAdd BLAST128

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili460 – 491Sequence analysisAdd BLAST32

Sequence similaritiesi

Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.UniRule annotationSAAS annotation

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

eggNOGiKOG4171 Eukaryota
COG2114 LUCA
GeneTreeiENSGT00760000118959
InParanoidiF8VQK3
KOiK12318
OMAiQNWPNIH
OrthoDBiEOG091G04KV
TreeFamiTF351403

Family and domain databases

Gene3Di3.30.70.1230, 1 hit
3.90.1520.10, 1 hit
InterProiView protein in InterPro
IPR001054 A/G_cyclase
IPR018297 A/G_cyclase_CS
IPR038158 H-NOX_domain_sf
IPR011644 Heme_NO-bd
IPR011645 HNOB_dom_associated
IPR024096 NO_sig/Golgi_transp_ligand-bd
IPR029787 Nucleotide_cyclase
PfamiView protein in Pfam
PF00211 Guanylate_cyc, 1 hit
PF07700 HNOB, 1 hit
PF07701 HNOBA, 1 hit
SMARTiView protein in SMART
SM00044 CYCc, 1 hit
SUPFAMiSSF111126 SSF111126, 1 hit
SSF55073 SSF55073, 1 hit
PROSITEiView protein in PROSITE
PS00452 GUANYLATE_CYCLASE_1, 1 hit
PS50125 GUANYLATE_CYCLASE_2, 1 hit

Sequencei

Sequence statusi: Complete.

F8VQK3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSRRKISSES FSSLSSDYLE TSPEEEGECP LSRLCWNGSR SPPGPPGSRE
60 70 80 90 100
AAKAATSAPA ASAAAASAAV AAEYKRAQRR GRVNLDSLGE SISLLTAPLP
110 120 130 140 150
QTIHMTLKRT LQYYEHQVIG YRDAEKNFHN ISKRCSYADH SNKEEIEDVS
160 170 180 190 200
GILQCTANVL GLQFQEIQER FGEEFFKICF DENERVLRAV GSTLQDFFNG
210 220 230 240 250
FDALLEHIRT SFGKQATLES SSFLCKELPE GTLMLHYFHP HHTVGFAMLG
260 270 280 290 300
MIKAAGKRIY HLNVEVEQIE NEKLCFDGSN PSNCSCLTFL IKECETTQIT
310 320 330 340 350
KDNPQGTSQV PADLRISINT FCRAFPFHLM FDSNMVVLQL GEGLRKQLRY
360 370 380 390 400
DTHRALKFED CFEIVSPMIN ATFDRVLLRL STPFVIRTKP EASGTENEDK
410 420 430 440 450
VMEIKGQMIH VPESSAILFL GSPCVDKLDE LMGRGLHLSD IPIHDATRDV
460 470 480 490 500
ILVGEQAKAQ DGLKKRMDKL KATLERTHQA LEEEKKKTVD LLYSIFPGDV
510 520 530 540 550
AQQLWQGQQV QARKFDDVTM LFSDIVGFTA ICAQCTPMQV ISMLNELYTR
560 570 580 590 600
FDHQCGLLDI YKVETIGDAY CVASGLHRKS LCHAKPIALM ALKMMELSEE
610 620 630 640 650
VLTPDGKAIQ MRIGIHSGSV LAGVVGVRMP RYCLFGNNVT LASKFESGSH
660 670 680 690 700
PRRINVSPTT YQLLKREDSF TFIPRSREEL PDNFPKEIPG VCYFLELRTD
710 720 730
PKPPKPSLSS SRIKKVSYNI GTMFLRETSL
Length:730
Mass (Da):81,831
Last modified:September 21, 2011 - v1
Checksum:iC3907834F882505C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC118473 Genomic DNA No translation available.
AC122444 Genomic DNA No translation available.
AC156642 Genomic DNA No translation available.
RefSeqiNP_001028494.1, NM_001033322.2
UniGeneiMm.91240

Genome annotation databases

EnsembliENSMUST00000115733; ENSMUSP00000111398; ENSMUSG00000041624
GeneIDi234889
KEGGimmu:234889
UCSCiuc009obc.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC118473 Genomic DNA No translation available.
AC122444 Genomic DNA No translation available.
AC156642 Genomic DNA No translation available.
RefSeqiNP_001028494.1, NM_001033322.2
UniGeneiMm.91240

3D structure databases

ProteinModelPortaliF8VQK3
SMRiF8VQK3
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000111398

PTM databases

iPTMnetiF8VQK3
PhosphoSitePlusiF8VQK3

Proteomic databases

MaxQBiF8VQK3
PaxDbiF8VQK3
PeptideAtlasiF8VQK3
PRIDEiF8VQK3

Protocols and materials databases

DNASUi234889
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000115733; ENSMUSP00000111398; ENSMUSG00000041624
GeneIDi234889
KEGGimmu:234889
UCSCiuc009obc.2 mouse

Organism-specific databases

CTDi2977
MGIiMGI:2660877 Gucy1a2

Phylogenomic databases

eggNOGiKOG4171 Eukaryota
COG2114 LUCA
GeneTreeiENSGT00760000118959
InParanoidiF8VQK3
KOiK12318
OMAiQNWPNIH
OrthoDBiEOG091G04KV
TreeFamiTF351403

Miscellaneous databases

SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000041624 Expressed in 23 organ(s), highest expression level in cerebral cortex
GenevisibleiF8VQK3 MM

Family and domain databases

Gene3Di3.30.70.1230, 1 hit
3.90.1520.10, 1 hit
InterProiView protein in InterPro
IPR001054 A/G_cyclase
IPR018297 A/G_cyclase_CS
IPR038158 H-NOX_domain_sf
IPR011644 Heme_NO-bd
IPR011645 HNOB_dom_associated
IPR024096 NO_sig/Golgi_transp_ligand-bd
IPR029787 Nucleotide_cyclase
PfamiView protein in Pfam
PF00211 Guanylate_cyc, 1 hit
PF07700 HNOB, 1 hit
PF07701 HNOBA, 1 hit
SMARTiView protein in SMART
SM00044 CYCc, 1 hit
SUPFAMiSSF111126 SSF111126, 1 hit
SSF55073 SSF55073, 1 hit
PROSITEiView protein in PROSITE
PS00452 GUANYLATE_CYCLASE_1, 1 hit
PS50125 GUANYLATE_CYCLASE_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiF8VQK3_MOUSE
AccessioniPrimary (citable) accession number: F8VQK3
Entry historyiIntegrated into UniProtKB/TrEMBL: September 21, 2011
Last sequence update: September 21, 2011
Last modified: November 7, 2018
This is version 60 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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