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Protein
Submitted name:

Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 3

Gene

Agap3

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Submitted name:
Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 3Imported
Gene namesi
Name:Agap3Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:2183446 Agap3

Subcellular locationi

PTM / Processingi

Proteomic databases

MaxQBiF8VQE9
PeptideAtlasiF8VQE9
PRIDEiF8VQE9

Expressioni

Gene expression databases

BgeeiENSMUSG00000023353 Expressed in 274 organ(s), highest expression level in cerebellum
ExpressionAtlasiF8VQE9 baseline and differential
GenevisibleiF8VQE9 MM

Structurei

3D structure databases

ProteinModelPortaliF8VQE9
SMRiF8VQE9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini402 – 640PHInterPro annotationAdd BLAST239
Domaini661 – 781Arf-GAPInterPro annotationAdd BLAST121
Domaini788 – 877ANK_REP_REGIONInterPro annotationAdd BLAST90
Repeati820 – 852ANKPROSITE-ProRule annotationAdd BLAST33

Keywords - Domaini

ANK repeatPROSITE-ProRule annotation, Zinc-fingerPROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0705 Eukaryota
COG5347 LUCA
GeneTreeiENSGT00760000118874
OMAiCSGTHRH
OrthoDBiEOG091G123A
TreeFamiTF317762

Family and domain databases

CDDicd00204 ANK, 1 hit
Gene3Di1.25.40.20, 1 hit
2.30.29.30, 2 hits
3.30.40.160, 1 hit
InterProiView protein in InterPro
IPR002110 Ankyrin_rpt
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf
IPR037278 ARFGAP/RecO
IPR001164 ArfGAP_dom
IPR038508 ArfGAP_dom_sf
IPR027417 P-loop_NTPase
IPR011993 PH-like_dom_sf
IPR001849 PH_domain
IPR001806 Small_GTPase
IPR020849 Small_GTPase_Ras-type
PfamiView protein in Pfam
PF12796 Ank_2, 1 hit
PF01412 ArfGap, 1 hit
PF00071 Ras, 1 hit
PRINTSiPR00405 REVINTRACTNG
SMARTiView protein in SMART
SM00105 ArfGap, 1 hit
SM00233 PH, 1 hit
SUPFAMiSSF48403 SSF48403, 1 hit
SSF52540 SSF52540, 1 hit
SSF57863 SSF57863, 1 hit
PROSITEiView protein in PROSITE
PS50297 ANK_REP_REGION, 1 hit
PS50088 ANK_REPEAT, 1 hit
PS50115 ARFGAP, 1 hit
PS50003 PH_DOMAIN, 1 hit
PS51421 RAS, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All

F8VQE9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MNFQAGGGQS PQQQQSLAAP GTGGGGGGGA GGGGQFGGAG PGAGGGGPSQ
60 70 80 90 100
QLAGGPPQQF ALSNSAAIRA EIQRFESVHP NIYAIYDLIE RIEDLALQNQ
110 120 130 140 150
IREHVISIED SFVNSQEWTL SRSVPELKVG IVGNLSSGKS ALVHRYLTGT
160 170 180 190 200
YVQEESPEGG RFKKEIVVDG QSYLLLIRDE GGPPELQFAA WVDAVVFVFS
210 220 230 240 250
LEDEISFQTV YNYFLRLCSF RNASEVPMVL VGTQDAISAA NPRVIDDSRA
260 270 280 290 300
RKLSTDLKRC TYYETCATYG LNVERVFQDV AQKVVALRKK QQLAIGPCKS
310 320 330 340 350
LPNSPSHSAV SAASIPAVHI NQATNGGSSA FSDYSSSVPS TPSISQRELR
360 370 380 390 400
IETIAASSTP TPIRKQSKRR SNIFTSRKGA DLDREKKAAE CRVDSIGSGR
410 420 430 440 450
AIPIKQGILL KRSGKSLNKE WKKKYVTLCD NGLLTYHPSL HDYMQNIHGK
460 470 480 490 500
EIDLLRTTVK VPGKRLPRAT PTTAPGTSPR ANGLAMERSN TQLGGATGAP
510 520 530 540 550
HSASSTSLHS ERPHSSAWAG SRPGPEGLHQ RSCSVSSTDQ WSEAAALPAS
560 570 580 590 600
MQHPASGPAE SLSSSPKLEP PPSPHSNRKK HRGKKSTGTP RPDGPSSAAE
610 620 630 640 650
EAEESFEFVV VSLTGQTWHF EASTAEEREL WVQSVQAQIL ASLQGCRSAK
660 670 680 690 700
DKTRLGNQNT ALAVQAVRTV RGNSLCIDCE APNPDWASLN LGALMCIECS
710 720 730 740 750
GIHRHLGAHL SRVRSLDLDD WPPELLAVMT AMGNALANSV WEGALDGYSK
760 770 780 790 800
PGPEACREEK ERWIRAKYEQ KLFLAPLPSS DVPLGQQLLR AVVEDDLRLL
810 820 830 840 850
VMLLAHGSKE EVNETYGDGD GRTALHLSSA MANVVFTQLL IWYGVDVRSR
860 870 880 890 900
DARGLTPLAY ARRAGSQECA DILIQHGCPG EGCGLAPTPN REPANGTNPS
910
AELHRSPSIL
Length:910
Mass (Da):97,695
Last modified:September 21, 2011 - v1
Checksum:i9062E9155468DE5E
GO

Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q8VHH5AGAP3_MOUSE
Arf-GAP with GTPase, ANK repeat and...
Agap3 Centg3
910Annotation score:
A0A0G2JDW1A0A0G2JDW1_MOUSE
Arf-GAP with GTPase, ANK repeat and...
Agap3
578Annotation score:
A0A1D5RMG4A0A1D5RMG4_MOUSE
Arf-GAP with GTPase, ANK repeat and...
Agap3
396Annotation score:
A0A0G2JER6A0A0G2JER6_MOUSE
Arf-GAP with GTPase, ANK repeat and...
Agap3
445Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC120353 Genomic DNA No translation available.
RefSeqiNP_631892.2, NM_139153.2
UniGeneiMm.250703

Genome annotation databases

EnsembliENSMUST00000024123; ENSMUSP00000024123; ENSMUSG00000023353
GeneIDi213990
UCSCiuc008wrv.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC120353 Genomic DNA No translation available.
RefSeqiNP_631892.2, NM_139153.2
UniGeneiMm.250703

3D structure databases

ProteinModelPortaliF8VQE9
SMRiF8VQE9
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

MaxQBiF8VQE9
PeptideAtlasiF8VQE9
PRIDEiF8VQE9

Protocols and materials databases

DNASUi213990
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000024123; ENSMUSP00000024123; ENSMUSG00000023353
GeneIDi213990
UCSCiuc008wrv.1 mouse

Organism-specific databases

CTDi116988
MGIiMGI:2183446 Agap3

Phylogenomic databases

eggNOGiKOG0705 Eukaryota
COG5347 LUCA
GeneTreeiENSGT00760000118874
OMAiCSGTHRH
OrthoDBiEOG091G123A
TreeFamiTF317762

Miscellaneous databases

ChiTaRSiAgap3 mouse
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000023353 Expressed in 274 organ(s), highest expression level in cerebellum
ExpressionAtlasiF8VQE9 baseline and differential
GenevisibleiF8VQE9 MM

Family and domain databases

CDDicd00204 ANK, 1 hit
Gene3Di1.25.40.20, 1 hit
2.30.29.30, 2 hits
3.30.40.160, 1 hit
InterProiView protein in InterPro
IPR002110 Ankyrin_rpt
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf
IPR037278 ARFGAP/RecO
IPR001164 ArfGAP_dom
IPR038508 ArfGAP_dom_sf
IPR027417 P-loop_NTPase
IPR011993 PH-like_dom_sf
IPR001849 PH_domain
IPR001806 Small_GTPase
IPR020849 Small_GTPase_Ras-type
PfamiView protein in Pfam
PF12796 Ank_2, 1 hit
PF01412 ArfGap, 1 hit
PF00071 Ras, 1 hit
PRINTSiPR00405 REVINTRACTNG
SMARTiView protein in SMART
SM00105 ArfGap, 1 hit
SM00233 PH, 1 hit
SUPFAMiSSF48403 SSF48403, 1 hit
SSF52540 SSF52540, 1 hit
SSF57863 SSF57863, 1 hit
PROSITEiView protein in PROSITE
PS50297 ANK_REP_REGION, 1 hit
PS50088 ANK_REPEAT, 1 hit
PS50115 ARFGAP, 1 hit
PS50003 PH_DOMAIN, 1 hit
PS51421 RAS, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiF8VQE9_MOUSE
AccessioniPrimary (citable) accession number: F8VQE9
Entry historyiIntegrated into UniProtKB/TrEMBL: September 21, 2011
Last sequence update: September 21, 2011
Last modified: September 12, 2018
This is version 68 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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