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UniProtKB - F8VQB6 (MYO10_MOUSE)

Protein

Unconventional myosin-X

Gene

Myo10

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. MYO10 binds to actin filaments and actin bundles and functions as plus end-directed motor. The tail domain binds to membranous compartments containing phosphatidylinositol 3,4,5-trisphosphate or integrins, and mediates cargo transport along actin filaments (By similarity). Regulates cell shape, cell spreading and cell adhesion. Stimulates the formation and elongation of filopodia. May play a role in neurite outgrowth and axon guidance. In hippocampal neurons it induces the formation of dendritic filopodia by trafficking the actin-remodeling protein VASP to the tips of filopodia, where it promotes actin elongation. Plays a role in formation of the podosome belt in osteoclasts.By similarity2 Publications
Isoform Headless: Functions as a dominant-negative regulator of isoform 1, suppressing its filopodia-inducing and axon outgrowth-promoting activities. In hippocampal neurons, it increases VASP retention in spine heads to induce spine formation and spine head expansion.

Caution

Represents an unconventional myosin. This protein should not be confused with the conventional myosin-10 (MYH10).Curated
Originally predicted to contain a coiled coil domain but shown to contain a stable SAH domain instead.Curated

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi157 – 164ATPPROSITE-ProRule annotation8

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

View the complete GO annotation on QuickGO ...

GO - Biological processi

  • cell motility Source: MGI
  • cytoskeleton-dependent intracellular transport Source: UniProtKB
  • positive regulation of cell-cell adhesion Source: MGI
  • regulation of cell shape Source: UniProtKB
  • regulation of filopodium assembly Source: UniProtKB
View the complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActin-binding, Calmodulin-binding, Motor protein, Myosin
Biological processTransport
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-MMU-2029482 Regulation of actin dynamics for phagocytic cup formation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Unconventional myosin-X
Alternative name(s):
Unconventional myosin-10
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Myo10
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 15

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...MGIi		MGI:107716 Myo10

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Cell projection, Cytoplasm, Cytoskeleton, Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004162441 – 2062Unconventional myosin-XAdd BLAST2062

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1N-acetylmethionineBy similarity1
Modified residuei961PhosphoserineBy similarity1
Modified residuei964PhosphoserineBy similarity1
Modified residuei967PhosphoserineBy similarity1
Modified residuei1162PhosphothreonineBy similarity1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

The initiator methionine for isoform Headless is removed.

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		F8VQB6

MaxQB - The MaxQuant DataBase

More...MaxQBi		F8VQB6

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		F8VQB6

PeptideAtlas

More...PeptideAtlasi		F8VQB6

PRoteomics IDEntifications database

More...PRIDEi		F8VQB6

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		F8VQB6

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		F8VQB6

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Detected in brain, heart, kidney, liver, stomach, skeletal muscle, lung, testis and skin. Isoform Headless is expressed in embryonic and neuronal stem cells, and enriched in proliferating and migrating cells.2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSMUSG00000022272 Expressed in 311 organ(s), highest expression level in cumulus cell

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		F8VQB6 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		F8VQB6 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Monomer, when in an inactive confomation in the cytosol. Homodimer in its active, membrane-bound conformation; antiparallel coiled coil-mediated dimer formation. Interacts with ECPAS. Interacts with DCC and ITGB5; the presence of DCC inhibits ITGB5 binding. Interacts with tubulin; ITGB5 or DCC binding inhibits tubulin binding. Interacts strongly with CALM3 and weakly with CALM, the CALM3 interaction is essential for function in filopodial extension and motility. Interacts with ITGB1, ITGB3 and ITGB5 (By similarity). Interacts with NEO1. Interacts with VASP.By similarity2 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
Neo1P977983EBI-6445959,EBI-774991

GO - Molecular functioni

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...BioGridi		201661, 1 interactor

Protein interaction database and analysis system

More...IntActi		F8VQB6, 4 interactors

STRING: functional protein association networks

More...STRINGi		10090.ENSMUSP00000106087

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...ProteinModelPortali		F8VQB6

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		F8VQB6

Database of comparative protein structure models

More...ModBasei		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini63 – 739Myosin motorPROSITE-ProRule annotationAdd BLAST677
Domaini742 – 771IQ 1PROSITE-ProRule annotationAdd BLAST30
Domaini765 – 794IQ 2PROSITE-ProRule annotationAdd BLAST30
Domaini788 – 817IQ 3PROSITE-ProRule annotationAdd BLAST30
Domaini1216 – 1314PH 1PROSITE-ProRule annotationAdd BLAST99
Domaini1396 – 1501PH 2PROSITE-ProRule annotationAdd BLAST106
Domaini1551 – 1699MyTH4PROSITE-ProRule annotationAdd BLAST149
Domaini1704 – 2048FERMPROSITE-ProRule annotationAdd BLAST345

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni619 – 641Actin-bindingPROSITE-ProRule annotationAdd BLAST23
Regioni815 – 907SAHBy similarity1 PublicationAdd BLAST93
Regioni882 – 932Mediates antiparallel dimerizationBy similarityAdd BLAST51

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

Interaction between the motor domain and the tail leads to an inactive, monomeric conformation. Phospholipid binding via the PH domains leads to the formation of the active, dimeric form of the protein and strongly increases actin-dependent ATPase activity and motor activity (By similarity).By similarity
Interacts with membranes containing phosphatidylinositol-3,4,5-trisphosphate via the PH domains.By similarity
IQ 3 domain mediates high-affinity calcium-dependent binding to CALM3/CLP.By similarity
The SAH (single alpha-helix) region is characterized by a high content of charged residues which are predicted to stabilize the alpha-helical structure by ionic bonds. It can refold after extension suggesting an in vivo force-dependent function. The isolated SAH domain is monomeric; however, in its distal part seems to form a semirigid helical structure which overlaps with a region shown to mediate antiparallel coiled coil-mediated dimerization.Curated

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG4229 Eukaryota
COG5022 LUCA

Ensembl GeneTree

More...GeneTreei		ENSGT00940000155469

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		HOG000007044

The HOVERGEN Database of Homologous Vertebrate Genes

More...HOVERGENi		HBG052553

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		F8VQB6

KEGG Orthology (KO)

More...KOi		K12559

Database of Orthologous Groups

More...OrthoDBi		EOG091G006V

TreeFam database of animal gene trees

More...TreeFami		TF316834

Family and domain databases

Conserved Domains Database

More...CDDi		cd14473 FERM_B-lobe, 1 hit
cd14873 MYSc_Myo10, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.20.80.10, 1 hit
1.25.40.530, 1 hit
2.30.29.30, 4 hits
3.40.850.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR019749 Band_41_domain
IPR014352 FERM/acyl-CoA-bd_prot_sf
IPR035963 FERM_2
IPR019748 FERM_central
IPR000299 FERM_domain
IPR000048 IQ_motif_EF-hand-BS
IPR036961 Kinesin_motor_dom_sf
IPR031971 MYO10_CC
IPR001609 Myosin_head_motor_dom
IPR036124 MYSc_Myo10
IPR000857 MyTH4_dom
IPR038185 MyTH4_dom_sf
IPR027417 P-loop_NTPase
IPR011993 PH-like_dom_sf
IPR001849 PH_domain

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00373 FERM_M, 1 hit
PF00612 IQ, 3 hits
PF16735 MYO10_CC, 1 hit
PF00063 Myosin_head, 1 hit
PF00784 MyTH4, 1 hit
PF00169 PH, 2 hits

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR00193 MYOSINHEAVY

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00295 B41, 1 hit
SM00015 IQ, 3 hits
SM00242 MYSc, 1 hit
SM00139 MyTH4, 1 hit
SM00233 PH, 2 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF47031 SSF47031, 1 hit
SSF52540 SSF52540, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50057 FERM_3, 1 hit
PS50096 IQ, 3 hits
PS51456 MYOSIN_MOTOR, 1 hit
PS51016 MYTH4, 1 hit
PS50003 PH_DOMAIN, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative promoter usage. AlignAdd to basket

This entry has 2 described isoforms and 8 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: F8VQB6-1) [UniParc]FASTAAdd to basket
Also known as: 240kDa, FL-myo10

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MDSFFPEGAR VWLRENGQHF PSTVNSCAEG VVVFQTDYGQ VFTYKQSTIT 
        60         70         80         90        100
NQKVTAMHPL HEEGVDDMAS LAELHGGSIM YNLFQRYKRN QIYTYIGSII 
       110        120        130        140        150
ASVNPYQPIA GLYERATMEE YSRCHLGELP PHIFAIANEC YRCLWKRHDN 
       160        170        180        190        200
QCVLISGESG AGKTESTKLI LKFLSVISQQ TLDLGLQEKT SSVEQAILQS 
       210        220        230        240        250
SPIMEAFGNA KTVYNNNSSR FGKFVQLNIC QQGNIQGGRI VDYLLEKNRV 
       260        270        280        290        300
VRQNPGERNY HIFYALLAGL DQGEREEFYL SLPENYHYLN QSGCTEDKTI 
       310        320        330        340        350
SDQESFRQVI TAMEVMQFSK EEVREVLRLL AGILHLGNIE FITAGGAQIP 
       360        370        380        390        400
FKTALGRSAD LLGLDPTQLT DALTQRSMIL RGEEILTPLS VQQAVDSRDS 
       410        420        430        440        450
LAMALYARCF EWVIKKINSR IKGKDDFKSI GILDIFGFEN FEVNHFEQFN 
       460        470        480        490        500
INYANEKLQE YFNKHIFSLE QLEYSREGLV WEDIDWIDNG ECLDLIEKKL 
       510        520        530        540        550
GLLALINEES HFPQATDSTL LEKLHSQHAN NHFYVKPRVA VNNFGVKHYA 
       560        570        580        590        600
GEVQYDVRGI LEKNRDTFRD DLLNLLRESR FDFIYDLFEH VSSRNNQDTL 
       610        620        630        640        650
KCGSKHRRPT VSSQFKDSLH SLMATLSSSN PFFVRCIKPN TQKMPDQFDQ 
       660        670        680        690        700
VVVLNQLRYS GMLETVRIRK AGYAVRRPFQ DFYKRYKVLM RNLALPDDIR 
       710        720        730        740        750
GKCTVLLQVY DASNSEWQLG KTKVFLRESL EQKLEKRREE EIDRAAMVIR 
       760        770        780        790        800
AHILGYLARK QYRKVLCGVV TIQKNYRAFL ARKKFLHLKK AAIVFQKQLR 
       810        820        830        840        850
GQLARRVYRQ LLAEKRELEE KKRREEEKKR EEEERERERA QREADLLRAH 
       860        870        880        890        900
QEAETRRQQE LEALQKSQRE ADLTRELEKQ RENKQVEEIL RLEKEIEDLQ 
       910        920        930        940        950
RMKERQELSL TEASLQKLQQ LRDEELRRLE DEACRAAQEF LESLNFDEID 
       960        970        980        990       1000
ECVRNIERSL SVGSEISGEE LSELAESASG EKPNFNFSQP YPAEEEVDEG 
      1010       1020       1030       1040       1050
FEADDDAFKD SPNPSEHGHS DQRTSGIRTS DDSSEEDPYM NYTVVPTSPS 
      1060       1070       1080       1090       1100
ADSTVLLAAS MQDSASLHNS SSGESTYCMP QNNGDLPSPD GDYDYDQDDY 
      1110       1120       1130       1140       1150
EDGAITSGSS VTFSNSYGSQ WSPDYRYSVG TYNSSGAYRF SSEGAQSSFE 
      1160       1170       1180       1190       1200
DSEEDFDSRF DTDDELSYRR DSVYSCVTLP YFHSFLYMKG GLMNSWKRRW 
      1210       1220       1230       1240       1250
CVLKDETFLW FRSKQEALKQ GWLHKKGGGS STLSRRNWKK RWFVLRQSKL 
      1260       1270       1280       1290       1300
MYFENDSEEK LKGTVEVRTA KEIIDNTSKE NGIDIILADR TFHLIAESPE 
      1310       1320       1330       1340       1350
DASQWFSVLS QVHSSTDQEI REMHDEQANP QNAVGTLDVG LIDSVCASDS 
      1360       1370       1380       1390       1400
PDRPNSFVII TANRVLHCNA DTPEEMHHWI TLLQRSKGDT RVEGQEFIVR 
      1410       1420       1430       1440       1450
GWLHKEVKNS PKMSSLKLKK RWFVLTHNSL DYYKSSEKNA LKLGTLVLNS 
      1460       1470       1480       1490       1500
LCSVVPPDEK IFKETGYWNV TVYGRKHCYR LYTKLLNEAT RWSSAIQNVT 
      1510       1520       1530       1540       1550
DTKAPIDTPT QQLIQDIKEN CLNSDVVEQI YKRNPILRYT HHPLHSPLLP 
      1560       1570       1580       1590       1600
LPYGDINLNL LKDKGYTTLQ DEAIKIFNSL QQLESMSDPI PIIQGILQTG 
      1610       1620       1630       1640       1650
HDLRPLRDEL YCQLIKQTNK VPHPGSVGNL YSWQILTCLS CTFLPSRGIL 
      1660       1670       1680       1690       1700
KYLKFHLKRI REQFPGTEME KYALFIYESL KKTKCREFVP SRDEIEALIH 
      1710       1720       1730       1740       1750
RQEMTSTVYC HGGGSCKITI NSHTTAGEVV EKLIRGLAME DSRNMFALFE 
      1760       1770       1780       1790       1800
YNGQVDKAIE SRTIVADVLA KFEKLAATSE AGDAPWKFYF KLYCFLDTDS 
      1810       1820       1830       1840       1850
MPKDSVEFAF MFEQAHEAVI HGHHPAPEES LQVLAALRLQ YLQGDYTPHT 
      1860       1870       1880       1890       1900
SIPPLEEVYS VQRLRARISQ STKTFTPYER LEKRRTSFLE GTLRRSFRTG 
      1910       1920       1930       1940       1950
SVVRQKAEEE QMLDMWIKEE VCSARTSIID KWKKLQGMNQ EQAMAKYMAL 
      1960       1970       1980       1990       2000
IKEWPGYGST LFDVECKEGG FPQELWLGVS ADAVSVYKRG EGKPLEVFQY 
      2010       2020       2030       2040       2050
EHILSFGAPL ANTYKIVVDE RELLFETSEV VDVAKLMKAY ISMIVKKRYS 
      2060 
TTRSVSSQGS SR
Length:2,062
Mass (Da):237,323
Last modified:September 21, 2011 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iFD685BEE8B88DE30
GO
Isoform Headless (identifier: F8VQB6-2) [UniParc]FASTAAdd to basket
Also known as: 165kDa, Hdl-myo10

The sequence of this isoform differs from the canonical sequence as follows:
     1-643: Missing.

Note: Produced by alternative promoter usage.
Show »
Length:1,419
Mass (Da):163,803
Checksum:iA4213D2D117A6DFA
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 8 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F6UVU0F6UVU0_MOUSE
Unconventional myosin-X
Myo10
242Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D3YXW4D3YXW4_MOUSE
Unconventional myosin-X
Myo10
237Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D3YZ13D3YZ13_MOUSE
Unconventional myosin-X
Myo10
179Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D3YXU7D3YXU7_MOUSE
Unconventional myosin-X
Myo10
786Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D3Z2E0D3Z2E0_MOUSE
Unconventional myosin-X
Myo10
51Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D3Z2P4D3Z2P4_MOUSE
Unconventional myosin-X
Myo10
25Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9Q5G1E9Q5G1_MOUSE
Unconventional myosin-X
Myo10
1,316Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D3Z0V4D3Z0V4_MOUSE
Unconventional myosin-X
Myo10
104Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti77 – 78GS → VA in CAB56466 (PubMed:10799329).Curated2
Sequence conflicti253 – 254QN → RI in CAB56466 (PubMed:10799329).Curated2
Sequence conflicti273G → E in CAB56466 (PubMed:10799329).Curated1
Sequence conflicti501G → R in CAB56466 (PubMed:10799329).Curated1
Sequence conflicti870E → A in CAB56466 (PubMed:10799329).Curated1
Sequence conflicti984N → S in CAB56466 (PubMed:10799329).Curated1
Sequence conflicti993A → E in CAB56466 (PubMed:10799329).Curated1
Sequence conflicti1032D → E in CAB56466 (PubMed:10799329).Curated1
Sequence conflicti1042Y → D in CAB56466 (PubMed:10799329).Curated1
Sequence conflicti1083N → P in CAB56466 (PubMed:10799329).Curated1
Sequence conflicti1371D → Y in CAB56466 (PubMed:10799329).Curated1
Sequence conflicti1602D → H in CAB56466 (PubMed:10799329).Curated1
Sequence conflicti1647R → L in CAB56466 (PubMed:10799329).Curated1
Sequence conflicti1805S → G in CAB56466 (PubMed:10799329).Curated1
Sequence conflicti1939N → T in CAB56466 (PubMed:10799329).Curated1
Sequence conflicti1982D → E in CAB56466 (PubMed:10799329).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0549781 – 643Missing in isoform Headless. CuratedAdd BLAST643

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AJ249706 mRNA Translation: CAB56466.2
AC115746 Genomic DNA No translation available.
AC131178 Genomic DNA No translation available.
BC024692 mRNA Translation: AAH24692.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS37049.1 [F8VQB6-1]

Protein sequence database of the Protein Information Resource

More...PIRi		A59297

NCBI Reference Sequences

More...RefSeqi		NP_062345.2, NM_019472.2 [F8VQB6-1]
XP_006520088.1, XM_006520025.3 [F8VQB6-2]

UniGene gene-oriented nucleotide sequence clusters

More...UniGenei		Mm.60590

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENSMUST00000110457; ENSMUSP00000106087; ENSMUSG00000022272 [F8VQB6-1]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		17909

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		mmu:17909

UCSC genome browser

More...UCSCi		uc007vjc.1 mouse [F8VQB6-1]

Keywords - Coding sequence diversityi

Alternative promoter usage

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ249706 mRNA Translation: CAB56466.2
AC115746 Genomic DNA No translation available.
AC131178 Genomic DNA No translation available.
BC024692 mRNA Translation: AAH24692.1
CCDSiCCDS37049.1 [F8VQB6-1]
PIRiA59297
RefSeqiNP_062345.2, NM_019472.2 [F8VQB6-1]
XP_006520088.1, XM_006520025.3 [F8VQB6-2]
UniGeneiMm.60590

3D structure databases

ProteinModelPortaliF8VQB6
SMRiF8VQB6
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi201661, 1 interactor
IntActiF8VQB6, 4 interactors
STRINGi10090.ENSMUSP00000106087

PTM databases

iPTMnetiF8VQB6
PhosphoSitePlusiF8VQB6

Proteomic databases

EPDiF8VQB6
MaxQBiF8VQB6
PaxDbiF8VQB6
PeptideAtlasiF8VQB6
PRIDEiF8VQB6

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000110457; ENSMUSP00000106087; ENSMUSG00000022272 [F8VQB6-1]
GeneIDi17909
KEGGimmu:17909
UCSCiuc007vjc.1 mouse [F8VQB6-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		4651
MGIiMGI:107716 Myo10

Phylogenomic databases

eggNOGiKOG4229 Eukaryota
COG5022 LUCA
GeneTreeiENSGT00940000155469
HOGENOMiHOG000007044
HOVERGENiHBG052553
InParanoidiF8VQB6
KOiK12559
OrthoDBiEOG091G006V
TreeFamiTF316834

Enzyme and pathway databases

ReactomeiR-MMU-2029482 Regulation of actin dynamics for phagocytic cup formation

Miscellaneous databases

Protein Ontology

More...PROi		PR:F8VQB6

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSMUSG00000022272 Expressed in 311 organ(s), highest expression level in cumulus cell
ExpressionAtlasiF8VQB6 baseline and differential
GenevisibleiF8VQB6 MM

Family and domain databases

CDDicd14473 FERM_B-lobe, 1 hit
cd14873 MYSc_Myo10, 1 hit
Gene3Di1.20.80.10, 1 hit
1.25.40.530, 1 hit
2.30.29.30, 4 hits
3.40.850.10, 1 hit
InterProiView protein in InterPro
IPR019749 Band_41_domain
IPR014352 FERM/acyl-CoA-bd_prot_sf
IPR035963 FERM_2
IPR019748 FERM_central
IPR000299 FERM_domain
IPR000048 IQ_motif_EF-hand-BS
IPR036961 Kinesin_motor_dom_sf
IPR031971 MYO10_CC
IPR001609 Myosin_head_motor_dom
IPR036124 MYSc_Myo10
IPR000857 MyTH4_dom
IPR038185 MyTH4_dom_sf
IPR027417 P-loop_NTPase
IPR011993 PH-like_dom_sf
IPR001849 PH_domain
PfamiView protein in Pfam
PF00373 FERM_M, 1 hit
PF00612 IQ, 3 hits
PF16735 MYO10_CC, 1 hit
PF00063 Myosin_head, 1 hit
PF00784 MyTH4, 1 hit
PF00169 PH, 2 hits
PRINTSiPR00193 MYOSINHEAVY
SMARTiView protein in SMART
SM00295 B41, 1 hit
SM00015 IQ, 3 hits
SM00242 MYSc, 1 hit
SM00139 MyTH4, 1 hit
SM00233 PH, 2 hits
SUPFAMiSSF47031 SSF47031, 1 hit
SSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS50057 FERM_3, 1 hit
PS50096 IQ, 3 hits
PS51456 MYOSIN_MOTOR, 1 hit
PS51016 MYTH4, 1 hit
PS50003 PH_DOMAIN, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMYO10_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: F8VQB6
Secondary accession number(s): Q8R3S0, Q9JJY5
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 21, 2012
Last sequence update: September 21, 2011
Last modified: December 5, 2018
This is version 69 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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