UniProtKB - F8VQB6 (MYO10_MOUSE)
Unconventional myosin-X
Myo10
Functioni
Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. MYO10 binds to actin filaments and actin bundles and functions as a plus end-directed motor. Moves with higher velocity and takes larger steps on actin bundles than on single actin filaments (By similarity).
The tail domain binds to membranous compartments containing phosphatidylinositol 3,4,5-trisphosphate or integrins, and mediates cargo transport along actin filaments (By similarity).
Regulates cell shape, cell spreading and cell adhesion. Stimulates the formation and elongation of filopodia. In hippocampal neurons it induces the formation of dendritic filopodia by trafficking the actin-remodeling protein VASP to the tips of filopodia, where it promotes actin elongation. Plays a role in formation of the podosome belt in osteoclasts.
By similarity2 PublicationsFunctions as a dominant-negative regulator of isoform 1, suppressing its filopodia-inducing and axon outgrowth-promoting activities. In hippocampal neurons, it increases VASP retention in spine heads to induce spine formation and spine head expansion.
1 PublicationCaution
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 104 | ATPBy similarity | 1 | |
Binding sitei | 113 | ATPBy similarity | 1 | |
Binding sitei | 215 | ATPBy similarity | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 160 – 165 | ATPBy similarity | 6 |
GO - Molecular functioni
- actin filament binding Source: UniProtKB
- ATP binding Source: UniProtKB-KW
- calmodulin binding Source: UniProtKB-KW
- microfilament motor activity Source: UniProtKB
- phosphatidylinositol-3,4,5-trisphosphate binding Source: UniProtKB
- plus-end directed microfilament motor activity Source: UniProtKB
- spectrin binding Source: MGI
GO - Biological processi
- cell motility Source: MGI
- cytoskeleton-dependent intracellular transport Source: UniProtKB
- positive regulation of cell-cell adhesion Source: MGI
- regulation of cell shape Source: UniProtKB
- regulation of filopodium assembly Source: UniProtKB
Keywordsi
Molecular function | Actin-binding, Calmodulin-binding, Motor protein, Myosin |
Biological process | Transport |
Ligand | ATP-binding, Nucleotide-binding |
Enzyme and pathway databases
Reactomei | R-MMU-2029482, Regulation of actin dynamics for phagocytic cup formation |
Names & Taxonomyi
Protein namesi | Recommended name: Unconventional myosin-XAlternative name(s): Unconventional myosin-10 |
Gene namesi | Name:Myo10 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:107716, Myo10 |
VEuPathDBi | HostDB:ENSMUSG00000022272 |
Subcellular locationi
Cytoplasm and Cytosol
Plasma membrane
Cytoskeleton
Other locations
- lamellipodium By similarity
- ruffle By similarity
- filopodium tip
- cell cortex
Note: May be in an inactive, monomeric conformation in the cytosol. Detected in cytoplasmic punctae and in cell projections. Colocalizes with actin fibers. Interacts with microtubules. Undergoes forward and rearward movements within filopodia. Interaction with membranes containing phosphatidylinositol 3,4,5-trisphosphate mediates localization at filopodium membranes (By similarity).By similarity
Cytoskeleton
- myosin complex Source: UniProtKB-KW
Cytosol
- cytosol Source: MGI
Nucleus
- nucleolus Source: MGI
Plasma Membrane
- filopodium membrane Source: UniProtKB-SubCell
- plasma membrane Source: MGI
Other locations
- cell cortex Source: UniProtKB-SubCell
- filopodium Source: MGI
- filopodium tip Source: UniProtKB
- lamellipodium Source: MGI
- neuron projection Source: MGI
- neuronal cell body Source: MGI
- ruffle Source: MGI
Keywords - Cellular componenti
Cell membrane, Cell projection, Cytoplasm, Cytoskeleton, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000416244 | 1 – 2062 | Unconventional myosin-XAdd BLAST | 2062 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 1 | N-acetylmethionineBy similarity | 1 | |
Modified residuei | 961 | PhosphoserineBy similarity | 1 | |
Modified residuei | 964 | PhosphoserineBy similarity | 1 | |
Modified residuei | 967 | PhosphoserineBy similarity | 1 | |
Modified residuei | 1162 | PhosphothreonineBy similarity | 1 |
Post-translational modificationi
Keywords - PTMi
Acetylation, PhosphoproteinProteomic databases
EPDi | F8VQB6 |
jPOSTi | F8VQB6 |
MaxQBi | F8VQB6 |
PaxDbi | F8VQB6 |
PeptideAtlasi | F8VQB6 |
PRIDEi | F8VQB6 |
ProteomicsDBi | 293602 [F8VQB6-1] 293603 [F8VQB6-2] |
PTM databases
iPTMneti | F8VQB6 |
PhosphoSitePlusi | F8VQB6 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSMUSG00000022272, Expressed in cumulus cell and 331 other tissues |
ExpressionAtlasi | F8VQB6, baseline and differential |
Genevisiblei | F8VQB6, MM |
Interactioni
Subunit structurei
Monomer, when in an inactive conformation in the cytosol. Homodimer in its active, membrane-bound conformation; antiparallel coiled coil-mediated dimer formation.
Interacts with ECPAS.
Interacts with DCC and ITGB5; the presence of DCC inhibits ITGB5 binding.
Interacts with tubulin; ITGB5 or DCC binding inhibits tubulin binding.
Interacts strongly with CALM3 and weakly with CALM, the CALM3 interaction is essential for function in filopodial extension and motility.
Interacts with ITGB1, ITGB3 and ITGB5 (By similarity).
Interacts with NEO1.
Interacts with VASP.
By similarity2 PublicationsBinary interactionsi
F8VQB6
With | #Exp. | IntAct |
---|---|---|
Neo1 [P97798] | 3 | EBI-6445959,EBI-774991 |
GO - Molecular functioni
- actin filament binding Source: UniProtKB
- calmodulin binding Source: UniProtKB-KW
- spectrin binding Source: MGI
Protein-protein interaction databases
BioGRIDi | 201661, 4 interactors |
IntActi | F8VQB6, 4 interactors |
STRINGi | 10090.ENSMUSP00000106087 |
Miscellaneous databases
RNActi | F8VQB6, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 63 – 739 | Myosin motorPROSITE-ProRule annotationAdd BLAST | 677 | |
Domaini | 742 – 771 | IQ 1PROSITE-ProRule annotationAdd BLAST | 30 | |
Domaini | 765 – 794 | IQ 2PROSITE-ProRule annotationAdd BLAST | 30 | |
Domaini | 788 – 817 | IQ 3PROSITE-ProRule annotationAdd BLAST | 30 | |
Domaini | 1216 – 1314 | PH 1PROSITE-ProRule annotationAdd BLAST | 99 | |
Domaini | 1396 – 1501 | PH 2PROSITE-ProRule annotationAdd BLAST | 106 | |
Domaini | 1551 – 1699 | MyTH4PROSITE-ProRule annotationAdd BLAST | 149 | |
Domaini | 1704 – 2048 | FERMPROSITE-ProRule annotationAdd BLAST | 345 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 619 – 641 | Actin-bindingPROSITE-ProRule annotationAdd BLAST | 23 | |
Regioni | 814 – 882 | SAHBy similarityAdd BLAST | 69 | |
Regioni | 822 – 844 | DisorderedSequence analysisAdd BLAST | 23 | |
Regioni | 963 – 1047 | DisorderedSequence analysisAdd BLAST | 85 | |
Regioni | 1062 – 1089 | DisorderedSequence analysisAdd BLAST | 28 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 883 – 933 | By similarityAdd BLAST | 51 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 1006 – 1035 | Basic and acidic residuesSequence analysisAdd BLAST | 30 | |
Compositional biasi | 1062 – 1083 | Polar residuesSequence analysisAdd BLAST | 22 |
Domaini
Sequence similaritiesi
Keywords - Domaini
Coiled coil, RepeatPhylogenomic databases
eggNOGi | KOG4229, Eukaryota |
GeneTreei | ENSGT00940000155469 |
HOGENOMi | CLU_001626_1_0_1 |
InParanoidi | F8VQB6 |
OMAi | CFNWIIR |
PhylomeDBi | F8VQB6 |
TreeFami | TF316834 |
Family and domain databases
CDDi | cd14473, FERM_B-lobe, 1 hit cd13202, FERM_C_MyoX, 1 hit cd14873, MYSc_Myo10, 1 hit |
Gene3Di | 1.20.80.10, 1 hit 1.25.40.530, 1 hit 2.30.29.30, 4 hits 3.40.850.10, 1 hit |
InterProi | View protein in InterPro IPR019749, Band_41_domain IPR014352, FERM/acyl-CoA-bd_prot_sf IPR035963, FERM_2 IPR019748, FERM_central IPR000299, FERM_domain IPR000048, IQ_motif_EF-hand-BS IPR036961, Kinesin_motor_dom_sf IPR031971, MYO10_CC IPR001609, Myosin_head_motor_dom IPR041797, MyoX_FERM_C IPR040640, MyoX_N_SH3 IPR036124, MYSc_Myo10 IPR000857, MyTH4_dom IPR038185, MyTH4_dom_sf IPR027417, P-loop_NTPase IPR011993, PH-like_dom_sf IPR001849, PH_domain |
Pfami | View protein in Pfam PF00373, FERM_M, 1 hit PF00612, IQ, 3 hits PF16735, MYO10_CC, 1 hit PF00063, Myosin_head, 1 hit PF00784, MyTH4, 1 hit PF00169, PH, 2 hits PF18597, SH3_19, 1 hit |
PRINTSi | PR00193, MYOSINHEAVY |
SMARTi | View protein in SMART SM00295, B41, 1 hit SM00015, IQ, 3 hits SM00242, MYSc, 1 hit SM00139, MyTH4, 1 hit SM00233, PH, 2 hits |
SUPFAMi | SSF47031, SSF47031, 1 hit SSF52540, SSF52540, 1 hit |
PROSITEi | View protein in PROSITE PS50057, FERM_3, 1 hit PS50096, IQ, 3 hits PS51456, MYOSIN_MOTOR, 1 hit PS51016, MYTH4, 1 hit PS50003, PH_DOMAIN, 2 hits |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative promoter usage. AlignAdd to basketThis entry has 2 described isoforms and 8 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MDSFFPEGAR VWLRENGQHF PSTVNSCAEG VVVFQTDYGQ VFTYKQSTIT
60 70 80 90 100
NQKVTAMHPL HEEGVDDMAS LAELHGGSIM YNLFQRYKRN QIYTYIGSII
110 120 130 140 150
ASVNPYQPIA GLYERATMEE YSRCHLGELP PHIFAIANEC YRCLWKRHDN
160 170 180 190 200
QCVLISGESG AGKTESTKLI LKFLSVISQQ TLDLGLQEKT SSVEQAILQS
210 220 230 240 250
SPIMEAFGNA KTVYNNNSSR FGKFVQLNIC QQGNIQGGRI VDYLLEKNRV
260 270 280 290 300
VRQNPGERNY HIFYALLAGL DQGEREEFYL SLPENYHYLN QSGCTEDKTI
310 320 330 340 350
SDQESFRQVI TAMEVMQFSK EEVREVLRLL AGILHLGNIE FITAGGAQIP
360 370 380 390 400
FKTALGRSAD LLGLDPTQLT DALTQRSMIL RGEEILTPLS VQQAVDSRDS
410 420 430 440 450
LAMALYARCF EWVIKKINSR IKGKDDFKSI GILDIFGFEN FEVNHFEQFN
460 470 480 490 500
INYANEKLQE YFNKHIFSLE QLEYSREGLV WEDIDWIDNG ECLDLIEKKL
510 520 530 540 550
GLLALINEES HFPQATDSTL LEKLHSQHAN NHFYVKPRVA VNNFGVKHYA
560 570 580 590 600
GEVQYDVRGI LEKNRDTFRD DLLNLLRESR FDFIYDLFEH VSSRNNQDTL
610 620 630 640 650
KCGSKHRRPT VSSQFKDSLH SLMATLSSSN PFFVRCIKPN TQKMPDQFDQ
660 670 680 690 700
VVVLNQLRYS GMLETVRIRK AGYAVRRPFQ DFYKRYKVLM RNLALPDDIR
710 720 730 740 750
GKCTVLLQVY DASNSEWQLG KTKVFLRESL EQKLEKRREE EIDRAAMVIR
760 770 780 790 800
AHILGYLARK QYRKVLCGVV TIQKNYRAFL ARKKFLHLKK AAIVFQKQLR
810 820 830 840 850
GQLARRVYRQ LLAEKRELEE KKRREEEKKR EEEERERERA QREADLLRAH
860 870 880 890 900
QEAETRRQQE LEALQKSQRE ADLTRELEKQ RENKQVEEIL RLEKEIEDLQ
910 920 930 940 950
RMKERQELSL TEASLQKLQQ LRDEELRRLE DEACRAAQEF LESLNFDEID
960 970 980 990 1000
ECVRNIERSL SVGSEISGEE LSELAESASG EKPNFNFSQP YPAEEEVDEG
1010 1020 1030 1040 1050
FEADDDAFKD SPNPSEHGHS DQRTSGIRTS DDSSEEDPYM NYTVVPTSPS
1060 1070 1080 1090 1100
ADSTVLLAAS MQDSASLHNS SSGESTYCMP QNNGDLPSPD GDYDYDQDDY
1110 1120 1130 1140 1150
EDGAITSGSS VTFSNSYGSQ WSPDYRYSVG TYNSSGAYRF SSEGAQSSFE
1160 1170 1180 1190 1200
DSEEDFDSRF DTDDELSYRR DSVYSCVTLP YFHSFLYMKG GLMNSWKRRW
1210 1220 1230 1240 1250
CVLKDETFLW FRSKQEALKQ GWLHKKGGGS STLSRRNWKK RWFVLRQSKL
1260 1270 1280 1290 1300
MYFENDSEEK LKGTVEVRTA KEIIDNTSKE NGIDIILADR TFHLIAESPE
1310 1320 1330 1340 1350
DASQWFSVLS QVHSSTDQEI REMHDEQANP QNAVGTLDVG LIDSVCASDS
1360 1370 1380 1390 1400
PDRPNSFVII TANRVLHCNA DTPEEMHHWI TLLQRSKGDT RVEGQEFIVR
1410 1420 1430 1440 1450
GWLHKEVKNS PKMSSLKLKK RWFVLTHNSL DYYKSSEKNA LKLGTLVLNS
1460 1470 1480 1490 1500
LCSVVPPDEK IFKETGYWNV TVYGRKHCYR LYTKLLNEAT RWSSAIQNVT
1510 1520 1530 1540 1550
DTKAPIDTPT QQLIQDIKEN CLNSDVVEQI YKRNPILRYT HHPLHSPLLP
1560 1570 1580 1590 1600
LPYGDINLNL LKDKGYTTLQ DEAIKIFNSL QQLESMSDPI PIIQGILQTG
1610 1620 1630 1640 1650
HDLRPLRDEL YCQLIKQTNK VPHPGSVGNL YSWQILTCLS CTFLPSRGIL
1660 1670 1680 1690 1700
KYLKFHLKRI REQFPGTEME KYALFIYESL KKTKCREFVP SRDEIEALIH
1710 1720 1730 1740 1750
RQEMTSTVYC HGGGSCKITI NSHTTAGEVV EKLIRGLAME DSRNMFALFE
1760 1770 1780 1790 1800
YNGQVDKAIE SRTIVADVLA KFEKLAATSE AGDAPWKFYF KLYCFLDTDS
1810 1820 1830 1840 1850
MPKDSVEFAF MFEQAHEAVI HGHHPAPEES LQVLAALRLQ YLQGDYTPHT
1860 1870 1880 1890 1900
SIPPLEEVYS VQRLRARISQ STKTFTPYER LEKRRTSFLE GTLRRSFRTG
1910 1920 1930 1940 1950
SVVRQKAEEE QMLDMWIKEE VCSARTSIID KWKKLQGMNQ EQAMAKYMAL
1960 1970 1980 1990 2000
IKEWPGYGST LFDVECKEGG FPQELWLGVS ADAVSVYKRG EGKPLEVFQY
2010 2020 2030 2040 2050
EHILSFGAPL ANTYKIVVDE RELLFETSEV VDVAKLMKAY ISMIVKKRYS
2060
TTRSVSSQGS SR
The sequence of this isoform differs from the canonical sequence as follows:
1-643: Missing.
Computationally mapped potential isoform sequencesi
There are 8 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketD3YZ13 | D3YZ13_MOUSE | Unconventional myosin-X | Myo10 | 179 | Annotation score: | ||
D3YXU7 | D3YXU7_MOUSE | Unconventional myosin-X | Myo10 | 786 | Annotation score: | ||
D3YXW4 | D3YXW4_MOUSE | Unconventional myosin-X | Myo10 | 237 | Annotation score: | ||
F6UVU0 | F6UVU0_MOUSE | Unconventional myosin-X | Myo10 | 242 | Annotation score: | ||
D3Z2E0 | D3Z2E0_MOUSE | Unconventional myosin-X | Myo10 | 51 | Annotation score: | ||
D3Z2P4 | D3Z2P4_MOUSE | Unconventional myosin-X | Myo10 | 25 | Annotation score: | ||
E9Q5G1 | E9Q5G1_MOUSE | Unconventional myosin-X | Myo10 | 1,316 | Annotation score: | ||
D3Z0V4 | D3Z0V4_MOUSE | Unconventional myosin-X | Myo10 | 104 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 77 – 78 | GS → VA in CAB56466 (PubMed:10799329).Curated | 2 | |
Sequence conflicti | 253 – 254 | QN → RI in CAB56466 (PubMed:10799329).Curated | 2 | |
Sequence conflicti | 273 | G → E in CAB56466 (PubMed:10799329).Curated | 1 | |
Sequence conflicti | 501 | G → R in CAB56466 (PubMed:10799329).Curated | 1 | |
Sequence conflicti | 870 | E → A in CAB56466 (PubMed:10799329).Curated | 1 | |
Sequence conflicti | 984 | N → S in CAB56466 (PubMed:10799329).Curated | 1 | |
Sequence conflicti | 993 | A → E in CAB56466 (PubMed:10799329).Curated | 1 | |
Sequence conflicti | 1032 | D → E in CAB56466 (PubMed:10799329).Curated | 1 | |
Sequence conflicti | 1042 | Y → D in CAB56466 (PubMed:10799329).Curated | 1 | |
Sequence conflicti | 1083 | N → P in CAB56466 (PubMed:10799329).Curated | 1 | |
Sequence conflicti | 1371 | D → Y in CAB56466 (PubMed:10799329).Curated | 1 | |
Sequence conflicti | 1602 | D → H in CAB56466 (PubMed:10799329).Curated | 1 | |
Sequence conflicti | 1647 | R → L in CAB56466 (PubMed:10799329).Curated | 1 | |
Sequence conflicti | 1805 | S → G in CAB56466 (PubMed:10799329).Curated | 1 | |
Sequence conflicti | 1939 | N → T in CAB56466 (PubMed:10799329).Curated | 1 | |
Sequence conflicti | 1982 | D → E in CAB56466 (PubMed:10799329).Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_054978 | 1 – 643 | Missing in isoform Headless. CuratedAdd BLAST | 643 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AJ249706 mRNA Translation: CAB56466.2 AC115746 Genomic DNA No translation available. AC131178 Genomic DNA No translation available. BC024692 mRNA Translation: AAH24692.1 |
CCDSi | CCDS37049.1 [F8VQB6-1] |
PIRi | A59297 |
RefSeqi | NP_062345.2, NM_019472.2 [F8VQB6-1] XP_006520088.1, XM_006520025.3 [F8VQB6-2] |
Genome annotation databases
Ensembli | ENSMUST00000110457; ENSMUSP00000106087; ENSMUSG00000022272 [F8VQB6-1] |
GeneIDi | 17909 |
KEGGi | mmu:17909 |
UCSCi | uc007vjc.1, mouse [F8VQB6-1] |
Keywords - Coding sequence diversityi
Alternative promoter usageSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AJ249706 mRNA Translation: CAB56466.2 AC115746 Genomic DNA No translation available. AC131178 Genomic DNA No translation available. BC024692 mRNA Translation: AAH24692.1 |
CCDSi | CCDS37049.1 [F8VQB6-1] |
PIRi | A59297 |
RefSeqi | NP_062345.2, NM_019472.2 [F8VQB6-1] XP_006520088.1, XM_006520025.3 [F8VQB6-2] |
3D structure databases
SMRi | F8VQB6 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 201661, 4 interactors |
IntActi | F8VQB6, 4 interactors |
STRINGi | 10090.ENSMUSP00000106087 |
PTM databases
iPTMneti | F8VQB6 |
PhosphoSitePlusi | F8VQB6 |
Proteomic databases
EPDi | F8VQB6 |
jPOSTi | F8VQB6 |
MaxQBi | F8VQB6 |
PaxDbi | F8VQB6 |
PeptideAtlasi | F8VQB6 |
PRIDEi | F8VQB6 |
ProteomicsDBi | 293602 [F8VQB6-1] 293603 [F8VQB6-2] |
Protocols and materials databases
Antibodypediai | 4455, 127 antibodies from 24 providers |
DNASUi | 17909 |
Genome annotation databases
Ensembli | ENSMUST00000110457; ENSMUSP00000106087; ENSMUSG00000022272 [F8VQB6-1] |
GeneIDi | 17909 |
KEGGi | mmu:17909 |
UCSCi | uc007vjc.1, mouse [F8VQB6-1] |
Organism-specific databases
CTDi | 4651 |
MGIi | MGI:107716, Myo10 |
VEuPathDBi | HostDB:ENSMUSG00000022272 |
Phylogenomic databases
eggNOGi | KOG4229, Eukaryota |
GeneTreei | ENSGT00940000155469 |
HOGENOMi | CLU_001626_1_0_1 |
InParanoidi | F8VQB6 |
OMAi | CFNWIIR |
PhylomeDBi | F8VQB6 |
TreeFami | TF316834 |
Enzyme and pathway databases
Reactomei | R-MMU-2029482, Regulation of actin dynamics for phagocytic cup formation |
Miscellaneous databases
BioGRID-ORCSi | 17909, 2 hits in 65 CRISPR screens |
ChiTaRSi | Myo10, mouse |
PROi | PR:F8VQB6 |
RNActi | F8VQB6, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000022272, Expressed in cumulus cell and 331 other tissues |
ExpressionAtlasi | F8VQB6, baseline and differential |
Genevisiblei | F8VQB6, MM |
Family and domain databases
CDDi | cd14473, FERM_B-lobe, 1 hit cd13202, FERM_C_MyoX, 1 hit cd14873, MYSc_Myo10, 1 hit |
Gene3Di | 1.20.80.10, 1 hit 1.25.40.530, 1 hit 2.30.29.30, 4 hits 3.40.850.10, 1 hit |
InterProi | View protein in InterPro IPR019749, Band_41_domain IPR014352, FERM/acyl-CoA-bd_prot_sf IPR035963, FERM_2 IPR019748, FERM_central IPR000299, FERM_domain IPR000048, IQ_motif_EF-hand-BS IPR036961, Kinesin_motor_dom_sf IPR031971, MYO10_CC IPR001609, Myosin_head_motor_dom IPR041797, MyoX_FERM_C IPR040640, MyoX_N_SH3 IPR036124, MYSc_Myo10 IPR000857, MyTH4_dom IPR038185, MyTH4_dom_sf IPR027417, P-loop_NTPase IPR011993, PH-like_dom_sf IPR001849, PH_domain |
Pfami | View protein in Pfam PF00373, FERM_M, 1 hit PF00612, IQ, 3 hits PF16735, MYO10_CC, 1 hit PF00063, Myosin_head, 1 hit PF00784, MyTH4, 1 hit PF00169, PH, 2 hits PF18597, SH3_19, 1 hit |
PRINTSi | PR00193, MYOSINHEAVY |
SMARTi | View protein in SMART SM00295, B41, 1 hit SM00015, IQ, 3 hits SM00242, MYSc, 1 hit SM00139, MyTH4, 1 hit SM00233, PH, 2 hits |
SUPFAMi | SSF47031, SSF47031, 1 hit SSF52540, SSF52540, 1 hit |
PROSITEi | View protein in PROSITE PS50057, FERM_3, 1 hit PS50096, IQ, 3 hits PS51456, MYOSIN_MOTOR, 1 hit PS51016, MYTH4, 1 hit PS50003, PH_DOMAIN, 2 hits |
MobiDBi | Search... |
Entry informationi
Entry namei | MYO10_MOUSE | |
Accessioni | F8VQB6Primary (citable) accession number: F8VQB6 Secondary accession number(s): Q8R3S0, Q9JJY5 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | March 21, 2012 |
Last sequence update: | September 21, 2011 | |
Last modified: | February 23, 2022 | |
This is version 87 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Direct protein sequencing, Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families