Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein
Submitted name:

Mitogen-activated protein kinase kinase kinase 1

Gene

Map3k1

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-MMU-166058 MyD88:Mal cascade initiated on plasma membrane
R-MMU-2871796 FCERI mediated MAPK activation
R-MMU-975138 TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
R-MMU-975871 MyD88 cascade initiated on plasma membrane

Names & Taxonomyi

Protein namesi
Submitted name:
Mitogen-activated protein kinase kinase kinase 1Imported
Gene namesi
Name:Map3k1Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 13

Organism-specific databases

MGIiMGI:1346872 Map3k1

PTM / Processingi

Proteomic databases

MaxQBiF8VQ72
PeptideAtlasiF8VQ72
PRIDEiF8VQ72

Expressioni

Gene expression databases

BgeeiENSMUSG00000021754
ExpressionAtlasiF8VQ72 baseline and differential
GenevisibleiF8VQ72 MM

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

IntActiF8VQ72, 2 interactors

Structurei

3D structure databases

ProteinModelPortaliF8VQ72
SMRiF8VQ72
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini333 – 361SWIM-typeInterPro annotationAdd BLAST29
Domaini438 – 487RING-typeInterPro annotationAdd BLAST50
Domaini1224 – 1489Protein kinaseInterPro annotationAdd BLAST266

Keywords - Domaini

Zinc-fingerPROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG4279 Eukaryota
ENOG410XQGS LUCA
GeneTreeiENSGT00800000124036
KOiK04416
OMAiSTHFTRM
OrthoDBiEOG091G03WB
TreeFamiTF105112

Family and domain databases

Gene3Di1.25.10.10, 1 hit
3.30.40.10, 1 hit
InterProiView protein in InterPro
IPR011989 ARM-like
IPR016024 ARM-type_fold
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR008271 Ser/Thr_kinase_AS
IPR001841 Znf_RING
IPR013083 Znf_RING/FYVE/PHD
IPR007527 Znf_SWIM
PfamiView protein in Pfam
PF00069 Pkinase, 1 hit
PF04434 SWIM, 1 hit
SMARTiView protein in SMART
SM00220 S_TKc, 1 hit
SUPFAMiSSF48371 SSF48371, 1 hit
SSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit
PS50089 ZF_RING_2, 1 hit
PS50966 ZF_SWIM, 1 hit

Sequencei

Sequence statusi: Complete.

F8VQ72-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAAAGDRAS SSGFPGAAAA SPEAGGGGGG GGALQGSGAP AAGAAGLLRE
60 70 80 90 100
PGSAGRERAD WRRRQLRKVR SVELDQLPEQ PLFLAAASPP CPSTSPSPEP
110 120 130 140 150
ADAAAGASRF QPAAGPPPPG AASRCGSHSA ELAAARDSGA RSPAGAEPPS
160 170 180 190 200
AAAPSGREME NKETLKGLHK MEDRPEERMI REKLKATCMP AWKHEWLERR
210 220 230 240 250
NRRGPVVVKP IPIKGDGSEM NNLAAEPQGE GQAGSAAPAP KGRRSPSPGS
260 270 280 290 300
SPSGRSVKPE SPGVRRKRVS PVPFQSGRIT PPRRAPSPDG FSPYSPEETS
310 320 330 340 350
RRVNKVMRAR LYLLQQIGPN SFLIGGDSPD NKYRVFIGPQ NCSCGRGAFC
360 370 380 390 400
IHLLFVMLRV FQLEPSDPML WRKTLKNFEV ESLFQKYHSR RSSRIKAPSR
410 420 430 440 450
NTIQKFVSRM SNCHTLSSSS TSTSSSENSI KDEEEQMCPI CLLGMLDEES
460 470 480 490 500
LTVCEDGCRN KLHHHCMSIW AEECRRNREP LICPLCRSKW RSHDFYSHEL
510 520 530 540 550
SSPVESPTSL RAVQQPSSPQ QPVAGSQRRN QESSFNLTHF GTQQIPSAYK
560 570 580 590 600
DLAEPWIQVF GMELVGCLFS RNWNVREMAL RRLSHDVSGA LLLANGESTG
610 620 630 640 650
NSGGGSGGSL SAGAASGSSQ PSISGDVVEA CCSVLSIVCA DPVYKVYVAA
660 670 680 690 700
LKTLRAMLVY TPCHSLAERI KLQRLLRPVV DTILVKCADA NSRTSQLSIS
710 720 730 740 750
TVLELCKGQA GELAVGREIL KAGSIGVGGV DYVLSCILGN QAESNNWQEL
760 770 780 790 800
LGRLCLIDRL LLEFPAEFYP HIVSTDVSQA EPVEIRYKKL LSLLTFALQS
810 820 830 840 850
IDNSHSMVGK LSRRIYLSSA RMVTAVPAVF SKLVTMLNAS GSTHFTRMRR
860 870 880 890 900
RLMAIADEVE IAEVIQLGVE DTVDGHQDSL QVLAPASCLE NSSLEHTVHR
910 920 930 940 950
EKTGKGLSAT RLSASSEDIS DRLAGVSVGL PSSTTTEQPK PAVQTKGRPH
960 970 980 990 1000
SQCLNSSPLS HAQLMFPAPS APCSSAPSVP DISKHRPQAF VPCKIPSASP
1010 1020 1030 1040 1050
QTQRKFSLQF QRNCSEHRDS DQLSPVFTQS RPPPSSNIHR PKPSRPVPGS
1060 1070 1080 1090 1100
TSKLGDATKS SMTLDLGSAS RCDDSFGGGG NSGNAVIPSE ETVFTPVEDK
1110 1120 1130 1140 1150
CRLDVNTELN SSIEDLLEAS MPSSDTTVTF KSEVAVLSPE KAENDDTYKD
1160 1170 1180 1190 1200
DVNHNQKCKE KMEAEEEEAL AIAMAMSASQ DALPIVPQLQ VENGEDIIII
1210 1220 1230 1240 1250
QQDTPETLPG HTKAKQPYRE DAEWLKGQQI GLGAFSSCYQ AQDVGTGTLM
1260 1270 1280 1290 1300
AVKQVTYVRN TSSEQEEVVE ALREEIRMMG HLNHPNIIRM LGATCEKSNY
1310 1320 1330 1340 1350
NLFIEWMAGG SVAHLLSKYG AFKESVVINY TEQLLRGLSY LHENQIIHRD
1360 1370 1380 1390 1400
VKGANLLIDS TGQRLRIADF GAAARLASKG TGAGEFQGQL LGTIAFMAPE
1410 1420 1430 1440 1450
VLRGQQYGRS CDVWSVGCAI IEMACAKPPW NAEKHSNHLA LIFKIASATT
1460 1470 1480 1490
APSIPSHLSP GLRDVALRCL ELQPQDRPPS RELLKHPVFR TTW
Length:1,493
Mass (Da):161,407
Last modified:September 21, 2011 - v1
Checksum:i8E913AE6781B370A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC118704 Genomic DNA No translation available.
RefSeqiNP_036075.2, NM_011945.2
UniGeneiMm.15918

Genome annotation databases

EnsembliENSMUST00000109267; ENSMUSP00000104890; ENSMUSG00000021754
GeneIDi26401
KEGGimmu:26401
UCSCiuc007rwa.1 mouse

Similar proteinsi

Entry informationi

Entry nameiF8VQ72_MOUSE
AccessioniPrimary (citable) accession number: F8VQ72
Entry historyiIntegrated into UniProtKB/TrEMBL: September 21, 2011
Last sequence update: September 21, 2011
Last modified: July 18, 2018
This is version 67 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health