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Protein
Submitted name:

Excision repair cross-complementing rodent repair deficiency, complementation group 6

Gene

Ercc6

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-MMU-5250924 B-WICH complex positively regulates rRNA expression
R-MMU-6781823 Formation of TC-NER Pre-Incision Complex
R-MMU-6782135 Dual incision in TC-NER
R-MMU-6782210 Gap-filling DNA repair synthesis and ligation in TC-NER
R-MMU-73762 RNA Polymerase I Transcription Initiation

Names & Taxonomyi

Protein namesi
Submitted name:
Excision repair cross-complementing rodent repair deficiency, complementation group 6Imported
Gene namesi
Name:Ercc6Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 14

Organism-specific databases

MGIiMGI:1100494 Ercc6

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Proteomic databases

MaxQBiF8VPZ5
PaxDbiF8VPZ5
PRIDEiF8VPZ5

PTM databases

iPTMnetiF8VPZ5
PhosphoSitePlusiF8VPZ5

Expressioni

Gene expression databases

BgeeiENSMUSG00000054051 Expressed in 43 organ(s), highest expression level in dorsal root ganglion
GenevisibleiF8VPZ5 MM

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

ComplexPortaliCPX-1133 B-WICH chromatin remodelling complex
STRINGi10090.ENSMUSP00000066256

Structurei

3D structure databases

ProteinModelPortaliF8VPZ5
SMRiF8VPZ5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini515 – 691Helicase ATP-bindingInterPro annotationAdd BLAST177
Domaini839 – 998Helicase C-terminalInterPro annotationAdd BLAST160

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili164 – 191Sequence analysisAdd BLAST28

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

eggNOGiKOG0387 Eukaryota
ENOG410XP4Z LUCA
GeneTreeiENSGT00590000083118
InParanoidiF8VPZ5
KOiK10841
OMAiQVDSAIH
OrthoDBiEOG091G03VL
TreeFamiTF101236

Family and domain databases

CDDicd00079 HELICc, 1 hit
Gene3Di3.40.50.10810, 1 hit
InterProiView protein in InterPro
IPR014001 Helicase_ATP-bd
IPR001650 Helicase_C
IPR027417 P-loop_NTPase
IPR038718 SNF2-like_sf
IPR000330 SNF2_N
PfamiView protein in Pfam
PF00271 Helicase_C, 1 hit
PF00176 SNF2_N, 1 hit
SMARTiView protein in SMART
SM00487 DEXDc, 1 hit
SM00490 HELICc, 1 hit
SUPFAMiSSF52540 SSF52540, 2 hits
PROSITEiView protein in PROSITE
PS51192 HELICASE_ATP_BIND_1, 1 hit
PS51194 HELICASE_CTER, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

F8VPZ5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MFHEEVPNST HPQEQDCLPS QHANAYKDMP VGQENGGVSE AGECLSSTSC
60 70 80 90 100
EYGPSTSAEA CVLAATRRGP TLLHIDRHQI PAVEPSAQAL ELQGLGVDVY
110 120 130 140 150
DQAVLEQGVL QQVDSAMHEA SCVAQLADAE KEYQSVLDDL MSCTTSLRQI
160 170 180 190 200
NKIIEQLSPQ AASNRDINRK LDSVKRQKYN KEQQLKKITA KQKRLQAILG
210 220 230 240 250
GAGVQVELDH ASLEEDDAEP GPSCLGSMLM PAQETAWEEL IRTGQMTPFG
260 270 280 290 300
TPAPQKQEKK PRKIMLNEAS GFEKYLAEQA QLSFERKKQA ATKRTAKKAI
310 320 330 340 350
VISESSRAAI ETKADQRSQV LSQTDKRLKK HSRKLQRRAL QFQGKVGLPS
360 370 380 390 400
GKKPLEPEVR PEAEGDTEGE ESGSSPTDGE EEEEQEEEEG VASLSSDDVS
410 420 430 440 450
YELKPLRKRQ KYQKKVPVQE IDDDFFPSSE EEDEAMEGRG GGRKVARRQD
460 470 480 490 500
DGDEDYYKQR LRRWNRLRLQ DKEKRLKLED DSEESDAEFD EGFKVPGFLF
510 520 530 540 550
KKLFKYQQTG VRWLWELHCQ QAGGILGDEM GLGKTIQIIA FLAGLSYSKI
560 570 580 590 600
RTRGSNYRFE GLGPTIIVCP TTVMHQWVKE FHTWWPPFRV AVLHETGSYT
610 620 630 640 650
HKKERLIRDI VYCHGVLITS YSYIRLMQDD ISRHDWHYVI LDEGHKIRNP
660 670 680 690 700
NAAVTLACKQ FRTPHRIILS GSPMQNNLRE LWSLFDFIFP GKLGTLPVFM
710 720 730 740 750
EQFSVPITMG GYSNASPVQV KTAYKCACVL RDTINPYLLR RMKSDVKMSL
760 770 780 790 800
SLPDKNEQVL FCRLTDEQHK VYQNFIDSKA VYRILNGENQ IFSGLVALRK
810 820 830 840 850
ICNHPDLFSG GPKNASGPPE DELEEEQFGH WRRSGKMIVV ESLLKIWHRQ
860 870 880 890 900
GQRVLLFSQS RQMLHILEVF LRAHKYSYLK MDGTTTIASR QPLITKYNED
910 920 930 940 950
TSIFVFLLTT RVGGLGVNLT GANRVIIYDP DWNPSTDTQA RERAWRIGQK
960 970 980 990 1000
KQVTVYRLLT AGTIEEKIYH RQIFKQFLTN RVLKDPKQRR FFKSNDLYEL
1010 1020 1030 1040 1050
FTLTSPDASQ GTETSAIFAG TGSSIQTPKC QLKKRTSTVL GTDPKCKKPP
1060 1070 1080 1090 1100
VSDTPANAAT LIGEKPKAAG ATGRSVTSGE SGPFKGDHDT NGNRASSVAF
1110 1120 1130 1140 1150
GEETDAGSTL EHLSVMSGDG KHSDSPTVDH TSRPPVEAST SEKQGSSYAG
1160 1170 1180 1190 1200
ARCQAQTEPV PMSEQMEGQF SKYKSKRKHD ASEEETTEKR PQPKQKAKNS
1210 1220 1230 1240 1250
KHCRDAKFEG TRVPHLVKKR RYRQQTSEQE GGAKDRSSDD YVLEKLFKKS
1260 1270 1280 1290 1300
VGVHSVVRHD AIIDGSSPDY VLVEAEANRV AQDALKALRL SRQQCLGAAS
1310 1320 1330 1340 1350
GVPTWTGHRG ISGAPTGVKN RFGQKRDSSL PVQHPSSLTE KTQNNMKKEG
1360 1370 1380 1390 1400
KAHTPEHFSG KEDGASVSGA PSSSSLLARM RARNHMILPE RLESDSEHLA
1410 1420 1430 1440 1450
EAAAVPPCGT EHDDLLVDMR NFIAFQAQVD GQASTQEILQ EFESKLSVAQ
1460 1470 1480
SCVFRELLRN LCNFHRTPGG EGIWKLKPEY C
Length:1,481
Mass (Da):165,958
Last modified:September 21, 2011 - v1
Checksum:i8907FDB060B94B73
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A2I3BQP1A0A2I3BQP1_MOUSE
Excision repair cross-complementing...
Ercc6
48Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC154412 Genomic DNA No translation available.
RefSeqiNP_001074690.1, NM_001081221.1
XP_006519183.1, XM_006519120.3
UniGeneiMm.318310

Genome annotation databases

EnsembliENSMUST00000066807; ENSMUSP00000066256; ENSMUSG00000054051
GeneIDi319955
KEGGimmu:319955
UCSCiuc007sze.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC154412 Genomic DNA No translation available.
RefSeqiNP_001074690.1, NM_001081221.1
XP_006519183.1, XM_006519120.3
UniGeneiMm.318310

3D structure databases

ProteinModelPortaliF8VPZ5
SMRiF8VPZ5
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

ComplexPortaliCPX-1133 B-WICH chromatin remodelling complex
STRINGi10090.ENSMUSP00000066256

PTM databases

iPTMnetiF8VPZ5
PhosphoSitePlusiF8VPZ5

Proteomic databases

MaxQBiF8VPZ5
PaxDbiF8VPZ5
PRIDEiF8VPZ5

Protocols and materials databases

DNASUi319955
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000066807; ENSMUSP00000066256; ENSMUSG00000054051
GeneIDi319955
KEGGimmu:319955
UCSCiuc007sze.1 mouse

Organism-specific databases

CTDi2074
MGIiMGI:1100494 Ercc6

Phylogenomic databases

eggNOGiKOG0387 Eukaryota
ENOG410XP4Z LUCA
GeneTreeiENSGT00590000083118
InParanoidiF8VPZ5
KOiK10841
OMAiQVDSAIH
OrthoDBiEOG091G03VL
TreeFamiTF101236

Enzyme and pathway databases

ReactomeiR-MMU-5250924 B-WICH complex positively regulates rRNA expression
R-MMU-6781823 Formation of TC-NER Pre-Incision Complex
R-MMU-6782135 Dual incision in TC-NER
R-MMU-6782210 Gap-filling DNA repair synthesis and ligation in TC-NER
R-MMU-73762 RNA Polymerase I Transcription Initiation

Miscellaneous databases

SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000054051 Expressed in 43 organ(s), highest expression level in dorsal root ganglion
GenevisibleiF8VPZ5 MM

Family and domain databases

CDDicd00079 HELICc, 1 hit
Gene3Di3.40.50.10810, 1 hit
InterProiView protein in InterPro
IPR014001 Helicase_ATP-bd
IPR001650 Helicase_C
IPR027417 P-loop_NTPase
IPR038718 SNF2-like_sf
IPR000330 SNF2_N
PfamiView protein in Pfam
PF00271 Helicase_C, 1 hit
PF00176 SNF2_N, 1 hit
SMARTiView protein in SMART
SM00487 DEXDc, 1 hit
SM00490 HELICc, 1 hit
SUPFAMiSSF52540 SSF52540, 2 hits
PROSITEiView protein in PROSITE
PS51192 HELICASE_ATP_BIND_1, 1 hit
PS51194 HELICASE_CTER, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiF8VPZ5_MOUSE
AccessioniPrimary (citable) accession number: F8VPZ5
Entry historyiIntegrated into UniProtKB/TrEMBL: September 21, 2011
Last sequence update: September 21, 2011
Last modified: November 7, 2018
This is version 65 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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