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Protein
Submitted name:

Ubiquitin-specific peptidase 9, Y chromosome

Gene

Usp9y

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • cysteine-type endopeptidase activity Source: GO_Central
  • thiol-dependent ubiquitin-specific protease activity Source: GO_Central

GO - Biological processi

Protein family/group databases

MEROPS protease database

More...
MEROPSi
C19.051

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Ubiquitin-specific peptidase 9, Y chromosomeImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Usp9yImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome Y

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:1313274 Usp9y

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
F8VPU6

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
F8VPU6

PeptideAtlas

More...
PeptideAtlasi
F8VPU6

PRoteomics IDEntifications database

More...
PRIDEi
F8VPU6

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000069044 Expressed in 14 organ(s), highest expression level in cleaving embryo

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
F8VPU6 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000088727

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
F8VPU6

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
F8VPU6

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1559 – 1958USPInterPro annotationAdd BLAST400

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the peptidase C19 family.SAAS annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1866 Eukaryota
COG5077 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000155375

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
F8VPU6

KEGG Orthology (KO)

More...
KOi
K11840

Identification of Orthologs from Complete Genome Data

More...
OMAi
ERMILPM

Database of Orthologous Groups

More...
OrthoDBi
625455at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
F8VPU6

TreeFam database of animal gene trees

More...
TreeFami
TF323966

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR016024 ARM-type_fold
IPR038765 Papain_like_cys_pep_sf
IPR001394 Peptidase_C19_UCH
IPR018200 USP_CS
IPR028889 USP_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00443 UCH, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48371 SSF48371, 1 hit
SSF54001 SSF54001, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00972 USP_1, 1 hit
PS00973 USP_2, 1 hit
PS50235 USP_3, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

F8VPU6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTITTRGSPV GENESQGQTS DGQPQPSFQQ NQISSSDSSN ETSPTTPPYE
60 70 80 90 100
QGQGDAPPQH EEEDPSFPHT DLAKLEDMIN RSRWVVPVLP KGELEVLLEA
110 120 130 140 150
SIDLTKKGLD VKSEACQRFF RDVLTVSFSK ILMDEAVSGW KFEIHRCIIN
160 170 180 190 200
NTHRLVELCV AKLSQDWFPF LELLAIALNP HCKFHVYNGA RPCESVSSSV
210 220 230 240 250
QFPEDELFAC SPDLHSPKGW LVDLINTFGT LNGFQILHDR FTSGSALNVQ
260 270 280 290 300
TIAALIKPFG QCYEFLTQHT LRKYFIPVIE VVPQILQKLT NEELKKETKT
310 320 330 340 350
EVKNDTISMI IKFLKNLASR IPGQEETVKN LETFRLKMIL RLLQISSFNG
360 370 380 390 400
KMNALNEINK VLSSVSYYTH GHGNSEEEWL TVERMTEWIQ QNNILSIVLQ
410 420 430 440 450
DSLHQPQYVE KIEKILRFVI KEKALTLQDL NNIWAAQAGK HEAIVKNVHD
460 470 480 490 500
LLAKLAWNFS PEQLDHLFDC FKASWTNASK KQREKLLELI RRLAEDDKDG
510 520 530 540 550
VMAHKVLNLL WNLAHSDDVP VDIMDLALSA HIKILDYSCS QDRDTQKIQW
560 570 580 590 600
IDCFIEEFRT NNKWVIPALK QIKEICSLFG EAPQNLSQTH QSPRVFYRHD
610 620 630 640 650
LISQLQHNHA LVTLVAENLA AYMNSIRLYA RDHEDYDPQT VRLGSRYSHV
660 670 680 690 700
QEVQERLNFL RFLLKDGQLW LCVSQAKQIW NCLAENAVYF SDREACFMWY
710 720 730 740 750
SKLMGDEPDL HPDINKEFFE SNVLQLDPSL LTENGMKCFE RFFKTVNCRE
760 770 780 790 800
GKLMIKRKIY MMDDLDLIGL DYLWKVVIQS NDDISSRAID LLKEIYTSLG
810 820 830 840 850
PKLQANQVVI HEDFIQSCFD RLKASYDTLC VLDSEKDNIF SCARQEAIRM
860 870 880 890 900
VRILTVLREY ISEYDSDYHE ERMILPMSRA FRGKHLSFTV RFPNQGKEVE
910 920 930 940 950
DLDILSHTNA TIGSVRRCIL NRMNVNVAHT KIELFIGGEL VASEDDRKLV
960 970 980 990 1000
EQLNLKDKSL ITAKFIQINS NMPSSPDSSS DSSAGPPGNH SHNNYRDVSN
1010 1020 1030 1040 1050
PEMEKCLPGV IMSLQPRYIS FLWQVADLGS MLTVPTLRDG ARILMKLMPP
1060 1070 1080 1090 1100
DSTTLEQLRA LCSDHVNLGE RRLGQSLHSL FFGSSASQVL YLTEVVYTLL
1110 1120 1130 1140 1150
MPAGAPLADI SSDFQYHFLK SGGLPLVLSM LIQNNFLPNT DVETRRDAYF
1160 1170 1180 1190 1200
SALKIAKLLL TIVGYGHVQA IAEACQPVAD GTDPKTPINQ VTHDQAVVLQ
1210 1220 1230 1240 1250
NALQSIPNPS SECMLRNVSV HLAQQISGLA SRYIPDICVI RAIQKIIWAA
1260 1270 1280 1290 1300
GCGSLELVFS PNEDITETYK MTTSTRSNLE VKDEQVCCEA LEVMTLCFAL
1310 1320 1330 1340 1350
IPTAMDSLNK EKAWQSFVID LLLYCPSKTV RQLAQEQFFL ICTRCCMGHR
1360 1370 1380 1390 1400
PLLFFITLLF TILGGAANEK GKHSDVYFTL LRRLLTYAYN SNIQVPNVDV
1410 1420 1430 1440 1450
LLNDEIDWLK RVRDYIKNTG ETNVEDPILE GHLGVTKELL SFQSPEKKYH
1460 1470 1480 1490 1500
IGCKTGGANL VKELIDYFIF PASKAYLQYM RSGELPIKQA IPVCGSPATI
1510 1520 1530 1540 1550
NAGFELLVAL AFGCVRNLKQ IVNCLTELFY IGTPVTTCEA VGEWEYLPPV
1560 1570 1580 1590 1600
GPRPPKGFVG LKNAGATCYM NSVIQQLYMI PSIRNSILAI DSIWSDTDDD
1610 1620 1630 1640 1650
IFKGEKQDSE NNVDPRDDVF RYPHQFEDKP TLSKVEDRKE YNIAVLKHLQ
1660 1670 1680 1690 1700
ITFGHLAASQ LQYYVPKGFW QQFRLWGEPV NLREQHDALE FFNSLVDSLD
1710 1720 1730 1740 1750
EAFKALGYPT VLSKVLGGSF ADQKICQGCP HRYECEESFT TLNVDIRNHQ
1760 1770 1780 1790 1800
NLLDSLEQYV KGDLLEGANA YHCEKCDKKV DTVKRLLIKK LPSVLTIQLK
1810 1820 1830 1840 1850
RFDYDWEREC AIKFNDYFEF PRELDMEPYT VAGATKLEGD SVNPQTQLIK
1860 1870 1880 1890 1900
QNEQSESVIP GSTKYRLVGV LVHSGQANGG HYYSYIIQRN GKDSKRSHWF
1910 1920 1930 1940 1950
KFDDGDVTEC KMDDDEEMKN QCFGGEYMGE VFDHMMKRMS YRRQKRWWNA
1960 1970 1980 1990 2000
YILFYERMDI TDEDDEIITY ISELTFTRPH QIMSPAIERS VWKQNVQFLH
2010 2020 2030 2040 2050
NQMQFSLEYF QFIKKLLTCN AVYLSPAPGQ DHLLPEAEDI TMISIQLASR
2060 2070 2080 2090 2100
FLFTTGFHTK KIIRGPANDW YDALCILLRH SKNVRFWFVH NVLFNVSNRF
2110 2120 2130 2140 2150
SEYLLECPSA EIRGTFAKLI VFIAHFSLQD GSSPSPFTSP FANPGPYSQI
2160 2170 2180 2190 2200
YDNLSLSDHL LKAVLSLLRR EVSEHGRHLQ QYFNLFIMYA SLGLAEKTQL
2210 2220 2230 2240 2250
LKLNVPATFM LVSLDEGPGP PVKYQYAELS KLHSVVSQLI RCCSVSSRMQ
2260 2270 2280 2290 2300
SSINGNPPLP NPFGDPNLSQ PIMPIQQNVA DILFMRTTYM KKVIEDCSNS
2310 2320 2330 2340 2350
EDTVKLLLFC CWENPQFSCS VLSELLWQVA HSHAYELQPY LDLLLQIILF
2360 2370 2380 2390 2400
EDSWQAHRIH NALKGIPNDQ DGLFDTIQHS KNHHQKRAYQ CIKWMVTLFN
2410 2420 2430 2440 2450
SCPVAYQILQ GNGDLKNKWT WAMEWLGDEL ERKPYSGNPQ YTYSNWSPPV
2460 2470 2480 2490 2500
QSNETANGYF LEKSHSAKMK LTKACDLYPE EDPDDQDALD EHVSHAPQDR
2510 2520 2530 2540 2550
TFYLYSHRSH YQQNYVPEQP FSGPASHHLN NPQKNDKPQE THESNEEISS

CLIKDQ
Length:2,556
Mass (Da):292,267
Last modified:September 21, 2011 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i7FBB3C6FD80ADE49
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AC145393 Genomic DNA No translation available.
AC145592 Genomic DNA No translation available.

NCBI Reference Sequences

More...
RefSeqi
NP_683745.2, NM_148943.2

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Mm.347376

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000091188; ENSMUSP00000088727; ENSMUSG00000069044

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
107868

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:107868

UCSC genome browser

More...
UCSCi
uc009uzo.1 mouse

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC145393 Genomic DNA No translation available.
AC145592 Genomic DNA No translation available.
RefSeqiNP_683745.2, NM_148943.2
UniGeneiMm.347376

3D structure databases

ProteinModelPortaliF8VPU6
SMRiF8VPU6
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000088727

Protein family/group databases

MEROPSiC19.051

Proteomic databases

MaxQBiF8VPU6
PaxDbiF8VPU6
PeptideAtlasiF8VPU6
PRIDEiF8VPU6

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000091188; ENSMUSP00000088727; ENSMUSG00000069044
GeneIDi107868
KEGGimmu:107868
UCSCiuc009uzo.1 mouse

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
8287
MGIiMGI:1313274 Usp9y

Phylogenomic databases

eggNOGiKOG1866 Eukaryota
COG5077 LUCA
GeneTreeiENSGT00940000155375
InParanoidiF8VPU6
KOiK11840
OMAiERMILPM
OrthoDBi625455at2759
PhylomeDBiF8VPU6
TreeFamiTF323966

Miscellaneous databases

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000069044 Expressed in 14 organ(s), highest expression level in cleaving embryo
GenevisibleiF8VPU6 MM

Family and domain databases

InterProiView protein in InterPro
IPR016024 ARM-type_fold
IPR038765 Papain_like_cys_pep_sf
IPR001394 Peptidase_C19_UCH
IPR018200 USP_CS
IPR028889 USP_dom
PfamiView protein in Pfam
PF00443 UCH, 1 hit
SUPFAMiSSF48371 SSF48371, 1 hit
SSF54001 SSF54001, 1 hit
PROSITEiView protein in PROSITE
PS00972 USP_1, 1 hit
PS00973 USP_2, 1 hit
PS50235 USP_3, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiF8VPU6_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: F8VPU6
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: September 21, 2011
Last sequence update: September 21, 2011
Last modified: January 16, 2019
This is version 58 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
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