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Protein

FERM, ARHGEF and pleckstrin domain-containing protein 1

Gene

Farp1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Functions as guanine nucleotide exchange factor for RAC1. May play a role in semaphorin signaling. Plays a role in the assembly and disassembly of dendritic filopodia, the formation of dendritic spines, regulation of dendrite length and ultimately the formation of synapses (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein, Guanine-nucleotide releasing factor

Names & Taxonomyi

Protein namesi
Recommended name:
FERM, ARHGEF and pleckstrin domain-containing protein 1
Alternative name(s):
FERM, RhoGEF and pleckstrin domain-containing protein 1
Gene namesi
Name:Farp1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 14

Organism-specific databases

MGIiMGI:2446173 Farp1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell junction, Cell membrane, Cell projection, Cytoplasm, Membrane, Synapse, Synaptosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004223361 – 1048FERM, ARHGEF and pleckstrin domain-containing protein 1Add BLAST1048

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei20PhosphoserineCombined sources1
Modified residuei23PhosphoserineCombined sources1
Modified residuei24PhosphothreonineCombined sources1
Modified residuei340PhosphoserineBy similarity1
Modified residuei373PhosphoserineCombined sources1
Modified residuei389PhosphoserineCombined sources1
Modified residuei403PhosphoserineCombined sources1
Modified residuei427PhosphoserineCombined sources1
Modified residuei433PhosphoserineCombined sources1
Modified residuei437PhosphoserineCombined sources1
Modified residuei512PhosphoserineCombined sources1
Modified residuei516PhosphoserineBy similarity1
Modified residuei836PhosphoserineBy similarity1
Modified residuei875PhosphoserineCombined sources1
Modified residuei881PhosphoserineCombined sources1
Modified residuei886PhosphothreonineBy similarity1
Modified residuei892PhosphoserineCombined sources1
Modified residuei899PhosphoserineCombined sources1
Modified residuei902PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiF8VPU2
PaxDbiF8VPU2
PeptideAtlasiF8VPU2
PRIDEiF8VPU2

PTM databases

iPTMnetiF8VPU2
PhosphoSitePlusiF8VPU2

Expressioni

Tissue specificityi

Detected in brain cortex, hippocampus, striatum, olfactory bulb, cerebellum and hindbrain (at protein level).1 Publication

Gene expression databases

BgeeiENSMUSG00000025555 Expressed in 257 organ(s), highest expression level in dorsal pancreas
ExpressionAtlasiF8VPU2 baseline and differential
GenevisibleiF8VPU2 MM

Interactioni

Subunit structurei

Interacts with CADM1. Interacts with RAC1 (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi230134, 3 interactors
IntActiF8VPU2, 2 interactors
STRINGi10090.ENSMUSP00000026635

Structurei

3D structure databases

ProteinModelPortaliF8VPU2
SMRiF8VPU2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini40 – 320FERMPROSITE-ProRule annotationAdd BLAST281
Domaini542 – 733DHPROSITE-ProRule annotationAdd BLAST192
Domaini762 – 859PH 1PROSITE-ProRule annotationAdd BLAST98
Domaini935 – 1032PH 2PROSITE-ProRule annotationAdd BLAST98

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi449 – 455Poly-Glu7

Domaini

Intramolecular interaction between the DH domain and the PH domains can stabilize the protein in an autoinhibited conformation.By similarity

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG3531 Eukaryota
ENOG410XP7Q LUCA
GeneTreeiENSGT00920000148976
HOGENOMiHOG000007957
InParanoidiF8VPU2
KOiK17477
OMAiNAHIRGD
OrthoDBiEOG091G015W
TreeFamiTF351276

Family and domain databases

CDDicd14473 FERM_B-lobe, 1 hit
cd00160 RhoGEF, 1 hit
Gene3Di1.20.80.10, 1 hit
1.20.900.10, 1 hit
2.30.29.30, 2 hits
InterProiView protein in InterPro
IPR019749 Band_41_domain
IPR035899 DBL_dom_sf
IPR000219 DH-domain
IPR000798 Ez/rad/moesin-like
IPR014847 FERM-adjacent
IPR014352 FERM/acyl-CoA-bd_prot_sf
IPR035963 FERM_2
IPR019748 FERM_central
IPR019747 FERM_CS
IPR000299 FERM_domain
IPR018979 FERM_N
IPR018980 FERM_PH-like_C
IPR011993 PH-like_dom_sf
IPR001849 PH_domain
IPR029071 Ubiquitin-like_domsf
PfamiView protein in Pfam
PF08736 FA, 1 hit
PF09380 FERM_C, 1 hit
PF00373 FERM_M, 1 hit
PF09379 FERM_N, 1 hit
PF00169 PH, 2 hits
PF00621 RhoGEF, 1 hit
PRINTSiPR00935 BAND41
PR00661 ERMFAMILY
SMARTiView protein in SMART
SM00295 B41, 1 hit
SM01195 FA, 1 hit
SM01196 FERM_C, 1 hit
SM00233 PH, 2 hits
SM00325 RhoGEF, 1 hit
SUPFAMiSSF47031 SSF47031, 1 hit
SSF48065 SSF48065, 1 hit
SSF54236 SSF54236, 1 hit
PROSITEiView protein in PROSITE
PS50010 DH_2, 1 hit
PS00660 FERM_1, 1 hit
PS50057 FERM_3, 1 hit
PS50003 PH_DOMAIN, 2 hits

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

F8VPU2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGEIEQKPTP ASRLGAPENS GISTLERGQK PPPTPSGKLM TVKIQMLDDT
60 70 80 90 100
QEAFEVPQRA PGKVLFDAVC NHLNLVEGDY FGLEFPDHRK IVVWLDLLKP
110 120 130 140 150
IVKQIRRPKH VVVKFVVKFF PPDHTQLQEE LTRYLFALQV KQDLAQGRLT
160 170 180 190 200
CNDTSAALLI SHIVQSEIGD FDEALDREHL AKNKYVPQQD ALEDRIMEFH
210 220 230 240 250
HSHVGQTPAE SDFQLLEVAR RLEMYGIRLH PAKDREGTKI NLAVANTGIL
260 270 280 290 300
VFQGFTKINA FNWAKVRKLS FKRKRFLIKL RPDVNSSYQD TLEFLMAGRD
310 320 330 340 350
FCKSFWKICV EHHAFFRLFE EPKPKPKPVL FSRGSSFRFS GRTQKQVLDY
360 370 380 390 400
VKEGGHKKVQ FERKHSKIHS TRSLVSQPTA PNSEVPKQSP QSASLTFGEG
410 420 430 440 450
TESPGGQSCQ QAKETKACTL ELGPHQSPAL PKSPPGSKAA DGTTVVPPEE
460 470 480 490 500
EEEEEGGKDG IRPSNPQPPQ PSTGSLTGSP HLSELSINSQ GGAAPANVTL
510 520 530 540 550
SPNLSPDNKQ ASPLISPLLN DQACPRTDDE EEGRRKRFPT DKAYYIAKEV
560 570 580 590 600
STTERTYLKD LEVIASWFQS TVSKEDSMPE ALKSLIFPNF EPLHKFHTNF
610 620 630 640 650
LKEIEQRLAL WEGRSNAHVR GDYQRIGDVM LKNIQGMKHL AAHLWKHSEA
660 670 680 690 700
LEALETSIKG SRRLEHFCRD FELQKVCYLP LNTFLLRPLH RLMHYKHVLE
710 720 730 740 750
RLCKHHPPNH ADFRDCRAAL AEITEMVAQL HGTMIKMENF QKLHELKKDL
760 770 780 790 800
IGIDNLVTPG REFIRLGSLS KLSGKGLQQR MFFLFNDVLL YTSRGLTASN
810 820 830 840 850
QFKVHGQLPL YGMTIEESEE EWGVPHCLTL RGQRQSIIVA ASSRSEMEKW
860 870 880 890 900
MEDIQMAIDL AEKSNGPTPE LLASSPPDNK SPDEATAADQ ESEDDLSASR
910 920 930 940 950
TSLERQAPHR GNTMVHVCWH RSTSVSMVDF SIAVENQLSG NLLRKFKNSN
960 970 980 990 1000
GWQKLWVVFT NFCLFFYKSH QDSHPLASLP LLGYSLTIPS ESENIHKDYV
1010 1020 1030 1040
FKLHFKSHVY YFRAESEYTF ERWMEVIRSA TSSASRAHIL SHKESHLY
Length:1,048
Mass (Da):118,875
Last modified:September 21, 2011 - v1
Checksum:i6F626F96959B735A
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9Q805E9Q805_MOUSE
FERM, ARHGEF and pleckstrin domain-...
Farp1
211Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti619V → I in AAI41230 (PubMed:15489334).Curated1
Sequence conflicti751I → V in AAI41230 (PubMed:15489334).Curated1
Sequence conflicti758T → I in AAI41230 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC154618 Genomic DNA No translation available.
AC165163 Genomic DNA No translation available.
AC167566 Genomic DNA No translation available.
BC141229 mRNA Translation: AAI41230.1
CCDSiCCDS37015.1
RefSeqiNP_598843.3, NM_134082.3
XP_006518977.1, XM_006518914.3
UniGeneiMm.223980

Genome annotation databases

EnsembliENSMUST00000026635; ENSMUSP00000026635; ENSMUSG00000025555
GeneIDi223254
KEGGimmu:223254
UCSCiuc007vaa.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC154618 Genomic DNA No translation available.
AC165163 Genomic DNA No translation available.
AC167566 Genomic DNA No translation available.
BC141229 mRNA Translation: AAI41230.1
CCDSiCCDS37015.1
RefSeqiNP_598843.3, NM_134082.3
XP_006518977.1, XM_006518914.3
UniGeneiMm.223980

3D structure databases

ProteinModelPortaliF8VPU2
SMRiF8VPU2
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi230134, 3 interactors
IntActiF8VPU2, 2 interactors
STRINGi10090.ENSMUSP00000026635

PTM databases

iPTMnetiF8VPU2
PhosphoSitePlusiF8VPU2

Proteomic databases

MaxQBiF8VPU2
PaxDbiF8VPU2
PeptideAtlasiF8VPU2
PRIDEiF8VPU2

Protocols and materials databases

DNASUi223254
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000026635; ENSMUSP00000026635; ENSMUSG00000025555
GeneIDi223254
KEGGimmu:223254
UCSCiuc007vaa.1 mouse

Organism-specific databases

CTDi10160
MGIiMGI:2446173 Farp1

Phylogenomic databases

eggNOGiKOG3531 Eukaryota
ENOG410XP7Q LUCA
GeneTreeiENSGT00920000148976
HOGENOMiHOG000007957
InParanoidiF8VPU2
KOiK17477
OMAiNAHIRGD
OrthoDBiEOG091G015W
TreeFamiTF351276

Miscellaneous databases

ChiTaRSiFarp1 mouse
PROiPR:F8VPU2
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000025555 Expressed in 257 organ(s), highest expression level in dorsal pancreas
ExpressionAtlasiF8VPU2 baseline and differential
GenevisibleiF8VPU2 MM

Family and domain databases

CDDicd14473 FERM_B-lobe, 1 hit
cd00160 RhoGEF, 1 hit
Gene3Di1.20.80.10, 1 hit
1.20.900.10, 1 hit
2.30.29.30, 2 hits
InterProiView protein in InterPro
IPR019749 Band_41_domain
IPR035899 DBL_dom_sf
IPR000219 DH-domain
IPR000798 Ez/rad/moesin-like
IPR014847 FERM-adjacent
IPR014352 FERM/acyl-CoA-bd_prot_sf
IPR035963 FERM_2
IPR019748 FERM_central
IPR019747 FERM_CS
IPR000299 FERM_domain
IPR018979 FERM_N
IPR018980 FERM_PH-like_C
IPR011993 PH-like_dom_sf
IPR001849 PH_domain
IPR029071 Ubiquitin-like_domsf
PfamiView protein in Pfam
PF08736 FA, 1 hit
PF09380 FERM_C, 1 hit
PF00373 FERM_M, 1 hit
PF09379 FERM_N, 1 hit
PF00169 PH, 2 hits
PF00621 RhoGEF, 1 hit
PRINTSiPR00935 BAND41
PR00661 ERMFAMILY
SMARTiView protein in SMART
SM00295 B41, 1 hit
SM01195 FA, 1 hit
SM01196 FERM_C, 1 hit
SM00233 PH, 2 hits
SM00325 RhoGEF, 1 hit
SUPFAMiSSF47031 SSF47031, 1 hit
SSF48065 SSF48065, 1 hit
SSF54236 SSF54236, 1 hit
PROSITEiView protein in PROSITE
PS50010 DH_2, 1 hit
PS00660 FERM_1, 1 hit
PS50057 FERM_3, 1 hit
PS50003 PH_DOMAIN, 2 hits
ProtoNetiSearch...

Entry informationi

Entry nameiFARP1_MOUSE
AccessioniPrimary (citable) accession number: F8VPU2
Secondary accession number(s): C4IXU2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 29, 2013
Last sequence update: September 21, 2011
Last modified: October 10, 2018
This is version 66 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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