We will be switching to the new UniProt website on Tuesday, June 28. Please explore and share your feedback.
Take me to UniProt BETA
UniProtKB - F8VPU0 (F8VPU0_MOUSE)
Protein
Transcriptional enhancer factor TEF-5
Gene
Tead3
Organism
Mus musculus (Mouse)
Status
Functioni
Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis.
UniRule annotationRegions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
DNA bindingi | 54 – 130 | TEAPROSITE-ProRule annotationAdd BLAST | 77 |
GO - Molecular functioni
- DNA binding Source: UniProtKB-UniRule
- DNA-binding transcription factor activity Source: UniProtKB-UniRule
GO - Biological processi
- hippo signaling Source: UniProtKB-UniRule
- positive regulation of transcription by RNA polymerase II Source: InterPro
Keywordsi
Molecular function | DNA-bindingUniRule annotationARBA annotation |
Biological process | Transcription, Transcription regulationUniRule annotationARBA annotation |
Names & Taxonomyi
Protein namesi | Recommended name: Transcriptional enhancer factor TEF-5UniRule annotation |
Gene namesi | Name:Tead3Imported |
Organismi | Mus musculus (Mouse)Imported |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:109241, Tead3 |
VEuPathDBi | HostDB:ENSMUSG00000002249 |
Subcellular locationi
Nucleus
- Nucleus UniRule annotationARBA annotation
Nucleus
- nucleus Source: UniProtKB-SubCell
Keywords - Cellular componenti
NucleusUniRule annotationARBA annotationPTM / Processingi
Proteomic databases
jPOSTi | F8VPU0 |
MaxQBi | F8VPU0 |
ProteomicsDBi | 373706 |
PTM databases
SwissPalmi | F8VPU0 |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000002249, Expressed in urinary bladder and 270 other tissues |
ExpressionAtlasi | F8VPU0, baseline and differential |
Genevisiblei | F8VPU0, MM |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 54 – 130 | TEAInterPro annotationAdd BLAST | 77 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 57 | DisorderedSequence analysisAdd BLAST | 57 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 22 – 40 | Polar residuesSequence analysisAdd BLAST | 19 |
Phylogenomic databases
GeneTreei | ENSGT00950000182956 |
OMAi | XYEPLAP |
OrthoDBi | 823827at2759 |
PhylomeDBi | F8VPU0 |
TreeFami | TF313443 |
Family and domain databases
Gene3Di | 6.10.20.40, 1 hit |
InterProi | View protein in InterPro IPR000818, TEA/ATTS_dom IPR038096, TEA/ATTS_sf IPR027253, TEF-5 IPR016361, TEF_metazoa IPR041086, YBD |
Pfami | View protein in Pfam PF01285, TEA, 1 hit PF17725, YBD, 1 hit |
PIRSFi | PIRSF002603, TEF, 1 hit PIRSF500720, TEF-5, 1 hit |
PRINTSi | PR00065, TEADOMAIN |
SMARTi | View protein in SMART SM00426, TEA, 1 hit |
PROSITEi | View protein in PROSITE PS00554, TEA_1, 1 hit PS51088, TEA_2, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All
F8VPU0-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MQLGGLARRG SGHPGGSGPE PKATSTIASN SWTANSSPGE AREDGSEGLD
60 70 80 90 100
KGLDNDAEGV WSPDIEQSFQ EALAIYPPCG RRKIILSDEG KMYGRNELIA
110 120 130 140 150
RYIKLRTGKT RTRKQVSSHI QVLARKKVRE YQVGIKAMNL DQVSKDKALQ
160 170 180 190 200
SMASMSSAQI VSASVLQNKF SPPSPLPQAV FSSSSRFWSS PPLLGQQPGP
210 220 230 240 250
SQDIKPFAQP AYPIQPPLPP ALNSYESLAP LPPAAASATA SAPAWQDRTI
260 270 280 290 300
ASSRLRLLEY SAFMEVQRDP DTYSKHLFVH IGQTNPAFSD PPLEAVDVRQ
310 320 330 340 350
IYDKFPEKKG GLKELYEKGP PNAFFLVKFW ADLNSTIQEG PGAFYGVSSQ
360 370 380 390 400
YSSADSMTIS VSTKVCSFGK QVVEKVETEY ARLENGRFVY RIHRSPMCEY
410 420 430 440 450
MINFIHKLKH LPEKYMMNSV LENFTILQVV TSRDSQETLL VIAFVFEVST
460
SEHGAQHHVY KLVKD
Computationally mapped potential isoform sequencesi
There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketP70210 | TEAD3_MOUSE | Transcriptional enhancer factor TEF... | Tead3 Tcf13r2, Tef5 | 439 | Annotation score: | ||
F6TTJ9 | F6TTJ9_MOUSE | Transcriptional enhancer factor TEF... | Tead3 | 439 | Annotation score: | ||
A0A3F2YNR7 | A0A3F2YNR7_MOUSE | Transcriptional enhancer factor TEF... | Tead3 | 439 | Annotation score: |
Sequence databases
RefSeqi | NP_001091696.2, NM_001098226.3 |
Genome annotation databases
Ensembli | ENSMUST00000114799.8; ENSMUSP00000110447.2; ENSMUSG00000002249.22 |
GeneIDi | 21678 |
UCSCi | uc008bqs.2, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
RefSeqi | NP_001091696.2, NM_001098226.3 |
3D structure databases
SMRi | F8VPU0 |
ModBasei | Search... |
PTM databases
SwissPalmi | F8VPU0 |
Proteomic databases
jPOSTi | F8VPU0 |
MaxQBi | F8VPU0 |
ProteomicsDBi | 373706 |
Protocols and materials databases
Antibodypediai | 6662, 260 antibodies from 30 providers |
DNASUi | 21678 |
Genome annotation databases
Ensembli | ENSMUST00000114799.8; ENSMUSP00000110447.2; ENSMUSG00000002249.22 |
GeneIDi | 21678 |
UCSCi | uc008bqs.2, mouse |
Organism-specific databases
CTDi | 7005 |
MGIi | MGI:109241, Tead3 |
VEuPathDBi | HostDB:ENSMUSG00000002249 |
Phylogenomic databases
GeneTreei | ENSGT00950000182956 |
OMAi | XYEPLAP |
OrthoDBi | 823827at2759 |
PhylomeDBi | F8VPU0 |
TreeFami | TF313443 |
Miscellaneous databases
BioGRID-ORCSi | 21678, 4 hits in 72 CRISPR screens |
ChiTaRSi | Tead3, mouse |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000002249, Expressed in urinary bladder and 270 other tissues |
ExpressionAtlasi | F8VPU0, baseline and differential |
Genevisiblei | F8VPU0, MM |
Family and domain databases
Gene3Di | 6.10.20.40, 1 hit |
InterProi | View protein in InterPro IPR000818, TEA/ATTS_dom IPR038096, TEA/ATTS_sf IPR027253, TEF-5 IPR016361, TEF_metazoa IPR041086, YBD |
Pfami | View protein in Pfam PF01285, TEA, 1 hit PF17725, YBD, 1 hit |
PIRSFi | PIRSF002603, TEF, 1 hit PIRSF500720, TEF-5, 1 hit |
PRINTSi | PR00065, TEADOMAIN |
SMARTi | View protein in SMART SM00426, TEA, 1 hit |
PROSITEi | View protein in PROSITE PS00554, TEA_1, 1 hit PS51088, TEA_2, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | F8VPU0_MOUSE | |
Accessioni | F8VPU0Primary (citable) accession number: F8VPU0 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | November 16, 2011 |
Last sequence update: | November 16, 2011 | |
Last modified: | May 25, 2022 | |
This is version 76 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |