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Protein
Submitted name:

Ecotropic viral integration site 5 protein

Gene

Evi5

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Submitted name:
Ecotropic viral integration site 5 proteinImported
Gene namesi
Name:Evi5Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:104736 Evi5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Proteomic databases

MaxQBiF8VPT6
PeptideAtlasiF8VPT6
PRIDEiF8VPT6

Expressioni

Gene expression databases

BgeeiENSMUSG00000011831 Expressed in 292 organ(s), highest expression level in sciatic nerve
ExpressionAtlasiF8VPT6 baseline and differential
GenevisibleiF8VPT6 MM

Interactioni

GO - Molecular functioni

Structurei

3D structure databases

ProteinModelPortaliF8VPT6
SMRiF8VPT6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini163 – 348Rab-GAP TBCInterPro annotationAdd BLAST186

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili86 – 106Sequence analysisAdd BLAST21
Coiled coili142 – 162Sequence analysisAdd BLAST21
Coiled coili422 – 449Sequence analysisAdd BLAST28
Coiled coili525 – 545Sequence analysisAdd BLAST21
Coiled coili559 – 614Sequence analysisAdd BLAST56
Coiled coili622 – 647Sequence analysisAdd BLAST26
Coiled coili661 – 681Sequence analysisAdd BLAST21
Coiled coili686 – 713Sequence analysisAdd BLAST28

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

eggNOGiKOG4436 Eukaryota
ENOG410YWJY LUCA
GeneTreeiENSGT00750000117238
KOiK20242
OrthoDBiEOG091G08YC
TreeFamiTF317184

Family and domain databases

InterProiView protein in InterPro
IPR031214 Evi5
IPR000195 Rab-GTPase-TBC_dom
IPR035969 Rab-GTPase_TBC_sf
PANTHERiPTHR22957:SF254 PTHR22957:SF254, 1 hit
PfamiView protein in Pfam
PF00566 RabGAP-TBC, 1 hit
SMARTiView protein in SMART
SM00164 TBC, 1 hit
SUPFAMiSSF47923 SSF47923, 2 hits
PROSITEiView protein in PROSITE
PS50086 TBC_RABGAP, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 5 potential isoforms that are computationally mapped.Show allAlign All

F8VPT6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVTTKMTAAF RNPNRRQVAT DKVAEKLSST LSWVKNTVSH TVSQMASQVA
60 70 80 90 100
SPSASLHTTS SSTTLSTPTQ SPSSPSKLSP DDLELLAKLE EQNRLIETDS
110 120 130 140 150
KSLRSVNGSR RNSGSSLVSS SSASSNLSHL EEDSWILWGR IVNEWDDVRK
160 170 180 190 200
KKEKQVKELV RKGIPHHFRA IVWQLLCNAQ SMTIKDQYSE LLKMTSPCEK
210 220 230 240 250
LIRRDIARTY PEHNFFKEKD SLGQEVLFNV MKAYSLVDRE VGYCQGSAFI
260 270 280 290 300
VGLLLMQMPE EEAFCVFVKL MQDYRLRELF KPSMAELGLC MYQFECMIQE
310 320 330 340 350
YLPELFVHFQ SQSFHTSMYA SSWFLTIFLT TFPLPIATRI FDIFMSEGLE
360 370 380 390 400
IVFRVGLALL QMNQAELMQL DMEGMLQHFQ KVIPHQFDGG PEKLIQSAYQ
410 420 430 440 450
VKYNSKKMKK LEKEYTTIKT KEMEEQGEIK RLRTENRLLK QRIETLEKHK
460 470 480 490 500
CSSTYNEDFV LQLEKELVQA RLSEAESQCA LKEMQDKVLD IEKKNNSFPD
510 520 530 540 550
ENNIARLQEE LIAVKLREAE AIMGLKELRQ QVRTLEEHWQ RHLARTSGRW
560 570 580 590 600
KDPPKKNAVN ELQDELMSIR LREAETQAEI REMKQRMMEM ETQNQINSNQ
610 620 630 640 650
LRRAEQEVNS LQEKVCSLSV KNKGLLAQLS EAKRRQAEIE CKNKEEVMAV
660 670 680 690 700
RLREADSIAA VAELQQHIAE LEIQKEEGKL QGQLNRSDSN QYIRELKDQI
710 720 730 740 750
AELTHELRCL KGQRDFSSRP PFDGIHIVSH LIGDDELFHS SDEDFIDSSL
760 770 780 790 800
QESAIGFPLH RKSGPMSLNP ALADGSESEA EDGMLGPQES DPEAPQKQPP

QRESYSTTV
Length:809
Mass (Da):92,901
Last modified:September 21, 2011 - v1
Checksum:i131F80A2CF184FD5
GO

Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
P97366EVI5_MOUSE
Ecotropic viral integration site 5 ...
Evi5
809Annotation score:
E9Q9B1E9Q9B1_MOUSE
Ecotropic viral integration site 5 ...
Evi5
365Annotation score:
E9PWR7E9PWR7_MOUSE
Ecotropic viral integration site 5 ...
Evi5
660Annotation score:
E9Q7X9E9Q7X9_MOUSE
Ecotropic viral integration site 5 ...
Evi5
222Annotation score:
Q3TMK4Q3TMK4_MOUSE
Ecotropic viral integration site 5 ...
Evi5
376Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC138666 Genomic DNA No translation available.
RefSeqiNP_031990.2, NM_007964.2
UniGeneiMm.35796

Genome annotation databases

EnsembliENSMUST00000112642; ENSMUSP00000108261; ENSMUSG00000011831
GeneIDi14020
KEGGimmu:14020
UCSCiuc008ynb.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC138666 Genomic DNA No translation available.
RefSeqiNP_031990.2, NM_007964.2
UniGeneiMm.35796

3D structure databases

ProteinModelPortaliF8VPT6
SMRiF8VPT6
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

MaxQBiF8VPT6
PeptideAtlasiF8VPT6
PRIDEiF8VPT6

Protocols and materials databases

DNASUi14020
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000112642; ENSMUSP00000108261; ENSMUSG00000011831
GeneIDi14020
KEGGimmu:14020
UCSCiuc008ynb.1 mouse

Organism-specific databases

CTDi7813
MGIiMGI:104736 Evi5

Phylogenomic databases

eggNOGiKOG4436 Eukaryota
ENOG410YWJY LUCA
GeneTreeiENSGT00750000117238
KOiK20242
OrthoDBiEOG091G08YC
TreeFamiTF317184

Miscellaneous databases

SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000011831 Expressed in 292 organ(s), highest expression level in sciatic nerve
ExpressionAtlasiF8VPT6 baseline and differential
GenevisibleiF8VPT6 MM

Family and domain databases

InterProiView protein in InterPro
IPR031214 Evi5
IPR000195 Rab-GTPase-TBC_dom
IPR035969 Rab-GTPase_TBC_sf
PANTHERiPTHR22957:SF254 PTHR22957:SF254, 1 hit
PfamiView protein in Pfam
PF00566 RabGAP-TBC, 1 hit
SMARTiView protein in SMART
SM00164 TBC, 1 hit
SUPFAMiSSF47923 SSF47923, 2 hits
PROSITEiView protein in PROSITE
PS50086 TBC_RABGAP, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiF8VPT6_MOUSE
AccessioniPrimary (citable) accession number: F8VPT6
Entry historyiIntegrated into UniProtKB/TrEMBL: September 21, 2011
Last sequence update: September 21, 2011
Last modified: November 7, 2018
This is version 61 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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