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Entry version 58 (08 May 2019)
Sequence version 1 (21 Sep 2011)
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Protein
Submitted name:

Lactase

Gene

Lct

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei1753NucleophilePROSITE-ProRule annotation1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • beta-glucosidase activity Source: GO_Central
  • lactase activity Source: MGI
  • transferase activity Source: MGI

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionGlycosidaseUniRule annotation, Hydrolase

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-MMU-189085 Digestion of dietary carbohydrate

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
LactaseImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:LctImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:104576 Lct

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei1887 – 1907HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 21Sequence analysisAdd BLAST21
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_500337923322 – 1931Sequence analysisAdd BLAST1910

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
F8VPT3

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
F8VPT3

PeptideAtlas

More...
PeptideAtlasi
F8VPT3

PRoteomics IDEntifications database

More...
PRIDEi
F8VPT3

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
F8VPT3

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
F8VPT3

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000026354 Expressed in 73 organ(s), highest expression level in small intestine

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
F8VPT3 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000073190

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
F8VPT3

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Keywords - Domaini

SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0626 Eukaryota
COG2723 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000155324

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
F8VPT3

KEGG Orthology (KO)

More...
KOi
K01229

Identification of Orthologs from Complete Genome Data

More...
OMAi
KSAYFFT

Database of Orthologous Groups

More...
OrthoDBi
408001at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
F8VPT3

TreeFam database of animal gene trees

More...
TreeFami
TF314803

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001360 Glyco_hydro_1
IPR018120 Glyco_hydro_1_AS
IPR033132 Glyco_hydro_1_N_CS
IPR017853 Glycoside_hydrolase_SF

The PANTHER Classification System

More...
PANTHERi
PTHR10353 PTHR10353, 4 hits

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00232 Glyco_hydro_1, 4 hits

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00131 GLHYDRLASE1

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF51445 SSF51445, 4 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00572 GLYCOSYL_HYDROL_F1_1, 1 hit
PS00653 GLYCOSYL_HYDROL_F1_2, 3 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

F8VPT3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MELPWTALFL STFLLGLSCQ GNDWESDRNF ISAAGPLTND LVHNLNHPLG
60 70 80 90 100
KQGSDLVAGD TDIYVCQQPL PSFLPQYFSS LRASQVTHYK VLLSWAQLLP
110 120 130 140 150
KGSSKNPDQE AVQCYRQLLQ SLKDAQLQPM VVLFHQMPPT STIQRDGGFA
160 170 180 190 200
DLFADYATLA FQSFGDLVEI WFTFSDLEKV IMGLPHQHLK ASGLQTLSDA
210 220 230 240 250
HRKAFDVYHR KYSSQGGKLS VVLKAEDLPK LLPDPSSAAL VKGSVDFLSL
260 270 280 290 300
DLSYDCQSIS TLPQKLSELQ NLEPKVKVFV YTLKPQDCPS TGMSPASLLF
310 320 330 340 350
RLLEAINKDQ VQTVGFDVSA FLSCTSSSEE SPSCSLTYSS LALQSEQQHE
360 370 380 390 400
TVVSSFPGSA YQRVWAALAN QSREERDAFL QDVFPEGFLW GVSTGAFNVE
410 420 430 440 450
GGWAEGGRGP SIWDHYSNLN AAESQATAKV ASDSYHKPVS DVALLRGLRA
460 470 480 490 500
DVYKFSISWS RIFPFGQRTS PNLQGVAYYN KLIDSLLDSQ VEPMATLFHW
510 520 530 540 550
DLPQALQEQG GWQNESVVDA FLDYAAFCFS TFGDRVKLWV TFHEPWVISY
560 570 580 590 600
AGYGTGQHAP AISDPGVASF KVAHLILKAH ARTWHHYNYH HRQKQQGRVG
610 620 630 640 650
IVLNSDWAEP LDGKSPQDLA AAERYLHFML GWFAHPIFID GDYPAALRAQ
660 670 680 690 700
IQHTNQQCGR PLAQLPEFTE AEKRLLKGSA DFLGLSHYTS RLISKAGQQT
710 720 730 740 750
CIPSYDNIGG FSQHVDPKWP QTASPWIRVV PWGIRRLLRF ASLEYTKGKL
760 770 780 790 800
PIFLAGNGMP IGEGSDLFDD SMRVNYLNLY INEVLKAVKE DSVDVRSYIA
810 820 830 840 850
RSLIDGYEGP LGYSQRFGLY HVNFNDSSRP RTPRKSAYFF TSIIEKNGFP
860 870 880 890 900
AKKVKRNPLP LKADFSSRAR AAFSFPSEVP SKAKVVWEKF SRQPKFERDL
910 920 930 940 950
FYHGTFRDDF LWGVSSSAYQ IEGGWDADGK GPSIWDNFTH TPGNGVKDNA
960 970 980 990 1000
TGDIACDSYH QLDADINILR TLKVKSYRFS ISWPRIFPTG RNSSINKQGV
1010 1020 1030 1040 1050
DYYNKLIDRL LESNIFPMVT LFHWDLPQAL QDIGGWENPS LIELFDSYAD
1060 1070 1080 1090 1100
FCFKTFGDRV KFWMTFNEPW CSAVLGYSSG IFPPNVQDPG SLSYKVSHVI
1110 1120 1130 1140 1150
IKAHARVYHT YDEKYRQEQK GVISLSLNTH WVEPKDPGVQ RDVEAADRML
1160 1170 1180 1190 1200
QFNLGWFAHP IFKNGDYPDV MKWNVGNRSE LQHLASSRLP SFTEEEKNYI
1210 1220 1230 1240 1250
RGTADVFCIN TYTSVFAQHV TPRLNPPSYD NDMELKASDM NSSALISMMH
1260 1270 1280 1290 1300
QDVPWGMRRL LNWIKEEYGN IPIYITENGQ GLTNPTLDDT ERIFYHKTYI
1310 1320 1330 1340 1350
NEALKAYRLD GVDLRGYSAW ALMDNFEWLH GYTMRFGLYH VDFDHVNRPR
1360 1370 1380 1390 1400
TARASARYYT EVITNNGMPL AKEDEFLYGE FPKGFIWSAA SASYQVEGAW
1410 1420 1430 1440 1450
RADGKGLSIW DTFSHTPLKI GNDDNGDVAC DSYHKIAEDV VALQNLGVSH
1460 1470 1480 1490 1500
YRFSISWPRI LPDGTTKFIN EAGLNYYVRF IDALLAAGIT PQVTMYHWDL
1510 1520 1530 1540 1550
PQALQDVGGW ENETVVQRFK DYADVLFRRL GDKVKFWITL NEPFVIAAHG
1560 1570 1580 1590 1600
YGSGVSAPGI SFRPGTAPYT AGHNLIKAHA EAWHLYNSTY RNSQGGVISI
1610 1620 1630 1640 1650
TISSDWAEPR DPSNQEDVEA ARRYVQFMGG WFAHPIFKNG DYPEVMKTRI
1660 1670 1680 1690 1700
RDRSLAAGLN KSRLPEFTES EKKKIQGTFD FFGFNHYTTV LAYNLNYAAA
1710 1720 1730 1740 1750
VSSFDADRGV ASITDRSWPD SGSFWLKMTP FGFRRILNWL KEEYNNPLIY
1760 1770 1780 1790 1800
VTENGVSRRG DPELNDTDRI YYLRSYINEA LKAVRDKVDL RGYTVWSIMD
1810 1820 1830 1840 1850
NFEWATGFAE RFGVHFVNRS DPSLPRIPKA SAKVYASIVR CNGFPDPAQG
1860 1870 1880 1890 1900
PHPCLQQPED AGPTASPVKS EVPFLGLMLG TAEAQTALYV LFALVLLGVC
1910 1920 1930
SVAFLLYKYC KRSKQGTTQP GHHGLSQISS F
Length:1,931
Mass (Da):217,802
Last modified:September 21, 2011 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i162821F8CCBED384
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AC161809 Genomic DNA No translation available.

NCBI Reference Sequences

More...
RefSeqi
NP_001074547.1, NM_001081078.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000073490; ENSMUSP00000073190; ENSMUSG00000026354

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
226413

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:226413

UCSC genome browser

More...
UCSCi
uc007clm.1 mouse

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC161809 Genomic DNA No translation available.
RefSeqiNP_001074547.1, NM_001081078.2

3D structure databases

SMRiF8VPT3
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000073190

PTM databases

iPTMnetiF8VPT3
PhosphoSitePlusiF8VPT3

Proteomic databases

MaxQBiF8VPT3
PaxDbiF8VPT3
PeptideAtlasiF8VPT3
PRIDEiF8VPT3

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000073490; ENSMUSP00000073190; ENSMUSG00000026354
GeneIDi226413
KEGGimmu:226413
UCSCiuc007clm.1 mouse

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
3938
MGIiMGI:104576 Lct

Phylogenomic databases

eggNOGiKOG0626 Eukaryota
COG2723 LUCA
GeneTreeiENSGT00940000155324
InParanoidiF8VPT3
KOiK01229
OMAiKSAYFFT
OrthoDBi408001at2759
PhylomeDBiF8VPT3
TreeFamiTF314803

Enzyme and pathway databases

ReactomeiR-MMU-189085 Digestion of dietary carbohydrate

Miscellaneous databases

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000026354 Expressed in 73 organ(s), highest expression level in small intestine
GenevisibleiF8VPT3 MM

Family and domain databases

InterProiView protein in InterPro
IPR001360 Glyco_hydro_1
IPR018120 Glyco_hydro_1_AS
IPR033132 Glyco_hydro_1_N_CS
IPR017853 Glycoside_hydrolase_SF
PANTHERiPTHR10353 PTHR10353, 4 hits
PfamiView protein in Pfam
PF00232 Glyco_hydro_1, 4 hits
PRINTSiPR00131 GLHYDRLASE1
SUPFAMiSSF51445 SSF51445, 4 hits
PROSITEiView protein in PROSITE
PS00572 GLYCOSYL_HYDROL_F1_1, 1 hit
PS00653 GLYCOSYL_HYDROL_F1_2, 3 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiF8VPT3_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: F8VPT3
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: September 21, 2011
Last sequence update: September 21, 2011
Last modified: May 8, 2019
This is version 58 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
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