Alpi

Functionⁱ

Catalytic activityⁱ

A phosphate monoester + H₂O = an alcohol + phosphate.UniRule annotation

GO - Molecular functionⁱ

alkaline phosphatase activity Source: MGI
magnesium ion binding Source: MGI
protein homodimerization activity Source: MGI
zinc ion binding Source: MGI

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

cellular response to BMP stimulus
Source: MGI
Inferred from direct assayⁱ
- 21324897
dephosphorylation Source: MGI
phosphorus metabolic process Source: MGI

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	HydrolaseUniRule annotation
Ligand	MagnesiumUniRule annotation, ZincUniRule annotation

Enzyme and pathway databases

Reactomeⁱ	R-MMU-1483166 Synthesis of PA R-MMU-163125 Post-translational modification: synthesis of GPI-anchored proteins R-MMU-8935690 Digestion

Reactomeⁱ

R-MMU-1483166 Synthesis of PA
R-MMU-163125 Post-translational modification: synthesis of GPI-anchored proteins
R-MMU-8935690 Digestion

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Alkaline phosphataseUniRule annotation (EC:3.1.3.1UniRule annotation)
Gene namesⁱ	Name:AlpiImported
Organismⁱ	Mus musculus (Mouse)Imported
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome 1

Organism-specific databases

MGIⁱ	MGI:1924018 Alpi

Subcellular locationⁱ

GO - Cellular component

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Signal peptideⁱ	1 – 20	Sequence analysisAdd BLAST		20
ChainⁱPRO_5003379231	21 – 554	Alkaline phosphataseSequence analysisAdd BLAST		534

Proteomic databases

MaxQB - The MaxQuant DataBase More...MaxQBⁱ	F8VPQ6
PaxDbⁱ	F8VPQ6
PeptideAtlas More...PeptideAtlasⁱ	F8VPQ6
PRIDEⁱ	F8VPQ6

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSMUSG00000079440 Expressed in 30 organ(s), highest expression level in intestine
Genevisibleⁱ	F8VPQ6 MM

Interactionⁱ

GO - Molecular functionⁱ

protein homodimerization activity Source: MGI

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

STRINGⁱ	10090.ENSMUSP00000108895

STRINGⁱ

10090.ENSMUSP00000108895

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	F8VPQ6
SMRⁱ	F8VPQ6
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the alkaline phosphatase family.UniRule annotation

Keywords - Domainⁱ

SignalSequence analysis

Phylogenomic databases

eggNOGⁱ	KOG4126 Eukaryota COG1785 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000008704
InParanoidⁱ	F8VPQ6
KEGG Orthology (KO) More...KOⁱ	K01077
OMAⁱ	IDMAHHA
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G067H
PhylomeDBⁱ	F8VPQ6
TreeFamⁱ	TF323513

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd16012 ALP, 1 hit
Gene3Dⁱ	3.40.720.10, 1 hit
InterProⁱ	View protein in InterPro IPR017849 Alkaline_Pase-like_a/b/a IPR001952 Alkaline_phosphatase IPR018299 Alkaline_phosphatase_AS IPR017850 Alkaline_phosphatase_core_sf
PANTHERⁱ	PTHR11596 PTHR11596, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00245 Alk_phosphatase, 1 hit
PRINTSⁱ	PR00113 ALKPHPHTASE
SMARTⁱ	View protein in SMART SM00098 alkPPc, 1 hit
SUPFAMⁱ	SSF53649 SSF53649, 1 hit
PROSITEⁱ	View protein in PROSITE PS00123 ALKALINE_PHOSPHATASE, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

F8VPQ6-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MQGDWVLLLF LGLRIHLSFG IIPAEEENPA FWNKKAAEAL DAAKKLQPIQ 
        60         70         80         90        100
TSAKNLIIFL GDGMGVPTVT ATRILKGQLE GHLGPETPLA MDLFPYMALS 
       110        120        130        140        150
KTYNVDRQVP DSAGTATAYL CGVKANYKTI GLSAAARLDQ CNTTFGNEVF 
       160        170        180        190        200
SVMYRAKKAG KSVGVVTTTR VQHASPAGTY AHTVNRNWYS DAEMPASALQ 
       210        220        230        240        250
DGCKDIATQL ISNMDIDVIL GGGRKFMFPK GTPDPEYPSD SNQSGTRLDD 
       260        270        280        290        300
QNLVQTWLSK HQGARYVWNR SELIQASQDP AVTHLMGLFE PTEMKYDANR 
       310        320        330        340        350
NPSVDPSLAE MTEVAVRMLS RNPQGFYLFV EGGRIDQGHH AGTAYLALTE 
       360        370        380        390        400
AVMFDSAIEK ASQLTNEKDT LILITADHSH VFAFGGYTLR GTSIFGLAPL 
       410        420        430        440        450
KALDDKSYTS ILYGNGPGYE LKSGNRPNVT EAQSVDPNYK QQAAVPLSSE 
       460        470        480        490        500
THGGEDVAIF ARGPQAHLVH GVQEQNYIAH VMAFAGCLEP YTDCGLAPPA 
       510        520        530        540        550
GQSPVITPGQ ATTTNNAAGQ ATTTNNAAGQ ATVLLSLQLL VSMLLLVGTA 

MVVS

Length:554

Mass (Da):59,532

Last modified:September 21, 2011 - v1

Checksum:ⁱE51C56EE7DB6D7F8

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AC102611 Genomic DNA No translation available. AC138595 Genomic DNA No translation available.
NCBI Reference Sequences More...RefSeqⁱ	NP_001074551.1, NM_001081082.2
UniGeneⁱ	Mm.58068

Genome annotation databases

Ensemblⁱ	ENSMUST00000113270; ENSMUSP00000108895; ENSMUSG00000079440
GeneIDⁱ	76768
KEGGⁱ	mmu:76768
UCSC genome browser More...UCSCⁱ	uc007bwa.2 mouse

Protein	Similar proteins		Species	Score	Length	Source
F8VPQ6	Alkaline phosphatase (Fragment)		MOUSE		553	UniRef90_F8VPQ6
UPI000A3163C8		MUSCR		564
UPI000A319698		MUSCR		538

Protein	Similar proteins		Species	Score	Length	Source
F8VPQ6	Intestinal-type alkaline phosphatase 1	)	RAT		540	UniRef50_P15693
Alkaline phosphatase, germ cell type		MOUSE		529
Alkaline phosphatase		GADMO		477
Intestinal-type alkaline phosphatase		BOVIN		533
Intestinal-type alkaline phosphatase		HUMAN		528
+355

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AC102611 Genomic DNA No translation available. AC138595 Genomic DNA No translation available.
RefSeqⁱ	NP_001074551.1, NM_001081082.2
UniGeneⁱ	Mm.58068

3D structure databases

ProteinModelPortalⁱ	F8VPQ6
SMRⁱ	F8VPQ6
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

STRINGⁱ	10090.ENSMUSP00000108895

STRINGⁱ

10090.ENSMUSP00000108895

Proteomic databases

MaxQBⁱ	F8VPQ6
PaxDbⁱ	F8VPQ6
PeptideAtlasⁱ	F8VPQ6
PRIDEⁱ	F8VPQ6

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	76768
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENSMUST00000113270; ENSMUSP00000108895; ENSMUSG00000079440
GeneIDⁱ	76768
KEGGⁱ	mmu:76768
UCSCⁱ	uc007bwa.2 mouse

Organism-specific databases

CTDⁱ	248
MGIⁱ	MGI:1924018 Alpi

Phylogenomic databases

eggNOGⁱ	KOG4126 Eukaryota COG1785 LUCA
GeneTreeⁱ	ENSGT00390000008704
InParanoidⁱ	F8VPQ6
KOⁱ	K01077
OMAⁱ	IDMAHHA
OrthoDBⁱ	EOG091G067H
PhylomeDBⁱ	F8VPQ6
TreeFamⁱ	TF323513

Enzyme and pathway databases

Reactomeⁱ	R-MMU-1483166 Synthesis of PA R-MMU-163125 Post-translational modification: synthesis of GPI-anchored proteins R-MMU-8935690 Digestion

Reactomeⁱ

R-MMU-1483166 Synthesis of PA
R-MMU-163125 Post-translational modification: synthesis of GPI-anchored proteins
R-MMU-8935690 Digestion

Miscellaneous databases

SOURCEⁱ	Search...

SOURCEⁱ

Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000079440 Expressed in 30 organ(s), highest expression level in intestine
Genevisibleⁱ	F8VPQ6 MM

Family and domain databases

CDDⁱ	cd16012 ALP, 1 hit
Gene3Dⁱ	3.40.720.10, 1 hit
InterProⁱ	View protein in InterPro IPR017849 Alkaline_Pase-like_a/b/a IPR001952 Alkaline_phosphatase IPR018299 Alkaline_phosphatase_AS IPR017850 Alkaline_phosphatase_core_sf
PANTHERⁱ	PTHR11596 PTHR11596, 1 hit
Pfamⁱ	View protein in Pfam PF00245 Alk_phosphatase, 1 hit
PRINTSⁱ	PR00113 ALKPHPHTASE
SMARTⁱ	View protein in SMART SM00098 alkPPc, 1 hit
SUPFAMⁱ	SSF53649 SSF53649, 1 hit
PROSITEⁱ	View protein in PROSITE PS00123 ALKALINE_PHOSPHATASE, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	F8VPQ6_MOUSE
Accessionⁱ	F8VPQ6Primary (citable) accession number: F8VPQ6
Entry historyⁱ	Integrated into UniProtKB/TrEMBL:	September 21, 2011
	Last sequence update:	September 21, 2011
	Last modified:	September 12, 2018
	This is version 55 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Unreviewed (UniProtKB/TrEMBL)

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - F8VPQ6 (F8VPQ6_MOUSE)

Your basket is currently empty. i <p>When browsing through different UniProt proteins, you can use the ‘basket’ to save them, so that you can back to find or analyse them later.<p><a href='/help/basket' target='_top'>More...</a></p>

Alkaline phosphatase

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Plasma Membrane

Other locations

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

UniProt is an ELIXIR core data resource

Your basket is currently empty. ⁱ

Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ