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Protein

Alkaline phosphatase

Gene

Alpi

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalytic activityi

A phosphate monoester + H2O = an alcohol + phosphate.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolaseUniRule annotation
LigandMagnesiumUniRule annotation, ZincUniRule annotation

Enzyme and pathway databases

ReactomeiR-MMU-1483166 Synthesis of PA
R-MMU-163125 Post-translational modification: synthesis of GPI-anchored proteins
R-MMU-8935690 Digestion

Names & Taxonomyi

Protein namesi
Recommended name:
Alkaline phosphataseUniRule annotation (EC:3.1.3.1UniRule annotation)
Gene namesi
Name:AlpiImported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:1924018 Alpi

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20Sequence analysisAdd BLAST20
ChainiPRO_500337923121 – 554Alkaline phosphataseSequence analysisAdd BLAST534

Proteomic databases

MaxQBiF8VPQ6
PaxDbiF8VPQ6
PeptideAtlasiF8VPQ6
PRIDEiF8VPQ6

Expressioni

Gene expression databases

BgeeiENSMUSG00000079440 Expressed in 30 organ(s), highest expression level in intestine
GenevisibleiF8VPQ6 MM

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000108895

Structurei

3D structure databases

ProteinModelPortaliF8VPQ6
SMRiF8VPQ6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the alkaline phosphatase family.UniRule annotation

Keywords - Domaini

SignalSequence analysis

Phylogenomic databases

eggNOGiKOG4126 Eukaryota
COG1785 LUCA
GeneTreeiENSGT00390000008704
InParanoidiF8VPQ6
KOiK01077
OMAiIDMAHHA
OrthoDBiEOG091G067H
PhylomeDBiF8VPQ6
TreeFamiTF323513

Family and domain databases

CDDicd16012 ALP, 1 hit
Gene3Di3.40.720.10, 1 hit
InterProiView protein in InterPro
IPR017849 Alkaline_Pase-like_a/b/a
IPR001952 Alkaline_phosphatase
IPR018299 Alkaline_phosphatase_AS
IPR017850 Alkaline_phosphatase_core_sf
PANTHERiPTHR11596 PTHR11596, 1 hit
PfamiView protein in Pfam
PF00245 Alk_phosphatase, 1 hit
PRINTSiPR00113 ALKPHPHTASE
SMARTiView protein in SMART
SM00098 alkPPc, 1 hit
SUPFAMiSSF53649 SSF53649, 1 hit
PROSITEiView protein in PROSITE
PS00123 ALKALINE_PHOSPHATASE, 1 hit

Sequencei

Sequence statusi: Complete.

F8VPQ6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MQGDWVLLLF LGLRIHLSFG IIPAEEENPA FWNKKAAEAL DAAKKLQPIQ
60 70 80 90 100
TSAKNLIIFL GDGMGVPTVT ATRILKGQLE GHLGPETPLA MDLFPYMALS
110 120 130 140 150
KTYNVDRQVP DSAGTATAYL CGVKANYKTI GLSAAARLDQ CNTTFGNEVF
160 170 180 190 200
SVMYRAKKAG KSVGVVTTTR VQHASPAGTY AHTVNRNWYS DAEMPASALQ
210 220 230 240 250
DGCKDIATQL ISNMDIDVIL GGGRKFMFPK GTPDPEYPSD SNQSGTRLDD
260 270 280 290 300
QNLVQTWLSK HQGARYVWNR SELIQASQDP AVTHLMGLFE PTEMKYDANR
310 320 330 340 350
NPSVDPSLAE MTEVAVRMLS RNPQGFYLFV EGGRIDQGHH AGTAYLALTE
360 370 380 390 400
AVMFDSAIEK ASQLTNEKDT LILITADHSH VFAFGGYTLR GTSIFGLAPL
410 420 430 440 450
KALDDKSYTS ILYGNGPGYE LKSGNRPNVT EAQSVDPNYK QQAAVPLSSE
460 470 480 490 500
THGGEDVAIF ARGPQAHLVH GVQEQNYIAH VMAFAGCLEP YTDCGLAPPA
510 520 530 540 550
GQSPVITPGQ ATTTNNAAGQ ATTTNNAAGQ ATVLLSLQLL VSMLLLVGTA

MVVS
Length:554
Mass (Da):59,532
Last modified:September 21, 2011 - v1
Checksum:iE51C56EE7DB6D7F8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC102611 Genomic DNA No translation available.
AC138595 Genomic DNA No translation available.
RefSeqiNP_001074551.1, NM_001081082.2
UniGeneiMm.58068

Genome annotation databases

EnsembliENSMUST00000113270; ENSMUSP00000108895; ENSMUSG00000079440
GeneIDi76768
KEGGimmu:76768
UCSCiuc007bwa.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC102611 Genomic DNA No translation available.
AC138595 Genomic DNA No translation available.
RefSeqiNP_001074551.1, NM_001081082.2
UniGeneiMm.58068

3D structure databases

ProteinModelPortaliF8VPQ6
SMRiF8VPQ6
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000108895

Proteomic databases

MaxQBiF8VPQ6
PaxDbiF8VPQ6
PeptideAtlasiF8VPQ6
PRIDEiF8VPQ6

Protocols and materials databases

DNASUi76768
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000113270; ENSMUSP00000108895; ENSMUSG00000079440
GeneIDi76768
KEGGimmu:76768
UCSCiuc007bwa.2 mouse

Organism-specific databases

CTDi248
MGIiMGI:1924018 Alpi

Phylogenomic databases

eggNOGiKOG4126 Eukaryota
COG1785 LUCA
GeneTreeiENSGT00390000008704
InParanoidiF8VPQ6
KOiK01077
OMAiIDMAHHA
OrthoDBiEOG091G067H
PhylomeDBiF8VPQ6
TreeFamiTF323513

Enzyme and pathway databases

ReactomeiR-MMU-1483166 Synthesis of PA
R-MMU-163125 Post-translational modification: synthesis of GPI-anchored proteins
R-MMU-8935690 Digestion

Miscellaneous databases

SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000079440 Expressed in 30 organ(s), highest expression level in intestine
GenevisibleiF8VPQ6 MM

Family and domain databases

CDDicd16012 ALP, 1 hit
Gene3Di3.40.720.10, 1 hit
InterProiView protein in InterPro
IPR017849 Alkaline_Pase-like_a/b/a
IPR001952 Alkaline_phosphatase
IPR018299 Alkaline_phosphatase_AS
IPR017850 Alkaline_phosphatase_core_sf
PANTHERiPTHR11596 PTHR11596, 1 hit
PfamiView protein in Pfam
PF00245 Alk_phosphatase, 1 hit
PRINTSiPR00113 ALKPHPHTASE
SMARTiView protein in SMART
SM00098 alkPPc, 1 hit
SUPFAMiSSF53649 SSF53649, 1 hit
PROSITEiView protein in PROSITE
PS00123 ALKALINE_PHOSPHATASE, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiF8VPQ6_MOUSE
AccessioniPrimary (citable) accession number: F8VPQ6
Entry historyiIntegrated into UniProtKB/TrEMBL: September 21, 2011
Last sequence update: September 21, 2011
Last modified: September 12, 2018
This is version 55 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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