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UniProtKB - F8VPQ2 (ARI4A_MOUSE)

Entry version 74 (07 Oct 2020)
Sequence version 1 (21 Sep 2011)
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Protein

AT-rich interactive domain-containing protein 4A

Gene

Arid4a

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

DNA-binding protein which modulates activity of several transcription factors including RB1 (retinoblastoma-associated protein) and AR (androgen receptor) (PubMed:17043311, PubMed:23487765). May function as part of an mSin3A repressor complex (By similarity). Has no intrinsic transcriptional activity (PubMed:23487765). Plays a role in the regulation of epigenetic modifications at the PWS/AS imprinting center near the SNRPN promoter, where it might function as part of a complex with RB1 and ARID4B (PubMed:17043311). Involved in spermatogenesis, together with ARID4B, where it acts as a transcriptional coactivator for AR and enhances expression of genes required for sperm maturation (PubMed:23487765). Regulates expression of the tight junction protein CLDN3 in the testis, which is important for integrity of the blood-testis barrier (PubMed:23487765). Plays a role in myeloid homeostasis where it regulates the histone methylation state of bone marrow cells and expression of various genes involved in hematopoiesis (PubMed:18728284). May function as a leukemia suppressor (PubMed:18728284).By similarity3 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionChromatin regulator, DNA-binding
Biological processDifferentiation, Spermatogenesis, Transcription, Transcription regulation

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-MMU-3214815, HDACs deacetylate histones

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
AT-rich interactive domain-containing protein 4A1 PublicationImported
Short name:
ARID domain-containing protein 4A
Alternative name(s):
Retinoblastoma-binding protein 11 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Arid4a1 PublicationImported
Synonyms:Rbbp11 Publication, Rbp11 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 12

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...MGIi		MGI:2444354, Arid4a

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Viable and fertile, although females have reduced fertility (PubMed:17043311, PubMed:18728284). At two months of age, animals show abnormal blood cell production accompanied by mild anemia, leukopenia and thrombocytopenia. Hematologic abnormalities become progressively more severe with age (PubMed:18728284). Monocytosis is observed at 5 months onwards, along with splenomegaly and hepatomegaly (PubMed:18728284). Approximately 12% of animals develop acute myeloid leukemia (AML) and/or myeloid sarcoma (PubMed:18728284). Mortality increases rapidly from age 6 months onwards, with no survival past 22 months (PubMed:18728284). Expansion of hematopoietic stem cell and common myeloid progenitor cell populations, and their downstream lineage, is observed in bone marrow and spleen; the effect is most significant in spleen (PubMed:18728284). Bone marrow cells show altered patterns of histone methylation and significantly increased levels of both H3K4me3 and H3K9me3 (PubMed:18728284). Expression of HOXB3, HOXB5, HOXB6, HOXB8 and PITX2 in bone marrow cells is reduced (PubMed:18728284). No effect on histone methlyation at the PWS/AS imprinting center (PubMed:17043311). Double knockouts with ARID4B heterozygotes show a more severe hematologic phenotype with 83% of animals progressing to AML, and with earlier age of onset (PubMed:18728284). In bone marrow cells, expression of FOXP3 is significantly reduced (PubMed:18728284). Males show progressive reduction in fertility from 2 months of age onwards, with reduced testis size and variable defects in seminal vesicle formation (PubMed:23487765). Spermatogenesis is partially blocked from the meiois II stage onwards leading to reduced numbers of mature spermatozoa (PubMed:23487765). Expression in testis of CLDN3, an androgen receptor-regulated gene, is significantly reduced (PubMed:23487765). Expression of PTGDS is also reduced, whereas expression of INHA and EMB is moderately increased (PubMed:23487765). Maternal-specific trimethylation of H4K20 and H3K9 at the PWS/AS imprinting center is significantly reduced (PubMed:17043311).3 Publications

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004449951 – 1261AT-rich interactive domain-containing protein 4AAdd BLAST1261

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki481Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei679PhosphoserineBy similarity1
Modified residuei719PhosphoserineBy similarity1
Cross-linki723Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki743Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei867PhosphoserineBy similarity1
Modified residuei1113PhosphoserineBy similarity1
Modified residuei1149PhosphoserineBy similarity1

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		F8VPQ2

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		F8VPQ2

MaxQB - The MaxQuant DataBase

More...MaxQBi		F8VPQ2

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		F8VPQ2

PRoteomics IDEntifications database

More...PRIDEi		F8VPQ2

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		F8VPQ2

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		F8VPQ2

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in Sertoli cells of the testis.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSMUSG00000048118, Expressed in zygote and 254 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		F8VPQ2, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		F8VPQ2, MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Identified in mSin3A corepressor complexes together with SIN3A, SIN3B, RBBP4, RBBP7, SAP30, BRMS1, HDAC1 and HDAC2 (By similarity).

Interacts with BRMS1 (By similarity).

Interacts with RB1 (By similarity).

Interacts with ARID4B (PubMed:17043311).

Interacts with AR (PubMed:23487765).

By similarity2 Publications

Protein-protein interaction databases

ComplexPortal: manually curated resource of macromolecular complexes

More...ComplexPortali		CPX-3441, SIN3A histone deacetylase complex, ES cell-specific variant
CPX-3443, SIN3A histone deacetylase complex
CPX-3444, SIN3B histone deacetylase complex

STRING: functional protein association networks

More...STRINGi		10090.ENSMUSP00000035512

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		F8VPQ2, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		F8VPQ2

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini309 – 401ARIDPROSITE-ProRule annotationAdd BLAST93

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni4 – 121DNA-bindingBy similarityAdd BLAST118
Regioni571 – 638Chromodomain-likeBy similarityAdd BLAST68
Regioni955 – 968Retinoblastoma protein bindingBy similarityAdd BLAST14

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The function of the chromodomain-like region is uncertain. One study suggests that it mediates binding to lysine-methlyated histone tails, with strongest affinity for H4K20me3 and H3K36me3. However, another study failed to find any interaction between this domain and histone H4K20me3 peptide.By similarity

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG2744, Eukaryota
KOG3001, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000156159

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_007419_1_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		F8VPQ2

KEGG Orthology (KO)

More...KOi		K19194

Identification of Orthologs from Complete Genome Data

More...OMAi		SEKTEWY

Database of Orthologous Groups

More...OrthoDBi		329541at2759

TreeFam database of animal gene trees

More...TreeFami		TF106427

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.10.150.60, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR001606, ARID_dom
IPR036431, ARID_dom_sf
IPR016197, Chromo-like_dom_sf
IPR000953, Chromo/chromo_shadow_dom
IPR012603, RBB1NT
IPR002999, Tudor
IPR025995, Tudor-knot

Pfam protein domain database

More...Pfami		View protein in Pfam
PF01388, ARID, 1 hit
PF08169, RBB1NT, 1 hit
PF11717, Tudor-knot, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00501, BRIGHT, 1 hit
SM00298, CHROMO, 1 hit
SM00333, TUDOR, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF46774, SSF46774, 1 hit
SSF54160, SSF54160, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS51011, ARID, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

F8VPQ2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKAADEPAYL TVGTDVSAKY RGAFCEAKIK TVKRLVKVKV LLKQDNTTQL 
        60         70         80         90        100
VQDDQVKGPL RVGAIVETRT SDGSIQEAII SKLTDASWYT VVFDDGDERT 
       110        120        130        140        150
LRRTSLCLKG ERHFAESETL DQLPLTNPEH FGTPVIAKKT NRGRRSSLPI 
       160        170        180        190        200
TEDEKEEESS EEEDEDKRRL NDELLGKVVS VASTAESTGW YPALVVSPSC 
       210        220        230        240        250
NDDVTVKKDQ CLVRSFIDSK FYSIARKDIK ELDILTLPES ELCARPGLRR 
       260        270        280        290        300
ASVFLKGRIV PDNWKMDISE ILESSSSDDE ECPAEEHEEE KEKEAKKEEE 
       310        320        330        340        350
ELPEEELDPE ERDNFLQQLY KFMEDRGTPI NKPPVLGYKD LNLFKLFRLV 
       360        370        380        390        400
YHQGGCGNID SGAVWKQIYM DLGIPILNSA ASYNVKTAYR KYLYGFEEYC 
       410        420        430        440        450
RSANIQFRTI HHHEPKVKEE KKDFEDSMDE ALKEAPEMPL LDVKSEPEEN 
       460        470        480        490        500
TDSNSESDRE DTELKSPRGR RKIVRDANCI KKEIEEEKIE DKFLRDDLEN 
       510        520        530        540        550
KDAGDDDDDG DPAAKREHEL LFGRKSTPKN KEKKIKKPED SERDSDEEEE 
       560        570        580        590        600
KSQEREETES RCDSEGEDEE DDTEPCLTGT KVKVKYGRGK TQKIYEASIK 
       610        620        630        640        650
STEMDDGEIL YLVHYYGWNV RYDEWVKADR IIWPLDKGGP KKKQKKKVKN 
       660        670        680        690        700
KEDSEKDEKR DEERQKSKRG RPPLKSTFSP NMPYSLSKTS NSEGKSDSCS 
       710        720        730        740        750
SDSEADDQLE KSSGGEDLSP DVKEELEKNE NAHDDKLDEE NPKIVHISKE 
       760        770        780        790        800
NDRTQAQPSD TLTVEAGDSD QIVHIFGDKV DQVEEFKKQV EKSPKGKGRR 
       810        820        830        840        850
SKTKDLSLEL IKISPFGQEE AGSEAHGDVH SLEFSSLECK NFSSTEDDID 
       860        870        880        890        900
PYEKEKKLKR KILGQQSPEK KLRLDNGMEM TTGVSQERSD DGAGAEGMKG 
       910        920        930        940        950
AHVEQHFETE GEGMPSLTAE PDQGLQELTS EKSDSPAEEE PVHTPLKEEE 
       960        970        980        990       1000
DAMPLIGPET LVCHEVDLDD LDEKDKTSIE DVVVEGSESN SLASVPPALP 
      1010       1020       1030       1040       1050
PVAQHNFSVA SPLTLSQDES RSIKSESDIT IEVDSIAEES QEGLCERESA 
      1060       1070       1080       1090       1100
NGFEASVASG ACSIIAHERE SREKGQKRPS DGNSGLIAKK QKRTPKRTSA 
      1110       1120       1130       1140       1150
AAKTEKNGAG QSSDSEDLPA MDSSSNCTPV KRLTLPKSQK LPRSPARTSP 
      1160       1170       1180       1190       1200
HIKDAEKEKH REKHPNSSPR TYKWSFQLNE LDNMNSTERI SFLQEKLQEI 
      1210       1220       1230       1240       1250
RKYYMSLKSE VATIDRRRKR LKKKDREVSH AGASMSSASS DTGMSPSSSS 
      1260 
PPQNVLAVEC R
Length:1,261
Mass (Da):142,055
Last modified:September 21, 2011 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i4392BF421E3A00B8
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9Q9V1E9Q9V1_MOUSE
AT-rich interactive domain-containi...
Arid4a
531Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q8BY40Q8BY40_MOUSE
AT-rich interactive domain-containi...
Arid4a
295Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti419 – 420EE → KK in AAH25436 (PubMed:15489334).Curated2
Sequence conflicti491D → E in AAI58110 (PubMed:15489334).Curated1
Sequence conflicti534Missing in AAI57976 (PubMed:15489334).Curated1
Sequence conflicti535I → K in AAH58209 (PubMed:15489334).Curated1
Sequence conflicti732A → G in AAI57976 (PubMed:15489334).Curated1
Sequence conflicti786F → L in AAI57976 (PubMed:15489334).Curated1
Sequence conflicti1134T → S in AAI57976 (PubMed:15489334).Curated1
Sequence conflicti1138S → P in AAI57976 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AC112794 Genomic DNA No translation available.
AC132325 Genomic DNA No translation available.
BC025436 mRNA Translation: AAH25436.1
BC058209 mRNA Translation: AAH58209.1
BC157975 mRNA Translation: AAI57976.1
BC158109 mRNA Translation: AAI58110.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS36471.1

NCBI Reference Sequences

More...RefSeqi		NP_001074664.1, NM_001081195.1
XP_017170546.1, XM_017315057.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENSMUST00000046305; ENSMUSP00000035512; ENSMUSG00000048118

Database of genes from NCBI RefSeq genomes

More...GeneIDi		238247

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		mmu:238247

UCSC genome browser

More...UCSCi		uc007nud.1, mouse

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC112794 Genomic DNA No translation available.
AC132325 Genomic DNA No translation available.
BC025436 mRNA Translation: AAH25436.1
BC058209 mRNA Translation: AAH58209.1
BC157975 mRNA Translation: AAI57976.1
BC158109 mRNA Translation: AAI58110.1
CCDSiCCDS36471.1
RefSeqiNP_001074664.1, NM_001081195.1
XP_017170546.1, XM_017315057.1

3D structure databases

SMRiF8VPQ2
ModBaseiSearch...

Protein-protein interaction databases

ComplexPortaliCPX-3441, SIN3A histone deacetylase complex, ES cell-specific variant
CPX-3443, SIN3A histone deacetylase complex
CPX-3444, SIN3B histone deacetylase complex
STRINGi10090.ENSMUSP00000035512

PTM databases

iPTMnetiF8VPQ2
PhosphoSitePlusiF8VPQ2

Proteomic databases

EPDiF8VPQ2
jPOSTiF8VPQ2
MaxQBiF8VPQ2
PaxDbiF8VPQ2
PRIDEiF8VPQ2

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		11317, 59 antibodies

The DNASU plasmid repository

More...DNASUi		238247

Genome annotation databases

EnsembliENSMUST00000046305; ENSMUSP00000035512; ENSMUSG00000048118
GeneIDi238247
KEGGimmu:238247
UCSCiuc007nud.1, mouse

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		5926
MGIiMGI:2444354, Arid4a

Phylogenomic databases

eggNOGiKOG2744, Eukaryota
KOG3001, Eukaryota
GeneTreeiENSGT00940000156159
HOGENOMiCLU_007419_1_0_1
InParanoidiF8VPQ2
KOiK19194
OMAiSEKTEWY
OrthoDBi329541at2759
TreeFamiTF106427

Enzyme and pathway databases

ReactomeiR-MMU-3214815, HDACs deacetylate histones

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		238247, 4 hits in 24 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		Arid4a, mouse

Protein Ontology

More...PROi		PR:F8VPQ2
RNActiF8VPQ2, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSMUSG00000048118, Expressed in zygote and 254 other tissues
ExpressionAtlasiF8VPQ2, baseline and differential
GenevisibleiF8VPQ2, MM

Family and domain databases

Gene3Di1.10.150.60, 1 hit
InterProiView protein in InterPro
IPR001606, ARID_dom
IPR036431, ARID_dom_sf
IPR016197, Chromo-like_dom_sf
IPR000953, Chromo/chromo_shadow_dom
IPR012603, RBB1NT
IPR002999, Tudor
IPR025995, Tudor-knot
PfamiView protein in Pfam
PF01388, ARID, 1 hit
PF08169, RBB1NT, 1 hit
PF11717, Tudor-knot, 1 hit
SMARTiView protein in SMART
SM00501, BRIGHT, 1 hit
SM00298, CHROMO, 1 hit
SM00333, TUDOR, 1 hit
SUPFAMiSSF46774, SSF46774, 1 hit
SSF54160, SSF54160, 1 hit
PROSITEiView protein in PROSITE
PS51011, ARID, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiARI4A_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: F8VPQ2
Secondary accession number(s): B2RXT8
, B2RY61, Q05CI2, Q6PE90
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 12, 2018
Last sequence update: September 21, 2011
Last modified: October 7, 2020
This is version 74 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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