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Protein
Submitted name:

Dedicator of cytokinesis protein 3

Gene

Dock3

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-MMU-983231 Factors involved in megakaryocyte development and platelet production

Names & Taxonomyi

Protein namesi
Submitted name:
Dedicator of cytokinesis protein 3Imported
Gene namesi
Name:Dock3Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:2429763 Dock3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Proteomic databases

MaxQBiF8VPQ1
PeptideAtlasiF8VPQ1
PRIDEiF8VPQ1

Expressioni

Gene expression databases

BgeeiENSMUSG00000039716 Expressed in 123 organ(s), highest expression level in cerebral cortex
ExpressionAtlasiF8VPQ1 baseline and differential
GenevisibleiF8VPQ1 MM

Interactioni

GO - Molecular functioni

Structurei

3D structure databases

SMRiF8VPQ1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini6 – 67SH3InterPro annotationAdd BLAST62
Domaini421 – 599DHR-1InterPro annotationAdd BLAST179
Domaini1228 – 1635DHR-2InterPro annotationAdd BLAST408

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili1507 – 1531Sequence analysisAdd BLAST25

Sequence similaritiesi

Belongs to the DOCK family.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coilSequence analysis, SH3 domainPROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG1998 Eukaryota
ENOG410XQH7 LUCA
GeneTreeiENSGT00610000085806
KOiK05727
OMAiXQYETVV
OrthoDBiEOG091G00Q4
TreeFamiTF300423

Family and domain databases

CDDicd08695 C2_Dock-B, 1 hit
cd12048 SH3_DOCK3_B, 1 hit
Gene3Di2.60.40.150, 1 hit
InterProiView protein in InterPro
IPR016024 ARM-type_fold
IPR037811 C2_Dock-B
IPR035892 C2_domain_sf
IPR027007 DHR-1_domain
IPR027357 DHR-2
IPR026791 DOCK
IPR026800 DOCK3
IPR035767 DOCK3_SH3
IPR010703 DOCK_C
IPR032376 DOCK_N
IPR036028 SH3-like_dom_sf
IPR001452 SH3_domain
PANTHERiPTHR23317 PTHR23317, 1 hit
PTHR23317:SF66 PTHR23317:SF66, 1 hit
PfamiView protein in Pfam
PF06920 DHR-2, 1 hit
PF14429 DOCK-C2, 1 hit
PF16172 DOCK_N, 1 hit
PF07653 SH3_2, 1 hit
SMARTiView protein in SMART
SM00326 SH3, 1 hit
SUPFAMiSSF48371 SSF48371, 1 hit
SSF50044 SSF50044, 1 hit
PROSITEiView protein in PROSITE
PS51650 DHR_1, 1 hit
PS51651 DHR_2, 1 hit
PS50002 SH3, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 5 potential isoforms that are computationally mapped.Show allAlign All

F8VPQ1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MWTPTEEEKY GVVICSFRGS VPQGLVLEIG ETVQILEKCE GWYRGVSTKK
60 70 80 90 100
PNVKGLFPAN YIHLKKAIVS NRGQYETVVP LEDSIVTEVT TTLQEWASLW
110 120 130 140 150
KQLYVKHKVD LFYKLRHVMN ELIDLRRQLL SGHLTQDQVR EVKRHITVRL
160 170 180 190 200
DWGNEHLGLD LVPRKDFEVV DSDQISVSDL YKMHLSSRQS VQQSTSQVDT
210 220 230 240 250
MRPRHGETCR MPVPHHFFFS LKSFTYNTIG EDSDVFFSLY DMREGKQISE
260 270 280 290 300
RFLVRLNKNG GPRNPEKIER MCALFTDLSS KDMKRDLYIV AHVIRIGRML
310 320 330 340 350
LNDSKKGPAH LHYRRPYGCA VLSILDVLQS LTELKEEKDF VLKVYTCNNE
360 370 380 390 400
SEWTQIHENI IRKSSTKYSA PSASHGLIIS LQLFRGDMEQ IRRENPMIFN
410 420 430 440 450
RGLAITRKLG FPDVIMPGDI RNDLYLTLEK GDFERGGKSV QKNIEVTMYV
460 470 480 490 500
LYADGEILKD CISLGSGEPN RSSYHSFVLY HSNSPRWGEI IKLPIPIDRF
510 520 530 540 550
RGSHLRFEFR HCSTKDKGEK KLFGFAFSPL MRDDGTTLSD DIHELYVYKC
560 570 580 590 600
DENSTFNNHA LYLGLPCCKE DYNGCPNIPS SLIFQRSAKE SFFISTQLSS
610 620 630 640 650
TKLTQNVDLL ALLKWKAFPD RIMDILGRLR HVSGEEIVKF LQDILDTLFV
660 670 680 690 700
ILDDNTEKYG LLVFQSLVFI INLLRDIKYF HFRPVMDTYI QKHFAGALAY
710 720 730 740 750
KELIRCLKWY MDCSAELIRQ DHIQEAMRAL EYLFKFIVQS RILYSRATCG
760 770 780 790 800
MEEEQFRSSI QELFQSIRFV LSLDSRNSET LLFTQAALLN SFPTIFDELL
810 820 830 840 850
QMFTVQEVAE FVRGTLGSMP STVHIGQSMD VVKLQSIART VDSRLFSFSE
860 870 880 890 900
SRRILLPVVL HHIHLHLRQQ KELLICSGIL GSIFSIVKTS SLEADVMEEV
910 920 930 940 950
EMMVESLLDV LLQTLLTIMS KSHAQEAVRG QRCPQCTAEI TGEYVSCLLS
960 970 980 990 1000
LLRQMCDTHF QHLLDNFQSK DELKEFLLKI FCVFRNLMKM SVFPRDWMVM
1010 1020 1030 1040 1050
RLLTSNIIVT TVQYLSSALH KNFTETDFDF KVWNSYFSLA VLFINQPSLQ
1060 1070 1080 1090 1100
LEIITSAKRK KILDKYGDMR VMMAYELFSM WQNLGDHKIH FIPGMIGPFL
1110 1120 1130 1140 1150
GVTLVPQPEV RNIMIPIFHD MMDWEQRKNG NFKQVEAELI DKLDSMVSEG
1160 1170 1180 1190 1200
KGDESYRELF GLLTQLFGPY PSLLEKVEQE TWRETGISFV TSVTRLMERL
1210 1220 1230 1240 1250
LDYRDCMKGE ETENKKVGCT VNLMNFYKSE INKEEMYIRY IHKLCDMHLQ
1260 1270 1280 1290 1300
AENYTEAAFT LLLYCELLQW EDRPLREFLH YPSQTEWQRK EGLCRKIIHY
1310 1320 1330 1340 1350
FNKGKSWEFG IPLCRELACQ YESLYDYQSL SWIRKMEASY YDNIIEQQRL
1360 1370 1380 1390 1400
EPEFFRVGFY GRKFPFFLRN KEYVCRGHDY ERLEAFQQRM LSEFPQAVAM
1410 1420 1430 1440 1450
QHPNHPDDAI LQCDAQYLQI YAVTPIPDYV DVLQMDRVPD RVKSFYRVNN
1460 1470 1480 1490 1500
VRKFRYDRPF HKGPKDKDNE FKSLWIERTT LTLTHSLPGI SRWFEVERRE
1510 1520 1530 1540 1550
LVEVSPLENA IQVVENKNQE LRALISQYQH KQVHGNINLL SMCLNGVIDA
1560 1570 1580 1590 1600
AVNGGIARYQ EAFFDKDYIT KHPGDAEKIS QLKELMQEQV HVLGVGLAVH
1610 1620 1630 1640 1650
EKFVHPEMRP LHKKLIDQFQ MMRASLYHEF PGLDKLSPAC SGTSTPRGNV
1660 1670 1680 1690 1700
LASHSPMSPE NIKMTHRHSP MNLMGTGRHS SSSLSSHASS EAGNMMMMGD
1710 1720 1730 1740 1750
NSMGEAPEDL YHHMQLAYHN PRYQGSVTNV SVLSSSQASP SSSSLSSTHS
1760 1770 1780 1790 1800
APSQMITSAP SSTRGSPSLP DKYRHAREMM LLLPTHRDRP SSAMYPAAIL
1810 1820 1830 1840 1850
ENGQPPNFQR ALFQQVVGAC KPCSDPNLSM AEKGHYSLHF DAFHHPLGDT
1860 1870 1880 1890 1900
PPALPARTLR KSPLHPIPAS PTSPQSGLDG SNSTLSGSAS SGVSSLSESN
1910 1920 1930 1940 1950
FGHSSEAPPR TDTMDSMPSQ AWNGDEDLEP PYLPVHYSLS ESAVLDAIKS
1960 1970 1980 1990 2000
QPCRSHSAPG CVLPQDPMDP PALPPKPYHP RLPALEHDEG MLLREEAERP
2010 2020 2030
RGLHRKASLP PGSVKEEQAR LAWEHGRGEQ
Length:2,030
Mass (Da):233,278
Last modified:September 21, 2011 - v1
Checksum:iFCB25215D5857837
GO

Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q8CIQ7DOCK3_MOUSE
Dedicator of cytokinesis protein 3
Dock3 Moca
2,027Annotation score:
F6VMI1F6VMI1_MOUSE
Dedicator of cytokinesis protein 3
Dock3
552Annotation score:
F7CVM6F7CVM6_MOUSE
Dedicator of cytokinesis protein 3
Dock3
241Annotation score:
F6YXW9F6YXW9_MOUSE
Dedicator of cytokinesis protein 3
Dock3
241Annotation score:
F7AGL4F7AGL4_MOUSE
Dedicator of cytokinesis protein 3
Dock3
87Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC121608 Genomic DNA No translation available.
AC123065 Genomic DNA No translation available.
AC147636 Genomic DNA No translation available.
AL672070 Genomic DNA No translation available.
AL672208 Genomic DNA No translation available.
RefSeqiNP_700462.2, NM_153413.2
UniGeneiMm.150259

Genome annotation databases

EnsembliENSMUST00000044532; ENSMUSP00000047652; ENSMUSG00000039716
GeneIDi208869
KEGGimmu:208869
UCSCiuc009rkv.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC121608 Genomic DNA No translation available.
AC123065 Genomic DNA No translation available.
AC147636 Genomic DNA No translation available.
AL672070 Genomic DNA No translation available.
AL672208 Genomic DNA No translation available.
RefSeqiNP_700462.2, NM_153413.2
UniGeneiMm.150259

3D structure databases

SMRiF8VPQ1
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

MaxQBiF8VPQ1
PeptideAtlasiF8VPQ1
PRIDEiF8VPQ1

Protocols and materials databases

DNASUi208869
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000044532; ENSMUSP00000047652; ENSMUSG00000039716
GeneIDi208869
KEGGimmu:208869
UCSCiuc009rkv.1 mouse

Organism-specific databases

CTDi1795
MGIiMGI:2429763 Dock3

Phylogenomic databases

eggNOGiKOG1998 Eukaryota
ENOG410XQH7 LUCA
GeneTreeiENSGT00610000085806
KOiK05727
OMAiXQYETVV
OrthoDBiEOG091G00Q4
TreeFamiTF300423

Enzyme and pathway databases

ReactomeiR-MMU-983231 Factors involved in megakaryocyte development and platelet production

Miscellaneous databases

SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000039716 Expressed in 123 organ(s), highest expression level in cerebral cortex
ExpressionAtlasiF8VPQ1 baseline and differential
GenevisibleiF8VPQ1 MM

Family and domain databases

CDDicd08695 C2_Dock-B, 1 hit
cd12048 SH3_DOCK3_B, 1 hit
Gene3Di2.60.40.150, 1 hit
InterProiView protein in InterPro
IPR016024 ARM-type_fold
IPR037811 C2_Dock-B
IPR035892 C2_domain_sf
IPR027007 DHR-1_domain
IPR027357 DHR-2
IPR026791 DOCK
IPR026800 DOCK3
IPR035767 DOCK3_SH3
IPR010703 DOCK_C
IPR032376 DOCK_N
IPR036028 SH3-like_dom_sf
IPR001452 SH3_domain
PANTHERiPTHR23317 PTHR23317, 1 hit
PTHR23317:SF66 PTHR23317:SF66, 1 hit
PfamiView protein in Pfam
PF06920 DHR-2, 1 hit
PF14429 DOCK-C2, 1 hit
PF16172 DOCK_N, 1 hit
PF07653 SH3_2, 1 hit
SMARTiView protein in SMART
SM00326 SH3, 1 hit
SUPFAMiSSF48371 SSF48371, 1 hit
SSF50044 SSF50044, 1 hit
PROSITEiView protein in PROSITE
PS51650 DHR_1, 1 hit
PS51651 DHR_2, 1 hit
PS50002 SH3, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiF8VPQ1_MOUSE
AccessioniPrimary (citable) accession number: F8VPQ1
Entry historyiIntegrated into UniProtKB/TrEMBL: September 21, 2011
Last sequence update: September 21, 2011
Last modified: November 7, 2018
This is version 61 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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