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Protein
Submitted name:

Zinc finger CCCH type-containing 7B

Gene

Zc3h7b

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri485 – 509C3H1-typePROSITE-ProRule annotationAdd BLAST25
Zinc fingeri617 – 639C3H1-typePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri755 – 783C3H1-typePROSITE-ProRule annotationAdd BLAST29
Zinc fingeri887 – 915C3H1-typePROSITE-ProRule annotationAdd BLAST29

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

LigandMetal-binding, Zinc

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Zinc finger CCCH type-containing 7BImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Zc3h7bImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 15

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:1328310 Zc3h7b

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
F8VPP8

MaxQB - The MaxQuant DataBase

More...
MaxQBi
F8VPP8

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
F8VPP8

PeptideAtlas

More...
PeptideAtlasi
F8VPP8

PRoteomics IDEntifications database

More...
PRIDEi
F8VPP8

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000022390 Expressed in 242 organ(s), highest expression level in brain

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
F8VPP8 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000105181

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
F8VPP8

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
F8VPP8

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati36 – 69TPRPROSITE-ProRule annotationAdd BLAST34
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini82 – 149TPR_REGIONInterPro annotationAdd BLAST68
Repeati82 – 115TPRPROSITE-ProRule annotationAdd BLAST34
Domaini485 – 509C3H1-typeInterPro annotationAdd BLAST25
Domaini617 – 639C3H1-typeInterPro annotationAdd BLAST23
Domaini755 – 783C3H1-typeInterPro annotationAdd BLAST29
Domaini887 – 915C3H1-typeInterPro annotationAdd BLAST29

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili917 – 937Sequence analysisAdd BLAST21

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri485 – 509C3H1-typePROSITE-ProRule annotationAdd BLAST25
Zinc fingeri617 – 639C3H1-typePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri755 – 783C3H1-typePROSITE-ProRule annotationAdd BLAST29
Zinc fingeri887 – 915C3H1-typePROSITE-ProRule annotationAdd BLAST29

Keywords - Domaini

Coiled coilSequence analysis, TPR repeatPROSITE-ProRule annotation, Zinc-fingerPROSITE-ProRule annotationSAAS annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IN1T Eukaryota
ENOG410YBKB LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000018542

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
F8VPP8

Identification of Orthologs from Complete Genome Data

More...
OMAi
ACYSRIG

Database of Orthologous Groups

More...
OrthoDBi
369231at2759

TreeFam database of animal gene trees

More...
TreeFami
TF329017

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.25.40.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR013026 TPR-contain_dom
IPR011990 TPR-like_helical_dom_sf
IPR019734 TPR_repeat
IPR039691 ZC3H7A/B
IPR036236 Znf_C2H2_sf
IPR000571 Znf_CCCH
IPR036855 Znf_CCCH_sf

The PANTHER Classification System

More...
PANTHERi
PTHR14928 PTHR14928, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00642 zf-CCCH, 2 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00028 TPR, 2 hits
SM00356 ZnF_C3H1, 4 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48452 SSF48452, 1 hit
SSF57667 SSF57667, 1 hit
SSF90229 SSF90229, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50005 TPR, 2 hits
PS50293 TPR_REGION, 1 hit
PS50103 ZF_C3H1, 4 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

F8VPP8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MERQKRKADI EKGLQFIQST LPLKQEEYEA FLLKLVQNLF AEGNDLFREK
60 70 80 90 100
DYKQALVQYM EGLNVADYAA SDQVALPREL LCKLHVNRAA CYFTMGLYEK
110 120 130 140 150
ALEDSEKALG LDGESIRALF RKARALNELG RHKEAYECSS RCSLALPHDE
160 170 180 190 200
NVTQLGQELA QKLGLRVRKA YKRPQELETF SLLSNGAPAG LTDQGTSNGL
210 220 230 240 250
GSIDDIETDC YVDLRGSPAL LPSTPTMPLF PHVLDLLAPL DGSSRTLPGT
260 270 280 290 300
EGLDDFSDGD VFGPELDTLL DSLSLVQGGL PGSGMPSELP QLIPVFPGGT
310 320 330 340 350
PLLPPVVGGS IPVSSPLPPA SFGLVMDPSR KLAASVLDAL DSPGPTLDPL
360 370 380 390 400
DLLPYSEARL GALDSFGSAR GSLDKPDSFL EETSSQDHRP PSSTQKPAPS
410 420 430 440 450
PEPSMPNTTL LIKNPLAATH EFKQACQLCY PKTGPRAGDY TYREGLEHKC
460 470 480 490 500
RRDVLLGRLR SSENQIWKRI RPRPTKTSFV GSYYLCKDMI NKQDCKYGDN
510 520 530 540 550
CTFAYHQEEI DVWTEERKGT LNRDLLFDPL GGVKRGSLTI AKLLKEHQGI
560 570 580 590 600
FTFLCEICFD SKPRIISKGT KDSPSVCSNL AAKHSFYNNK CLVHIVRSTS
610 620 630 640 650
LKYSKIRQFQ EHFQFDVCRH EVRYGCLRED SCHFAHSFIE LKVWLLQQYS
660 670 680 690 700
GMTHEDIVQE SKKYWQQMEA HAGKASSGLG APRTHGPSTF DLQMKFVCGQ
710 720 730 740 750
CWRNGQVVEP DKDLKYCSAK ARHCWTKERR VLLVMSKAKR KWVSVRPLPS
760 770 780 790 800
IRNFPQQYDL CIHAQNGRKC QYVGNCSFAH SPEERDMWTF MKENKILDMQ
810 820 830 840 850
QTYDMWLKKH NPGKPGEGTP ISSREGEKQI QMPTDYADIM MGYHCWLCGK
860 870 880 890 900
NSNSKKQWQQ HIQSEKHKEK VFTSDSDASG WAYRFPMGEF RLCDRLQKGK
910 920 930 940 950
ACPDGDKCRC AHGQEELNEW LDRREVLKQK LAKARKDMLL CPRDDDFGKY
960 970 980
NFLLQEDGDT TGATPDAPVA ATATAATTTT GE
Length:982
Mass (Da):110,292
Last modified:September 21, 2011 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i2AC62EE9723179E7
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A2R8VHI0A0A2R8VHI0_MOUSE
Zinc finger CCCH type-containing 7B
Zc3h7b
151Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AC158970 Genomic DNA No translation available.

NCBI Reference Sequences

More...
RefSeqi
NP_001074485.1, NM_001081016.1
XP_017172009.1, XM_017316520.1

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Mm.432075

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000109554; ENSMUSP00000105181; ENSMUSG00000022390

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
20286

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:20286

UCSC genome browser

More...
UCSCi
uc007wxe.1 mouse

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC158970 Genomic DNA No translation available.
RefSeqiNP_001074485.1, NM_001081016.1
XP_017172009.1, XM_017316520.1
UniGeneiMm.432075

3D structure databases

ProteinModelPortaliF8VPP8
SMRiF8VPP8
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000105181

Proteomic databases

jPOSTiF8VPP8
MaxQBiF8VPP8
PaxDbiF8VPP8
PeptideAtlasiF8VPP8
PRIDEiF8VPP8

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
20286
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000109554; ENSMUSP00000105181; ENSMUSG00000022390
GeneIDi20286
KEGGimmu:20286
UCSCiuc007wxe.1 mouse

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
23264
MGIiMGI:1328310 Zc3h7b

Phylogenomic databases

eggNOGiENOG410IN1T Eukaryota
ENOG410YBKB LUCA
GeneTreeiENSGT00390000018542
InParanoidiF8VPP8
OMAiACYSRIG
OrthoDBi369231at2759
TreeFamiTF329017

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
Zc3h7b mouse

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000022390 Expressed in 242 organ(s), highest expression level in brain
GenevisibleiF8VPP8 MM

Family and domain databases

Gene3Di1.25.40.10, 1 hit
InterProiView protein in InterPro
IPR013026 TPR-contain_dom
IPR011990 TPR-like_helical_dom_sf
IPR019734 TPR_repeat
IPR039691 ZC3H7A/B
IPR036236 Znf_C2H2_sf
IPR000571 Znf_CCCH
IPR036855 Znf_CCCH_sf
PANTHERiPTHR14928 PTHR14928, 1 hit
PfamiView protein in Pfam
PF00642 zf-CCCH, 2 hits
SMARTiView protein in SMART
SM00028 TPR, 2 hits
SM00356 ZnF_C3H1, 4 hits
SUPFAMiSSF48452 SSF48452, 1 hit
SSF57667 SSF57667, 1 hit
SSF90229 SSF90229, 2 hits
PROSITEiView protein in PROSITE
PS50005 TPR, 2 hits
PS50293 TPR_REGION, 1 hit
PS50103 ZF_C3H1, 4 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiF8VPP8_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: F8VPP8
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: September 21, 2011
Last sequence update: September 21, 2011
Last modified: January 16, 2019
This is version 63 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
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